top

  Info

  • Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.

  Info

  • Utilizzare questo link per rimuovere la selezione effettuata.
Advances in Application of Stem Cells: From Bench to Clinics / / edited by Firdos Alam Khan
Advances in Application of Stem Cells: From Bench to Clinics / / edited by Firdos Alam Khan
Edizione [1st ed. 2021.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Humana, , 2021
Descrizione fisica 1 online resource (320 pages)
Disciplina 610
616.02774
Collana Stem Cell Biology and Regenerative Medicine
Soggetto topico Stem cells
Medicine - Research
Biology - Research
Regenerative medicine
Biomedical engineering
Stem Cell Biology
Translational Research
Regenerative Medicine and Tissue Engineering
Biomedical Engineering and Bioengineering
ISBN 3-030-78101-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Basics of stem cell biology -- Types and classifications stem cells -- Method of isolation and characterization of stem cells -- Differentiation of stem cells into neuronal lineage: In vitro cell culture, In vivo transplantation in animal models -- Differentiation of stem cells into cardiomyocyte lineage: In vitro cell culture, In vivo transplantation in animal models -- Differentiation of stem cells into hepatocyte lineage: In vitro cell culture, In vivo transplantation in animal models -- Differentiation of stem cells into pancreatic lineage: In vitro cell culture, In vivo transplantation in animal models -- Application of stem cells in treatment of bone diseases: pre-clinical and clinical perspectives -- Stem cells in regenerative medicine: clinical trials -- Stem cell production: Scale up, GMP production, Bioreactor -- Stem cell based products in the market -- Commercialization, IPR and market of stem cell products.
Record Nr. UNINA-9910502987503321
Cham : , : Springer International Publishing : , : Imprint : Humana, , 2021
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
All Around Suboptimal Health : Advanced Approaches by Predictive, Preventive and Personalised Medicine for Healthy Populations / / edited by Wei Wang
All Around Suboptimal Health : Advanced Approaches by Predictive, Preventive and Personalised Medicine for Healthy Populations / / edited by Wei Wang
Edizione [1st ed. 2024.]
Pubbl/distr/stampa Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2024
Descrizione fisica 1 online resource (286 pages)
Disciplina 362.1068
Collana Advances in Predictive, Preventive and Personalised Medicine
Soggetto topico Medicine, Preventive
Health promotion
Health services administration
Primary care (Medicine)
Medicine - Research
Biology - Research
Health Promotion and Disease Prevention
Health Care Management
Primary Care Medicine
Translational Research
ISBN 3-031-46891-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto 1. Suboptimal health management in the framework of 3P medicine -- 2. Definition of SHS -- 3. Mitochondrion – The subordinated partner who agreed to come short but insists in healthy life -- 4. SHS and the economic impact to healthcare from the perspective of 3P medicine -- 5. Tools of predictive diagnostics – Status quo and outlook -- 6. Risk Factors, Health Status, and Risk Groups in Suboptimal Health Condition -- 7. Treatment algorithm tailored to individuals with non-communicable diseases: The innovative utility of suboptimal health concept from the predictive preventive and personalised medical care perspective -- 8. Approaches for measuring reversible damage to the health -- 9. Leveraging supervised machine learning for determining the link between suboptimal health status and the prognosis of chronic diseases -- 10. Integrative approach to investigate suboptimal health status and endothelial dysfunction -- 11. Individualised Preventive Measurements of SHS -- 12. Early vascular ageing in young adults is instrumental as the screening tool to combat CVD epidemics in the population -- 13. Personalized management of physiologic/ophthalmologic particularities for predictive approach and targeted prevention of primary angle closure glaucoma applied to persons at risk -- 14. Multi-faceted medical care to meet individual needs of subjects with excessive BMI: Professional oral hygiene and periodontal health are in focus of 3PM -- 15. Systemic inflammation as the health-related communication tool between the human host and gut microbiota in the framework of Predictive, Preventive and Personalized Medicine -- 16. Conventional and traditional medicine – a “hand-in-hand” collaboration benefiting the patient and healthcare at large -- 17. Tourism, Suboptimal Health Status, and Dementia.
Record Nr. UNINA-9910835054003321
Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2024
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Behavioral Neuroscience of Alcohol Addiction : Translational Studies and Human Phenotypes / / edited by Wolfgang H. Sommer, Rainer Spanagel
Behavioral Neuroscience of Alcohol Addiction : Translational Studies and Human Phenotypes / / edited by Wolfgang H. Sommer, Rainer Spanagel
Autore Sommer Wolfgang H
Edizione [1st ed. 2025.]
Pubbl/distr/stampa Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2025
Descrizione fisica 1 online resource (473 pages)
Disciplina 612.8
Altri autori (Persone) SpanagelRainer
Collana Current Topics in Behavioral Neurosciences
Soggetto topico Psychobiology
Human behavior
Neuropharmacology
Medicine - Research
Biology - Research
Behavioral Neuroscience
Translational Research
ISBN 3-032-01585-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Part 3 Experimental studies to human alcohol use and addiction -- Modelling Relapse Situations in the Human Laboratory -- Etiological Momentary Assessment of alcohol behaviour in humans -- The Dopamine System in Mediating Alcohol Effects in Humans -- Molecular imaging studies of alcohol use disorder -- The continuing challenges of studying parallel behaviors in humans and animal models -- MRI as an objective tool for animal human translation of alcohol effects -- Part 4 Treatment Approaches to AUD -- Approaches to AUD treatment based on Memory Retrieval and Counter Conditioning -- Approach bias retraining and other behavioral approaches in AUD -- New Approaches to Addiction Treatment based on Learning and Memory -- Brain stimulation to modulate alcohol behavior in animals and humans -- Role of the microbiome and the gut-brain axis in alcohol use disorder potential implication for treatment development.
Record Nr. UNINA-9911031565903321
Sommer Wolfgang H  
Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2025
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Behavioral Neuroscience of Alcohol Addiction : Basic Mechanisms and Animal Studies / / edited by Wolfgang H. Sommer, Rainer Spanagel
Behavioral Neuroscience of Alcohol Addiction : Basic Mechanisms and Animal Studies / / edited by Wolfgang H. Sommer, Rainer Spanagel
Autore Sommer Wolfgang H
Edizione [1st ed. 2025.]
Pubbl/distr/stampa Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2025
Descrizione fisica 1 online resource (623 pages)
Disciplina 612.8
Altri autori (Persone) SpanagelRainer
Collana Current Topics in Behavioral Neurosciences
Soggetto topico Psychobiology
Human behavior
Neuropharmacology
Medicine - Research
Biology - Research
Behavioral Neuroscience
Translational Research
ISBN 3-032-01581-2
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Part 1 Conceptualizing and modeling alcohol addiction -- Behavioral Neurobiology of Alcohol Addiction a Decade of great Challenges, new Hypes and Hopes -- Theoretical frameworks and mechanistic aspects of alcohol addiction Alcohol addiction as a reward deficit stress surfeit disorder -- Animal Models of Excessive Alcohol Consumption -- Modeling Brain Gene Expression in Alcohol Use Disorder with Genetic Animal Models -- From Natural Behavior to Drug Screening Invertebrates as Models to Study Mechanisms Associated with Alcohol Use Disorders -- Good Preclinical Practice Guidelines for the Development of Novel Pharmacological Targets for Relapse Prevention -- Part 2 Specific mechanisms of alcohol use and addiction -- Role of Metabolism on Alcohol Preference, Addiction, and Treatment -- Synaptic Effects Induced by Alcohol -- Epigenetic Dysregulation in Alcohol Associated Behaviors Preclinical and Clinical Evidence -- The Relationship Between Oxytocin and Alcohol Dependence -- Neural Circuitries and Alcohol Use Disorder Cutting Corners in the Cycle -- Encoding of alcohol related behaviors in the rodent brain.
Record Nr. UNINA-9911031575103321
Sommer Wolfgang H  
Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2025
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Biosensors for Personalized Healthcare / / edited by Kuldeep Mahato, Pranjal Chandra
Biosensors for Personalized Healthcare / / edited by Kuldeep Mahato, Pranjal Chandra
Autore Mahato Kuldeep
Edizione [1st ed. 2024.]
Pubbl/distr/stampa Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2024
Descrizione fisica 1 online resource (426 pages)
Disciplina 610.72
Altri autori (Persone) ChandraPranjal
Soggetto topico Medicine - Research
Biology - Research
Molecular probes
Biomedical Research
Translational Research
Biological Sensors and Probes
ISBN 9789819754731
9819754739
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction to Biosensors for Personalized Health -- Non-Invasive Biomarkers for Disease Diagnosis and Health Monitoring -- Affinity-based clinical biomarkers for early disease detection -- Fundamentals, Fabrication, Engineering, and Prototyping Aspects of Bioelectronics and Biosensors for Biomedical Analysis -- Signal Amplification Strategies for Biosensing of Clinically Important Analytes.-Materials for developing electrochemical biosensing systems -- Personalized on-chip sample evaluation devices for biomedical applications: advantages, challenges and opportunities -- Nanozyme mediated biosensing -- Mechanisms for analytes biosensing -- The development process of point-of-care sensor-based detection modules for biomedical diagnoses -- Biosensors for rapid and early detection of chronic diseases -- Advances in affinity-based biosensing mechanisms for direct detection /monitoring of the biomarkers -- Sweat, interstitial fluid, and saliva based wearable devices for continuous monitoring of metabolites and biomarkers -- Implantable biosensors for personalized healthcare -- Ingestible biosensors for personalized health.
Record Nr. UNINA-9910906194703321
Mahato Kuldeep  
Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2024
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Brain and Mental Health in Ageing / / edited by Gurcharan Kaur, Suresh I. S. Rattan
Brain and Mental Health in Ageing / / edited by Gurcharan Kaur, Suresh I. S. Rattan
Edizione [1st ed. 2024.]
Pubbl/distr/stampa Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2024
Descrizione fisica 1 online resource (515 pages)
Disciplina 612.82
Collana Healthy Ageing and Longevity
Soggetto topico Mental health
Aging
Medicine - Research
Biology - Research
Quality of life
Neuropsychology
Mental Health
Ageing
Biomedical Research
Quality of Life Research
Translational Research
ISBN 3-031-68513-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Part-1: Concepts, definitions and historical perspectives -- Chapter-01: Defining, re-defining, and understanding the brain and mental health during ageing -- Chapter-02: Social, historical and anthropological aspects of research on the brain and ental health in aging -- Chapter-03: Understanding hormesis for optimizing brain health -- Part-2: Biological modulators of the ageing brain -- Chapter-04: Dietary constituents for mental health promotion and healthy ageing -- Chapter-05: Physical activity and dietary interventions for mental health in ageing and longevity -- Chapter-06: Immunity, immunosenescence, brain and cognitive/mental health -- Chapter-07 Neurovirology and Brain Health – A Microglial Perspective -- Chapter-08: Gut microbiota-brain axis in healthy aging -- Chapter-09: Connexin-mediated nuroglial gap Junction communication: Unravelling its significance in brain health and aging -- Chapter-10: Maintenance of mitochondrial dynamics for healthy brain aging -- Part-3: Brain health maintenance, promotion and recovery in ageing -- Chapter-11: Phytochemicals and vitagenes for a healthy brain -- Chapter-12: Infection, neuroinflammation and interventions for healthy brain and longevity -- Chapter-13: Nutraceuticals as an intervention for healthy brain aging -- Chapter-14: Pharmacological interventions for maintaining brain health in ageing -- Chapter-15: Sleep and circadian rhythms as modulators of mental health in Ageing -- Part-4: Mental health maintenance, promotion and recovery in ageing -- Chapter-16: The impact of psychopathology and psychological well-being on cognitive health -- Chapter-17: The neuroscience of positive emotions and gratitude in healthy ageing and longevity -- Chapter-18: Cognitive profiles across normal and unhealthy ageing -- Chapter-19: Sleep and Mental Health in the Aging Population -- Chapter-20: Brain health of women beyond middle age: hormonal and non-hormonal perspective -- Chapter-21: Psychobiotics: a restorative intervention for lifestyle-induced deteriorations of mental health -- Chapter-22: Autism and ADHD in old age -- Chapter-23: Epigenetic regulation of age-associated neuropsychiatric disorders.
Record Nr. UNINA-9910887886903321
Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2024
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Breaking Free : Liang Qichao’s “Unfettered Translation” and Its Legacy / / by Lin Jiang
Breaking Free : Liang Qichao’s “Unfettered Translation” and Its Legacy / / by Lin Jiang
Autore Jiang Lin <1953 January->
Edizione [1st ed. 2024.]
Pubbl/distr/stampa Singapore : , : Springer Nature Singapore : , : Imprint : Palgrave Macmillan, , 2024
Descrizione fisica 1 online resource (277 pages)
Disciplina 951.035092
Soggetto topico Medicine - Research
Biology - Research
Intercultural communication
Culture - Study and teaching
China - History
Translational Research
Intercultural Communication
Cultural Studies
History of China
ISBN 9789819751426
981975142X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Chapter 1. Introduction -- Chapter 2. Definition and Formation of Liang’s “Unfettered Translation” -- Chapter 3. The Skopos Theory and “Unfettered Translation” -- Chapter 4. Translation Style of Liang’s “Unfettered Translation” -- Chapter 5. Cultural Significance of Liang’s “Unfettered Translation” -- Chapter 6. Conclusion.
Record Nr. UNINA-9910879591803321
Jiang Lin <1953 January->  
Singapore : , : Springer Nature Singapore : , : Imprint : Palgrave Macmillan, , 2024
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Broadly Engaged Team Science in Clinical and Translational Research / / edited by Debra Lerner, Marisha E. Palm, Thomas W. Concannon
Broadly Engaged Team Science in Clinical and Translational Research / / edited by Debra Lerner, Marisha E. Palm, Thomas W. Concannon
Edizione [1st ed. 2022.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022
Descrizione fisica 1 online resource (254 pages)
Disciplina 610.72
Collana Biomedical and Life Sciences Series
Soggetto topico Medicine - Research
Biology - Research
Clinical medicine - Research
Public health
Political planning
Social medicine
Biomedical Research
Translational Research
Clinical Research
Public Health
Policy Formulation
Health, Medicine and Society
ISBN 9783030830281
3030830284
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto 1. Introduction -- Part I Transforming Research with Broad Engagement -- 2. The Transformative Power of Broadly Engaged Team Science: A Moth-er’s Quest to Understand PXE -- 3. Broadly Engaged Team Science in Neonatal Research -- 4. Patient Advocates in Cancer Care: A Rich Tradition and Evolving Role -- 5. National Kidney Foundation Patient Network -- 6. Broadly Engaged Team Science Comes to Life in a Design Lab -- 7. Tufts Center for the Study of Drug Development Employs Broadly Engaged Team Science to Explore the Challenges of Pharmaceutical Research and Development -- Part II. Integrating Communities and Stakeholders into Broadly Engaged Team Science -- 8. Social Movements and Stakeholder Engagement -- 9. A Basic Scientist’s Journey: Engaging Public Stakeholders Through Civic Science -- 10. Lessons in Public Involvement from Across the Pond -- 11. Leveling the Playing Field for Community Stakeholders: Examining Practices to Improve Engagement and Address Power Dynamics -- 12. A Theory of Stakeholder-driven Community Diffusion -- 13. Monitoring and Evaluation of Stakeholder Engagement in Health Research -- Part III. Applying Broadly Engaged Team Science: Case Studies -- 14. Insiders and Outsiders: A Case Study of Fostering Research Partnerships between Academic Health Centers and Corrections Institutions -- 15. Responding to the Community: HOPE (Healthy Outcomes from Positive Experiences) -- 16. Students as Key Collaborators in Tackling Early Stage Research Ideas -- 17. Engaging Stakeholders to Decrease Study Start-up Delays -- 18. Health Literacy and Broadly Engaged Team Science: How One Study Team Used Plain Language Principles to Share Findings with Affected Communities -- 19. Utilizing Patient Navigators to Promote Equitable and Accountable Research -- 20. Asian American Research in the Post-Atlanta Era: Driving Community-engaged Research That Is More Meaningful, Responsive, and Actionable for Local Communities -- 21. Stakeholder Engagement in Predictive Model Development for Clinical Decision Support -- Part IV. Creating an Institutional Environment of Support for Broadly Engaged Team Science -- 22. Research Administration Practices for Proposal Development and Post-Award Management of Stakeholders and Community Participants -- 23. Starting Off Right: Supporting Community Involvement in the Evaluation of Research Proposals -- 24. Role of Broadly Engaged Team Science in the Inclusion of Minority Populations as Research Participants and in All Roles on Research Teams -- 25. Rewarding Team Science in Tenure and Promotion Practices: An Operational Imperative for the Academic Research Enterprise of the 21st Century -- Epilogue.
Record Nr. UNINA-9910548175703321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Cognitive Functioning in Schizophrenia: Leveraging the RDoC Framework / / edited by Deanna M. Barch, Jared W. Young
Cognitive Functioning in Schizophrenia: Leveraging the RDoC Framework / / edited by Deanna M. Barch, Jared W. Young
Edizione [1st ed. 2023.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023
Descrizione fisica 1 online resource (505 pages)
Disciplina 616.8982
Collana Current Topics in Behavioral Neurosciences
Soggetto topico Medicine - Research
Biology - Research
Medical sciences
Drug development
Pharmacology
Genetics - Research
Clinical medicine - Research
Biochemical markers
Translational Research
Preclinical Research
Genetics Research
Clinical Research
Biomarkers
ISBN 3-031-26441-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto MATRICS – an update -- Cognitive [Computational] Neuroscience Test Reliability and Clinical Applications for Serious mental illness (CNTRaCS) Consortium: Progress and Future Directions -- Attention in Schizophrenia -- Perceptual Functioning -- Episodic Memory and Schizophrenia: From Characterization of Relational Memory Impairments to Neuroimaging Biomarkers -- Working Memory in People with Schizophrenia -- "Targeting Frontal Gamma Activity with Neurofeedback to Improve Working Memory in Schizophrenia" -- Cognitive Dysfunction as a Risk Factor for Psychosis -- Environmental Risk Factors and Cognitive Outcomes in Psychosis: Pre-, Perinatal, and Early Life Adversity -- Developmental manipulation-induced changes in cognitive functioning -- Genetic underpinnings of cognitive dysfunction in schizophrenia -- Primate models of cognitive deficit re schizophrenia -- Olfactory cognitive deficits -- Medication/Anticholinergic burden impacting cognition in schizophrenia An Update on Treatment of Cognitive Impairment Associated with Schizophrenia -- Cannabis & cognition -- Sex/gender differences -- Neuroinflammation linked to cognition.
Record Nr. UNINA-9910672440403321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Curcumin and Neurodegenerative Diseases : From Traditional to Translational Medicines / / edited by Mahendra Rai, Chistiane M. Feitosa
Curcumin and Neurodegenerative Diseases : From Traditional to Translational Medicines / / edited by Mahendra Rai, Chistiane M. Feitosa
Autore Rai Mahendra
Edizione [1st ed. 2023.]
Pubbl/distr/stampa Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023
Descrizione fisica 1 online resource (483 pages)
Disciplina 616.8
Altri autori (Persone) FeitosaChistiane M
Soggetto topico Nervous system - Diseases
Neuropharmacology
Medicine - Research
Biology - Research
Neurological Disorders
Translational Research
ISBN 9789819977314
9819977312
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Chapter 1_Turmeric in Neurodegenerative diseases: An overview -- Chapter 2_Turmeric: Does it work in neurodegenerative disorders? Separating myth from reality -- Chapter 3_Curcumin bioavailability and constraints of its systemic effects -- Chapter 4_Traditional uses of Turmeric in Neurodegenerative diseases -- Chapter 5_Curcuma from kitchen to cure for neurodegenerative diseases -- Chapter 6_Curcuma used in neurodegenerative diseases: Applications in Ayurveda and Chinese medicines -- Chapter 7_Secondary metabolites of Turmeric (essential oils/extracts) -- Chapter 8_Curcuminoids and Sesquiterpenoids from Curcuma longa Rhizomes: Are they better against cancer or neurodegenerative disorders? - Chapter 9_Curcuma in aging (age-related neurodegenerative diseases) -- Chapter 10_Pharmacokinetics and pharmacodynamics of curcumin -- Chapter 11_Curcuma, curcumin and its nanoparticles in Parkinson's disease -- Chapter 12_Curcumin as a novel therapy for brain diseases -- Chapter 13_Curcumin induced Neuroprotection in cerebral Ischemia -- Chapter 14_Neural Stem cell therapy in combination with Curcumin -- Chapter 15_The use of curcumin in Parkinson’s disease -- Chapter 16_Effects of curcumin on mitochondrial dysfunction in NDs -- Chapter 17_Clinical trials and evidence-based approaches to evaluate curcumin efficacy in human health and disease -- Chapter 18_Nanocurcumin in neurodegenerative -- Chapter 19_Role of Nanocurcumin in Alzheimer’s disease -- Chapter 20_Modification of curcumin scaffold in the search for new effective therapeutic agents against NDs -- Chapter 21_Curcumin-loaded nanoparticles in neurodegenerative diseases -- Chapter 22_Curcumin nanoformulation in neurodegnerative diseases -- Chapter 23_Patents in Curcuma/ Curcumin related to Neurodegenerative diseases.
Record Nr. UNINA-9910838272403321
Rai Mahendra  
Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui