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Animals as sentinels of environmental health hazards [[electronic resource] ] : Committee on Animals as Monitors of Environmental Hazards, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
| Animals as sentinels of environmental health hazards [[electronic resource] ] : Committee on Animals as Monitors of Environmental Hazards, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1991 |
| Descrizione fisica | 1 online resource (172 p.) |
| Disciplina | 615.9/02 |
| Soggetto topico |
Toxicology - Animal models
Biological monitoring Health risk assessment |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-21436-8
9786610214365 0-309-59489-8 0-585-08526-9 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910455423103321 |
| Washington, D.C., : National Academy Press, 1991 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Animals as sentinels of environmental health hazards [[electronic resource] ] : Committee on Animals as Monitors of Environmental Hazards, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
| Animals as sentinels of environmental health hazards [[electronic resource] ] : Committee on Animals as Monitors of Environmental Hazards, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1991 |
| Descrizione fisica | 1 online resource (172 p.) |
| Disciplina | 615.9/02 |
| Soggetto topico |
Toxicology - Animal models
Biological monitoring Health risk assessment |
| ISBN |
1-280-21436-8
9786610214365 0-309-59489-8 0-585-08526-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910778709603321 |
| Washington, D.C., : National Academy Press, 1991 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Animals as sentinels of environmental health hazards : Committee on Animals as Monitors of Environmental Hazards, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
| Animals as sentinels of environmental health hazards : Committee on Animals as Monitors of Environmental Hazards, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1991 |
| Descrizione fisica | 1 online resource (172 p.) |
| Disciplina | 615.9/02 |
| Soggetto topico |
Toxicology - Animal models
Biological monitoring Health risk assessment |
| ISBN |
1-280-21436-8
9786610214365 0-309-59489-8 0-585-08526-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Animals as Sentinels of Environmental Health Hazards -- Copyright -- Preface -- Contents -- Executive Summary -- INTRODUCTION -- Purpose of the Study -- Current Use of Animal Sentinels in Risk Assessment -- CONCEPTS AND DEFINITIONS -- Characteristics of Animal Sentinel Systems -- Species -- Exposure Sources -- Duration of Exposure -- Measures of Effect -- Reference Populations -- Objectives of Monitoring Animals Sentinels -- Advantages and Limitations of Animal Sentinel Systems -- Multifactorial Causality -- Measurement of Exposure and Extrapolation to Humans -- FOOD ANIMALS AS SENTINELS -- COMPANION ANIMALS AS SENTINELS -- FISH AND OTHER WILDLIFE AS SENTINELS -- ANIMAL SENTINELS IN RISK ASSESSMENT -- SELECTION AND APPLICATION OF ANIMAL SENTINEL SYSTEMS IN RISK ASSESSMENT -- CONCLUSIONS AND RECOMMENDATIONS -- STRUCTURE OF THE REPORT -- 1 Introduction -- OVERVIEW -- PURPOSE OF THE STUDY -- HISTORICAL USE OF ANIMAL SENTINELS -- CURRENT USE OF ANIMAL SENTINELS IN RISK ASSESSMENT -- STRUCTURE OF THE REPORT -- 2 Concepts and Definitions -- CHARACTERISTICS OF ANIMAL SENTINEL SYSTEMS -- Species -- A sentinel should have a measurable response (including accumulation of tissue residues) to the agent or class of agents... -- A sentinel should have a territory or home range that overlaps the area to be monitored -- A sentinel species should be easily enumerated and captured -- A sentinel species must have sufficient population size and density to permit enumeration -- Exposure Sources -- Duration of Exposure -- Measures of Effect -- Reference Populations -- OBJECTIVES OF MONITORING ANIMAL SENTINELS -- Human Health Effects -- Contamination of the Food Chain -- Environmental Contamination -- Adverse Effects on Animals -- ANIMAL SENTINEL SYSTEMS IN OBSERVATIONAL EPIDEMIOLOGIC STUDIES -- Descriptive Epidemiology -- Analytic Epidemiologic.
ANIMAL SENTINEL SYSTEMS IN EXPERIMENTAL EPIDEMIOLOGY -- ADVANTAGES AND LIMITATIONS OF ANIMAL SENTINEL SYSTEMS -- Multifactorial Causality -- Measurement of Exposure and Extrapolation to Humans -- 3 Food Animals as Sentinels -- DESCRIPTIVE EPIDEMIOLOGIC STUDIES -- U.S. Department of Agriculture -- Food Safety and Inspection Service -- National Animal Health Monitoring System -- Market Cattle Identification Program -- Food and Drug Administration -- Shellfish Monitoring Programs -- The National Animal Poison Information Network -- Outbreak Investigation -- Methyl Mercury in Fish -- Polychlorinated Biphenyls in Chickens -- Polybrominated Biphenyls in Cattle -- ANALYTIC EPIDEMIOLOGIC STUDIES -- Sheep and Heavy Metals -- Cattle and Heavy Metals -- Cattle and Fluoride -- SUMMARY -- 4 Companion Animals as Sentinels -- DESCRIPTIVE EPIDEMIOLOGIC STUDIES -- Veterinary Medicine Data Program -- Poison-Control Centers -- ANALYTIC EPIDEMIOLOGIC STUDIES -- Canine Mesothelioma and Asbestos Exposure -- Canine Bladder Cancer and Insecticide Exposure -- Lead Poisoning -- Breast Cancer in Dogs -- Diet and Risk of Breast Cancer -- Diet and Survival with Breast Cancer -- Birds and Polytetrafluoroethylene Exposure -- Low-Level Radiation and Cancer -- Cancer in Vietnam-Service Dogs -- Animal Neoplasm Registry -- SUMMARY -- 5 Fish and Other Wildlife as Sentinels -- DESCRIPTIVE EPIDEMIOLOGIC STUDIES -- National Programs -- National Status and Trends Program -- Mussel Watch -- National Contaminant Biomonitoring Program -- Registry of Tumors in Lower Animals -- Penrose Laboratory of Comparative Pathology -- Quarterly Wildlife Mortality Report -- State/Regional/Local Programs -- Great Lakes -- Chesapeake Bay -- Puget Sound -- Sacramento-San Joaquin Estuary -- ANALYTIC EPIDEMIOLOGIC STUDIES -- Initial Identification of Hazardous Agents. Hazard Identification of Chemical Mixtures -- Indication of Bioavailability of Chemicals at Hazardous-Waste Sites -- Water-Quality Monitoring -- Indicators of Air Pollution -- Risk Characterization of Species Under Study -- Dose-Response Relationships -- Contamination of Human Food Chain -- IN SITU STUDIES -- Fish -- Planarians -- Starlings -- Earthworms -- Honey Bees -- SUMMARY -- 6 Animal Sentinels in Risk Assessment -- USE OF ANIMAL SENTINEL SYSTEMS IN EXPOSURE ASSESSMENT -- Animals as General Environmental Monitors -- Animals as Monitors of Their Own Exposure -- Animals as Monitors of Exposure of Their Consumers -- Animals as Surrogate Monitors of Human Exposure -- USE OF ANIMAL SENTINEL SYSTEMS IN HAZARD IDENTIFICATION -- Early Warnings: Initial Identification of Hazardous Agents -- Hazard Identification for Chemical Mixtures -- USE OF ANIMAL SENTINEL SYSTEMS IN DOSE-RESPONSE ASSESSMENT -- USE OF ANIMAL SENTINEL SYSTEMS IN RISK CHARACTERIZATION -- Risks to Animal Species Under Study -- Risk to Consumers of Animal Species Under Study -- Risk to Humans: Animal Sentinels as Surrogates -- USE OF ANIMAL SENTINEL SYSTEMS IN RISK MANAGEMENT -- Management of Risks to Animal Species Under Study -- Management of Risks to Consumers of Animal Species Under Study -- Management of Risks to Human Health: Animal Sentinels as Surrogates -- Animal Sentinel Systems as Monitors of Effectiveness of Risk Management Actions -- SUMMARY -- 7 Selection and Application of Animal Sentinel Systems in Risk Assessment -- SYSTEM DESIGN -- IMPLEMENTATION -- VALIDATION -- PROGRAM INTEGRATION -- 8 Conclusions and Recommendations -- References -- Appendix Workshop Participants. |
| Record Nr. | UNINA-9910812191003321 |
| Washington, D.C., : National Academy Press, 1991 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Inhalation toxicology
| Inhalation toxicology |
| Pubbl/distr/stampa | New York, NY, : Hemisphere Pub. Corp., 1989- |
| Disciplina | 616 |
| Soggetto topico |
Toxicology - Animal models
Pulmonary toxicology Pulmonary toxicology - Periodicals Toxicology - Animal models - Periodicals Air Pollutants - toxicity Respiratory System - drug effects Toxicologie pulmonaire - Périodiques Toxicologie - Modèles animaux - Périodiques Toxicologie - Modèles animaux Toxicologie pulmonaire |
| Soggetto genere / forma |
Periodical
periodicals. Periodicals. Périodiques. |
| Soggetto non controllato | Health & Social Care |
| ISSN | 1091-7691 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910154524403321 |
| New York, NY, : Hemisphere Pub. Corp., 1989- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Zebrafish [[electronic resource] ] : methods for assessing drug safety and toxicity / / edited by Patricia McGrath
| Zebrafish [[electronic resource] ] : methods for assessing drug safety and toxicity / / edited by Patricia McGrath |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, 2011 |
| Descrizione fisica | 1 online resource (362 p.) |
| Disciplina | 597/.482 |
| Altri autori (Persone) | McGrathPatricia <1949-> |
| Soggetto topico |
Logperch - Genetics
Drugs - Safety measures Toxicology - Animal models Fish as laboratory animals Animal models in research |
| ISBN |
1-283-39799-4
9786613397997 1-118-10214-2 1-118-10213-4 1-118-10216-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Zebrafish: Methods for Assessing Drug Safety and Toxicity; Contents; Preface; Contributors; Acknowledgments; 1. The Reproductive Biology and Spawning of Zebrafish in Laboratory Settings; 1.1 Introduction; 1.2 Overview of Zebrafish Reproductive Biology and Behavior; 1.3 Spawning Techniques and Technology; 1.4 Determining Factors for Reproduction in Laboratory Stocks of Zebrafish; 1.5 Conclusions; References; 2. Developmental Toxicity Assessment in Zebrafish; 2.1 Introduction; 2.2 Methods; 2.3 Results; 2.4 Discussion; References; 3. Use of Emerging Models for Developmental Toxicity Testing
3.1 Importance of Assessing Developmental Toxicity3.2 Current Methods for Assessing Developmental Toxicity; 3.3 Use of Emerging Models for Developmental Toxicity Testing; 3.4 New Guidelines for Chemical Testing Using Zebrafish; 3.5 Conclusions; References; 4. Assessment of Drug-Induced Cardiotoxicity in Zebrafish; 4.1 Introduction; 4.2 Zebrafish Heart; 4.3 Summary of Cardiotoxicity Study Design and Results; 4.4 Materials and Methods; 4.5 Results; 4.6 Conclusions; References; 5. Cardiotoxicity Studies in Zebrafish; 5.1 Introduction; 5.2 Repolarization Toxicity 5.3 Initial Screening: Bradycardia5.4 High-Resolution Assays of Repolarization; 5.5 Future Directions; References; 6. In Vivo Recording of the Adult Zebrafish Electrocardiogram; 6.1 Introduction; 6.2 Optimization of Zebrafish Electrocardiogram Recording; 6.3 Basic Intervals; 6.4 Drug Effects; 6.5 Conclusions; References; 7. Hematopoietic and Vascular System Toxicity; 7.1 Introduction; 7.2 Hematopoiesis and Vascular Development in the Zebrafish; 7.3 Morphological and Functional Assays to Assess Toxicity; 7.4 Summary; Acknowledgment; References; 8. Hepatotoxicity Testing in Larval Zebrafish 8.1 Introduction: The Larval Zebrafish Model8.2 Liver Development; 8.3 Hepatic Gene Knockdown and Mutation; 8.4 Hepatotoxicity Testing in Drug Discovery; 8.5 Phenotypic-Based Larval Zebrafish Hepatotoxicity Screens; 8.6 Secondary and Mechanistic Liver Assays; 8.7 Conclusions; References; 9. Whole Zebrafish Cytochrome P450 Assay for Assessing Drug Metabolism and Safety; 9.1 Introduction; 9.2 Background and Significance; 9.3 Materials and Methods; 9.4 Results; 9.5 Conclusions; Acknowledgment; References; 10. Methods for Assessing Neurotoxicity in Zebrafish; 10.1 Introduction 10.2 Limitations of Current Neurotoxicity Testing10.3 Assessing Neurotoxicity in Zebrafish; 10.4 Summary; Acknowledgments; References; 11. Zebrafish: A Predictive Model for Assessing Cancer Drug-Induced Organ Toxicity; 11.1 Introduction; 11.2 Materials and Methods; 11.3 Results; 11.4 Conclusions; Reference; 12. Locomotion and Behavioral Toxicity in Larval Zebrafish: Background, Methods, and Data; 12.1 Introduction; 12.2 Background; 12.3 Locomotion; 12.4 Zebrafish Models; 12.5 Analyzing Larval Locomotion; 12.6 Chemical Effects on Larval Locomotion; 12.7 Conclusions; Acknowledgments; References 13. Zebrafish: A Predictive Model for Assessing Seizure Liability |
| Record Nr. | UNINA-9910141196203321 |
| Hoboken, N.J., : John Wiley & Sons, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Zebrafish : methods for assessing drug safety and toxicity / / edited by Patricia McGrath
| Zebrafish : methods for assessing drug safety and toxicity / / edited by Patricia McGrath |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, 2011 |
| Descrizione fisica | 1 online resource (362 p.) |
| Disciplina | 597/.482 |
| Altri autori (Persone) | McGrathPatricia <1949-> |
| Soggetto topico |
Logperch - Genetics
Drugs - Safety measures Toxicology - Animal models Fish as laboratory animals Animal models in research |
| ISBN |
1-283-39799-4
9786613397997 1-118-10214-2 1-118-10213-4 1-118-10216-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Zebrafish: Methods for Assessing Drug Safety and Toxicity; Contents; Preface; Contributors; Acknowledgments; 1. The Reproductive Biology and Spawning of Zebrafish in Laboratory Settings; 1.1 Introduction; 1.2 Overview of Zebrafish Reproductive Biology and Behavior; 1.3 Spawning Techniques and Technology; 1.4 Determining Factors for Reproduction in Laboratory Stocks of Zebrafish; 1.5 Conclusions; References; 2. Developmental Toxicity Assessment in Zebrafish; 2.1 Introduction; 2.2 Methods; 2.3 Results; 2.4 Discussion; References; 3. Use of Emerging Models for Developmental Toxicity Testing
3.1 Importance of Assessing Developmental Toxicity3.2 Current Methods for Assessing Developmental Toxicity; 3.3 Use of Emerging Models for Developmental Toxicity Testing; 3.4 New Guidelines for Chemical Testing Using Zebrafish; 3.5 Conclusions; References; 4. Assessment of Drug-Induced Cardiotoxicity in Zebrafish; 4.1 Introduction; 4.2 Zebrafish Heart; 4.3 Summary of Cardiotoxicity Study Design and Results; 4.4 Materials and Methods; 4.5 Results; 4.6 Conclusions; References; 5. Cardiotoxicity Studies in Zebrafish; 5.1 Introduction; 5.2 Repolarization Toxicity 5.3 Initial Screening: Bradycardia5.4 High-Resolution Assays of Repolarization; 5.5 Future Directions; References; 6. In Vivo Recording of the Adult Zebrafish Electrocardiogram; 6.1 Introduction; 6.2 Optimization of Zebrafish Electrocardiogram Recording; 6.3 Basic Intervals; 6.4 Drug Effects; 6.5 Conclusions; References; 7. Hematopoietic and Vascular System Toxicity; 7.1 Introduction; 7.2 Hematopoiesis and Vascular Development in the Zebrafish; 7.3 Morphological and Functional Assays to Assess Toxicity; 7.4 Summary; Acknowledgment; References; 8. Hepatotoxicity Testing in Larval Zebrafish 8.1 Introduction: The Larval Zebrafish Model8.2 Liver Development; 8.3 Hepatic Gene Knockdown and Mutation; 8.4 Hepatotoxicity Testing in Drug Discovery; 8.5 Phenotypic-Based Larval Zebrafish Hepatotoxicity Screens; 8.6 Secondary and Mechanistic Liver Assays; 8.7 Conclusions; References; 9. Whole Zebrafish Cytochrome P450 Assay for Assessing Drug Metabolism and Safety; 9.1 Introduction; 9.2 Background and Significance; 9.3 Materials and Methods; 9.4 Results; 9.5 Conclusions; Acknowledgment; References; 10. Methods for Assessing Neurotoxicity in Zebrafish; 10.1 Introduction 10.2 Limitations of Current Neurotoxicity Testing10.3 Assessing Neurotoxicity in Zebrafish; 10.4 Summary; Acknowledgments; References; 11. Zebrafish: A Predictive Model for Assessing Cancer Drug-Induced Organ Toxicity; 11.1 Introduction; 11.2 Materials and Methods; 11.3 Results; 11.4 Conclusions; Reference; 12. Locomotion and Behavioral Toxicity in Larval Zebrafish: Background, Methods, and Data; 12.1 Introduction; 12.2 Background; 12.3 Locomotion; 12.4 Zebrafish Models; 12.5 Analyzing Larval Locomotion; 12.6 Chemical Effects on Larval Locomotion; 12.7 Conclusions; Acknowledgments; References 13. Zebrafish: A Predictive Model for Assessing Seizure Liability |
| Record Nr. | UNINA-9910824873503321 |
| Hoboken, N.J., : John Wiley & Sons, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
