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Mammalian TRP channels as molecular targets [[electronic resource] /] / [editors, Derek J. Chadwick (organizer) and Jamie A. Goode]
| Mammalian TRP channels as molecular targets [[electronic resource] /] / [editors, Derek J. Chadwick (organizer) and Jamie A. Goode] |
| Pubbl/distr/stampa | Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, 2004 |
| Descrizione fisica | 1 online resource (287 p.) |
| Disciplina |
571.6/4
571.64 |
| Altri autori (Persone) |
ChadwickDerek
GoodeJamie |
| Collana | Novartis Foundation symposium |
| Soggetto topico | TRP channels |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-27158-2
9786610271580 0-470-66817-2 0-470-86257-2 0-470-86258-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
MAMMALIAN TRP CHANNELS AS MOLECULAR TARGETS; Contents; Chair's introduction; Molecular genetics of Drosophila TRP channels; Discussion; Mammalian TRPC channel subunit assembly; Discussion; TRPC channel interactions with calmodulin and IP(3) receptors; Discussion; Plasma membrane localization of TRPC channels: role of caveolar lipid rafts; Discussion; Assembly and gating of TRPC channels in signalling microdomains; Discussion; General discussion I; Activation, subunit composition and physiological relevance of DAG-sensitive TRPC proteins; Discussion; Signalling mechanisms for TRPC3 channels
DiscussionDiversity of TRP channel activation; Discussion; General discussion II; Regulation of Drosophila TRP channels by lipid messengers; Discussion; Control of TRPC and store-operated channels by protein kinase C; Discussion; TRPC4 and TRPC4 deficient mice; Discussion; TRP channels as drug targets; Discussion; Role of TRP channels in oxidative stress; Discussion; Distribution of TRPC channels in a visceral sensory pathway; Discussion; Emerging roles of TRPM channels; Discussion; Final discussion; Index of contributors; Subject index |
| Record Nr. | UNINA-9910145906203321 |
| Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mammalian TRP channels as molecular targets [[electronic resource] /] / [editors, Derek J. Chadwick (organizer) and Jamie A. Goode]
| Mammalian TRP channels as molecular targets [[electronic resource] /] / [editors, Derek J. Chadwick (organizer) and Jamie A. Goode] |
| Pubbl/distr/stampa | Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, 2004 |
| Descrizione fisica | 1 online resource (287 p.) |
| Disciplina |
571.6/4
571.64 |
| Altri autori (Persone) |
ChadwickDerek
GoodeJamie |
| Collana | Novartis Foundation symposium |
| Soggetto topico | TRP channels |
| ISBN |
1-280-27158-2
9786610271580 0-470-66817-2 0-470-86257-2 0-470-86258-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
MAMMALIAN TRP CHANNELS AS MOLECULAR TARGETS; Contents; Chair's introduction; Molecular genetics of Drosophila TRP channels; Discussion; Mammalian TRPC channel subunit assembly; Discussion; TRPC channel interactions with calmodulin and IP(3) receptors; Discussion; Plasma membrane localization of TRPC channels: role of caveolar lipid rafts; Discussion; Assembly and gating of TRPC channels in signalling microdomains; Discussion; General discussion I; Activation, subunit composition and physiological relevance of DAG-sensitive TRPC proteins; Discussion; Signalling mechanisms for TRPC3 channels
DiscussionDiversity of TRP channel activation; Discussion; General discussion II; Regulation of Drosophila TRP channels by lipid messengers; Discussion; Control of TRPC and store-operated channels by protein kinase C; Discussion; TRPC4 and TRPC4 deficient mice; Discussion; TRP channels as drug targets; Discussion; Role of TRP channels in oxidative stress; Discussion; Distribution of TRPC channels in a visceral sensory pathway; Discussion; Emerging roles of TRPM channels; Discussion; Final discussion; Index of contributors; Subject index |
| Record Nr. | UNINA-9910830157103321 |
| Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mammalian TRP channels as molecular targets / / [editors, Derek J. Chadwick (organizer) and Jamie A. Goode]
| Mammalian TRP channels as molecular targets / / [editors, Derek J. Chadwick (organizer) and Jamie A. Goode] |
| Pubbl/distr/stampa | Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, 2004 |
| Descrizione fisica | 1 online resource (287 p.) |
| Disciplina | 571.6/4 |
| Altri autori (Persone) |
ChadwickDerek
GoodeJamie |
| Collana | Novartis Foundation symposium |
| Soggetto topico | TRP channels |
| ISBN |
9786610271580
9781280271588 1280271582 9780470668177 0470668172 9780470862575 0470862572 9780470862582 0470862580 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
MAMMALIAN TRP CHANNELS AS MOLECULAR TARGETS; Contents; Chair's introduction; Molecular genetics of Drosophila TRP channels; Discussion; Mammalian TRPC channel subunit assembly; Discussion; TRPC channel interactions with calmodulin and IP(3) receptors; Discussion; Plasma membrane localization of TRPC channels: role of caveolar lipid rafts; Discussion; Assembly and gating of TRPC channels in signalling microdomains; Discussion; General discussion I; Activation, subunit composition and physiological relevance of DAG-sensitive TRPC proteins; Discussion; Signalling mechanisms for TRPC3 channels
DiscussionDiversity of TRP channel activation; Discussion; General discussion II; Regulation of Drosophila TRP channels by lipid messengers; Discussion; Control of TRPC and store-operated channels by protein kinase C; Discussion; TRPC4 and TRPC4 deficient mice; Discussion; TRP channels as drug targets; Discussion; Role of TRP channels in oxidative stress; Discussion; Distribution of TRPC channels in a visceral sensory pathway; Discussion; Emerging roles of TRPM channels; Discussion; Final discussion; Index of contributors; Subject index |
| Record Nr. | UNINA-9911019354703321 |
| Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Transient Receptor Potential (TRP) Channels in Drug Discovery : Old Concepts & New Thoughts / / Susan M. Huang, Arpad Szallasi
| Transient Receptor Potential (TRP) Channels in Drug Discovery : Old Concepts & New Thoughts / / Susan M. Huang, Arpad Szallasi |
| Autore | Huang Susan M. |
| Pubbl/distr/stampa | Basel : , : MDPI - Multidisciplinary Digital Publishing Institute, , 2018 |
| Descrizione fisica | 1 online resource (vi, 250 pages) |
| Disciplina | 572.696 |
| Soggetto topico | TRP channels |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Transient Receptor Potential |
| Record Nr. | UNINA-9910597956203321 |
Huang Susan M.
|
||
| Basel : , : MDPI - Multidisciplinary Digital Publishing Institute, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
TRP channels as therapeutic targets : from basic science to clinical use / / edited by Arpad Szallasi ; contributors, M. Allen McAlexander [and fifty-nine others]
| TRP channels as therapeutic targets : from basic science to clinical use / / edited by Arpad Szallasi ; contributors, M. Allen McAlexander [and fifty-nine others] |
| Pubbl/distr/stampa | Amsterdam, [Netherlands] : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (530 p.) |
| Disciplina | 572.696 |
| Soggetto topico | TRP channels |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use; Copyright; Contents; Contributors; Preface; Chapter 1: An Introduction to Transient Receptor Potential Ion Channels and Their Roles in Disease; Discovery and General Properties of TRP Channels; TRP Channels in Normal Physiology; TRP Channels and Sensory Physiology; TRP Channels and Cardiovascular Function; TRP Channels and Gastrointestinal Function; TRP Channels and Urological Function; TRP Channels and the Brain; TRP Channels and Immune Function; TRP Channels and Development; TRP Channels and Disease
Therapeutic Strategies Based on TRP Channel ModulationAcknowledgment; References; Chapter 2: Transient Receptor Potential Dysfunctions in Hereditary Diseases: TRP Channelopathies and Beyond; Introduction; TRPC Channelopathies; TRPV Channelopathies; TRPM Channelopathies; TRPA Channelopathies; TRPML Channelopathies; TRPP Channelopathies; Conclusions; Acknowledgments; References; Chapter 3: The Role of TRPV1 in Acquired Diseases: Therapeutic Potential of TRPV1 Modulators; Introduction; TRPV1 and Pain; TRPV1 and Gastrointestinal System-Related Disease; TRPV1 and Urinary System-Related Diseases TRPV1 and Central Nervous System-Related DiseasesTRPV1 and Respiratory System-Related Diseases; TRPV1 and Cancer; TRPV1 and Cardiovascular System-Related Diseases; TRPV1 and Metabolic Diseases; TRPV1 and Other Disease Conditions; Conclusions; Acknowledgment; References; Chapter 4: TRP Gene Polymorphism and Disease Risk; TRP Gene Polymorphism; TRPA1 ; The TRPC Subfamily; The TRPM Subfamily; The TRPML Subfamily; The TRPV Subfamily; Disease Risk, Clinical Diagnosis, and Personalized Medicine; References; Chapter 5: Use of Topical Capsaicin for Pain Relief; Introduction; Pharmacodynamics PharmacokineticsEfficacy and Therapeutic Uses; Postherpetic Neuralgia; HIV -Associated Distal Sensory Polyneuropathy; Other Neuropathic Pain States; Safety and Tolerability; Delivery of Treatment with Capsaicin 8% Patch-Practical Aspects; Application Procedure for the Capsaicin 8% Patch; Postprocedural Instructions for Patients; References; Chapter 6: TRPV1 Agonist Cytotoxicity for Chronic Pain Relief: From Mechanistic Understanding to Clinical Application; Introduction; Mechanisms of TRPV1 Agonist Therapeutic Action; Four Main Determinants of TRPV1 Agonist Actions Selectivity of RTX at the Cellular LevelRTX Produces a Prolonged Channel Open Time; TRPV1 Is Selectively Expressed in Subpopulations of DRG Neurons; RTX Is Administered Locally; Companion Dog and Human Studies; Companion (Pet) Dog Models of Chronic Pain; TRPV1 Agonists in the Companion Dog Model of Bone Cancer; TRPV1 Agonists in the Companion Dog Model of Osteoarthritis; Human Studies; References; Chapter 7: Intravesical Capsaicin and Resiniferatoxin for Bladder Disorders; Capsaicin and Resiniferatoxin Targets and Effects in the Urinary Bladder The Rationale for Using Vanilloids to Overcome Lower Urinary Tract Symptoms |
| Record Nr. | UNINA-9910788295403321 |
| Amsterdam, [Netherlands] : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
TRP channels as therapeutic targets : from basic science to clinical use / / edited by Arpad Szallasi ; contributors, M. Allen McAlexander [and fifty-nine others]
| TRP channels as therapeutic targets : from basic science to clinical use / / edited by Arpad Szallasi ; contributors, M. Allen McAlexander [and fifty-nine others] |
| Pubbl/distr/stampa | Amsterdam, [Netherlands] : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (530 p.) |
| Disciplina | 572.696 |
| Soggetto topico | TRP channels |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use; Copyright; Contents; Contributors; Preface; Chapter 1: An Introduction to Transient Receptor Potential Ion Channels and Their Roles in Disease; Discovery and General Properties of TRP Channels; TRP Channels in Normal Physiology; TRP Channels and Sensory Physiology; TRP Channels and Cardiovascular Function; TRP Channels and Gastrointestinal Function; TRP Channels and Urological Function; TRP Channels and the Brain; TRP Channels and Immune Function; TRP Channels and Development; TRP Channels and Disease
Therapeutic Strategies Based on TRP Channel ModulationAcknowledgment; References; Chapter 2: Transient Receptor Potential Dysfunctions in Hereditary Diseases: TRP Channelopathies and Beyond; Introduction; TRPC Channelopathies; TRPV Channelopathies; TRPM Channelopathies; TRPA Channelopathies; TRPML Channelopathies; TRPP Channelopathies; Conclusions; Acknowledgments; References; Chapter 3: The Role of TRPV1 in Acquired Diseases: Therapeutic Potential of TRPV1 Modulators; Introduction; TRPV1 and Pain; TRPV1 and Gastrointestinal System-Related Disease; TRPV1 and Urinary System-Related Diseases TRPV1 and Central Nervous System-Related DiseasesTRPV1 and Respiratory System-Related Diseases; TRPV1 and Cancer; TRPV1 and Cardiovascular System-Related Diseases; TRPV1 and Metabolic Diseases; TRPV1 and Other Disease Conditions; Conclusions; Acknowledgment; References; Chapter 4: TRP Gene Polymorphism and Disease Risk; TRP Gene Polymorphism; TRPA1 ; The TRPC Subfamily; The TRPM Subfamily; The TRPML Subfamily; The TRPV Subfamily; Disease Risk, Clinical Diagnosis, and Personalized Medicine; References; Chapter 5: Use of Topical Capsaicin for Pain Relief; Introduction; Pharmacodynamics PharmacokineticsEfficacy and Therapeutic Uses; Postherpetic Neuralgia; HIV -Associated Distal Sensory Polyneuropathy; Other Neuropathic Pain States; Safety and Tolerability; Delivery of Treatment with Capsaicin 8% Patch-Practical Aspects; Application Procedure for the Capsaicin 8% Patch; Postprocedural Instructions for Patients; References; Chapter 6: TRPV1 Agonist Cytotoxicity for Chronic Pain Relief: From Mechanistic Understanding to Clinical Application; Introduction; Mechanisms of TRPV1 Agonist Therapeutic Action; Four Main Determinants of TRPV1 Agonist Actions Selectivity of RTX at the Cellular LevelRTX Produces a Prolonged Channel Open Time; TRPV1 Is Selectively Expressed in Subpopulations of DRG Neurons; RTX Is Administered Locally; Companion Dog and Human Studies; Companion (Pet) Dog Models of Chronic Pain; TRPV1 Agonists in the Companion Dog Model of Bone Cancer; TRPV1 Agonists in the Companion Dog Model of Osteoarthritis; Human Studies; References; Chapter 7: Intravesical Capsaicin and Resiniferatoxin for Bladder Disorders; Capsaicin and Resiniferatoxin Targets and Effects in the Urinary Bladder The Rationale for Using Vanilloids to Overcome Lower Urinary Tract Symptoms |
| Record Nr. | UNINA-9910822970403321 |
| Amsterdam, [Netherlands] : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
TRP ion channel function in sensory transduction and cellular signaling cascades / / edited by Wolfgang B. Liedtke, with Stefan Heller
| TRP ion channel function in sensory transduction and cellular signaling cascades / / edited by Wolfgang B. Liedtke, with Stefan Heller |
| Pubbl/distr/stampa | Boca Raton, FL : , : CRC/Taylor & Francis, , 2007 |
| Descrizione fisica | 1 online resource (502 p.) |
| Disciplina |
572.3
572/.3 |
| Altri autori (Persone) |
LiedtkeWolfgang B
HellerStefan |
| Collana | Frontiers in neuroscience |
| Soggetto topico | TRP channels |
| ISBN |
0-429-12715-4
1-280-73308-X 9786610733088 1-4200-0584-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Series Preface; Preface; The Editors; Contributors; Abstract; Contents; Chapter 1. The TRPC Family of Ion Channels: Relation to the TRP Superfamily and Role in Receptor- and Store- Operated Calcium Entry; Chapter 2. Multiple Mechanisms of TRPC Activation; Chapter 3. TRPC2 and the Molecular Biology of Pheromone Detection in Mammals; Chapter 4. TRP Channels and Axon Pathfinding; Chapter 5. TRPV1 Receptors and Signal Transduction; Chapter 6. Complex Regulation of TRPV1 by Vanilloids; Chapter 7. TRPV2: A Calcium- Permeable Cation Channel Regulated by Insulin-Like Growth Factors
Chapter 8. Molecular Mechanisms of TRPV4 Gating Chapter 9. TRPV4: A Multifunctional Nonselective Cation Channel with Complex Regulation; Chapter 10. TRPV4 and TRPM3 as Volume-Regulated Cation Channels; Chapter 11. TRPA1:A Sensory Channel of Many Talents; Chapter 12. TRPA1 in Auditory and Nociceptive Organs; Chapter 13. TRPM8: The Cold and Menthol Receptor; Chapter 14. Activation Mechanisms and Functional Roles of TRPP2 Cation Channels; Chapter 15. The Ca2+-Activated TRP Channels: TRPM4 and TRPM5; Chapter 16. Genetics Can Be Painless: Molecular Genetic Analysis of Nociception in Drosophila Chapter 17. TRPV Family Ion Channels and Other Molecular Components Required for Hearing and Proprioception in Drosophila Chapter 18. The TRPV Channel in C. elegans Serotonergic Neurons; Chapter 19. TRP Channel Functioning in Mating and Fertilization; Chapter 20. The Role of TRP Channels in Thermosensation; Chapter 21. Voltage and Temperature Gating of ThermoTRP Channels; Chapter 22. TRPV Channels' Function in Osmo- and Mechanotransduction; Chapter 23. TRP Channel Trafficking; Chapter 24. Protein-Protein Interactions in TRPC Channel Complexes Chapter 25. Structural Insights into the Function of TRP Channels Chapter 26. Functional Significance of Transient Receptor Potential Channels in Vascular Function; Chapter 27. Role of TRPV4 in the Mechanotransduction of Shear Stress in Endothelial Cells; Chapter 28. A New Insight into the Function of TRPV2 in Circulatory Organs; Chapter 29. The Role of TRPV 4 in the Kidney; Chapter 30. The TRPV4 Channel in Ciliatd Epithelia; Chapter 31. Protease-Activated Receptors: Mechanisms by Which Proteases Sensitize TRPV Channels to Induce Neurogenic Inflannation and Pain; Index; Back Cover |
| Record Nr. | UNISA-996320721103316 |
| Boca Raton, FL : , : CRC/Taylor & Francis, , 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
TRP ion channel function in sensory transduction and cellular signaling cascades / / edited by Wolfgang B. Liedtke, with Stefan Heller
| TRP ion channel function in sensory transduction and cellular signaling cascades / / edited by Wolfgang B. Liedtke, with Stefan Heller |
| Pubbl/distr/stampa | Boca Raton, FL, : CRC/Taylor & Francis, c2007 |
| Descrizione fisica | 1 online resource (502 p.) |
| Disciplina | 572/.3 |
| Altri autori (Persone) |
LiedtkeWolfgang B
HellerStefan |
| Collana | Frontiers in neuroscience |
| Soggetto topico | TRP channels |
| ISBN |
1-04-020257-8
0-429-12715-4 1-280-73308-X 9786610733088 1-4200-0584-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Series Preface; Preface; The Editors; Contributors; Abstract; Contents; Chapter 1. The TRPC Family of Ion Channels: Relation to the TRP Superfamily and Role in Receptor- and Store- Operated Calcium Entry; Chapter 2. Multiple Mechanisms of TRPC Activation; Chapter 3. TRPC2 and the Molecular Biology of Pheromone Detection in Mammals; Chapter 4. TRP Channels and Axon Pathfinding; Chapter 5. TRPV1 Receptors and Signal Transduction; Chapter 6. Complex Regulation of TRPV1 by Vanilloids; Chapter 7. TRPV2: A Calcium- Permeable Cation Channel Regulated by Insulin-Like Growth Factors
Chapter 8. Molecular Mechanisms of TRPV4 Gating Chapter 9. TRPV4: A Multifunctional Nonselective Cation Channel with Complex Regulation; Chapter 10. TRPV4 and TRPM3 as Volume-Regulated Cation Channels; Chapter 11. TRPA1:A Sensory Channel of Many Talents; Chapter 12. TRPA1 in Auditory and Nociceptive Organs; Chapter 13. TRPM8: The Cold and Menthol Receptor; Chapter 14. Activation Mechanisms and Functional Roles of TRPP2 Cation Channels; Chapter 15. The Ca2+-Activated TRP Channels: TRPM4 and TRPM5; Chapter 16. Genetics Can Be Painless: Molecular Genetic Analysis of Nociception in Drosophila Chapter 17. TRPV Family Ion Channels and Other Molecular Components Required for Hearing and Proprioception in Drosophila Chapter 18. The TRPV Channel in C. elegans Serotonergic Neurons; Chapter 19. TRP Channel Functioning in Mating and Fertilization; Chapter 20. The Role of TRP Channels in Thermosensation; Chapter 21. Voltage and Temperature Gating of ThermoTRP Channels; Chapter 22. TRPV Channels' Function in Osmo- and Mechanotransduction; Chapter 23. TRP Channel Trafficking; Chapter 24. Protein-Protein Interactions in TRPC Channel Complexes Chapter 25. Structural Insights into the Function of TRP Channels Chapter 26. Functional Significance of Transient Receptor Potential Channels in Vascular Function; Chapter 27. Role of TRPV4 in the Mechanotransduction of Shear Stress in Endothelial Cells; Chapter 28. A New Insight into the Function of TRPV2 in Circulatory Organs; Chapter 29. The Role of TRPV 4 in the Kidney; Chapter 30. The TRPV4 Channel in Ciliatd Epithelia; Chapter 31. Protease-Activated Receptors: Mechanisms by Which Proteases Sensitize TRPV Channels to Induce Neurogenic Inflannation and Pain; Index; Back Cover |
| Record Nr. | UNINA-9910146252403321 |
| Boca Raton, FL, : CRC/Taylor & Francis, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
