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Building satellites is easier / / Phyllis Nimmo Marsh
| Building satellites is easier / / Phyllis Nimmo Marsh |
| Autore | Marsh Phyllis Nimmo |
| Pubbl/distr/stampa | Greenbelt, Maryland : , : National Aeronautics and Space Administration, Goddard Space Flight Center, , June 1996 |
| Descrizione fisica | 1 online resource (v, 107 pages) |
| Collana | NASA technical memorandum |
| Soggetto topico |
Diseases
Sensory feedback Head (anatomy) Thyroid gland Anxiety Injuries Blood pressure Emotions Neurotic depression |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910707007403321 |
Marsh Phyllis Nimmo
|
||
| Greenbelt, Maryland : , : National Aeronautics and Space Administration, Goddard Space Flight Center, , June 1996 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Ciba Foundation Colloquia on Endocrinology . Volume 10 Regulation and mode of action of thyroid hormones / / editors for the Ciba Foundation, G. E. W. Wolstenholme and Elaine C. P. Millar
| Ciba Foundation Colloquia on Endocrinology . Volume 10 Regulation and mode of action of thyroid hormones / / editors for the Ciba Foundation, G. E. W. Wolstenholme and Elaine C. P. Millar |
| Pubbl/distr/stampa | London, : J. & A. Churchill |
| Descrizione fisica | 1 online resource (346 p.) |
| Disciplina |
599.01
599.0133 |
| Altri autori (Persone) |
WolstenholmeG. E. W (Gordon Ethelbert Ward)
MillarElaine C. P |
| Collana | Novartis Foundation Symposia |
| Soggetto topico |
Thyroid hormones
Thyroid gland |
| ISBN |
9786613620675
9781280590849 128059084X 9780470719022 0470719028 9780470716496 0470716495 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CIBA FOUNDATION COLLOQUIA ON ENDOCRINOLOGY VOLUME 10; CONTENTS; Chairman's opening remarks; Hypothalamus-pituitary -thyroid relationships; Discussion; Contribution to the regulation of thyroid activity; Discussion; The influence of the central nervous system on the control of thyrotrophin secretion; Discussion; Pituitary cytology in relation to thyrotrophic hormone secretion; Discussion; Effects of hypophysectomy on organic iodine formation in rat thyroids; Discussion; Factors influencing the thyroidal iodide pump; Discussion; The ""feed-back"" hypothesis of the control of thyroid function
DiscussionGeneral Discussion; Hormone synthesis in the iodine-deficient thyroid gland; Discussion; Enzymic aspects of thyronine metabolism and its iodinated derivatives; Discussion; The metabolism of thyroid hormones by kidney and the biological activity of the products; Discussion; On the presence of 3 : 5 : 3'-triiodothyroacetic acid and 3 : 3'-diiodothyronine in rat muscle and kidney after administration of 3 : 5 : 3'-triiodo-L-thyronine; Discussion; The distribution and metabolism of thyroid hormones; The deiodination of thyroid hormones in vitro; Discussion; General Discussion Hepatic regulation of thyroxine metabolismDiscussion; Thyroid hormones at the peripheral tissue level: metabolism and mode of action; Discussion; Cellular actions of thyroxine and similar compounds; Discussion; Some observations on the clinical effects of triiodothyroacetic acid; Discussion; The influence of the thyroid gland upon immune responses of different species to bacterial infection; Discussion; General Discussion |
| Altri titoli varianti | Regulation and mode of action of thyroid hormones |
| Record Nr. | UNINA-9911019189403321 |
| London, : J. & A. Churchill | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Goiter : Causes and Treatment / / edited by Neeraj Kumar Agrawal
| Goiter : Causes and Treatment / / edited by Neeraj Kumar Agrawal |
| Pubbl/distr/stampa | London, United Kingdom : , : IntechOpen, , 2020 |
| Descrizione fisica | 1 online resource (144 pages) : illustrations |
| Disciplina | 616.44 |
| Soggetto topico |
Thyroid Diseases
Thyroid gland |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Goiter |
| Record Nr. | UNINA-9910688577103321 |
| London, United Kingdom : , : IntechOpen, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Journal of thyroid research
| Journal of thyroid research |
| Pubbl/distr/stampa | New York, NY, : SAGE-Hindawi Access to Research |
| Soggetto topico |
Thyroid gland
Thyroid gland - Diseases Thyroid hormones Endocrine System Diseases Thyroid Diseases Thyroid Gland Thyroid Hormones |
| Soggetto genere / forma |
Fulltext
Internet Resources. Periodicals. Periodical |
| ISSN | 2042-0072 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996212661803316 |
| New York, NY, : SAGE-Hindawi Access to Research | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Journal of thyroid research
| Journal of thyroid research |
| Pubbl/distr/stampa | New York, NY, : SAGE-Hindawi Access to Research |
| Soggetto topico |
Thyroid gland
Thyroid gland - Diseases Thyroid hormones Endocrine System Diseases Thyroid Diseases Thyroid Gland Thyroid Hormones Tiroide |
| Soggetto genere / forma |
Periodical
Fulltext Periodicals. Revistes electròniques |
| ISSN | 2042-0072 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910139482103321 |
| New York, NY, : SAGE-Hindawi Access to Research | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Thyroid and Brain Understanding the Actions of Thyroid Hormones in Brain Development and Function / Juan Bernal
| Thyroid and Brain Understanding the Actions of Thyroid Hormones in Brain Development and Function / Juan Bernal |
| Autore | Bernal Juan |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Sharjah : , : Bentham Science Publishers, , 2024 |
| Descrizione fisica | 1 online resource (343 pages) |
| Soggetto topico |
Thyroid hormones
Thyroid gland |
| ISBN |
9789815274226
9815274228 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Foreword -- Preface -- Acknowledgements -- Dedication -- An Introduction to Thyroid Physiology -- INTRODUCTION -- THE UNIQUENESS OF THE THYROID GLAND -- Embryology -- The Thyroid Follicles -- Thyroid Hormone Synthesis -- CIRCULATING THYROID HORMONES -- THYROID HORMONE METABOLISM -- Deiodinases -- Type 1 Deiodinase (DIO1) -- Type 2 Deiodinase (DIO2) -- Type 3 Deiodinase (DIO3) -- Thyronamines -- THYROID HORMONE ACTION -- Type 1: Nuclear Receptor-Dependent Signaling with Direct Binding to DNA -- Type 2: Nuclear Receptor-Dependent Signaling with Indirect Binding to DNA -- Type 3: Nuclear Receptor-Dependent Signaling without DNA Binding -- Type 4: Nuclear Receptor-Independent Signaling -- The Endocrine Disruptor Bisphenol A (BPA) and its Interaction with Thyroid Hormone Receptors -- EVOLUTIONARY ASPECTS OF THYROID HORMONES -- CONCLUDING REMARKS -- REFERENCES -- Congenital Hypothyroidism -- INTRODUCTION -- PRIMARY CONGENITAL HYPOTHYROIDISM -- Thyroid Dysgenesis -- Thyroid Dyshormonogenesis -- Iodide Transporters -- Iodide Oxidation and Organification -- Thyroglobulin -- Dehalogenase -- TSH Resistance -- CENTRAL CONGENITAL HYPOTHYROIDISM -- DEVELOPMENTAL ARREST IN CONGENITAL HYPOTHYROIDISM -- Untreated Congenital Hypothyroidism -- Persistence of Brain Damage Despite Early Treatment -- CONCLUDING REMARKS -- REFERENCES -- Deiodinases in the Brain -- INTRODUCTION -- THYROXINE, A TRIIODOTHYRONINE PRECURSOR -- DEIODINASES IN THE RODENT BRAIN -- Type 1 Deiodinase -- Type 2 Deiodinase -- Developmental Changes in Type-2 Deiodinase Activity -- Dio2 Regional and Cellular Expression in the Brain -- The Paracrine Model of Deiodination and Action -- The Significance of Dio2 Expression in Astrocytes -- How the Lack of DIO2 Impacts the Brain -- Type 3 Deiodinase.
Developmental Changes in Type-3 Deiodinase Activity -- How the Lack of DIO3 Impacts the Brain -- REGULATION OF DEIODINASE BRAIN EXPRESSION AND ACTIVITY -- DEIODINASES IN THE HUMAN BRAIN -- Thyroid Hormone Concentrations and Deiodinase Activity in the Human Fetal Brain -- DIO2 in Stem Cells of the Developing Human Fetal Cerebral Cortex -- Genetic Deficiencies in Deiodinase Function -- The Thr92Ala-DIO2 Polymorphism -- CONCLUDING REMARKS -- REFERENCES -- Unraveling the Role of Maternal Thyroid Hormones on Fetal Development -- INTRODUCTION -- PLACENTAL PERMEABILITY TO THYROID HORMONES IN RODENTS -- The Relevance of T4 as the Source of T3 in the Fetal Brain -- THE PERMEABILITY OF THE HUMAN PLACENTA TO THYROID HORMONES -- Maternal Thyroid Hormones in the Fetus During Early Pregnancy -- MATERNAL HYPOTHYROIDISM AND HYPOTHYROXINEMIA -- Maternal Hypothyroidism and Infant Brain Development: Experimental Studies -- Maternal Clinical Hypothyroidism -- Maternal Hypothyroxinemia -- CONCLUDING REMARKS -- REFERENCES -- Endemic Goiter and Cretinism: Pathophysiology of Iodine Deficiency -- INTRODUCTION -- THE IODINE CYCLE -- Iodine Requirements -- ENDEMIC GOITER AND CRETINISM -- Neurological Manifestations of Endemic Cretinism -- Pathogenesis -- Myxedematous Cretinism -- PHYSIOLOGICAL MECHANISMS SET IN MOTION BY IODINE DEFICIENCY IN EXPERIMENTAL ANIMALS -- Thyroid Autoregulation -- Thyroidal Iodotyrosine Dehalogenase -- Mechanisms Leading to Preferential Secretion of T3 -- Changes in Thyroid Hormone Deiodination in Extrathyroidal Organs -- Iodine Deficiency in Developing Rats -- The Sheep Model -- CONCLUDING REMARKS -- REFERENCES -- Cellular Transporters for Thyroid Hormones -- INTRODUCTION -- PROTEIN FAMILIES WITH THYROID HORMONE TRANSPORTING ACTIVITY -- Bile Acid Transporters -- Amino Acid Transporters -- Organic Anion Transporter Polypeptides (OATPs). A Syndrome of Cerebral Hypometabolism and Juvenile Neurodegeneration Caused by Mutated SLCO1C1 -- Monocarboxylate Transporters -- Monocarboxylate Transporter 8 (MCT8) -- Monocarboxylate Transporter 10 (MCT10) -- TRANSPORT OF THYROID HORMONES THROUGH THE BRAIN BARRIERS -- The Blood-Brain Barrier (BBB) -- The Blood-Cerebrospinal Fluid Barrier (BCSFB) -- The Meningeal Barrier -- Circumventricular Organs -- Transient Embryonic CSF-Brain Barrier -- TRANSPORT OF THYROID HORMONES IN OTHER ORGANISMS -- Thyroid Hormone Transporters in Zebrafish -- Thyroid Hormone Transport in Chicken -- CONCLUDING REMARKS -- REFERENCES -- The Allan-Herndon-Dudley Syndrome: Pathophysiology and Mouse Models of MCT8 Deficiency -- INTRODUCTION -- THE ALLAN-HERNDON-DUDLEY SYNDROME (ORPHANET #300523) -- Clinical Aspects -- Histopathological Changes in the MCT8-Deficient Brain -- Histopathology of MCT8-Deficient Fetus Brain -- Histopathology of an MCT8-Deficient Child Brain -- MCT8 DEFICIENCY IN MICE -- Altered Thyroid Gland Secretion and Tissue Deiodinase Activity -- Changes in Thyroid Gland Secretion -- Changes in Deiodinase Activities -- Proposed Sequence of Events in MCT8 Deficiency -- The Phenotype of MCT8-Deficient Mice -- Peripheral Metabolism -- Brain Metabolism -- Brain Architecture and Function -- Perinatal Brain Hyperthyroidism -- MOUSE MODELS OF ALLAN-HERNDON-DUDLEY SYNDROME -- Mice Deficient in MCT8 and OATP1C1 -- Mice Deficient in MCT8 and DIO2 -- The MCT8P253L Variant -- THERAPEUTIC APPROACHES -- Thyroxine -- Intraamniotic Thyroxine Treatment -- Diiodothyropropionic Acid (DITPA) -- 3,5,3'-Triiodothyroacetic Acid -- Sobetirome -- Sodium Phenylbutyrate (NaPB) -- Gene Therapy -- CONCLUDING REMARKS -- REFERENCES -- Thyroid Hormone Receptors in the Brain: Distribution and Deletion Effects on Brain Structure and Behavior -- INTRODUCTION. T3 RECEPTOR EXPRESSION IN THE RODENT BRAIN -- Early Expression and Distribution of Receptor mRNAs -- Receptor Protein Distribution -- Receptor Expression in Different Cell Types -- UNDERSTANDING RECEPTOR FUNCTION THROUGH MOUSE GENETIC MODIFICATIONS -- The Phenotypes of Thyroid Hormone Receptor Knockout Mice -- TRα1 in the Control of Emotions, Learning, and Memory -- What the Receptor Gene Deletions Tell About Their in vivo Functions -- Why Receptor Deletion is Not Equivalent to Hormone Deprivation: Aporeceptor Function -- Aporeceptor Function in Developmental Timing Control -- T3 RECEPTOR EXPRESSION IN THE HUMAN FETAL BRAIN -- CONCLUDING REMARKS -- REFERENCES -- Pathophysiology and Mouse Models of Thyroid Hormone Resistance Syndromes: A Focus on the Brain -- INTRODUCTION -- GENERAL ASPECTS OF RTH -- THE BRAIN PHENOTYPE OF RTH -- Resistance to Thyroid Hormone Due to THRB Mutations (RTHβ) -- Resistance to Thyroid Hormone Due to THRA Mutations (RTHα) -- Compound TRα1 and TRα2 Mutations -- MOUSE MODELS OF RTH -- The PV Mutation -- The Family S Mutation -- The R384C Mutation -- The ThraAMI Allele and TRα1L400R Mutation -- CONCLUDING REMARKS -- REFERENCES -- Thyroid Hormone-Regulated Genes in the Brain -- INTRODUCTION -- PATTERNS OF BRAIN GENE REGULATION BY THYROID HORMONE IN VIVO -- Controlling Gene Expression Timing -- Reelin Expression -- Myelin Gene Expression -- Regional Control of Gene Expression -- Regional Control of Neurogranin (Nrgn) Expression -- THOUSANDS OF GENES ARE SENSITIVE TO THYROID HORMONE IN VIVO -- The Diversity of Genes Regulated by Thyroid Hormone -- Are There Universal T3 Transcriptionally-Responsive Genes? -- THE CAMK4 SIGNALING NETWORK -- PRIMARY AND SECONDARY T3 RESPONSES IN PRIMARY CEREBRO-CORTICAL CELLS -- Developmental and Growth Factor Genes -- Genes Involved in the Control of Cell Migration -- Ephrins and Ephrin Receptors. Chemorepulsive Molecules: Slit and Robo -- Semaphorins -- Genes Encoding Extracellular Matrix Proteins -- Transcription Factors -- Retinoic Acid Metabolism -- Potassium Channels -- Neurotransmitter Receptors -- Genes Enriched in Cortex Layers Neurons -- THYROID HORMONE SIGNALING IN GABAERGIC CELLS -- THYROID HORMONE SIGNALING IN ASTROCYTES -- CONCLUDING REMARKS -- REFERENCES -- Actions of Thyroid Hormones on Myelination -- INTRODUCTION -- THE GENERATION OF OLIGODENDROCYTES -- Oligodendrogenesis in Humans -- THYROID HORMONES AND MYELINATION -- Actions of Thyroid Hormone on Oligodendrocyte Differentiation -- Regulated Genes -- Role of the Thyroid Hormone Receptor Isoforms -- NUCLEAR MAGNETIC RESONANCE TECHNIQUES FOR STUDYING MYELINATION IN VIVO -- T1- and T2-Weighted Images -- Diffusion Tensor Imaging -- Magnetization Transfer Imaging -- Magnetic Resonance Spectroscopy -- Brain Magnetic Resonance Studies on Hypothyroid States -- Congenital Hypothyroidism -- Maternal Hypothyroidism -- Allan-Herndon-Dudley Syndrome -- CONCLUDING REMARKS -- REFERENCES -- How Thyroid Hormones Shape the Brain -- INTRODUCTION -- THYROID HORMONES PROMOTE AXODENDRITIC DEVELOPMENT -- ROLE OF THYROID HORMONES IN THE DEVELOPMENT OF SPECIFIC BRAIN REGIONS -- The Cerebral Cortex -- The First Trimester -- The Second Trimester and Beyond -- The Impact of Thyroid Hormone Deficiency on the Cerebral Cortex -- Thyroid Hormone Action during Cortical Development: Unraveling the Complexity -- The Adult Cerebral Cortex -- The Hippocampus -- Cell Types of the Hippocampus -- The Role of Thyroid Hormones -- The Cerebellum -- Cerebellar Cell Types -- Cerebellar Cortical Development -- The Hypothyroid Cerebellum -- The Striatum -- Effects of Experimental Hypothyroidism -- Genes Regulated by Thyroid Hormones in the Striatum -- SENSE ORGANS -- The Retina -- Retinal Cell Types. Role of Thyroid Hormones. |
| Record Nr. | UNINA-9911117451803321 |
|
Bernal Juan
|
||
| Sharjah : , : Bentham Science Publishers, , 2024 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Thyroid and Brain Understanding the Actions of Thyroid Hormones in Brain Development and Function / Juan Bernal
| Thyroid and Brain Understanding the Actions of Thyroid Hormones in Brain Development and Function / Juan Bernal |
| Autore | Bernal Juan |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Sharjah : , : Bentham Science Publishers, , 2024 |
| Descrizione fisica | 1 online resource (343 pages) |
| Soggetto topico |
Thyroid hormones
Thyroid gland |
| ISBN |
9789815274226
9815274228 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Foreword -- Preface -- Acknowledgements -- Dedication -- An Introduction to Thyroid Physiology -- INTRODUCTION -- THE UNIQUENESS OF THE THYROID GLAND -- Embryology -- The Thyroid Follicles -- Thyroid Hormone Synthesis -- CIRCULATING THYROID HORMONES -- THYROID HORMONE METABOLISM -- Deiodinases -- Type 1 Deiodinase (DIO1) -- Type 2 Deiodinase (DIO2) -- Type 3 Deiodinase (DIO3) -- Thyronamines -- THYROID HORMONE ACTION -- Type 1: Nuclear Receptor-Dependent Signaling with Direct Binding to DNA -- Type 2: Nuclear Receptor-Dependent Signaling with Indirect Binding to DNA -- Type 3: Nuclear Receptor-Dependent Signaling without DNA Binding -- Type 4: Nuclear Receptor-Independent Signaling -- The Endocrine Disruptor Bisphenol A (BPA) and its Interaction with Thyroid Hormone Receptors -- EVOLUTIONARY ASPECTS OF THYROID HORMONES -- CONCLUDING REMARKS -- REFERENCES -- Congenital Hypothyroidism -- INTRODUCTION -- PRIMARY CONGENITAL HYPOTHYROIDISM -- Thyroid Dysgenesis -- Thyroid Dyshormonogenesis -- Iodide Transporters -- Iodide Oxidation and Organification -- Thyroglobulin -- Dehalogenase -- TSH Resistance -- CENTRAL CONGENITAL HYPOTHYROIDISM -- DEVELOPMENTAL ARREST IN CONGENITAL HYPOTHYROIDISM -- Untreated Congenital Hypothyroidism -- Persistence of Brain Damage Despite Early Treatment -- CONCLUDING REMARKS -- REFERENCES -- Deiodinases in the Brain -- INTRODUCTION -- THYROXINE, A TRIIODOTHYRONINE PRECURSOR -- DEIODINASES IN THE RODENT BRAIN -- Type 1 Deiodinase -- Type 2 Deiodinase -- Developmental Changes in Type-2 Deiodinase Activity -- Dio2 Regional and Cellular Expression in the Brain -- The Paracrine Model of Deiodination and Action -- The Significance of Dio2 Expression in Astrocytes -- How the Lack of DIO2 Impacts the Brain -- Type 3 Deiodinase.
Developmental Changes in Type-3 Deiodinase Activity -- How the Lack of DIO3 Impacts the Brain -- REGULATION OF DEIODINASE BRAIN EXPRESSION AND ACTIVITY -- DEIODINASES IN THE HUMAN BRAIN -- Thyroid Hormone Concentrations and Deiodinase Activity in the Human Fetal Brain -- DIO2 in Stem Cells of the Developing Human Fetal Cerebral Cortex -- Genetic Deficiencies in Deiodinase Function -- The Thr92Ala-DIO2 Polymorphism -- CONCLUDING REMARKS -- REFERENCES -- Unraveling the Role of Maternal Thyroid Hormones on Fetal Development -- INTRODUCTION -- PLACENTAL PERMEABILITY TO THYROID HORMONES IN RODENTS -- The Relevance of T4 as the Source of T3 in the Fetal Brain -- THE PERMEABILITY OF THE HUMAN PLACENTA TO THYROID HORMONES -- Maternal Thyroid Hormones in the Fetus During Early Pregnancy -- MATERNAL HYPOTHYROIDISM AND HYPOTHYROXINEMIA -- Maternal Hypothyroidism and Infant Brain Development: Experimental Studies -- Maternal Clinical Hypothyroidism -- Maternal Hypothyroxinemia -- CONCLUDING REMARKS -- REFERENCES -- Endemic Goiter and Cretinism: Pathophysiology of Iodine Deficiency -- INTRODUCTION -- THE IODINE CYCLE -- Iodine Requirements -- ENDEMIC GOITER AND CRETINISM -- Neurological Manifestations of Endemic Cretinism -- Pathogenesis -- Myxedematous Cretinism -- PHYSIOLOGICAL MECHANISMS SET IN MOTION BY IODINE DEFICIENCY IN EXPERIMENTAL ANIMALS -- Thyroid Autoregulation -- Thyroidal Iodotyrosine Dehalogenase -- Mechanisms Leading to Preferential Secretion of T3 -- Changes in Thyroid Hormone Deiodination in Extrathyroidal Organs -- Iodine Deficiency in Developing Rats -- The Sheep Model -- CONCLUDING REMARKS -- REFERENCES -- Cellular Transporters for Thyroid Hormones -- INTRODUCTION -- PROTEIN FAMILIES WITH THYROID HORMONE TRANSPORTING ACTIVITY -- Bile Acid Transporters -- Amino Acid Transporters -- Organic Anion Transporter Polypeptides (OATPs). A Syndrome of Cerebral Hypometabolism and Juvenile Neurodegeneration Caused by Mutated SLCO1C1 -- Monocarboxylate Transporters -- Monocarboxylate Transporter 8 (MCT8) -- Monocarboxylate Transporter 10 (MCT10) -- TRANSPORT OF THYROID HORMONES THROUGH THE BRAIN BARRIERS -- The Blood-Brain Barrier (BBB) -- The Blood-Cerebrospinal Fluid Barrier (BCSFB) -- The Meningeal Barrier -- Circumventricular Organs -- Transient Embryonic CSF-Brain Barrier -- TRANSPORT OF THYROID HORMONES IN OTHER ORGANISMS -- Thyroid Hormone Transporters in Zebrafish -- Thyroid Hormone Transport in Chicken -- CONCLUDING REMARKS -- REFERENCES -- The Allan-Herndon-Dudley Syndrome: Pathophysiology and Mouse Models of MCT8 Deficiency -- INTRODUCTION -- THE ALLAN-HERNDON-DUDLEY SYNDROME (ORPHANET #300523) -- Clinical Aspects -- Histopathological Changes in the MCT8-Deficient Brain -- Histopathology of MCT8-Deficient Fetus Brain -- Histopathology of an MCT8-Deficient Child Brain -- MCT8 DEFICIENCY IN MICE -- Altered Thyroid Gland Secretion and Tissue Deiodinase Activity -- Changes in Thyroid Gland Secretion -- Changes in Deiodinase Activities -- Proposed Sequence of Events in MCT8 Deficiency -- The Phenotype of MCT8-Deficient Mice -- Peripheral Metabolism -- Brain Metabolism -- Brain Architecture and Function -- Perinatal Brain Hyperthyroidism -- MOUSE MODELS OF ALLAN-HERNDON-DUDLEY SYNDROME -- Mice Deficient in MCT8 and OATP1C1 -- Mice Deficient in MCT8 and DIO2 -- The MCT8P253L Variant -- THERAPEUTIC APPROACHES -- Thyroxine -- Intraamniotic Thyroxine Treatment -- Diiodothyropropionic Acid (DITPA) -- 3,5,3'-Triiodothyroacetic Acid -- Sobetirome -- Sodium Phenylbutyrate (NaPB) -- Gene Therapy -- CONCLUDING REMARKS -- REFERENCES -- Thyroid Hormone Receptors in the Brain: Distribution and Deletion Effects on Brain Structure and Behavior -- INTRODUCTION. T3 RECEPTOR EXPRESSION IN THE RODENT BRAIN -- Early Expression and Distribution of Receptor mRNAs -- Receptor Protein Distribution -- Receptor Expression in Different Cell Types -- UNDERSTANDING RECEPTOR FUNCTION THROUGH MOUSE GENETIC MODIFICATIONS -- The Phenotypes of Thyroid Hormone Receptor Knockout Mice -- TRα1 in the Control of Emotions, Learning, and Memory -- What the Receptor Gene Deletions Tell About Their in vivo Functions -- Why Receptor Deletion is Not Equivalent to Hormone Deprivation: Aporeceptor Function -- Aporeceptor Function in Developmental Timing Control -- T3 RECEPTOR EXPRESSION IN THE HUMAN FETAL BRAIN -- CONCLUDING REMARKS -- REFERENCES -- Pathophysiology and Mouse Models of Thyroid Hormone Resistance Syndromes: A Focus on the Brain -- INTRODUCTION -- GENERAL ASPECTS OF RTH -- THE BRAIN PHENOTYPE OF RTH -- Resistance to Thyroid Hormone Due to THRB Mutations (RTHβ) -- Resistance to Thyroid Hormone Due to THRA Mutations (RTHα) -- Compound TRα1 and TRα2 Mutations -- MOUSE MODELS OF RTH -- The PV Mutation -- The Family S Mutation -- The R384C Mutation -- The ThraAMI Allele and TRα1L400R Mutation -- CONCLUDING REMARKS -- REFERENCES -- Thyroid Hormone-Regulated Genes in the Brain -- INTRODUCTION -- PATTERNS OF BRAIN GENE REGULATION BY THYROID HORMONE IN VIVO -- Controlling Gene Expression Timing -- Reelin Expression -- Myelin Gene Expression -- Regional Control of Gene Expression -- Regional Control of Neurogranin (Nrgn) Expression -- THOUSANDS OF GENES ARE SENSITIVE TO THYROID HORMONE IN VIVO -- The Diversity of Genes Regulated by Thyroid Hormone -- Are There Universal T3 Transcriptionally-Responsive Genes? -- THE CAMK4 SIGNALING NETWORK -- PRIMARY AND SECONDARY T3 RESPONSES IN PRIMARY CEREBRO-CORTICAL CELLS -- Developmental and Growth Factor Genes -- Genes Involved in the Control of Cell Migration -- Ephrins and Ephrin Receptors. Chemorepulsive Molecules: Slit and Robo -- Semaphorins -- Genes Encoding Extracellular Matrix Proteins -- Transcription Factors -- Retinoic Acid Metabolism -- Potassium Channels -- Neurotransmitter Receptors -- Genes Enriched in Cortex Layers Neurons -- THYROID HORMONE SIGNALING IN GABAERGIC CELLS -- THYROID HORMONE SIGNALING IN ASTROCYTES -- CONCLUDING REMARKS -- REFERENCES -- Actions of Thyroid Hormones on Myelination -- INTRODUCTION -- THE GENERATION OF OLIGODENDROCYTES -- Oligodendrogenesis in Humans -- THYROID HORMONES AND MYELINATION -- Actions of Thyroid Hormone on Oligodendrocyte Differentiation -- Regulated Genes -- Role of the Thyroid Hormone Receptor Isoforms -- NUCLEAR MAGNETIC RESONANCE TECHNIQUES FOR STUDYING MYELINATION IN VIVO -- T1- and T2-Weighted Images -- Diffusion Tensor Imaging -- Magnetization Transfer Imaging -- Magnetic Resonance Spectroscopy -- Brain Magnetic Resonance Studies on Hypothyroid States -- Congenital Hypothyroidism -- Maternal Hypothyroidism -- Allan-Herndon-Dudley Syndrome -- CONCLUDING REMARKS -- REFERENCES -- How Thyroid Hormones Shape the Brain -- INTRODUCTION -- THYROID HORMONES PROMOTE AXODENDRITIC DEVELOPMENT -- ROLE OF THYROID HORMONES IN THE DEVELOPMENT OF SPECIFIC BRAIN REGIONS -- The Cerebral Cortex -- The First Trimester -- The Second Trimester and Beyond -- The Impact of Thyroid Hormone Deficiency on the Cerebral Cortex -- Thyroid Hormone Action during Cortical Development: Unraveling the Complexity -- The Adult Cerebral Cortex -- The Hippocampus -- Cell Types of the Hippocampus -- The Role of Thyroid Hormones -- The Cerebellum -- Cerebellar Cell Types -- Cerebellar Cortical Development -- The Hypothyroid Cerebellum -- The Striatum -- Effects of Experimental Hypothyroidism -- Genes Regulated by Thyroid Hormones in the Striatum -- SENSE ORGANS -- The Retina -- Retinal Cell Types. Role of Thyroid Hormones. |
| Record Nr. | UNINA-9911152599203321 |
|
Bernal Juan
|
||
| Sharjah : , : Bentham Science Publishers, , 2024 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Thyroid research
| Thyroid research |
| Pubbl/distr/stampa | [London], : BioMed Central Ltd., ©2008- |
| Soggetto topico |
Thyroid gland
Thyroid gland - Diseases Endocrinology Thyroid Diseases Thyroid Gland |
| Soggetto genere / forma |
Periodicals.
Fulltext Internet Resource Periodical |
| Soggetto non controllato | Clinical Endocrinology |
| ISSN | 1756-6614 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996210549203316 |
| [London], : BioMed Central Ltd., ©2008- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Thyroid research
| Thyroid research |
| Pubbl/distr/stampa | [London], : BioMed Central Ltd., ©2008- |
| Soggetto topico |
Thyroid gland
Thyroid gland - Diseases Endocrinology Thyroid Diseases Thyroid Gland |
| Soggetto genere / forma |
Periodical
Fulltext Internet Resource Periodicals. |
| ISSN | 1756-6614 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910146310003321 |
| [London], : BioMed Central Ltd., ©2008- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Thyroid research & practice
| Thyroid research & practice |
| Pubbl/distr/stampa | Cochin : , : Indian Thyroid Society |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Thyroid gland
Thyroid gland - Diseases Thyroid Gland Thyroid Diseases Thyroïde Thyroïde - Maladies |
| Soggetto genere / forma |
Periodical
periodicals. Periodicals. Périodiques. |
| ISSN | 2250-1452 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
Thyroid research and practice
TRP |
| Record Nr. | UNINA-9910141348203321 |
| Cochin : , : Indian Thyroid Society | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Thyroid gland
(10)
- Thyroid Diseases (6)
- Thyroid Gland (5)
- Thyroid gland - Diseases (5)
- Thyroid hormones (5)