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Novel vaccination strategies [[electronic resource] /] / edited by Stefan H.E. Kaufmann
| Novel vaccination strategies [[electronic resource] /] / edited by Stefan H.E. Kaufmann |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2004 |
| Descrizione fisica | 1 online resource (672 p.) |
| Disciplina | 615.372 |
| Altri autori (Persone) | KaufmannS. H. E (Stefan H. E.) |
| Soggetto topico |
Vaccines
Vaccines - Synthesis Vacunes Vacunació Resposta immunitària |
| Soggetto genere / forma |
Electronic books.
Llibres electrònics |
| ISBN |
1-280-72268-1
9786610722686 3-527-60609-2 1-280-55857-1 9786610558575 3-527-60144-9 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Novel Vaccination Strategies; Contents; Novel Vaccination Strategies; Preface; Acknowledgements; List of Contributors; Colour Plates; Part I; 1 Challenges for the Vaccine Developer, including Correlates of Protection; 1.1 Introduction; 1.2 Mechanisms of Protection within the Immune System; 1.3 Protection against Viruses; 1.4 HIV/AIDS as an Example of a Persisting Virus; 1.5 Protection against Extracellular Bacteria; 1.6 Protection against Intracellular Bacteria; 1.7 Protection against Parasites; 1.8 Conclusions; References; Part II Vaccination and Immune Response
2 Shaping Adaptive Immunity against Pathogens: The Contribution of Innate Immune Responses2.1 Introduction; 2.2 Activation of Innate Immunity: Sensing the Enemy; 2.2.1 Pathogen-associated Molecular Patterns; 2.2.2 Host Cellular Sensors; 2.2.2.1 Dendritic Cells; 2.2.2.2 Mast Cells; 2.2.3 Nonpeptide MHC Ligands Triggering Invariant T-cell Receptors; 2.3 Translating Innate Immune Activation into Regulatory Circuits: Molecular Pathways Shaping Adaptive Immunity; 2.3.1 TLR-initiated Signaling Cascades; 2.3.2 Molecules Involved in Recruiting Effector Cells; 2.3.2.1 Defensins; 2.3.2.2 Chemokines 2.3.3 Molecules Involved in T and B Cell Differentiation2.3.3.1 Th1-inducing Cytokines; 2.3.3.2 Th2-inducing Cytokines; 2.4 Implications for Vaccine Development; References; 3 Adjuvant-induced Th2- and Th1-dominated Immune Responses in Vaccination; 3.1 Introduction; 3.2 The Two-Signal Model of Adjuvant-induced Immune Activation; 3.3 Th1 and Th2 Induction by Vaccine Adjuvants; 3.4 Antigen Dose Effects; 3.5 The Three-signal Model of Adjuvant-induced Immune Activation; 3.6 Th2 Induction by Adjuvants; 3.7 Differential Activation of DCs; 3.8 Inappropriate Th1/Th2 Responses to Vaccines 3.9 Human Th2 vaccines3.10 Human Th1 Vaccines; 3.11 Conclusion; References; 4 Memory; 4.1 Introduction; 4.2 Characteristics of Memory Cells; 4.3 CD8+ T Cell Memory; 4.3.1 Phenotyping Memory CD8+ T Cells; 4.3.2 Enhanced Responsiveness of Memory CD8(+) T cells: Potential Mechanisms; 4.3.3 Generation of Memory CD8+ T Cells; 4.3.4 Maintaining CD8+ T Cell Memory; 4.3.5 Models of CD8+ T cell Memory Generation; 4.4 CD4+ T Cell Memory; 4.4.1 Differentiation of Effector and Memory CD4+ T Cells; 4.4.2 Phenotype of Memory CD4+ T Cells; 4.4.3 Memory Generation and Maintenance 4.4.4 Trafficking of Memory CD4+ T Cells4.5 B cell Memory; 4.5.1 Generation of B Cell Memory; 4.5.2 Maintenance of B Cell Memory; 4.6 Conclusions; Acknowledgements; References; 5 T Cell-based Vaccines; Summary; 5.1 Introduction; 5.2 Ex-vivo Detection of Antigen-specific T Cells; 5.3 In-vivo Kinetics of Antigen-specific T Cell Responses; 5.4 Effector Function and Subtypes of Effector T Cells; 5.5 T Cell Receptor Repertoire, Avidity Maturation, and Epitope Competition; 5.6 Functional Heterogeneity of T Cell Memory; 5.7 Vaccination Strategies and Their Efficacy for T Cell-based Vaccination 5.8 Concluding Remarks |
| Record Nr. | UNINA-9910146240503321 |
| Weinheim, : Wiley-VCH, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Novel vaccination strategies [[electronic resource] /] / edited by Stefan H.E. Kaufmann
| Novel vaccination strategies [[electronic resource] /] / edited by Stefan H.E. Kaufmann |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2004 |
| Descrizione fisica | 1 online resource (672 p.) |
| Disciplina | 615.372 |
| Altri autori (Persone) | KaufmannS. H. E (Stefan H. E.) |
| Soggetto topico |
Vaccines
Vaccines - Synthesis Vacunes Vacunació Resposta immunitària |
| Soggetto genere / forma | Llibres electrònics |
| ISBN |
1-280-72268-1
9786610722686 3-527-60609-2 1-280-55857-1 9786610558575 3-527-60144-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Novel Vaccination Strategies; Contents; Novel Vaccination Strategies; Preface; Acknowledgements; List of Contributors; Colour Plates; Part I; 1 Challenges for the Vaccine Developer, including Correlates of Protection; 1.1 Introduction; 1.2 Mechanisms of Protection within the Immune System; 1.3 Protection against Viruses; 1.4 HIV/AIDS as an Example of a Persisting Virus; 1.5 Protection against Extracellular Bacteria; 1.6 Protection against Intracellular Bacteria; 1.7 Protection against Parasites; 1.8 Conclusions; References; Part II Vaccination and Immune Response
2 Shaping Adaptive Immunity against Pathogens: The Contribution of Innate Immune Responses2.1 Introduction; 2.2 Activation of Innate Immunity: Sensing the Enemy; 2.2.1 Pathogen-associated Molecular Patterns; 2.2.2 Host Cellular Sensors; 2.2.2.1 Dendritic Cells; 2.2.2.2 Mast Cells; 2.2.3 Nonpeptide MHC Ligands Triggering Invariant T-cell Receptors; 2.3 Translating Innate Immune Activation into Regulatory Circuits: Molecular Pathways Shaping Adaptive Immunity; 2.3.1 TLR-initiated Signaling Cascades; 2.3.2 Molecules Involved in Recruiting Effector Cells; 2.3.2.1 Defensins; 2.3.2.2 Chemokines 2.3.3 Molecules Involved in T and B Cell Differentiation2.3.3.1 Th1-inducing Cytokines; 2.3.3.2 Th2-inducing Cytokines; 2.4 Implications for Vaccine Development; References; 3 Adjuvant-induced Th2- and Th1-dominated Immune Responses in Vaccination; 3.1 Introduction; 3.2 The Two-Signal Model of Adjuvant-induced Immune Activation; 3.3 Th1 and Th2 Induction by Vaccine Adjuvants; 3.4 Antigen Dose Effects; 3.5 The Three-signal Model of Adjuvant-induced Immune Activation; 3.6 Th2 Induction by Adjuvants; 3.7 Differential Activation of DCs; 3.8 Inappropriate Th1/Th2 Responses to Vaccines 3.9 Human Th2 vaccines3.10 Human Th1 Vaccines; 3.11 Conclusion; References; 4 Memory; 4.1 Introduction; 4.2 Characteristics of Memory Cells; 4.3 CD8+ T Cell Memory; 4.3.1 Phenotyping Memory CD8+ T Cells; 4.3.2 Enhanced Responsiveness of Memory CD8(+) T cells: Potential Mechanisms; 4.3.3 Generation of Memory CD8+ T Cells; 4.3.4 Maintaining CD8+ T Cell Memory; 4.3.5 Models of CD8+ T cell Memory Generation; 4.4 CD4+ T Cell Memory; 4.4.1 Differentiation of Effector and Memory CD4+ T Cells; 4.4.2 Phenotype of Memory CD4+ T Cells; 4.4.3 Memory Generation and Maintenance 4.4.4 Trafficking of Memory CD4+ T Cells4.5 B cell Memory; 4.5.1 Generation of B Cell Memory; 4.5.2 Maintenance of B Cell Memory; 4.6 Conclusions; Acknowledgements; References; 5 T Cell-based Vaccines; Summary; 5.1 Introduction; 5.2 Ex-vivo Detection of Antigen-specific T Cells; 5.3 In-vivo Kinetics of Antigen-specific T Cell Responses; 5.4 Effector Function and Subtypes of Effector T Cells; 5.5 T Cell Receptor Repertoire, Avidity Maturation, and Epitope Competition; 5.6 Functional Heterogeneity of T Cell Memory; 5.7 Vaccination Strategies and Their Efficacy for T Cell-based Vaccination 5.8 Concluding Remarks |
| Record Nr. | UNINA-9910830702203321 |
| Weinheim, : Wiley-VCH, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Novel vaccination strategies / / edited by Stefan H.E. Kaufmann
| Novel vaccination strategies / / edited by Stefan H.E. Kaufmann |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2004 |
| Descrizione fisica | 1 online resource (672 p.) |
| Disciplina | 615.372 |
| Soggetto topico |
Vaccines
Vaccines - Synthesis Vacunes Vacunació Resposta immunitària |
| Soggetto genere / forma | Llibres electrònics |
| ISBN |
9786610722686
9786610558575 9781280722684 1280722681 9783527606092 3527606092 9781280558573 1280558571 9783527601448 3527601449 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Novel Vaccination Strategies; Contents; Novel Vaccination Strategies; Preface; Acknowledgements; List of Contributors; Colour Plates; Part I; 1 Challenges for the Vaccine Developer, including Correlates of Protection; 1.1 Introduction; 1.2 Mechanisms of Protection within the Immune System; 1.3 Protection against Viruses; 1.4 HIV/AIDS as an Example of a Persisting Virus; 1.5 Protection against Extracellular Bacteria; 1.6 Protection against Intracellular Bacteria; 1.7 Protection against Parasites; 1.8 Conclusions; References; Part II Vaccination and Immune Response
2 Shaping Adaptive Immunity against Pathogens: The Contribution of Innate Immune Responses2.1 Introduction; 2.2 Activation of Innate Immunity: Sensing the Enemy; 2.2.1 Pathogen-associated Molecular Patterns; 2.2.2 Host Cellular Sensors; 2.2.2.1 Dendritic Cells; 2.2.2.2 Mast Cells; 2.2.3 Nonpeptide MHC Ligands Triggering Invariant T-cell Receptors; 2.3 Translating Innate Immune Activation into Regulatory Circuits: Molecular Pathways Shaping Adaptive Immunity; 2.3.1 TLR-initiated Signaling Cascades; 2.3.2 Molecules Involved in Recruiting Effector Cells; 2.3.2.1 Defensins; 2.3.2.2 Chemokines 2.3.3 Molecules Involved in T and B Cell Differentiation2.3.3.1 Th1-inducing Cytokines; 2.3.3.2 Th2-inducing Cytokines; 2.4 Implications for Vaccine Development; References; 3 Adjuvant-induced Th2- and Th1-dominated Immune Responses in Vaccination; 3.1 Introduction; 3.2 The Two-Signal Model of Adjuvant-induced Immune Activation; 3.3 Th1 and Th2 Induction by Vaccine Adjuvants; 3.4 Antigen Dose Effects; 3.5 The Three-signal Model of Adjuvant-induced Immune Activation; 3.6 Th2 Induction by Adjuvants; 3.7 Differential Activation of DCs; 3.8 Inappropriate Th1/Th2 Responses to Vaccines 3.9 Human Th2 vaccines3.10 Human Th1 Vaccines; 3.11 Conclusion; References; 4 Memory; 4.1 Introduction; 4.2 Characteristics of Memory Cells; 4.3 CD8+ T Cell Memory; 4.3.1 Phenotyping Memory CD8+ T Cells; 4.3.2 Enhanced Responsiveness of Memory CD8(+) T cells: Potential Mechanisms; 4.3.3 Generation of Memory CD8+ T Cells; 4.3.4 Maintaining CD8+ T Cell Memory; 4.3.5 Models of CD8+ T cell Memory Generation; 4.4 CD4+ T Cell Memory; 4.4.1 Differentiation of Effector and Memory CD4+ T Cells; 4.4.2 Phenotype of Memory CD4+ T Cells; 4.4.3 Memory Generation and Maintenance 4.4.4 Trafficking of Memory CD4+ T Cells4.5 B cell Memory; 4.5.1 Generation of B Cell Memory; 4.5.2 Maintenance of B Cell Memory; 4.6 Conclusions; Acknowledgements; References; 5 T Cell-based Vaccines; Summary; 5.1 Introduction; 5.2 Ex-vivo Detection of Antigen-specific T Cells; 5.3 In-vivo Kinetics of Antigen-specific T Cell Responses; 5.4 Effector Function and Subtypes of Effector T Cells; 5.5 T Cell Receptor Repertoire, Avidity Maturation, and Epitope Competition; 5.6 Functional Heterogeneity of T Cell Memory; 5.7 Vaccination Strategies and Their Efficacy for T Cell-based Vaccination 5.8 Concluding Remarks |
| Record Nr. | UNINA-9911019996603321 |
| Weinheim, : Wiley-VCH, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
- Resposta immunitària (3)
- Vaccines (3)
-
Vaccines - Synthesis
(3)
- Vacunació (3)
- Vacunes (3)