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Telomere : a complex end of a chromosome / / edited by Marcelo L. Larramendy
| Telomere : a complex end of a chromosome / / edited by Marcelo L. Larramendy |
| Pubbl/distr/stampa | Rijeka, Croatia : , : IntechOpen, , [2016] |
| Descrizione fisica | 1 online resource (226 pages) : illustrations |
| Disciplina | 572.87 |
| Soggetto topico | Telomere |
| ISBN |
953-51-4150-3
953-51-2753-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
Telomere
Telomere â A Complex End of a Chromosome |
| Record Nr. | UNINA-9910317684903321 |
| Rijeka, Croatia : , : IntechOpen, , [2016] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Telomere territory and cancer / / Parvin Mehdipour, editor
| Telomere territory and cancer / / Parvin Mehdipour, editor |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | Dordrecht [Netherlands] ; ; New York, : Springer, 2013 |
| Descrizione fisica | 1 online resource (212 p.) |
| Disciplina | 572.87 |
| Altri autori (Persone) | MehdipourParvin |
| Soggetto topico |
Telomere
Telomerase Cancer cells |
| ISBN |
1-283-63389-2
9786613946348 94-007-4632-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Preface; Contents; Abbreviations and Acronyms; Contributors; Chapter-1; Telomerase: from Aging to Human Cancers; 1.1 Introduction; 1.2 Telomerase in Aging; 1.3 Telomerase in Leukemia; 1.4 Telomerase in Lymphomas; 1.5 Telomerase in Carcinomas; 1.6 Telomerase in Sarcomas; 1.7 Telomerase Targeted for Cancer Therapy; 1.8 Conclusions and Future Perspectives; References; Chapter-2; Telomerase: Basic and Clinical Approaches; 2.1 Introduction; 2.2 Telomerase Structure; 2.3 Telomerase Regulation; 2.3.1 Pretranslational Regulation; 2.3.2 Posttranscriptional Regulation; 2.3.3 Telomerase Activators
2.3.3.1 Akt kinase2.3.3.2 Protein kinase C and IP6; 2.3.4 Telomerase Repressors; 2.3.4.1 c-Abl; 2.3.4.2 PP2A; 2.4 Telomerase Activity and Expression of Its RNA Component (hTR) in Breast Cancer Patients (Adapted from Hosseini et al. 2006a Hosseini et al. 2006b); 2.4.1 Methods; 2.4.2 Results; 2.4.3 Discussion; 2.5 Expression of hTR and hTERT in Human Breast Cancer Patients: A Clinical Based Data (Adapted from Hosseini et al. 2006a Hosseini et al. 2006b); 2.5.1 Results; 2.5.2 Discussion; References; Chapter-3 Detection of Telomerase Activity: A New Strategy for Detecting Low Activity of Telomerase3.1 Introduction; 3.2 TRAP Assay; 3.3 TRAP-SPA; 3.4 Real-Time Quantitative Assay (RQ-TRAP); 3.5 ISTRAP; 3.6 PCR-Free Telomerase Detection; 3.7 TMA/HPA; 3.8 A New Strategy for Detecting Low Activity of Telomerase; 3.8.1 Material and Methods; 3.8.2 Results; 3.8.3 Discussion; References; Chapter-4; Telomere, Regulation and Tumorigenesis; 4.1 Introduction; 4.2 Telomeric DNA; 4.3 Telomeric Proteins and Its Regulation; 4.4 Telomeric Proteins and DNA Repair; 4.5 Telomeric Position Effect and Its Proteins 4.6 Telomere Protection and Maintenance4.7 Telomere Maintenance and DNA Damage Response; 4.8 Telomeres and Homologous Recombination; 4.9 Alternative Mechanism of Telomere Maintenance; 4.10 Telomere Function in Meiosis; 4.11 Telomere Dysfunction and Tumorigenesis; 4.12 Telomere and Telomerase in Brain Tumors; References; Chapter-5; Novel Hypothesis on Telomere Length: Heterogenic Targets as Genomic/Somatic Diverse Value in Breast Cancer and Brain Tumor; 5.1 Introduction; 5.1.1 Techniques to Measure TL At a Glance; 5.2 Cell; 5.2.1 Cell Is Core Spring of Our Life 5.2.2 The Initiative Reports on Tumor Evolution Contributed by5.2.3 Cells Live, Divide and Die; 5.3 Pedigree-Based Insight in Cancer; 5.3.1 The Characteristics and Impact of Pedigree-Based Research; 5.4 Diversity and Evolution; 5.4.1 Hypothesis and Tumorigenesis; 5.4.2 Questions on Some Facts in Cancer Biology; 5.4.3 Diversity; 5.5 Natural Selection; 5.6 Basic Facts About Telomere at a Glance; 5.7 Evolution and Novel Hypothesis on Telomere Length; 5.7.1 Modeling and Hypothesis; 5.7.2 Pedigree as a Core in Cancer Research; 5.7.2.1 Sample Designing; 5.7.2.2 Patients and Control Groups 5.7.2.3 Brief Strategy for Materials and Methods |
| Record Nr. | UNINA-9910437617403321 |
| Dordrecht [Netherlands] ; ; New York, : Springer, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Telomeres : Chromosome Sentinels
| Telomeres : Chromosome Sentinels |
| Autore | Saintome Carole |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Newark : , : John Wiley & Sons, Incorporated, , 2024 |
| Descrizione fisica | 1 online resource (399 pages) |
| Disciplina | 572.87 |
| Soggetto topico |
Telomere
Molecular biology |
| ISBN |
9781394300808
1394300808 9781394300785 1394300786 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover -- Title Page -- Copyright Page -- Contents -- Foreword -- Chapter 1. Telomeres: All's Well That Ends Well -- 1.1. Introduction -- 1.2. The beginning of the end -- 1.2.1. Chemists and biophysicists at work: G-quartets and G-quadruplexes disclose themselves -- 1.2.2. Biologists at work: telomeres disclose themselves -- 1.2.3. When and where G-quadruplexes and telomeres met -- 1.3. Telomeric architectures: from ciliates to other eukaryotes -- 1.3.1. Telomeric DNA and telomeric proteins -- 1.3.2. Telomeric structures -- 1.4. G-quadruplexes at telomeres -- 1.4.1. Secondary structures formed by repeats of telomeric motifs -- 1.4.2. G4s at telomeres: friendly or unfriendly structures? -- 1.5. References -- Chapter 2. Methods to Measure Telomere Lengths -- 2.1. Why does telomere length matter? -- 2.2. Methods for measuring telomere length -- 2.2.1. Terminal restriction fragment analysis (TRF) -- 2.2.2. Single telomere length analysis -- 2.2.3. Telomere shortest length assay -- 2.2.4. Quantitative-polymerase chain reaction -- 2.2.5. Quantitative-fluorescence in situ hybridization -- 2.2.6. Flow-fluorescence in situ hybridization -- 2.3. References -- Chapter 3. The Shelterin Complex -- 3.1. TRF1 and TRF2, structurally alike but… -- 3.1.1. Domains organization -- 3.1.2. Biological roles -- 3.2. RAP1 -- 3.3. TIN2 -- 3.4. TPP1-POT1 -- 3.5. Quaternary structure of the shelterin -- 3.6. Concluding remarks -- 3.7. References -- Chapter 4. Mammalian Telomere Organization and Dynamics in the Nuclear Volume -- 4.1. Introduction -- 4.2. Nuclear envelope and lamins: orchestrators of cell and genome architecture -- 4.2.1. The nuclear envelope landmarks -- 4.2.2. The nuclear envelope as a scaffold to organize nuclear architecture -- 4.2.3. Nuclear envelope disassembly during mitosis -- 4.3. Interplay between telomeres and nuclear structures.
4.4. Telomere tethering to the NE to promote meiotic pairing -- 4.5. Telomere organization and dynamics in the nucleus -- 4.6. Interaction between telomere chromatin and lamins during post-mitotic nuclear assembly -- 4.7. Interaction between telomere chromatin and lamins for telomere maintenance -- 4.8. Conclusion -- 4.9. References -- Chapter 5. Saccharomyces cerevisiae, a Model at the Forefront of Telomere Biology -- 5.1. Introduction -- 5.2. Telomere characterization: various experimental organisms for first historical experiments -- 5.3. Protection and proliferation: the telomere dilemma -- 5.3.1. Telomeric sequences: pattern conservation and length variations -- 5.3.2. Telomeric proteins -- 5.3.3. TERRA or telomere transcription -- 5.4. Telomere maintenance -- 5.4.1. The difficulties of moving replication fork through telomeres -- 5.4.2. The end replication problem -- 5.4.3. Telomerase: a solution to the problem of telomere shortening -- 5.5. Telomeres: one size for one identity -- 5.6. Telomeres, replicative senescence, aging and genomic instability -- 5.6.1. Aging and replicative senescence -- 5.6.2. Heterogeneity of senescence at the single cell level -- 5.7. Senescence escape phenomena and genomic instability -- 5.8. Conclusion -- 5.9. References -- Chapter 6. Dealing with Replication Stress at Telomeres -- 6.1. Introduction -- 6.1.1. Telomere, telomerase and shelterin -- 6.1.2. Aging, cancer and telomere syndromes -- 6.1.3. The telomere replication problem -- 6.2. Removal of the DNA structures that impede RF progression -- 6.2.1. G-quadruplex dissolution by helicases -- 6.2.2. G-quadruplex dissolution by single-strand binding proteins -- 6.2.3. T-loop dissolution -- 6.2.4. RNA:DNA hybrid removal -- 6.2.5. Topological constraints -- 6.3. Accessory factors that contribute to telomere replication l -- 6.3.1. The CST complex. 6.3.2. The MRN complex and CtIP -- 6.3.3. SLX4 -- 6.3.4. Timeless and AKTIP -- 6.3.5. RECQL helicases and SMARCAL1 translocase -- 6.4. Concluding remarks -- 6.5. References -- Chapter 7. A Brief History of Telomerase: Exceptional Women in Command -- 7.1. Acknowledgments -- 7.2. References -- Chapter 8. Telomerase: Structure and Mechanism -- 8.1. Introduction -- 8.2. Roles -- 8.3. Structures -- 8.3.1. The catalytic core -- 8.3.2. The holoenzyme -- 8.4. Biogenesis -- 8.5. Mechanism -- 8.6. Regulation -- 8.7. Disease and therapy -- 8.8. Conclusion -- 8.9. References -- Chapter 9. Alternative Lengthening of Telomeres -- 9.1. ALT cell markers -- 9.1.1. ALT telomeres are associated with PML bodies: APBs -- 9.1.2. Telomeres of heterogeneous size -- 9.1.3. The accumulation of extra-chromosomal circular telomeric DNA -- 9.1.4. Variant telomeric DNA repeats -- 9.1.5. Sister chromatid exchange at telomeres -- 9.1.6. The accumulation of TERRA -- 9.1.7. Loss of function of the ATRX signaling pathway -- 9.2. ALT mechanisms -- 9.3. Replicative stress and DNA repair pathway at ALT telomeres -- 9.4. The structure of chromatin at ALT telomeres -- 9.5. ALT and cancer -- 9.6. The ALT pathway: a non-pathological function? -- 9.7. Alternative pathways not involving recombination: evolutionary aspects -- 9.8. Appendix: experimental methods that allow the identification of the ALT phenotype in human cancer cells -- 9.9. References -- Chapter 10. TERRA, Telomeric Non-coding RNAs -- 10.1. Introduction -- 10.2. The human TERRAs -- 10.2.1. The majority of human telomeres are transcribed -- 10.2.2. Telomere length influences human TERRAs -- 10.2.3. Induction of human TERRA expression by different types of stress: metabolic, oxidative stress, heat shock or DNA damage -- 10.2.4. Human TERRAs form RNA:DNA hybrids at telomeres to form R-loops. 10.2.5. Other known functions of human TERRAs -- 10.3. The mouse TERRAs -- 10.3.1. The majority of murine telomeres are probably not transcribed -- 10.3.2. PAR-TERRA: a crucial role in homologous sex chromosome pairing and in the regulation of ATRX target gene expression -- 10.3.3. Known or predicted functions of murine TERRAs -- 10.4. Conclusion -- 10.5. References -- Chapter 11. Telomeres and Cancer -- 11.1. Introduction -- 11.2. Short telomeres and telomere-induced senescence are barriers to oncogenic development -- 11.3. Excessive shortening of telomeres promotes CIN in the early stages of cancer transformation -- 11.4. The contribution of telomere-driven CIN to tumor progression -- 11.5. The senescent microenvironment promotes cancer development -- 11.6. Mechanisms of cell immortalization -- 11.7. Therapeutic potential of telomeres and telomerase and prognostic value of telomere-related evaluations -- 11.8. Conclusion -- 11.9. Acknowledgments -- 11.10. References -- Chapter 12. Physiopathology of Telomeres -- 12.1. Introduction -- 12.2. Telomere length in blood -- 12.2.1. Measurement of telomere length -- 12.2.2. Telomere length in patients with telomeropathy -- 12.3. Different genes associated with telomere defects -- 12.3.1. Telomerase complex -- 12.3.2. Shelterin complex -- 12.3.3. CST complex (CTC1/STN1/TEN1) -- 12.3.4. Telomere stability factor -- 12.4. Different diseases associated with telomere defects -- 12.4.1. Dyskeratosis congenita (DC) -- 12.4.2. Hoyeraal-Hreidarsson (HH) syndrome -- 12.4.3. The Revesz syndrome -- 12.4.4. Coats plus syndrome -- 12.4.5. Bone marrow failure -- 12.4.6. Lung disease -- 12.4.7. Liver disease -- 12.4.8. Other clinical impairments -- 12.5. Genetic analysis and counseling -- 12.5.1. Genetic analysis of telomeropathies -- 12.5.2. Genetics of telomeropathies. 12.5.3. Telomeropathy genetic counseling in practice, management of rare diseases in France -- 12.5.4. Epigenetic heritability -- 12.6. Treatment of diseases associated with telomere defects -- 12.7. Compensatory somatic mutations in the TERT promoter -- 12.8. Missing heredity -- 12.9. Conclusion -- 12.10. References -- Chapter 13. Telomeres Targeting Agents -- 13.1. Introduction -- 13.2. Chemistry and in vitro properties of G4 ligands targeting telomeres -- 13.2.1. Condensed heteroaromatics: the first generations -- 13.2.2. Macrocyclic polyheteroaryles -- 13.2.3. Bisquinolinium and bisquinoline compounds with an aromatic dicarboxamide core (triazines, 360A, PhenDC3, PDS) -- 13.2.4. Alternative hybrid scaffolds derived from the series above -- 13.2.5. Telomeric localization of G4 ligands through imaging -- 13.3. Biological properties of G4 ligands targeting telomeres -- 13.4. Metal complexes targeting telomeres -- 13.5. Compounds targeting the proteins of the human shelterin complex -- 13.5.1. Inhibitors of the shelterin proteins binding to DNA -- 13.5.2. Inhibitors of protein-protein interactions involving the shelterin proteins -- 13.5.3. Chemical modulators of the shelterin proteins -- 13.6. Compounds targeting telomerase -- 13.6.1. Oligonucleotides as telomerase inhibitors -- 13.6.2. Small molecule as inhibitors of telomerase -- 13.6.3. Biologics as inhibitors of telomerase -- 13.7. General conclusion -- 13.8. Acknowledgments -- 13.9. References -- List of Authors -- Index -- EULA. |
| Record Nr. | UNINA-9911019395903321 |
Saintome Carole
|
||
| Newark : , : John Wiley & Sons, Incorporated, , 2024 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Telomeres [[electronic resource] ] : function, shortening and lengthening / / Leonardo Mancini, editor
| Telomeres [[electronic resource] ] : function, shortening and lengthening / / Leonardo Mancini, editor |
| Pubbl/distr/stampa | New York, : Nova Biomedical Books, c2009 |
| Descrizione fisica | 1 online resource (498 p.) |
| Disciplina | 572.8/7 |
| Altri autori (Persone) | ManciniLeonardo |
| Soggetto topico |
Telomere
Telomerase |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-60876-720-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910452470603321 |
| New York, : Nova Biomedical Books, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Telomeres [[electronic resource] ] : function, shortening and lengthening / / Leonardo Mancini, editor
| Telomeres [[electronic resource] ] : function, shortening and lengthening / / Leonardo Mancini, editor |
| Pubbl/distr/stampa | New York, : Nova Biomedical Books, c2009 |
| Descrizione fisica | 1 online resource (498 p.) |
| Disciplina | 572.8/7 |
| Altri autori (Persone) | ManciniLeonardo |
| Soggetto topico |
Telomere
Telomerase |
| ISBN | 1-60876-720-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Telomere dynamics and biology in human progeroid syndromes / Terence Davis, Hannah S.E. Tivey, and David Kipling -- The role of telomere-telomerase system in age-related fitness decline : a tameable process / Giacinto Libertini -- Cytogenetic evaluation of telomere dysfunction : chromosomal aberrations involving telomeres and interstitial telomeric sequences / Alejandro D. Bolzán -- Telomeres-telomerase biology and their role in renal and other chronic diseases / Kordinas Vasileios ... [et al.] -- Telomerase and telomere dynamics in cancer : clinical application for cancer diagnosis / Eiso Hiyama, Keiko Hiyama -- Telomeres and chromosome segregation / Antonella Sgura and Daniela Cimini -- Telomere-based genome-protective responses : a mammalian improvement on the bacterial SOS response? / Barbara A. Gilchrest, Mark S. Eller -- Telomere lengthening from oocyte to embryonic stem cell / Eva Pericuesta ... [et al.] -- Transcriptional activity at the telomeres of chironomus (diptera) : its possible role in the lengthening of the telomeres / J.L. Diez ... [et al.] --
Telomerase activity : application to diagnosis of human carcinoma / Liliana N. Guerra -- Telomere shortening in diabetes mellitus / Nicholas Tentolouris, Athanasia Papazafiropoulou -- Do alterations in the three-dimensional organization of telomeres indicate malignant transformation? / Sandrine Lacoste, Hans Knecht, and Sabine Mai -- Telomeres : function, shortening and lengthening / Barry Flanary -- Telomerase regulation in stem cells : how to flip the switch? / Rich Allsopp -- Telomere maintenance mechanisms in bone and soft tissue tumors / Toshihiro Matsuo ... [et al.] -- Genetic polymorphisms of human telomerase reverse transcriptase (hTERT) : mini review / Yumiko Matsubara, Mitsuru Murata, and Yasuo Ikeda -- Genetic inhibition of telomere lengthening in cancer prevention and treatment / F. Mathias Bollmann -- Telomeres : function, shortening, and lengthening / Barry Flanary -- Clinical implications of telomerase activity in human brain tumors / Hyoung-Joon Chun ... [et al.]. |
| Record Nr. | UNINA-9910779646103321 |
| New York, : Nova Biomedical Books, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Telomeres : function, shortening and lengthening / / Leonardo Mancini, editor
| Telomeres : function, shortening and lengthening / / Leonardo Mancini, editor |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | New York, : Nova Biomedical Books, c2009 |
| Descrizione fisica | 1 online resource (498 p.) |
| Disciplina | 572.8/7 |
| Altri autori (Persone) | ManciniLeonardo |
| Soggetto topico |
Telomere
Telomerase |
| ISBN | 1-60876-720-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Telomere dynamics and biology in human progeroid syndromes / Terence Davis, Hannah S.E. Tivey, and David Kipling -- The role of telomere-telomerase system in age-related fitness decline : a tameable process / Giacinto Libertini -- Cytogenetic evaluation of telomere dysfunction : chromosomal aberrations involving telomeres and interstitial telomeric sequences / Alejandro D. Bolzán -- Telomeres-telomerase biology and their role in renal and other chronic diseases / Kordinas Vasileios ... [et al.] -- Telomerase and telomere dynamics in cancer : clinical application for cancer diagnosis / Eiso Hiyama, Keiko Hiyama -- Telomeres and chromosome segregation / Antonella Sgura and Daniela Cimini -- Telomere-based genome-protective responses : a mammalian improvement on the bacterial SOS response? / Barbara A. Gilchrest, Mark S. Eller -- Telomere lengthening from oocyte to embryonic stem cell / Eva Pericuesta ... [et al.] -- Transcriptional activity at the telomeres of chironomus (diptera) : its possible role in the lengthening of the telomeres / J.L. Diez ... [et al.] --
Telomerase activity : application to diagnosis of human carcinoma / Liliana N. Guerra -- Telomere shortening in diabetes mellitus / Nicholas Tentolouris, Athanasia Papazafiropoulou -- Do alterations in the three-dimensional organization of telomeres indicate malignant transformation? / Sandrine Lacoste, Hans Knecht, and Sabine Mai -- Telomeres : function, shortening and lengthening / Barry Flanary -- Telomerase regulation in stem cells : how to flip the switch? / Rich Allsopp -- Telomere maintenance mechanisms in bone and soft tissue tumors / Toshihiro Matsuo ... [et al.] -- Genetic polymorphisms of human telomerase reverse transcriptase (hTERT) : mini review / Yumiko Matsubara, Mitsuru Murata, and Yasuo Ikeda -- Genetic inhibition of telomere lengthening in cancer prevention and treatment / F. Mathias Bollmann -- Telomeres : function, shortening, and lengthening / Barry Flanary -- Clinical implications of telomerase activity in human brain tumors / Hyoung-Joon Chun ... [et al.]. |
| Record Nr. | UNINA-9910969827703321 |
| New York, : Nova Biomedical Books, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Telomeres and telomerase [[electronic resource] /] / [editors, Derek J. Chadwick and Gail Cardew]
| Telomeres and telomerase [[electronic resource] /] / [editors, Derek J. Chadwick and Gail Cardew] |
| Pubbl/distr/stampa | Chichester, England ; ; New York, : John Wiley & Sons, 1997 |
| Descrizione fisica | 1 online resource (252 p.) |
| Disciplina |
572.8
572.87 |
| Altri autori (Persone) |
ChadwickDerek
CardewGail |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Telomere
Telomerase |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-34806-X
9786612348068 0-470-51543-0 0-470-51544-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
TELOMERES AND TELOMERASE; Contents; Participants; Introduction; The telomere and telomerase: how do they interact?; Telomerase and the chromosome end replication problem; General discussion I; The role of the EST genes in yeast telomere replication; Drosophila telornere elongation; General discussion I1; Raplp and telomere length regulation in yeast; Chromatin and ageing in yeast and in mammals; The limited reproductive life span of normal human cells in culture; Human ageing and telorneres; General discussion I11; Telomerase assays in the diagnosis and prognosis of cancer
Mouse models for the study of telomeraseGenetic control of telomerase and replicative senescence in human and rodent cells; Repair and processing events at DNA ends; Telomeres in the haemopoietic system; Final general discussion; Summary; Index of contributors; Subject index |
| Record Nr. | UNINA-9910144011303321 |
| Chichester, England ; ; New York, : John Wiley & Sons, 1997 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Telomeres and telomerase [[electronic resource] /] / [editors, Derek J. Chadwick and Gail Cardew]
| Telomeres and telomerase [[electronic resource] /] / [editors, Derek J. Chadwick and Gail Cardew] |
| Pubbl/distr/stampa | Chichester, England ; ; New York, : John Wiley & Sons, 1997 |
| Descrizione fisica | 1 online resource (252 p.) |
| Disciplina |
572.8
572.87 |
| Altri autori (Persone) |
ChadwickDerek
CardewGail |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Telomere
Telomerase |
| ISBN |
1-282-34806-X
9786612348068 0-470-51543-0 0-470-51544-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
TELOMERES AND TELOMERASE; Contents; Participants; Introduction; The telomere and telomerase: how do they interact?; Telomerase and the chromosome end replication problem; General discussion I; The role of the EST genes in yeast telomere replication; Drosophila telornere elongation; General discussion I1; Raplp and telomere length regulation in yeast; Chromatin and ageing in yeast and in mammals; The limited reproductive life span of normal human cells in culture; Human ageing and telorneres; General discussion I11; Telomerase assays in the diagnosis and prognosis of cancer
Mouse models for the study of telomeraseGenetic control of telomerase and replicative senescence in human and rodent cells; Repair and processing events at DNA ends; Telomeres in the haemopoietic system; Final general discussion; Summary; Index of contributors; Subject index |
| Record Nr. | UNINA-9910830010303321 |
| Chichester, England ; ; New York, : John Wiley & Sons, 1997 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Telomeres and telomerase / / [editors, Derek J. Chadwick and Gail Cardew]
| Telomeres and telomerase / / [editors, Derek J. Chadwick and Gail Cardew] |
| Pubbl/distr/stampa | Chichester, England ; ; New York, : John Wiley & Sons, 1997 |
| Descrizione fisica | 1 online resource (252 p.) |
| Disciplina |
572.8
572.87 |
| Altri autori (Persone) |
ChadwickDerek
CardewGail |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Telomere
Telomerase |
| ISBN |
9786612348068
9781282348066 128234806X 9780470515433 0470515430 9780470515440 0470515449 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
TELOMERES AND TELOMERASE; Contents; Participants; Introduction; The telomere and telomerase: how do they interact?; Telomerase and the chromosome end replication problem; General discussion I; The role of the EST genes in yeast telomere replication; Drosophila telornere elongation; General discussion I1; Raplp and telomere length regulation in yeast; Chromatin and ageing in yeast and in mammals; The limited reproductive life span of normal human cells in culture; Human ageing and telorneres; General discussion I11; Telomerase assays in the diagnosis and prognosis of cancer
Mouse models for the study of telomeraseGenetic control of telomerase and replicative senescence in human and rodent cells; Repair and processing events at DNA ends; Telomeres in the haemopoietic system; Final general discussion; Summary; Index of contributors; Subject index |
| Record Nr. | UNINA-9911019227303321 |
| Chichester, England ; ; New York, : John Wiley & Sons, 1997 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Telomere
(9)
- Telomerase (7)
- Cancer cells (1)
- Molecular biology (1)