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Diseases of importance in developing countries [[electronic resource] ] : establishing priorities / / by the Committee on Issues and Priorities for New Vaccine Development, Division of Health Promotion and Disease Prevention, Institute of Medicine
| Diseases of importance in developing countries [[electronic resource] ] : establishing priorities / / by the Committee on Issues and Priorities for New Vaccine Development, Division of Health Promotion and Disease Prevention, Institute of Medicine |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1986 |
| Descrizione fisica | 1 online resource (448 p.) |
| Collana | New vaccine development |
| Soggetto topico |
Vaccination - Developing countries
Vaccination - United States Vaccines - Research - Government policy |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-22176-3
9786610221769 0-309-56820-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910456440603321 |
| Washington, D.C., : National Academy Press, 1986 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Diseases of importance in developing countries : establishing priorities / / by the Committee on Issues and Priorities for New Vaccine Development, Division of Health Promotion and Disease Prevention, Institute of Medicine
| Diseases of importance in developing countries : establishing priorities / / by the Committee on Issues and Priorities for New Vaccine Development, Division of Health Promotion and Disease Prevention, Institute of Medicine |
| Pubbl/distr/stampa | Washington, D.C. : , : National Academy Press, , 1986 |
| Descrizione fisica | 1 online resource (xvi, 432 pages) |
| Collana | New vaccine development |
| Soggetto topico |
Vaccination - Developing countries
Vaccination - United States Vaccines - Research - Government policy |
| ISBN |
1-280-22176-3
9786610221769 0-309-56820-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910780010703321 |
| Washington, D.C. : , : National Academy Press, , 1986 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Diseases of importance in developing countries : establishing priorities / / by the Committee on Issues and Priorities for New Vaccine Development, Division of Health Promotion and Disease Prevention, Institute of Medicine
| Diseases of importance in developing countries : establishing priorities / / by the Committee on Issues and Priorities for New Vaccine Development, Division of Health Promotion and Disease Prevention, Institute of Medicine |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1986 |
| Descrizione fisica | 1 online resource (xvi, 432 pages) |
| Disciplina | 614.4 |
| Collana | New vaccine development |
| Soggetto topico |
Vaccination - Developing countries
Vaccination - United States Vaccines - Research - Government policy |
| ISBN |
9786610221769
9781280221767 1280221763 9780309568203 030956820X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
New Vaccine Development Establishing Priorities -- Copyright -- Acknowledgements -- Preface -- Abstract -- Contents -- Summary -- SELECTION OF CANDIDATES -- DETERMINATION OF HEALTH BENEFITS -- Disease Burden Estimates -- Infant Mortality Equivalence Values -- Total Disease Burden Values -- VACCINE CHARACTERISTICS -- Predictions of Vaccine Development -- Definition of Probable Vaccine Target Population -- Treatment of Vaccine Utilization -- Estimation of Time to Licensure, Time to Vaccine Adoption, and Delay of Vaccination Benefits: Discou... -- Estimation of Vaccine Preventable Illness -- Calculation of Potential Health Benefits for Each Vaccine -- Cost Calculations -- INTERPRETATION OF RESULTS -- FINDINGS, CONCLUSIONS, RECOMMENDATIONS -- REFERENCE -- 2 Priority Setting for Health-Related Investments: A Review of Methods -- METHODS FOR PROJECT RANKING AND SELECTION -- MULTIATTRIBUTE ACCOUNTING -- MULTIATTRIBUTE SCORING -- DECISION ANALYSIS WITH MULTIPLE OBJECTIVES -- COST-EFFECTIVENESS AND COST-UTILITY ANALYSIS -- BENEFIT-COST ANALYSIS -- SELECTION OF AN APPROACH -- ISSUES IN PROJECT RANKING METHODOLOGIES -- Sources of Estimates -- Sequential or "Lexicographic" Methods -- Interdependence Among Projects -- The "Portfolio" Question -- SUMMARY -- REFERENCES -- 3 Overview of the Analytic Approach -- METHOD -- Calculation Procedures -- INTERPRETATION OF RESULTS -- GUIDELINES -- Step 1 -- Step 2 -- SUMMARY -- REFERENCE -- 4 Comparison of Disease Burdens -- ELEMENTS OF THE SYSTEM FOR COMPARING MORBIDITY AND MORTALITY BURDENS ARISING FROM VARIOUS DISEASES -- Trade-Off Values -- Expression of Morbidity and Mortality Burdens -- Procedures Used in Deriving Disease Estimates -- Limitations of the Current Estimates -- VALUE JUDGMENTS IN QUANTIFYING MORBIDITY AND MORTALITY -- IME Perspective Used in This Study -- The Effect of Adopting Other IME Perspectives.
COMPARISON OF COSTS ASSOCIATED WITH DISEASES -- Estimating Aggregate Direct Costs of Diseases in the Developing World -- Estimating Costs for Diseases in Specific Countries or Regions -- Indirect Costs -- FINDINGS -- LIMITATIONS OF THE PROPOSED SYSTEM -- SUMMARY AND CONCLUSIONS -- RECOMMENDATIONS -- REFERENCES -- 5 Predictions on Vaccine Development -- THE NEED FOR PREDICTIONS -- SELECTION OF CANDIDATES -- VACCINE CANDIDATES AND TARGET POPULATIONS -- PREDICTIONS ON VACCINE DEVELOPMENT -- Probability of Successful Development -- Cost of Development -- Time to Licensure -- PREDICTIONS ON VACCINE CHARACTERISTICS -- Efficacy -- Adverse Reactions -- Production Technology, Delivery Requirements, and Cost per Dose -- Number of Doses and Route of Administration -- CONCLUSIONS -- REFERENCE -- 6 Assessing the Likely Utilization of New Vaccines -- VACCINE AVAILABILITY -- VACCINE UTILIZATION -- Prediction of Utilization in Defined Populations -- Utilization of Vaccines in the Developing World -- SUMMARY -- REFERENCES -- 7 Calculation and Comparison of the Health Benefits and Differential Costs Associated with Candidat... -- PROCEDURES -- Vaccine Characteristics -- Target Population -- Vaccine Preventable Illness -- Trends in Disease Burden and Population Numbers -- Adverse Reactions -- The Times for Occurrence of Vaccine-Associated Health Benefits and Cost Savings -- Time to Licensure -- Time to Adoption and Steady-State Yield of Benefits -- Costs -- THE TREATMENT OF VACCINE IMPROVEMENT PROJECTS -- RESULTS -- Health Benefits -- An Illustration of the Process -- Costs -- REFERENCES -- 8 Additional Issues in the Selection of Priorities for Accelerated Vaccine Development -- EQUITY CONSIDERATIONS IN CALCULATING DISEASE BURDENS AND VACCINE BENEFITS -- Age-Related Weights -- Effect of Infant Mortality on Fertility Control -- Lives Versus Cases Versus Days. The Aggregate Nature of the Disease Burden Calculations -- The Portfolio Approach for Ranking Vaccines for Research and Development Support -- INTERDEPENDENCE OF VACCINE DEVELOPMENT EFFORTS -- INTERDEPENDENCE OF IMMUNIZATION EFFORTS -- INDUSTRY INTEREST AND ACTIVITY: THE RESPECTIVE ROLES OF THE PUBLIC AND PRIVATE SECTORS -- INTEREST IN OTHER COUNTRIES OR INTERNATIONAL ORGANIZATIONS -- OTHER DIEASE CHARACTERSTICS RELEVANT TO ESTABLISHING PRIORITIES -- Alternative Disease Control Measures -- Epidemiologic and Clinical Features -- Potential for Disease Eradication -- Interaction with Other Diseases -- FINDINGS, CONCLUSIONS, AND RECOMMENDATIONS -- REFERENCES -- 9 Findings, Conclusions, and Recommendations -- The Central Analysis -- FINDINGS -- Disease Burden Assumptions -- Target Population and Assumptions on Vaccine Preventable Illness -- Discount Rate -- Alternative Development Scenario: Probability of Success -- Assessing the Effect of Differential Utilization -- CONCLUSIONS -- DISCUSSION -- RECOMMENDATIONS -- REFERENCE -- Appendix A Selection of Vaccine Candidates for Accelerated Development -- JUDGING THE FEASIBILITY OF ACCELERATED VACCINE DEVELOPMENT -- ACCELERATED VACCINE DEVELOPMENT AND BASIC RESEARCH PRIORITIES -- SELECTING CANDIDATES FOR ACCELERATED DEVELOPMENT -- REFERENCE -- Appendix B The Burden of Disease Resulting from Acute Respiratory Illness -- UNCERTAINTY IN THE DISEASE BURDEN ESTIMATES -- REFERENCES -- Appendix C The Burden of Disease Resulting from Diarrhea -- MODIFICATION OF DISEASE BURDENS BY APPLICATION OF CURRENTLY AVAILABLE REMEDIES -- SECOND-ORDER EFFECTS OF DISEASES -- UNCERTAINTY IN THE DISEASE BURDEN ESTIMATES -- REFERENCES -- Appendix D-1 The Prospects for Immunizing Against Dengue Virus -- DISEASE DESCRIPTION -- Limitations of Existing Vaccines -- PATHOGEN DESCRIPTION -- HOST IMMUNE RESPONSE -- DISTRIBUTION OF DISEASE. Geographic Distribution -- Disease Burden Estimates -- PROBABLE VACCINE TARGET POPULATION -- Vaccine Preventable Illness* -- SUITABILITY FOR VACCINE CONTROL -- Alternative Control Measures and Treatments -- PROSPECTS FOR VACCINE DEVELOPMENT -- REFERENCES -- Appendix D-2 The Prospects for Immunizing Against Escherichia coli -- DISEASE DESCRIPTION -- PATHOGEN DESCRIPTION -- HOST IMMUNE RESPONSE -- DISTRIBUTION OF DISEASE -- Geographic Distribution of Disease -- Disease Burden Estimates -- PROBABLE VACCINE TARGET POPULATION -- Vaccine Preventable Illness* -- SUITABILITY FOR VACCINE CONTROL -- Alternative Control Measures and Treatments -- PROSPECTS FOR VACCINE DEVELOPMENT -- REFERENCES -- Appendix D-3 The Prospects for Immunizing Against Hemophilus influenzae Type b -- DISEASE DESCRIPTION -- PATHOGEN DESCRIPTION -- HOST IMMUNE RESPONSE -- DISTRIBUTION OF DISEASE -- Geographic Distribution -- Disease Burden Estimates -- PROBABLE VACCINE TARGET POPULATION -- Vaccine Preventable Illness* -- SUITABILITY FOR VACCINE CONTROL -- Alternative Control Measures and Treatments -- PROSPECTS FOR VACCINE DEVELOPMENT -- REFERENCES -- Appendix D-4 The Prospects for Immunizing Against Hepatitis A Virus -- DISEASE DESCRIPTION -- PATHOGEN DESCRIPTION -- HOST IMMUNE RESPONSE -- DISTRIBUTION OF DISEASE -- Geographic Distribution -- Disease Burden Estimates -- PROBABLE VACCINE TARGET POPULATION -- Vaccine Preventable Illness* -- SUITABILITY FOR VACCINE CONTROL -- Alternative Control Measures and Treatments -- PROSPECTS FOR VACCINE DEVELOPMENT -- REFERENCES -- Appendix D-5 The Prospects for Immunizing Against Hepatitis B Virus -- DISEASE DESCRIPTION -- PATHOGEN DESCRIPTION -- HOST IMMUNE RESPONSE -- DISTRIBUTION OF DISEASE -- Geographic Distribution -- Disease Burden Estimates -- Acute Hepatitis B -- Primary Hepatocellular Carcinoma -- Cirrhosis. PROBABLE VACCINE TARGET POPULATION -- Vaccine Preventable Illness* -- SUITABILITY FOR VACCINE CONTROL -- Alternative Control Measures and Treatment -- PROSPECTS FOR VACCINE DEVELOPMENT -- REFERENCES -- Appendix D-6 The Prospects for Immunizing Against Japanese Encephalitis Virus -- DISEASE DESCRIPTION -- Existing Vaccines and Limitations -- PATHOGEN DESCRIPTION -- HOST IMMUNE RESPONSE -- DISTRIBUTION OF DISEASE -- Geographic Distribution -- Disease Burden Estimates -- PROBABLE VACCINE TARGET POPULATION -- Vaccine Preventable Illness* -- SUITABILITY FOR VACCINE CONTROL -- Alternative Control Measures and Treatments -- PROSPECTS FOR VACCINE DEVELOPMENT -- Status of Existing Vaccines -- Formalin-Inactivated Mouse Brain Vaccine -- Formalin-Inactivated Cell Culture Vaccine -- Live Attenuated Vaccine -- Potential for New Vaccines -- REFERENCES -- Appendix D-7 The Prospects for Immunizing Against Mycobacterium leprae -- DISEASE DESCRIPTION -- PATHOGEN DESCRIPTION -- HOST IMMUNE RESPONSE -- DISTRIBUTION OF DISEASE -- Geographic Distribution -- Disease Burden Estimates -- PROBABLE VACCINE TARGET POPULATION -- Vaccine Preventable Illness* -- SUITABILITY FOR VACCINE CONTROL -- Alternative Control Measures and Treatments -- PROSPECTS FOR VACCINE DEVELOPMENT -- Problems to be Overcome -- REFERENCES -- Appendix D-8 The Prospects for Immunizing Against Neisseria meningitidis -- DISEASE DESCRIPTION -- Previous Efforts at Vaccination -- PATHOGEN DESCRIPTION -- HOST IMMUNE RESPONSE -- DISTRIBUTION OF DISEASE -- Geographic Distribution -- Disease Burden Estimates -- Epidemic Meningococcal Meningitis -- Endemic Meningococcal Meningitis -- Uncertainty in the Disease Burden Estimates -- PROBABLE VACCINE TARGET POPULATION -- Vaccine Preventable Illness* -- SUITABILITY FOR VACCINE CONTROL -- Alternative Control Measures and Treatments -- PROSPECTS FOR VACCINE DEVELOPMENT. Potential New Vaccines. |
| Record Nr. | UNINA-9910958367603321 |
| Washington, D.C., : National Academy Press, 1986 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Diseases of importance in the United States [[electronic resource] /] / by the Committee on Issues and Priorities for New Vaccine Development, Division of Health Promotion and Disease Prevention, Institute of Medicine
| Diseases of importance in the United States [[electronic resource] /] / by the Committee on Issues and Priorities for New Vaccine Development, Division of Health Promotion and Disease Prevention, Institute of Medicine |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1985 |
| Descrizione fisica | 1 online resource (472 p.) |
| Disciplina | 614.4/7/0973 |
| Collana | New vaccine development : establishing priorities |
| Soggetto topico |
Vaccines - Research - Government policy
Vaccination - United States Vaccination - Developing countries |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-30039-X
9786611300395 0-309-11575-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
""Title""; ""Copyright""; ""Acknowledgments""; ""Preface""; ""Abstract""; ""Contents""; ""1 Summary""; ""Selection of Candidates""; ""Determination of Health Benefits""; ""Disease Burden Estimates""; ""Infant Mortality Equivalence Values""; ""Total Disease Burden Values""; ""Vaccine Characteristics""; ""Predictions of Vaccine Development""; ""Definition of Probable Vaccine Target Population""; ""Estimation of Vaccine Utilization""; ""Estimation of Time to Licensure, Time to vaccine Adoption, and Delay of Vaccination Benefits: Discounting""; ""Estimation of vaccine Preventable Illness""
""Calculation of Expected Health Benefits for Each Vaccine""""Cost Calculations""; ""Calculation of Morbidity Costs Averted by the Vaccine""; ""Vaccination Program Costs""; ""Integration of Costs""; ""Interpretation of Health Benefit and Net Cost Rankings""; ""Findings, Conclusions, Recommendations""; ""Recommendation""; ""Reference""; ""2 Priority Setting for Health Related Investments: A Review of Methods""; ""Methods for Project Ranking and Selection""; ""Multiattribute Accounting""; ""Multiattribute Scoring""; ""Decision Analysis With Multiple Objectives"" ""Cost-Effectiveness and Cost-Utility Analysis""""Benefit-Cost Analysis""; ""Selection of an Approach""; ""Issues in Project Ranking Methodologies""; ""Sources of Estimates""; ""Sequential or “Lexicographic� Methods""; ""Interdependence Among Projects""; ""The “Portfolio� Question""; ""Summary""; ""References""; ""3 Overview of the Analytic Approach""; ""Method""; ""Interpretation of Results""; ""Guidelines""; ""Definition of Dominance""; ""Step 1""; ""Step 2""; ""Step 3""; ""Step 4""; ""Summary""; ""4 Comparison of Disease Burdens and Costs"" ""Elements of the System for Comparing Morbidity and Mortality Burdens Arising From various Diseases""""Trade-Off Values""; ""Expression of Morbidity and Mortality Burdens""; ""Procedures Used in Deriving Disease Estimates""; ""Limitations of the Current Estimates""; ""Value Judgments in Quantifying Morbidity and Mortality""; ""IME Perspectives used in This Study""; ""The Effect of Adopting Other IME Perspectives""; ""Comparison of Direct Costs Resulting from Diseases""; ""Scope of Cost Calculations""; ""Procedures""; ""Findings""; ""Limitations of the Proposed System"" ""Summary and Conclusions""""Recommendations""; ""References""; ""5 Predictions on Vaccine Development""; ""The Need for Predictions""; ""Selection of Candidates""; ""Vaccine Candidates and Target Populations""; ""Predictions on Vaccine Development""; ""Probability of Successful Development""; ""Cost of Development""; ""Time to Licensure""; ""Comments""; ""Predictions on Vaccine Characteristics""; ""Efficacy""; ""Adverse Reactions""; ""Production Technology, Delivery Requirements, and Cost/Dose""; ""Number of Doses and Route of Administration""; ""Conclusions"" ""6 Assessing the Likely Utilization of New Vaccines"" |
| Record Nr. | UNINA-9910456246503321 |
| Washington, D.C., : National Academy Press, 1985 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Diseases of importance in the United States / / by the Committee on Issues and Priorities for New Vaccine Development, Division of Health Promotion and Disease Prevention, Institute of Medicine
| Diseases of importance in the United States / / by the Committee on Issues and Priorities for New Vaccine Development, Division of Health Promotion and Disease Prevention, Institute of Medicine |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1985 |
| Descrizione fisica | 1 online resource (472 pages) |
| Disciplina | 614.4/7/0973 |
| Collana | New vaccine development : establishing priorities |
| Soggetto topico |
Vaccines - Research - Government policy
Vaccination - United States Vaccination - Developing countries |
| ISBN |
1-281-30039-X
9786611300395 0-309-11575-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
""Title""; ""Copyright""; ""Acknowledgments""; ""Preface""; ""Abstract""; ""Contents""; ""1 Summary""; ""Selection of Candidates""; ""Determination of Health Benefits""; ""Disease Burden Estimates""; ""Infant Mortality Equivalence Values""; ""Total Disease Burden Values""; ""Vaccine Characteristics""; ""Predictions of Vaccine Development""; ""Definition of Probable Vaccine Target Population""; ""Estimation of Vaccine Utilization""; ""Estimation of Time to Licensure, Time to vaccine Adoption, and Delay of Vaccination Benefits: Discounting""; ""Estimation of vaccine Preventable Illness""
""Calculation of Expected Health Benefits for Each Vaccine"" ""Cost Calculations""; ""Calculation of Morbidity Costs Averted by the Vaccine""; ""Vaccination Program Costs""; ""Integration of Costs""; ""Interpretation of Health Benefit and Net Cost Rankings""; ""Findings, Conclusions, Recommendations""; ""Recommendation""; ""Reference""; ""2 Priority Setting for Health Related Investments: A Review of Methods""; ""Methods for Project Ranking and Selection""; ""Multiattribute Accounting""; ""Multiattribute Scoring""; ""Decision Analysis With Multiple Objectives"" ""Cost-Effectiveness and Cost-Utility Analysis"" ""Benefit-Cost Analysis""; ""Selection of an Approach""; ""Issues in Project Ranking Methodologies""; ""Sources of Estimates""; ""Sequential or 'Lexicographic' Methods""; ""Interdependence Among Projects""; ""The 'Portfolio' Question""; ""Summary""; ""References""; ""3 Overview of the Analytic Approach""; ""Method""; ""Interpretation of Results""; ""Guidelines""; ""Definition of Dominance""; ""Step 1""; ""Step 2""; ""Step 3""; ""Step 4""; ""Summary""; ""4 Comparison of Disease Burdens and Costs"" ""Elements of the System for Comparing Morbidity and Mortality Burdens Arising From various Diseases"" ""Trade-Off Values""; ""Expression of Morbidity and Mortality Burdens""; ""Procedures Used in Deriving Disease Estimates""; ""Limitations of the Current Estimates""; ""Value Judgments in Quantifying Morbidity and Mortality""; ""IME Perspectives used in This Study""; ""The Effect of Adopting Other IME Perspectives""; ""Comparison of Direct Costs Resulting from Diseases""; ""Scope of Cost Calculations""; ""Procedures""; ""Findings""; ""Limitations of the Proposed System"" ""Summary and Conclusions"" ""Recommendations""; ""References""; ""5 Predictions on Vaccine Development""; ""The Need for Predictions""; ""Selection of Candidates""; ""Vaccine Candidates and Target Populations""; ""Predictions on Vaccine Development""; ""Probability of Successful Development""; ""Cost of Development""; ""Time to Licensure""; ""Comments""; ""Predictions on Vaccine Characteristics""; ""Efficacy""; ""Adverse Reactions""; ""Production Technology, Delivery Requirements, and Cost/Dose""; ""Number of Doses and Route of Administration""; ""Conclusions""; ""6 Assessing the Likely Utilization of New Vaccines"" |
| Record Nr. | UNINA-9910780901103321 |
| Washington, D.C., : National Academy Press, 1985 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
