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Overcoming steroid insensitivity in respiratory disease [[electronic resource] /] / edited by Ian M. Adcock and Kian Fan Chung
| Overcoming steroid insensitivity in respiratory disease [[electronic resource] /] / edited by Ian M. Adcock and Kian Fan Chung |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2008 |
| Descrizione fisica | 1 online resource (310 p.) |
| Disciplina |
616.2
616.200461 |
| Altri autori (Persone) |
AdcockIan (Ian M.)
ChungK. Fan <1951-> |
| Soggetto topico |
Respiratory organs - Diseases - Chemotherapy
Steroid drugs Drug resistance |
| ISBN |
1-281-84122-6
9786611841225 0-470-98573-9 0-470-98572-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Overcoming Steroid Insensitivity in Respiratory Disease; Contents; List of Contributors; Preface; 1 Molecular Mechanisms of Glucocorticoid Receptor Action; 1.1 Introduction; 1.2 Glucocorticoid Receptor; 1.3 Gene Induction by GR; 1.4 GR Transactivation and Histone Acetylation; 1.5 Post-translational Modifications of GR; 1.6 Repression of NF-κB-induced Inflammatory GeneExpression by GR-NF-κB; 1.7 GR-NF-κB Cross-talk; 1.8 Role of HDAC2 in Glucocorticoid Function; 1.9 Overexpression of HDAC2 Restores Glucocorticoid Sensitivity in Alveolar Macrophages
1.10 Acetylation of hsp90 and Regulation of GR Function 1.11 Other Mechanisms of GR Action; 1.12 Conclusions; 2 Side Effects of Topical and Oral Glucocorticoids; 2.1 Introduction; 2.2 Glucocorticoid-induced Side Effects; 2.3 Summary; 3 Glucocorticoid Receptor Subtypes and Steroid Sensitivity; 3.1 Introduction; 3.2 Overview of Classic GR Function; 3.3 GR Subtypes Arising from Alternative Splicing; 3.4 GR Subtypes arising from Alternative Translation Initiation; 3.5 Conclusions; 4 Dissociated Glucocorticoids; 4.1 Introduction 4.2 Asthma and Chronic Obstructive Pulmonary Disease are Chronic Inflammatory Diseases of the Airways 4.3 Regulation of Inflammatory Gene Expression; 4.4 Effects on Inflammation; 4.5 Mechanisms of Glucocorticoid Action; 4.6 Dissociated Glucocorticoids; 4.7 GR Cross-talk with Other Nuclear Receptors and Coactivators; 4.8 Overcoming Steroid Insensitivity; 4.9 Glucorticoid-sparing Approaches to Anti-inflammatory Therapy; 4.10 Conclusion; 5 Generalized Glucocorticoid Insensitivity: Clinical Phenotype and Molecular Mechanisms; 5.1 Introduction; 5.2 Molecular Mechanisms of Glucocorticoid Resistance 5.3 Conclusions 6 Corticosteroid Responsiveness in Asthma: Clinical Aspects; 6.1 Introduction; 6.2 Effects of Corticosteroids in Asthma; 6.3 Definition of Corticosteroid Insensitivity; 6.4 Oral CS Responsiveness in Asthma; 6.5 ICS Responsiveness in Asthma; 6.6 CS Responsiveness in Severe Asthma; 6.7 Surrogates for CS Responsiveness in Asthma; 6.8 Pharmacokinetics of Systemic CS in Severe Asthma; 6.9 CS Responsiveness in Cigarette Smokers and Chronic Obstructive Pulmonary Disease; 6.10 Other Diseases of CS Insensitivity; 6.11 Conclusions 7 Glucocorticoid-insensitive Asthma: Molecular Mechanisms 7.1 Introduction; 7.2 GR Abnormalities; 7.3 GR Nuclear Translocation; 7.4 Cross-talk with Transcription Factors; 7.5 NF-κB, GR, Histones and Chromatin Remodelling; 7.6 Epigenetics and Asthma; 7.7 Conclusions; 8 Cigarette Smoke, Oxidative Stress and Corticosteroid Responsiveness; 8.1 Oxidative Stress; 8.2 Cigarette Smoke/Oxidative Stress-InducedNF-κB-mediated Pro-inflammatory Gene Expression; 8.3 Histone Acetylation and Deacetylation; 8.4 Corticosteroids; 8.5 Histone Deacetylases; 8.6 Reversing Glucocorticoids / Corticosteroid Resistance 8.7 Conclusion |
| Record Nr. | UNINA-9910144107803321 |
| Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Overcoming steroid insensitivity in respiratory disease [[electronic resource] /] / edited by Ian M. Adcock and Kian Fan Chung
| Overcoming steroid insensitivity in respiratory disease [[electronic resource] /] / edited by Ian M. Adcock and Kian Fan Chung |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2008 |
| Descrizione fisica | 1 online resource (310 p.) |
| Disciplina |
616.2
616.200461 |
| Altri autori (Persone) |
AdcockIan (Ian M.)
ChungK. Fan <1951-> |
| Soggetto topico |
Respiratory organs - Diseases - Chemotherapy
Steroid drugs Drug resistance |
| ISBN |
1-281-84122-6
9786611841225 0-470-98573-9 0-470-98572-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Overcoming Steroid Insensitivity in Respiratory Disease; Contents; List of Contributors; Preface; 1 Molecular Mechanisms of Glucocorticoid Receptor Action; 1.1 Introduction; 1.2 Glucocorticoid Receptor; 1.3 Gene Induction by GR; 1.4 GR Transactivation and Histone Acetylation; 1.5 Post-translational Modifications of GR; 1.6 Repression of NF-κB-induced Inflammatory GeneExpression by GR-NF-κB; 1.7 GR-NF-κB Cross-talk; 1.8 Role of HDAC2 in Glucocorticoid Function; 1.9 Overexpression of HDAC2 Restores Glucocorticoid Sensitivity in Alveolar Macrophages
1.10 Acetylation of hsp90 and Regulation of GR Function 1.11 Other Mechanisms of GR Action; 1.12 Conclusions; 2 Side Effects of Topical and Oral Glucocorticoids; 2.1 Introduction; 2.2 Glucocorticoid-induced Side Effects; 2.3 Summary; 3 Glucocorticoid Receptor Subtypes and Steroid Sensitivity; 3.1 Introduction; 3.2 Overview of Classic GR Function; 3.3 GR Subtypes Arising from Alternative Splicing; 3.4 GR Subtypes arising from Alternative Translation Initiation; 3.5 Conclusions; 4 Dissociated Glucocorticoids; 4.1 Introduction 4.2 Asthma and Chronic Obstructive Pulmonary Disease are Chronic Inflammatory Diseases of the Airways 4.3 Regulation of Inflammatory Gene Expression; 4.4 Effects on Inflammation; 4.5 Mechanisms of Glucocorticoid Action; 4.6 Dissociated Glucocorticoids; 4.7 GR Cross-talk with Other Nuclear Receptors and Coactivators; 4.8 Overcoming Steroid Insensitivity; 4.9 Glucorticoid-sparing Approaches to Anti-inflammatory Therapy; 4.10 Conclusion; 5 Generalized Glucocorticoid Insensitivity: Clinical Phenotype and Molecular Mechanisms; 5.1 Introduction; 5.2 Molecular Mechanisms of Glucocorticoid Resistance 5.3 Conclusions 6 Corticosteroid Responsiveness in Asthma: Clinical Aspects; 6.1 Introduction; 6.2 Effects of Corticosteroids in Asthma; 6.3 Definition of Corticosteroid Insensitivity; 6.4 Oral CS Responsiveness in Asthma; 6.5 ICS Responsiveness in Asthma; 6.6 CS Responsiveness in Severe Asthma; 6.7 Surrogates for CS Responsiveness in Asthma; 6.8 Pharmacokinetics of Systemic CS in Severe Asthma; 6.9 CS Responsiveness in Cigarette Smokers and Chronic Obstructive Pulmonary Disease; 6.10 Other Diseases of CS Insensitivity; 6.11 Conclusions 7 Glucocorticoid-insensitive Asthma: Molecular Mechanisms 7.1 Introduction; 7.2 GR Abnormalities; 7.3 GR Nuclear Translocation; 7.4 Cross-talk with Transcription Factors; 7.5 NF-κB, GR, Histones and Chromatin Remodelling; 7.6 Epigenetics and Asthma; 7.7 Conclusions; 8 Cigarette Smoke, Oxidative Stress and Corticosteroid Responsiveness; 8.1 Oxidative Stress; 8.2 Cigarette Smoke/Oxidative Stress-InducedNF-κB-mediated Pro-inflammatory Gene Expression; 8.3 Histone Acetylation and Deacetylation; 8.4 Corticosteroids; 8.5 Histone Deacetylases; 8.6 Reversing Glucocorticoids / Corticosteroid Resistance 8.7 Conclusion |
| Record Nr. | UNINA-9910812495003321 |
| Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
