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Computational toxicology : risk assessment for chemicals / / edited by Sean Ekins
| Computational toxicology : risk assessment for chemicals / / edited by Sean Ekins |
| Autore | Ekins Sean |
| Edizione | [1st edition] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2018 |
| Descrizione fisica | 1 online resource (425 pages) : illustrations (some color) |
| Disciplina | 615.90285 |
| Collana | Wiley series on technologies for the pharmaceutical industry |
| Soggetto topico |
Toxicology - Mathematical models
Toxicology - Computer simulation QSAR (Biochemistry) |
| ISBN |
1-119-28257-8
1-119-28259-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910270876803321 |
Ekins Sean
|
||
| Hoboken, New Jersey : , : Wiley, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Computational toxicology : risk assessment for chemicals / / edited by Sean Ekins
| Computational toxicology : risk assessment for chemicals / / edited by Sean Ekins |
| Autore | Ekins Sean |
| Edizione | [1st edition] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2018 |
| Descrizione fisica | 1 online resource (425 pages) : illustrations (some color) |
| Disciplina | 615.90285 |
| Collana | Wiley series on technologies for the pharmaceutical industry |
| Soggetto topico |
Toxicology - Mathematical models
Toxicology - Computer simulation QSAR (Biochemistry) |
| ISBN |
1-119-28257-8
1-119-28259-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910828867403321 |
|
Ekins Sean
|
||
| Hoboken, New Jersey : , : Wiley, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Computational toxicology [[electronic resource] ] : risk assessment for pharmaceutical and environmental chemicals / / edited by Sean Ekins
| Computational toxicology [[electronic resource] ] : risk assessment for pharmaceutical and environmental chemicals / / edited by Sean Ekins |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2007 |
| Descrizione fisica | 1 online resource (855 p.) |
| Disciplina |
615.9
615.9001/5118 |
| Altri autori (Persone) | EkinsSean |
| Collana | Wiley series on technologies for the pharmaceutical industry |
| Soggetto topico |
Toxicology - Mathematical models
Toxicology - Computer simulation QSAR (Biochemistry) |
| ISBN |
1-280-91669-9
9786610916696 0-470-14589-7 0-470-14588-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
COMPUTATIONAL TOXICOLOGY; CONTENTS; SERIES INTRODUCTION; PREFACE; ACKNOWLEDGMENTS; CONTRIBUTORS; PART I INTRODUCTION TO TOXICOLOGY METHODS; 1 An Introduction to Toxicology and Its Methodologies; 2 In vitro Toxicology: Bringing the In silico and In vivo Worlds Closer; 3 Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling; 4 Species Differences in Receptor-Mediated Gene Regulation; 5 Toxicogenomics and Systems Toxicology; PART II COMPUTATIONAL METHODS; 6 Toxicoinformatics: An Introduction
7 Computational Approaches for Assessment of Toxicity: A Historical Perspective and Current Status8 Current QSAR Techniques for Toxicology; PART III APPLYING COMPUTERS TO TOXICOLOGY ASSESSMENT: PHARMACEUTICAL; 9 The Prediction of Physicochemical Properties; 10 Applications of QSAR to Enzymes Involved in Toxicology; 11 QSAR Studies on Drug Transporters Involved in Toxicology; 12 Computational Modeling of Receptor-Mediated Toxicity; 13 Applications of QSAR Methods to Ion Channels; 14 Predictive Mutagenicity Computer Models 15 Novel Applications of Kernel-Partial Least Squares to Modeling a Comprehensive Array of Properties for Drug Discovery16 Homology Models Applied to Toxicology; 17 Crystal Structures of Toxicology Targets; 18 Expert Systems; 19 Strategies for Using Computational Toxicology Methods in Pharmaceutical R&D; 20 Application of Interpretable Models to ADME/TOX Problems; PART IV APPLYING COMPUTERS TO TOXICOLOGY ASSESSMENT: ENVIRONMENTAL; 21 The Toxicity and Risk of Chemical Mixtures; 22 Environmental and Ecological Toxicology: Computational Risk Assessment 23 Application of QSARs in Aquatic Toxicology24 Dermatotoxicology: Computational Risk Assessment; PART V NEW TECHNOLOGIES FOR TOXICOLOGY: FUTURE AND REGULATORY PERSPECTIVES; 25 Novel Cell Culture Systems: Nano and Microtechnology for Toxicology; 26 Future of Computational Toxicology: Broad Application into Human Disease and Therapeutics; 27 Computational Tools for Regulatory Needs; INDEX |
| Record Nr. | UNINA-9910143688003321 |
| Hoboken, N.J., : Wiley-Interscience, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Computational toxicology [[electronic resource] ] : risk assessment for pharmaceutical and environmental chemicals / / edited by Sean Ekins
| Computational toxicology [[electronic resource] ] : risk assessment for pharmaceutical and environmental chemicals / / edited by Sean Ekins |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2007 |
| Descrizione fisica | 1 online resource (855 p.) |
| Disciplina |
615.9
615.9001/5118 |
| Altri autori (Persone) | EkinsSean |
| Collana | Wiley series on technologies for the pharmaceutical industry |
| Soggetto topico |
Toxicology - Mathematical models
Toxicology - Computer simulation QSAR (Biochemistry) |
| ISBN |
1-280-91669-9
9786610916696 0-470-14589-7 0-470-14588-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
COMPUTATIONAL TOXICOLOGY; CONTENTS; SERIES INTRODUCTION; PREFACE; ACKNOWLEDGMENTS; CONTRIBUTORS; PART I INTRODUCTION TO TOXICOLOGY METHODS; 1 An Introduction to Toxicology and Its Methodologies; 2 In vitro Toxicology: Bringing the In silico and In vivo Worlds Closer; 3 Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling; 4 Species Differences in Receptor-Mediated Gene Regulation; 5 Toxicogenomics and Systems Toxicology; PART II COMPUTATIONAL METHODS; 6 Toxicoinformatics: An Introduction
7 Computational Approaches for Assessment of Toxicity: A Historical Perspective and Current Status8 Current QSAR Techniques for Toxicology; PART III APPLYING COMPUTERS TO TOXICOLOGY ASSESSMENT: PHARMACEUTICAL; 9 The Prediction of Physicochemical Properties; 10 Applications of QSAR to Enzymes Involved in Toxicology; 11 QSAR Studies on Drug Transporters Involved in Toxicology; 12 Computational Modeling of Receptor-Mediated Toxicity; 13 Applications of QSAR Methods to Ion Channels; 14 Predictive Mutagenicity Computer Models 15 Novel Applications of Kernel-Partial Least Squares to Modeling a Comprehensive Array of Properties for Drug Discovery16 Homology Models Applied to Toxicology; 17 Crystal Structures of Toxicology Targets; 18 Expert Systems; 19 Strategies for Using Computational Toxicology Methods in Pharmaceutical R&D; 20 Application of Interpretable Models to ADME/TOX Problems; PART IV APPLYING COMPUTERS TO TOXICOLOGY ASSESSMENT: ENVIRONMENTAL; 21 The Toxicity and Risk of Chemical Mixtures; 22 Environmental and Ecological Toxicology: Computational Risk Assessment 23 Application of QSARs in Aquatic Toxicology24 Dermatotoxicology: Computational Risk Assessment; PART V NEW TECHNOLOGIES FOR TOXICOLOGY: FUTURE AND REGULATORY PERSPECTIVES; 25 Novel Cell Culture Systems: Nano and Microtechnology for Toxicology; 26 Future of Computational Toxicology: Broad Application into Human Disease and Therapeutics; 27 Computational Tools for Regulatory Needs; INDEX |
| Record Nr. | UNINA-9910829834103321 |
| Hoboken, N.J., : Wiley-Interscience, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Computational toxicology [[electronic resource] ] : risk assessment for pharmaceutical and environmental chemicals / / edited by Sean Ekins
| Computational toxicology [[electronic resource] ] : risk assessment for pharmaceutical and environmental chemicals / / edited by Sean Ekins |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2007 |
| Descrizione fisica | 1 online resource (855 p.) |
| Disciplina |
615.9
615.9001/5118 |
| Altri autori (Persone) | EkinsSean |
| Collana | Wiley series on technologies for the pharmaceutical industry |
| Soggetto topico |
Toxicology - Mathematical models
Toxicology - Computer simulation QSAR (Biochemistry) |
| ISBN |
1-280-91669-9
9786610916696 0-470-14589-7 0-470-14588-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
COMPUTATIONAL TOXICOLOGY; CONTENTS; SERIES INTRODUCTION; PREFACE; ACKNOWLEDGMENTS; CONTRIBUTORS; PART I INTRODUCTION TO TOXICOLOGY METHODS; 1 An Introduction to Toxicology and Its Methodologies; 2 In vitro Toxicology: Bringing the In silico and In vivo Worlds Closer; 3 Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling; 4 Species Differences in Receptor-Mediated Gene Regulation; 5 Toxicogenomics and Systems Toxicology; PART II COMPUTATIONAL METHODS; 6 Toxicoinformatics: An Introduction
7 Computational Approaches for Assessment of Toxicity: A Historical Perspective and Current Status8 Current QSAR Techniques for Toxicology; PART III APPLYING COMPUTERS TO TOXICOLOGY ASSESSMENT: PHARMACEUTICAL; 9 The Prediction of Physicochemical Properties; 10 Applications of QSAR to Enzymes Involved in Toxicology; 11 QSAR Studies on Drug Transporters Involved in Toxicology; 12 Computational Modeling of Receptor-Mediated Toxicity; 13 Applications of QSAR Methods to Ion Channels; 14 Predictive Mutagenicity Computer Models 15 Novel Applications of Kernel-Partial Least Squares to Modeling a Comprehensive Array of Properties for Drug Discovery16 Homology Models Applied to Toxicology; 17 Crystal Structures of Toxicology Targets; 18 Expert Systems; 19 Strategies for Using Computational Toxicology Methods in Pharmaceutical R&D; 20 Application of Interpretable Models to ADME/TOX Problems; PART IV APPLYING COMPUTERS TO TOXICOLOGY ASSESSMENT: ENVIRONMENTAL; 21 The Toxicity and Risk of Chemical Mixtures; 22 Environmental and Ecological Toxicology: Computational Risk Assessment 23 Application of QSARs in Aquatic Toxicology24 Dermatotoxicology: Computational Risk Assessment; PART V NEW TECHNOLOGIES FOR TOXICOLOGY: FUTURE AND REGULATORY PERSPECTIVES; 25 Novel Cell Culture Systems: Nano and Microtechnology for Toxicology; 26 Future of Computational Toxicology: Broad Application into Human Disease and Therapeutics; 27 Computational Tools for Regulatory Needs; INDEX |
| Record Nr. | UNINA-9911018925603321 |
| Hoboken, N.J., : Wiley-Interscience, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Quantitative modeling in toxicology [[electronic resource] /] / editors, Kannan Krishnan, Melvin E. Andersen
| Quantitative modeling in toxicology [[electronic resource] /] / editors, Kannan Krishnan, Melvin E. Andersen |
| Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, : John Wiley & Sons, 2010 |
| Descrizione fisica | 1 online resource (505 p.) |
| Disciplina |
615.90015118
615.907 |
| Altri autori (Persone) |
KrishnanKannan <1961->
AndersenMelvin E |
| Soggetto topico |
Toxicology - Mathematical models
Biological models |
| ISBN |
1-282-68958-4
9786612689581 0-470-68626-X 0-470-68670-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Quantitative Modeling in Toxicology; Contents; Preface; About the Editors; About the Book; List of Contributors; SECTION 1 INTRODUCTION; 1 Quantitative Modeling in Toxicology: An Introduction; SECTION 2 PHYSIOLOGICALLY-BASED TOXICOKINETIC AND PHARMACOKINETIC (PBPK) MODELING; 2 PBPK Modeling: A Primer; 3 Pharmacokinetic Modeling of Manganese - An Essential Element; 4 Physiologically Based Modeling of Pharmacokinetic Interactions in Chemical Mixtures; 5 Physiological Parameters and Databases for PBPK Modeling; SECTION 3 MODELING TOXICANT-TARGET INTERACTIONS; 6 Modeling Cholinesterase Inhibition
7 Modeling of Protein Induction and Dose-Dependent Hepatic Sequestration8 Bistable Signaling Motifs and Cell Fate Decisions; 9 Ultrasensitive Response Motifs in Biochemical Networks; 10 Gene and Protein Expression - Modeling Nested Motifs in Cellular and Tissue Response Networks; 11 Modeling Liver and Kidney Cytotoxicity; SECTION 4 MODELING TISSUE AND ORGANISM RESPONSES; 12 Computational Model for Iodide Economy and the HPT Axis in the Adult Rat; 13 Two-Stage Clonal Growth Modeling of Cancer; 14 Statistical and Physiological Modeling of the Toxicity of Chemicals in Mixtures 15 (Q)SAR Models of Adverse Responses: Acute Systemic ToxicitySECTION 5 MODEL APPLICATION AND EVALUATION; 16 Modeling Exposures to Chemicals From Multiple Sources and Routes; 17 Probabilistic Reverse Dosimetry Modeling for Interpreting Biomonitoring Data; 18 Quantitative Modeling in Noncancer Risk Assessment; 19 Application of Physiologically Based Pharmacokinetic Modeling in Health Risk Assessment; 20 Uncertainty, Variability, and Sensitivity Analyses in Simulation Models; 21 Evaluation of Quantitative Models in Toxicology: Progress and Challenges; Index |
| Record Nr. | UNINA-9910139509603321 |
| Chichester, West Sussex ; ; Hoboken, : John Wiley & Sons, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Quantitative modeling in toxicology [[electronic resource] /] / editors, Kannan Krishnan, Melvin E. Andersen
| Quantitative modeling in toxicology [[electronic resource] /] / editors, Kannan Krishnan, Melvin E. Andersen |
| Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, : John Wiley & Sons, 2010 |
| Descrizione fisica | 1 online resource (505 p.) |
| Disciplina |
615.90015118
615.907 |
| Altri autori (Persone) |
KrishnanKannan <1961->
AndersenMelvin E |
| Soggetto topico |
Toxicology - Mathematical models
Biological models |
| ISBN |
1-282-68958-4
9786612689581 0-470-68626-X 0-470-68670-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Quantitative Modeling in Toxicology; Contents; Preface; About the Editors; About the Book; List of Contributors; SECTION 1 INTRODUCTION; 1 Quantitative Modeling in Toxicology: An Introduction; SECTION 2 PHYSIOLOGICALLY-BASED TOXICOKINETIC AND PHARMACOKINETIC (PBPK) MODELING; 2 PBPK Modeling: A Primer; 3 Pharmacokinetic Modeling of Manganese - An Essential Element; 4 Physiologically Based Modeling of Pharmacokinetic Interactions in Chemical Mixtures; 5 Physiological Parameters and Databases for PBPK Modeling; SECTION 3 MODELING TOXICANT-TARGET INTERACTIONS; 6 Modeling Cholinesterase Inhibition
7 Modeling of Protein Induction and Dose-Dependent Hepatic Sequestration8 Bistable Signaling Motifs and Cell Fate Decisions; 9 Ultrasensitive Response Motifs in Biochemical Networks; 10 Gene and Protein Expression - Modeling Nested Motifs in Cellular and Tissue Response Networks; 11 Modeling Liver and Kidney Cytotoxicity; SECTION 4 MODELING TISSUE AND ORGANISM RESPONSES; 12 Computational Model for Iodide Economy and the HPT Axis in the Adult Rat; 13 Two-Stage Clonal Growth Modeling of Cancer; 14 Statistical and Physiological Modeling of the Toxicity of Chemicals in Mixtures 15 (Q)SAR Models of Adverse Responses: Acute Systemic ToxicitySECTION 5 MODEL APPLICATION AND EVALUATION; 16 Modeling Exposures to Chemicals From Multiple Sources and Routes; 17 Probabilistic Reverse Dosimetry Modeling for Interpreting Biomonitoring Data; 18 Quantitative Modeling in Noncancer Risk Assessment; 19 Application of Physiologically Based Pharmacokinetic Modeling in Health Risk Assessment; 20 Uncertainty, Variability, and Sensitivity Analyses in Simulation Models; 21 Evaluation of Quantitative Models in Toxicology: Progress and Challenges; Index |
| Record Nr. | UNINA-9910830686103321 |
| Chichester, West Sussex ; ; Hoboken, : John Wiley & Sons, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Quantitative modeling in toxicology / / editors, Kannan Krishnan, Melvin E. Andersen
| Quantitative modeling in toxicology / / editors, Kannan Krishnan, Melvin E. Andersen |
| Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, : John Wiley & Sons, 2010 |
| Descrizione fisica | 1 online resource (505 p.) |
| Disciplina | 615.9001/5118 |
| Altri autori (Persone) |
KrishnanKannan <1961->
AndersenMelvin E |
| Soggetto topico |
Toxicology - Mathematical models
Biological models |
| ISBN |
9786612689581
9781282689589 1282689584 9780470686263 047068626X 9780470686706 0470686707 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Quantitative Modeling in Toxicology; Contents; Preface; About the Editors; About the Book; List of Contributors; SECTION 1 INTRODUCTION; 1 Quantitative Modeling in Toxicology: An Introduction; SECTION 2 PHYSIOLOGICALLY-BASED TOXICOKINETIC AND PHARMACOKINETIC (PBPK) MODELING; 2 PBPK Modeling: A Primer; 3 Pharmacokinetic Modeling of Manganese - An Essential Element; 4 Physiologically Based Modeling of Pharmacokinetic Interactions in Chemical Mixtures; 5 Physiological Parameters and Databases for PBPK Modeling; SECTION 3 MODELING TOXICANT-TARGET INTERACTIONS; 6 Modeling Cholinesterase Inhibition
7 Modeling of Protein Induction and Dose-Dependent Hepatic Sequestration8 Bistable Signaling Motifs and Cell Fate Decisions; 9 Ultrasensitive Response Motifs in Biochemical Networks; 10 Gene and Protein Expression - Modeling Nested Motifs in Cellular and Tissue Response Networks; 11 Modeling Liver and Kidney Cytotoxicity; SECTION 4 MODELING TISSUE AND ORGANISM RESPONSES; 12 Computational Model for Iodide Economy and the HPT Axis in the Adult Rat; 13 Two-Stage Clonal Growth Modeling of Cancer; 14 Statistical and Physiological Modeling of the Toxicity of Chemicals in Mixtures 15 (Q)SAR Models of Adverse Responses: Acute Systemic ToxicitySECTION 5 MODEL APPLICATION AND EVALUATION; 16 Modeling Exposures to Chemicals From Multiple Sources and Routes; 17 Probabilistic Reverse Dosimetry Modeling for Interpreting Biomonitoring Data; 18 Quantitative Modeling in Noncancer Risk Assessment; 19 Application of Physiologically Based Pharmacokinetic Modeling in Health Risk Assessment; 20 Uncertainty, Variability, and Sensitivity Analyses in Simulation Models; 21 Evaluation of Quantitative Models in Toxicology: Progress and Challenges; Index |
| Record Nr. | UNINA-9911019692503321 |
| Chichester, West Sussex ; ; Hoboken, : John Wiley & Sons, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
