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Atlas of dermatologic diseases in solid organ transplant recipients / / Jane Tomimori [and three others], editors
| Atlas of dermatologic diseases in solid organ transplant recipients / / Jane Tomimori [and three others], editors |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2022] |
| Descrizione fisica | 1 online resource (445 pages) |
| Disciplina | 616.5 |
| Soggetto topico |
Dermatology
Skin - Diseases Malalties de la pell Empelts de teixits Trasplantament d'òrgans Rebuig (Biologia) |
| Soggetto genere / forma |
Atles (Científic)
Llibres electrònics |
| ISBN | 3-031-13335-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910631094103321 |
| Cham, Switzerland : , : Springer, , [2022] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Challenges in pediatric kidney transplantation : a practical guide / / edited by Katherine E. Twombley
| Challenges in pediatric kidney transplantation : a practical guide / / edited by Katherine E. Twombley |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (429 pages) |
| Disciplina | 617.9540083 |
| Soggetto topico |
Pediatric nephrology
Kidneys - Transplantation Transplantation of organs, tissues, etc. in children Trasplantament renal Nefrologia pediàtrica Trasplantament d'òrgans |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-74783-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Contents -- Contributors -- Part I: Immunologic Challenges -- 1: Immunologic Challenges Pre-transplant -- Introduction -- What Is Human Leukocyte Antigen (HLA)? -- Pre-transplant -- How Does Sensitization Occur? -- Why Is HLA Compatibility Important? -- Epitope Mismatch -- How Are HLA Antibodies Detected and HLA Matching Performed? -- Antibody Detection -- Cell-Based Assays -- Solid-Phase Assays -- Is Median Fluorescent Intensity (MFI) Signal a Surrogate Measure of the Level of HLA Antibody? -- Peri-transplant -- The Virtual Crossmatch (vXM) in Transplantation -- Unexpected Crossmatch Scenarios -- Clinical Scenarios and Interpretation of Crossmatch Results in Kidney Transplantation -- Conclusion -- Questions and Answers with Explanation -- References -- 2: Challenges in Post-transplant Immunologic Monitoring -- Challenges in Post-transplant Immunologic Monitoring -- Conventional Monitoring Post-Transplant -- Serum Creatinine (Graft Function) -- Drug Monitoring and Variability -- Surveillance Monitoring of Donor-Specific Antibodies -- Non-HLA Antibodies -- Surveillance Biopsies (SBs) -- Innovative Biomarkers for Immunologic Monitoring Post-transplant -- Donor-Derived Cell-Free DNA (dd-cfDNA) -- Urinary Biomarkers -- Molecular Diagnostics -- The Future of Post-transplant Immune Monitoring -- Q& -- A -- Bibliography -- 3: Rejection Challenges: Diagnosis and Management -- A Brief History of Rejection -- An Evolving Paradigm of Rejection: From Discreet Episodic Events to a Fluctuating Continuum of Immune Alloreactivity -- Pathophysiology of Alloimmune Activation and Downstream Processes -- T Cell Development and Activation -- T Cell Migration and Mechanisms of Injury in T Cell-Mediated Rejection with the Allograft -- B Cell Development and Activation -- Alloantibodies and Antibody-Mediated Rejection -- Alloimmune Chronicity.
Detecting Rejection and Monitoring Its Course -- Clinical Monitoring and Biopsy Indication -- Surveillance Biopsies -- Follow-Up Biopsies -- Biomarkers for Rejection -- Gene Expression Signatures -- Chemokines -- Metabolomics -- Cell-Free DNA -- Predisposing Risk Factors for Rejection -- Recipient-Related Risks -- Donor-Recipient Interface -- Donor-Related Risks -- Silent Sensitization -- HLA Mismatch -- Post-transplant Factors -- Hyperacute Rejection -- Acute T Cell-Mediated Rejection (TCMR) -- Clinical and Histological Features -- Treatment of TCMR -- Corticosteroids -- Lymphocyte-Depleting Therapies -- Late Acute TCMR -- B Cell-Rich and Plasma Cell-Rich Acute Rejection -- B Cell-Rich Rejection -- Plasma Cell-Rich Acute Rejection -- Active Antibody-Mediated Rejection (AMR) -- Clinical and Histological Features -- Treatment of AMR -- Plasmapheresis and IVIG -- Rituximab -- Bortezomib -- Emerging Treatments -- Response to Treatment -- Chronic Active TCMR -- Clinical and Histological Features -- Management -- Chronic Active AMR -- Clinical and Histological Features -- Management -- Emerging Therapies -- Post Rejection Infection Prophylaxis -- Special Circumstances: Infection and Rejection -- AGPN and Rejection -- BK Virus and Rejection -- Case Studies -- References -- Part II: Infectious Challenges -- 4: Pretransplant Donor and Recipient Infectious Challenges -- Pretransplant Infectious Disease Evaluation -- Evaluation of the Pediatric Kidney Transplant Candidate -- HIV and Hepatitis Viruses -- Cytomegalovirus/Epstein-Barr Virus Serostatus of Donor and Recipient -- Cytomegalovirus -- Epstein-Barr Virus -- Mycobacterium tuberculosis -- Fungal Infections and Endemic Mycoses -- Parasitic Infections -- COVID-19 -- Urinary Tract Infections -- PHS Increased Risk Donors -- Window Period Duration and the Risk of Virus Transmission. Outcomes of PHS Increased Risk Donors in Pediatric Kidney Transplantation -- Informed Consent -- Posttransplant Testing -- Immunizations -- Preparing the Dialysis Patient for Transplantation -- Vaccine Schedule: Current American Academy of Pediatrics Recommendations -- Summary of recommendations with end stage kidney disease, including transplant candidates [62-64] -- Hepatitis B -- Influenza Vaccine -- Pneumococcal Vaccine [68, 69] -- Special Situations [70, 71] -- Household/Live Donor Vaccination -- Live Vaccines -- Varicella Vaccine -- Measles-Mumps-Rubella Vaccine -- Recombinant and Inactivated ("Killed") Vaccines -- DTaP/Tdap/dT Vaccine -- Poliovirus Vaccine -- Haemophilus Influenzae Type B Vaccine -- Hepatitis A Vaccine -- Hepatitis B Vaccine -- Meningococcal Vaccine -- Human Papillomavirus -- Updating Immunizations for the Dialysis Patient Awaiting Transplant -- Questions -- References -- 5: Post-transplant Recipient Infectious Challenges -- Introduction -- Opportunistic Post-Kidney Transplant Infections (CMV, EBV, and BK Virus and PJP) -- Cytomegalovirus (CMV) -- Risk Factors -- Clinical Presentation -- Screening -- Prophylaxis and Preemptive Therapy -- Treatment -- BK Virus -- Risk Factors -- Clinical Presentation -- Screening -- Treatment -- Epstein-Barr Virus -- Risk Factors -- Clinical Presentation -- Screening -- Treatment -- Pneumocystis jirovecii pneumonia (PJP) -- Resurgent Viral Infection Outbreaks: Measles and Mumps -- Cancer Risks -- Cancer Incidence -- Cancer Risk Factors -- Immunosuppression Burden -- EBV Recipient-Donor Sero-Mismatch -- Time Since Transplant -- HLA Haplotypes -- Pre-transplant Malignancy -- Age -- Gender -- Race -- Donor Source -- Recombinant Growth Hormone (rGH) Use -- Cancer Prevention Strategies -- Cancer Treatment -- Cancer Outcomes -- Urinary Tract Infections (UTI) -- Prevalence -- Risk Factors. Prevention -- Treatment -- Asymptomatic Bacteriuria -- Outcomes -- MOC Questions -- References -- Part III: Disease Challenges -- 6: Urological Considerations for Pediatric Renal Transplantation: CAKUT Challenges -- Urological Complications Post-transplant -- References -- 7: Rheumatologic Challenges -- Systemic Lupus Erythematosus -- Introduction -- Clinical Course of Renal Involvement and Outcomes -- Renal Transplantation in Lupus Nephritis -- Recurrence of Lupus Nephritis Post-transplantation -- Health Disparities in Systemic Lupus Erythematosus and Lupus Nephritis -- Conclusion -- IgA Vasculitis -- Introduction -- Clinical Course of Renal Involvement and Outcomes -- Renal Transplantation in IgAV Nephritis and Outcomes -- ANCA-Associated Vasculitis -- Introduction -- Clinical Course of Renal Involvement and Outcomes -- Renal Transplantation in Childhood AAV and Outcomes -- Conclusion -- References -- 8: Recurrent Disease Challenges in Pediatric Kidney Transplantation -- Introduction -- Atypical Hemolytic Uremic Syndrome (aHUS) -- Nature and Frequency of Primary Disease -- Considerations for Transplant Planning -- Risk Factors for Recurrence and Treatment of Recurrence -- Risk of Disease Recurrence in the Era of Eculizumab -- Additional Post-transplant Considerations -- C3 Glomerulopathy (C3G) -- Nature and Frequency of C3G -- Considerations for Transplant Planning -- Risk Factors for Recurrence and Treatment of C3G Recurrence -- IgA Nephropathy -- Nature and Frequency of IgA Nephropathy (IgAN) -- Risk Factors for Recurrence -- Considerations for Transplant Planning -- Treatment of IgAN Recurrence -- Impact of IgAN on Graft Function and Survival -- IgA Vasculitis (Henoch-Schonlein Purpura) -- Lupus Nephritis -- Nature and Frequency of Disease -- Risk for Disease Recurrence -- Considerations for Transplant Planning. Impact of RLN on Graft Function and Survival -- Other Diseases -- Primary Hyperoxaluria Type 1 (Oxalosis) -- Membranous Nephropathy -- Conclusion -- References -- 9: Nephrotic Syndrome Challenges: An Old Recurring Problem -- APOL1 -- Mechanism of Renal Injury -- Second Hit Modifiers -- Clinical Implications -- Pre-transplant Nephrectomy -- Proteinuria -- WT1 Mutation -- Disease Recurrence -- Genetic Mutations -- Living vs Deceased Donation -- Clinical Features Predictive of DR -- Circulating Factor and DR -- Treatment of Disease Recurrence -- Plasmapheresis -- Immunoadsorption -- Rituximab -- Cyclosporine -- Lipid Apheresis -- Questions -- Bibliography -- 10: Challenges of Maintaining Adequate Health and Well-Being, Growth, Nutrition, and Development in Pediatric Transplant Recipients -- Vaccinations -- Pre-transplant -- Post-transplant -- Vaccines and Travel -- Nutritional Challenges -- Pre-transplant -- CKD 2-5 Pre-dialysis -- Hemodialysis -- Peritoneal Dialysis -- Nutritional Management in CKD and Dialysis -- Enteral Nutrition Support -- Post-transplant -- Appetite and Weight -- Transition from Enteral to Oral Feeding -- Medication Effects -- Nutritional Management Post-transplant -- Food Safety -- Growth Challenges -- Growth Hormone Physiology -- Growth and CKD -- Growth After Kidney Transplant -- Outcomes -- Growth Hormone Utilization -- Indications and Contraindications for Growth Hormone -- Work-Up, Treatment, and Monitoring -- Work-Up -- Treatment -- Monitoring -- Safety of Growth Hormone in Transplant Recipients -- Metabolic Bone Disease -- Pathophysiology of CKD-BMD -- Bone Mineral Monitoring -- Post-transplant Bone Metabolism -- PTH, FGF-23, and Hypophosphatemia -- Hypomagnesemia -- Vitamin D -- Immunosuppression -- Role of Sex Hormones -- Prevention Strategies -- Steroid Minimization -- Diet and Physical Activity -- Treatment. Pharmacologic Therapies. |
| Record Nr. | UNINA-9910488710503321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Contemporary bone marrow transplantation / / edited by Mammen Chandy, Vivek S. Radhakrishnan, Reghu Sukumaran
| Contemporary bone marrow transplantation / / edited by Mammen Chandy, Vivek S. Radhakrishnan, Reghu Sukumaran |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (776 pages) |
| Disciplina | 617.44 |
| Collana | Organ and Tissue Transplantation |
| Soggetto topico |
Bone marrow - Transplantation
Medul·la òssia Trasplantament d'òrgans |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-36358-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910482973403321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Emerging transplant infections : clinical challenges and implications / / Michele I. Morris, Camille Nelson Kotton and Cameron R. Wolfe (editors)
| Emerging transplant infections : clinical challenges and implications / / Michele I. Morris, Camille Nelson Kotton and Cameron R. Wolfe (editors) |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (1737 pages) |
| Disciplina | 617.954 |
| Soggetto topico |
Transplantation of organs, tissues, etc - Complications
Transplantation immunology Infection Transplantation Immunology Infections Trasplantament d'òrgans Infeccions quirúrgiques Immunologia de la trasplantació |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-25869-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Contents -- About the Editors -- Contributors -- Part I: General Introduction -- 1 Impact of Infection on Transplant Outcomes: Transplant Infectious Disease Expertise as an Essential Component of Transplant ... -- Introduction -- The Essential Role of Infectious Disease Specialists in the Care of Transplant Patients -- Conclusion -- References -- 2 Introduction to Immunosuppression, Tolerance, and Infection Risk -- Introduction -- T-Cell, B-Cells, and the Innate Immune System Involvement in Rejection -- Other Elements of the Immune System Involved in Transplantation -- Therapeutics Impacting Immunosuppression -- Calcineurin Inhibitors -- Antiproliferative Agents -- mTOR Inhibitors -- Corticosteroids -- Co-stimulation Blockade -- Induction Therapies -- Anti-CD25 Monoclonal Antibodies -- Anti-CD52 Monoclonal Antibodies -- Polyclonal Antibodies -- Conclusion -- Key Points -- References -- 3 Changing Definition of Immunosuppression: Targeted Therapies and Resulting Emerging Infections and Their Prevention -- Introduction -- Belatacept -- Key Findings and Suggestions -- Basiliximab -- Key Findings and Suggestions -- Rituximab and Obinutuzumab -- Key Findings and Suggestions -- Alemtuzumab -- Key Findings and Suggestions -- Eculizumab -- Key Findings and Suggestions -- Ruxolitinib -- Key Findings and Suggestions -- Ibrutinib -- Key Findings and Suggestions -- Bortezomib -- Key Findings and Suggestions -- Brentuximab -- Key Findings and Suggestions -- Conclusions -- References -- 4 Stem Cell Transplantation: Infection Risk by Transplant Type and Emerging Trends in Infection Management -- Introduction -- Risk of Infection Post-HSCT -- General Immune Reconstitution After Hematopoietic Stem Cell Transplantation -- Aplastic Period -- NK Cells and T-Cells -- B-Cells and Immunoglobulins -- Graft-Versus-Host Disease.
Special Donor Populations -- Umbilical Cord Blood Transplantation -- Haploidentical Transplantation -- Pre-HSCT Recipient Infectious Disease Evaluation -- Prophylaxis and Management of Infection Post-HSCT -- Bacterial Infections -- Bloodstream Infections -- Diagnosis -- Management -- Gram-Positive Bacterial Infections -- Multidrug-Resistant Gram-Negative Bacterial Infections -- Bacterial Pneumonia -- Clostridioides Difficile -- Diagnosis -- Management -- Recurrent CDI -- Secondary Prophylaxis -- Fungal Infections -- Yeasts -- Disease Epidemiology -- Candida auris -- Diagnosis -- Blood Cultures -- Fungal Antigen Testing: Serum 1,3-Beta-D-Glucan -- Nanodiagnostics -- Candida auris-Specific Diagnostics -- Management -- Candida Species -- Candida auris -- Cryptococcus -- Molds -- Disease Epidemiology -- Clinical Impact -- Diagnosis -- Culture -- Galactomannan -- Aspergillus PCR -- Radiographic Studies -- Fungal Metabolite Testing -- Management -- Prophylaxis -- Treatment -- Pneumocystis Jiroveci -- Viral Infections -- Herpes Simplex Virus -- Varicella Zoster -- Cytomegalovirus -- Diagnosis -- Preemptive Management -- Prophylaxis: Shift in Management -- Drug-Resistant CMV Infection -- Epstein-Barr Virus -- Adenovirus -- BK Virus -- Parasitic Infections -- Toxoplasmosis -- Strongyloides -- Post-HSCT Vaccinations -- Conclusions -- Key Points -- Cross-References -- References -- 5 Evolving Epidemiology of Transplant Infections: Impact of Population Shifts and Climate Change -- Introduction -- Migration and Population Shift -- Modern Patterns of Human Migration and Infection -- Shifting Populations and the Changing Epidemiology of Infectious Diseases -- Preventative Strategies and Global Demographic Changes -- Climate Change and Infectious Diseases -- Climate Change and Parasitic Infections -- Climate Change and Vector-Borne Infections. Climate Change and Fungal Infections -- Climate Change and Bacterial Infections -- Conclusion -- Key Points -- References -- 6 Hospital Epidemiology and Infection Control in the Transplant Center -- Introduction -- Hand Hygiene -- Central Line-Associated Bloodstream Infections -- Catheter-Associated Urinary Tract Infections -- Clostridioides difficile -- Surgical Site Infections -- Preventing Infections Associated with the Healthcare Environment -- Environmental Mold -- Waterborne Pathogens -- Colonization with Multidrug-Resistant Organisms -- Respiratory Viruses -- Influenza -- Respiratory Syncytial Virus -- Adenovirus -- Other Respiratory Viruses -- Varicella-Zoster Virus -- Measles -- Healthcare Personnel Vaccination -- Conclusion -- Key Points -- Cross-References -- References -- 7 Antimicrobial Stewardship for Transplant Candidates and Recipients -- Introduction -- Implementing Antimicrobial Stewardship in Transplant Patients -- Formulary Management -- Pre-prescription Authorization and Post-prescriptive Review -- Antimicrobial Agent Selection -- Antibiotic Allergy Assessment -- Dose Optimization and Drug Interactions -- Intravenous-to-Oral Conversion -- Clinical Pathways and Guideline Development -- Diagnostic Test Stewardship -- Syndrome- and Drug-Specific Targets -- Antibiotic Stewardship -- Febrile Neutropenia -- Asymptomatic Bacteriuria in Organ Transplant Recipients -- Antiviral Stewardship -- Aerosolized Ribavirin for Management of RSV -- Cytomegalovirus (CMV) -- Antifungal Stewardship -- Antimicrobial Stewardship Program Metrics -- Conclusion -- Key Points -- References -- 8 Antimicrobial Prophylaxis in the Age of Emerging Transplant Infections -- Introduction -- Perioperative Antibacterial Prophylaxis in Solid Organ Transplantation -- Antibiotic Prophylaxis After Transplantation -- Antifungal Prophylaxis After Transplantation. Mycobacterial Prophylaxis After Transplantation -- Influenza Prophylaxis After Transplantation -- Herpes Simplex Virus and Varicella Zoster Virus Prophylaxis After Transplantation -- Cytomegalovirus Prophylaxis After Transplantation -- BK Polyomavirus Prophylaxis After Transplantation -- Parasitic Prophylaxis in Transplantation -- Conclusion -- Key Points -- References -- 9 Pretransplant Screening for Infection Exposure: Approach to the Patients with Epidemiologic and Geographic Risk Factors -- Introduction -- Bacterial Infections -- Bacterial Pathogens of Special Interest -- Mycobacterial Infections -- Tuberculosis -- Nontuberculous Mycobacteria -- M. abscessus -- Non-M. abscessus Non-M. tuberculosis Mycobacterial Infections -- Fungi -- Endemic Fungal Infections -- Histoplasmosis -- Blastomycosis -- Paracoccidioidomycosis -- Coccidioidomycosis -- Cryptococcosis -- Aspergillus and Other Molds -- Parasitic Infections -- Chagas Disease -- Schistosomiasis -- Strongyloidiasis -- Leishmaniasis -- Malaria -- Toxoplasmosis -- Viral Infections in the Transplant Candidate -- Blood-borne Pathogens -- Endemic Human Herpes Viruses -- Viral Infections with Geographic Associations -- Human Herpesvirus-8 (HHV-8) -- HTLV-1 -- Flaviviruses (Arboviruses) -- West Nile Virus (WNV) -- Zika, Chikungunya, and Dengue Viruses -- Conclusion -- KeyPoints -- References -- 10 Transplant Tourism and the Traveling Transplant Recipient: Infection Mitigation and Treatment Strategies -- Introduction -- Part 1: Transplant Tourism -- Introduction -- Transplant Tourism and Infectious Complications -- Conclusion -- Key Points -- Part 2: The Traveling Transplant Recipient -- Introduction -- Risk of Infection While Abroad -- Viral Infections -- Respiratory Viral Infections -- Influenza -- Measles -- Middle Eastern Respiratory Syndrome -- Gastrointestinal Viral Infections -- Norovirus. Hepatitis A -- Hepatitis B -- Hepatitis E -- Polio -- Vector-Borne Viral Infections -- Yellow Fever -- Japanese Encephalitis -- Dengue, Chikungunya, and Zika -- Rabies -- Bacterial Infections -- Salmonella enterica Serovar Typhi -- Vibrio cholerae -- Enterotoxigenic Escherichia coli (ETEC) -- Neisseria meningitidis -- Streptococcus pneumoniae -- Clostridium tetani -- Corynebacterium diphtheriae -- Bordetella pertussis -- Mycobacterial Infections -- Mycobacterium tuberculosis -- Fungal Infections -- Parasitic Infections -- Vector-Borne Parasite Infections -- Plasmodium Species -- Leishmania Species -- Trypanosoma Species -- Babesia Species -- Environmentally Transmitted Parasite Infections -- Strongyloides stercoralis -- Schistosoma Species -- Ingested Parasitic Infections -- Pre-departure Infectious Disease Evaluation and Recommendations -- Vaccine Recommendations -- Risk Reduction of Non-vaccine-Preventable Infections -- Prevention of Food-Borne Illnesses and Diarrhea -- Respiratory Infections -- Insect Protection -- Environmental Exposures -- Blood-Borne Pathogens -- Sexually Transmitted Infections (STI) -- Post-travel Evaluation -- Conclusion -- Key Points -- References -- 11 Preventative Health in Solid Organ Transplant: Safe Living Post-transplant -- Introduction -- Pre-transplant Evaluation -- Vaccination -- Everyday Living Strategies -- Activities of Leisure -- Sexual Health -- Food and Water Safety -- Animal and Insect Precautions -- Travel Advice -- Conclusion -- Key Points -- References -- 12 Vaccination Strategies in Solid Organ and Stem Cell Transplant -- Introduction to Vaccination in Transplant Recipients -- Specific Vaccine Recommendations -- Vaccination Against Influenza -- Vaccination Against Pneumococcal Disease -- Vaccination Against Meningococcal Disease -- Vaccination Against Hepatitis B Virus. Vaccination Against Hepatitis A Virus. |
| Record Nr. | UNINA-9910485605403321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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