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Linker strategies in solid-phase organic synthesis [[electronic resource] /] / edited by Peter J. H Scott
| Linker strategies in solid-phase organic synthesis [[electronic resource] /] / edited by Peter J. H Scott |
| Autore | Scott Peter J. H |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley, 2009 |
| Descrizione fisica | 1 online resource (707 p.) |
| Disciplina | 547.2 |
| Altri autori (Persone) | ScottPeter J. H |
| Soggetto topico |
Solid-phase synthesis
Organic compounds - Synthesis |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-33153-1
9786612331534 0-470-74904-0 0-470-74905-9 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Linker Strategies In Solid-Phase Organic Synthesis; Contents; Foreword; Preface; List of Contributors; About the Editor; Abbreviations; I INTRODUCTION; 1 General Overview; 1.1 Introduction, background and pivotal discoveries; 1.2 Fundamentals of conducting solid-phase organic chemistry; 1.2.1 Apparatus; 1.2.2 Typical solid supports; 1.2.3 Fluorous supports; 1.2.4 Linker strategies; 1.2.5 Challenges; 1.2.6 Linker groups; 1.3 Concluding comments; 1.4 Personal perspective and testimony: solid-phase Mannich chemistry; References; II TRADITIONAL LINKER UNITS FOR SOLID-PHASE ORGANIC SYNTHESIS
2 Electrophile Cleavable Linker Units2.1 Introduction; 2.2 Resins for use with electrophilic linkers; 2.3 Electrophile cleavable linkers; 2.3.1 Acid labile linkers; 2.4 Conclusion; References; 3 Nucleophile Cleavable Linker Units; 3.1 Introduction; 3.2 Linker units; 3.3 Nucleophilic labile linker units; 3.3.1 Cleavage by saponification or basic trans-esterification; 3.3.2 Cleavage by aminolysis; 3.3.3 Cleavage by hydrazinolysis; 3.3.4 Cleavage by Hydroxylamines; 3.3.5 Cleavage by other nucleophiles; 3.3.6 Linker cleavage by intramolecular nucleophilic reaction; 3.4 Conclusion; References 4 Cyclative Cleavage as a Solid-Phase Strategy4.1 Introduction; 4.2 C-N bond formation; 4.2.1 Cyclopeptides and cyclodepsipeptides; 4.2.2 Heterocycles, five-membered ring formation; 4.2.3 Heterocycles, six- and seven-membered ring formation; 4.3 C-O bond formation; 4.4 C-C bond formation; 4.5 Conclusion; References; 5 Photolabile Linker Units; 5.1 Introduction; 5.2 Linkers based on the ortho-nitrobenzyloxy function; 5.3 Linkers based on the ortho-nitrobenzylamino function; 5.4 Linkers based on the α-substituted ortho-nitrobenzyl group; 5.5 Linkers based on the ortho-nitroveratryl group 5.6 Linkers based on the phenacyl group5.7 Linkers based on the para-methoxyphenacyl group; 5.8 Linkers based on the benzoin group; 5.9 Linkers based on the pivaloyl group; 5.10 Traceless linkers; 5.11 Other types of photolabile linker units; 5.12 Conclusion; References; 6 Safety-Catch Linker Units; 6.1 Introduction; 6.2 Activation of a carbonyl group by the inductive effect (I-) of an adjacent substituent; 6.2.1 Kenner-type safety-catch linker; 6.2.2 N-boc-activated safety-catch linker; 6.2.3 Sulfide/sulfone safety-catch linker; 6.2.4 Dpr(phoc) safety-catch linker 6.3 Activation by the mesomeric effect (M-) of the -X-Y=Z moiety adjacent to a carbonyl group6.3.1 Carbonyl activation by oxidative aromatization; 6.3.2 Carbonyl activation by indole ring formation; 6.3.3 Benzyl/phenyl-hydrazide safety-catch linker; 6.3.4 Dehydration activated safety-catch linker; 6.4 Activation by the positive mesomeric effect (M+) of the -X-Y=Z moiety adjacent to a N-acyl or O-alkyl group; 6.4.1 Benzhydryl-based safety-catch linker; 6.4.2 Indole-based safety-catch linker; 6.4.3 Nitrobenzyl alcohol-based safety-catch linker; 6.5 Aromatic SNAr substitution 6.6 Fragmentation by β-elimination |
| Record Nr. | UNINA-9910140010803321 |
Scott Peter J. H
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| Hoboken, NJ, : Wiley, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Linker strategies in solid-phase organic synthesis / / edited by Peter J. H Scott
| Linker strategies in solid-phase organic synthesis / / edited by Peter J. H Scott |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley, 2009 |
| Descrizione fisica | 1 online resource (707 p.) |
| Disciplina | 547.2 |
| Altri autori (Persone) | ScottPeter J. H |
| Soggetto topico |
Solid-phase synthesis
Organic compounds - Synthesis |
| ISBN |
9786612331534
9781282331532 1282331531 9780470749043 0470749040 9780470749050 0470749059 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Linker Strategies In Solid-Phase Organic Synthesis; Contents; Foreword; Preface; List of Contributors; About the Editor; Abbreviations; I INTRODUCTION; 1 General Overview; 1.1 Introduction, background and pivotal discoveries; 1.2 Fundamentals of conducting solid-phase organic chemistry; 1.2.1 Apparatus; 1.2.2 Typical solid supports; 1.2.3 Fluorous supports; 1.2.4 Linker strategies; 1.2.5 Challenges; 1.2.6 Linker groups; 1.3 Concluding comments; 1.4 Personal perspective and testimony: solid-phase Mannich chemistry; References; II TRADITIONAL LINKER UNITS FOR SOLID-PHASE ORGANIC SYNTHESIS
2 Electrophile Cleavable Linker Units2.1 Introduction; 2.2 Resins for use with electrophilic linkers; 2.3 Electrophile cleavable linkers; 2.3.1 Acid labile linkers; 2.4 Conclusion; References; 3 Nucleophile Cleavable Linker Units; 3.1 Introduction; 3.2 Linker units; 3.3 Nucleophilic labile linker units; 3.3.1 Cleavage by saponification or basic trans-esterification; 3.3.2 Cleavage by aminolysis; 3.3.3 Cleavage by hydrazinolysis; 3.3.4 Cleavage by Hydroxylamines; 3.3.5 Cleavage by other nucleophiles; 3.3.6 Linker cleavage by intramolecular nucleophilic reaction; 3.4 Conclusion; References 4 Cyclative Cleavage as a Solid-Phase Strategy4.1 Introduction; 4.2 C-N bond formation; 4.2.1 Cyclopeptides and cyclodepsipeptides; 4.2.2 Heterocycles, five-membered ring formation; 4.2.3 Heterocycles, six- and seven-membered ring formation; 4.3 C-O bond formation; 4.4 C-C bond formation; 4.5 Conclusion; References; 5 Photolabile Linker Units; 5.1 Introduction; 5.2 Linkers based on the ortho-nitrobenzyloxy function; 5.3 Linkers based on the ortho-nitrobenzylamino function; 5.4 Linkers based on the α-substituted ortho-nitrobenzyl group; 5.5 Linkers based on the ortho-nitroveratryl group 5.6 Linkers based on the phenacyl group5.7 Linkers based on the para-methoxyphenacyl group; 5.8 Linkers based on the benzoin group; 5.9 Linkers based on the pivaloyl group; 5.10 Traceless linkers; 5.11 Other types of photolabile linker units; 5.12 Conclusion; References; 6 Safety-Catch Linker Units; 6.1 Introduction; 6.2 Activation of a carbonyl group by the inductive effect (I-) of an adjacent substituent; 6.2.1 Kenner-type safety-catch linker; 6.2.2 N-boc-activated safety-catch linker; 6.2.3 Sulfide/sulfone safety-catch linker; 6.2.4 Dpr(phoc) safety-catch linker 6.3 Activation by the mesomeric effect (M-) of the -X-Y=Z moiety adjacent to a carbonyl group6.3.1 Carbonyl activation by oxidative aromatization; 6.3.2 Carbonyl activation by indole ring formation; 6.3.3 Benzyl/phenyl-hydrazide safety-catch linker; 6.3.4 Dehydration activated safety-catch linker; 6.4 Activation by the positive mesomeric effect (M+) of the -X-Y=Z moiety adjacent to a N-acyl or O-alkyl group; 6.4.1 Benzhydryl-based safety-catch linker; 6.4.2 Indole-based safety-catch linker; 6.4.3 Nitrobenzyl alcohol-based safety-catch linker; 6.5 Aromatic SNAr substitution 6.6 Fragmentation by β-elimination |
| Record Nr. | UNINA-9911018973203321 |
| Hoboken, NJ, : Wiley, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nano Enhanced Phase Change Materials : Preparation, Properties and Applications / / edited by Zafar Said, Adarsh Kumar Pandey
| Nano Enhanced Phase Change Materials : Preparation, Properties and Applications / / edited by Zafar Said, Adarsh Kumar Pandey |
| Edizione | [1st ed. 2023.] |
| Pubbl/distr/stampa | Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023 |
| Descrizione fisica | 1 online resource (273 pages) |
| Disciplina | 620.11596 |
| Collana | Materials Horizons: From Nature to Nanomaterials |
| Soggetto topico |
Condensed matter
Solid-phase synthesis Nanotechnology Phase Transitions and Multiphase Systems Phase Transition and Critical Phenomena Solid-phase Synthesis |
| ISBN | 981-9954-75-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction to Nano Enhanced Phase Change Material -- Overview of PCMs -- Synthesis, characterization, and stability of NEPCM -- Influence of nanoparticles on thermophysical properties of PCMs -- Nanostructure–based colloidal suspension for thermal enhancement for NEPCM. . |
| Record Nr. | UNINA-9910751391103321 |
| Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Organic Synthesis on Solid Phase: Supports, Linkers, Reactions
| Organic Synthesis on Solid Phase: Supports, Linkers, Reactions |
| Autore | Dörwald Florencio Zaragoza |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH Imprint, 2002 |
| Descrizione fisica | 1 online resource (547 pages) |
| Disciplina | 547/.2 |
| Soggetto topico |
Solid-phase synthesis
Organic Chemistry Chemistry Physical Sciences & Mathematics |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-55855-5
9786610558551 3-527-60088-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910146239003321 |
|
Dörwald Florencio Zaragoza
|
||
| [Place of publication not identified], : Wiley VCH Imprint, 2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Organic Synthesis on Solid Phase: Supports, Linkers, Reactions
| Organic Synthesis on Solid Phase: Supports, Linkers, Reactions |
| Autore | Dörwald Florencio Zaragoza |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH Imprint, 2002 |
| Descrizione fisica | 1 online resource (547 pages) |
| Disciplina | 547/.2 |
| Soggetto topico |
Solid-phase synthesis
Organic Chemistry Chemistry Physical Sciences & Mathematics |
| ISBN |
1-280-55855-5
9786610558551 3-527-60088-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996204201703316 |
|
Dörwald Florencio Zaragoza
|
||
| [Place of publication not identified], : Wiley VCH Imprint, 2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Organic Synthesis on Solid Phase: Supports, Linkers, Reactions
| Organic Synthesis on Solid Phase: Supports, Linkers, Reactions |
| Autore | Dörwald Florencio Zaragoza |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH Imprint, 2002 |
| Descrizione fisica | 1 online resource (547 pages) |
| Disciplina | 547/.2 |
| Soggetto topico |
Solid-phase synthesis
Organic Chemistry Chemistry Physical Sciences & Mathematics |
| ISBN |
1-280-55855-5
9786610558551 3-527-60088-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910830586503321 |
|
Dörwald Florencio Zaragoza
|
||
| [Place of publication not identified], : Wiley VCH Imprint, 2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Organic Synthesis on Solid Phase: Supports, Linkers, Reactions
| Organic Synthesis on Solid Phase: Supports, Linkers, Reactions |
| Autore | Dörwald Florencio Zaragoza |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH Imprint, 2002 |
| Descrizione fisica | 1 online resource (547 pages) |
| Disciplina | 547/.2 |
| Soggetto topico |
Solid-phase synthesis
Organic Chemistry Chemistry Physical Sciences & Mathematics |
| ISBN |
1-280-55855-5
9786610558551 3-527-60088-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9911019739403321 |
|
Dörwald Florencio Zaragoza
|
||
| [Place of publication not identified], : Wiley VCH Imprint, 2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Solid phase synthesis and combinatorial technologies [[electronic resource] /] / Pierfausto Seneci
| Solid phase synthesis and combinatorial technologies [[electronic resource] /] / Pierfausto Seneci |
| Autore | Seneci Pierfausto <1960-> |
| Pubbl/distr/stampa | New York, : John Wiley & Sons, c2000 |
| Descrizione fisica | 1 online resource (653 p.) |
| Disciplina |
547.2
547/.2 |
| Soggetto topico |
Solid-phase synthesis
Combinatorial chemistry |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-36647-8
9786610366477 0-470-35261-2 0-471-46073-7 0-471-22039-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
SOLID-PHASE SYNTHESIS AND COMBINATORIAL TECHNOLOGIES; CONTENTS; Preface; 1 Solid-Phase Synthesis: Basic Principles; 1.1 Solid Supports; 1.2 Linkers; 1.3 Reaction Monitoring in Solid-Phase Synthesis; 1.4 Purity and Yield Determination in Solid-Phase Synthesis; References; 2 Solid-Phase Synthesis: Oligomeric Molecules; 2.1 Peptides; 2.2 Oligonucleotides; 2.3 Oligosaccharides; References; 3 Solid-Phase Synthesis: Small Organic Molecules; 3.1 Small Organic Molecules on Solid Phase: Target Selection and Solution Studies; 3.2 Small Organic Molecules on Solid Phase: Solid-Phase Synthesis
3.3 Small Organic Molecules on Solid Phase: From Solid-Phase Synthesis to Synthetic Organic Libraries3.4 An Example: Solid-Phase Synthesis of 1H-[2]Pyrindinones; 3.5 Solid-Phase Synthetic Strategies: Selected Examples; References; 4 Combinatorial Technologies: Basic Principles; 4.1 Combinatorial Technologies; 4.2 Combinatorial Libraries; References; 5 Synthetic Organic Libraries: Library Design and Properties; 5.1 Primary Libraries: Shooting in the Dark?; 5.2 Focused Libraries: High-Throughput Structure--Activity Relationships; 5.3 Biased-Targeted Libraries: Information-Rich Primary Libraries 5.4 Library Design via Computational ToolsReferences; 6 Synthetic Organic Libraries: Solid-Phase Discrete Libraries; 6.1 Synthesis of Solid-Phase Discrete Libraries; 6.2 Structure Determination, Quality Control, and Purification of Solid-Phase Discrete Libraries; 6.3 Examples of Solid-Phase Discrete Library Synthesis; 6.4 New Trends in Solid-Phase Discrete Library Synthesis; References; 7 Synthetic Organic Libraries: Solid-Phase Pool Libraries; 7.1 Synthesis of Solid-Phase Pool Libraries; 7.2 Direct Structure Determination of Positives from Solid-Phase Pool Libraries 7.3 Deconvolution Methods for Solid-Phase Pool Libraries7.4 Encoding Methods for Solid-Phase Pool Libraries; 7.5 New Trends in Solid-Phase Pool Libraries; References; 8 Synthetic Organic Libraries: Solution-Phase Libraries; 8.1 Solution- Versus Solid-Phase Synthetic Libraries: Which Ones to Use?; 8.2 Solution-Phase Discrete Libraries; 8.3 Purification of Solution-Phase Library Intermediates and Final Compounds: Liquid-Liquid and Solid-Phase Extraction Systems; 8.4 Solid-Phase Assisted Solution-Phase Library Synthesis and Purification 8.5 Soluble Supports in Solution-Phase Combinatorial Synthesis8.6 New Trends in Solution-Phase Combinatorial Synthesis; References; 9 Applications of Synthetic Libraries; 9.1 Pharmaceutical Applications; 9.2 Agrochemical and Food-Related Applications; 9.3 Applications to Combinatorial Reaction Optimization; 9.4 Applications to Catalysis; 9.5 Applications to Molecular Recognition; References; 10 Biosynthetic Combinatorial Libraries; 10.1 Biosynthetic Polypeptide Libraries; 10.2 Biosynthetic Oligonucleotide Libraries; 10.3 Combinatorial Biosynthesis of Natural Products 10.4 Combinatorial Biocatalysis |
| Record Nr. | UNINA-9910146070103321 |
|
Seneci Pierfausto <1960->
|
||
| New York, : John Wiley & Sons, c2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Solid phase synthesis and combinatorial technologies [[electronic resource] /] / Pierfausto Seneci
| Solid phase synthesis and combinatorial technologies [[electronic resource] /] / Pierfausto Seneci |
| Autore | Seneci Pierfausto <1960-> |
| Pubbl/distr/stampa | New York, : John Wiley & Sons, c2000 |
| Descrizione fisica | 1 online resource (653 p.) |
| Disciplina |
547.2
547/.2 |
| Soggetto topico |
Solid-phase synthesis
Combinatorial chemistry |
| ISBN |
1-280-36647-8
9786610366477 0-470-35261-2 0-471-46073-7 0-471-22039-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
SOLID-PHASE SYNTHESIS AND COMBINATORIAL TECHNOLOGIES; CONTENTS; Preface; 1 Solid-Phase Synthesis: Basic Principles; 1.1 Solid Supports; 1.2 Linkers; 1.3 Reaction Monitoring in Solid-Phase Synthesis; 1.4 Purity and Yield Determination in Solid-Phase Synthesis; References; 2 Solid-Phase Synthesis: Oligomeric Molecules; 2.1 Peptides; 2.2 Oligonucleotides; 2.3 Oligosaccharides; References; 3 Solid-Phase Synthesis: Small Organic Molecules; 3.1 Small Organic Molecules on Solid Phase: Target Selection and Solution Studies; 3.2 Small Organic Molecules on Solid Phase: Solid-Phase Synthesis
3.3 Small Organic Molecules on Solid Phase: From Solid-Phase Synthesis to Synthetic Organic Libraries3.4 An Example: Solid-Phase Synthesis of 1H-[2]Pyrindinones; 3.5 Solid-Phase Synthetic Strategies: Selected Examples; References; 4 Combinatorial Technologies: Basic Principles; 4.1 Combinatorial Technologies; 4.2 Combinatorial Libraries; References; 5 Synthetic Organic Libraries: Library Design and Properties; 5.1 Primary Libraries: Shooting in the Dark?; 5.2 Focused Libraries: High-Throughput Structure--Activity Relationships; 5.3 Biased-Targeted Libraries: Information-Rich Primary Libraries 5.4 Library Design via Computational ToolsReferences; 6 Synthetic Organic Libraries: Solid-Phase Discrete Libraries; 6.1 Synthesis of Solid-Phase Discrete Libraries; 6.2 Structure Determination, Quality Control, and Purification of Solid-Phase Discrete Libraries; 6.3 Examples of Solid-Phase Discrete Library Synthesis; 6.4 New Trends in Solid-Phase Discrete Library Synthesis; References; 7 Synthetic Organic Libraries: Solid-Phase Pool Libraries; 7.1 Synthesis of Solid-Phase Pool Libraries; 7.2 Direct Structure Determination of Positives from Solid-Phase Pool Libraries 7.3 Deconvolution Methods for Solid-Phase Pool Libraries7.4 Encoding Methods for Solid-Phase Pool Libraries; 7.5 New Trends in Solid-Phase Pool Libraries; References; 8 Synthetic Organic Libraries: Solution-Phase Libraries; 8.1 Solution- Versus Solid-Phase Synthetic Libraries: Which Ones to Use?; 8.2 Solution-Phase Discrete Libraries; 8.3 Purification of Solution-Phase Library Intermediates and Final Compounds: Liquid-Liquid and Solid-Phase Extraction Systems; 8.4 Solid-Phase Assisted Solution-Phase Library Synthesis and Purification 8.5 Soluble Supports in Solution-Phase Combinatorial Synthesis8.6 New Trends in Solution-Phase Combinatorial Synthesis; References; 9 Applications of Synthetic Libraries; 9.1 Pharmaceutical Applications; 9.2 Agrochemical and Food-Related Applications; 9.3 Applications to Combinatorial Reaction Optimization; 9.4 Applications to Catalysis; 9.5 Applications to Molecular Recognition; References; 10 Biosynthetic Combinatorial Libraries; 10.1 Biosynthetic Polypeptide Libraries; 10.2 Biosynthetic Oligonucleotide Libraries; 10.3 Combinatorial Biosynthesis of Natural Products 10.4 Combinatorial Biocatalysis |
| Record Nr. | UNISA-996211647403316 |
|
Seneci Pierfausto <1960->
|
||
| New York, : John Wiley & Sons, c2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Solid phase synthesis and combinatorial technologies [[electronic resource] /] / Pierfausto Seneci
| Solid phase synthesis and combinatorial technologies [[electronic resource] /] / Pierfausto Seneci |
| Autore | Seneci Pierfausto <1960-> |
| Pubbl/distr/stampa | New York, : John Wiley & Sons, c2000 |
| Descrizione fisica | 1 online resource (653 p.) |
| Disciplina |
547.2
547/.2 |
| Soggetto topico |
Solid-phase synthesis
Combinatorial chemistry |
| ISBN |
1-280-36647-8
9786610366477 0-470-35261-2 0-471-46073-7 0-471-22039-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
SOLID-PHASE SYNTHESIS AND COMBINATORIAL TECHNOLOGIES; CONTENTS; Preface; 1 Solid-Phase Synthesis: Basic Principles; 1.1 Solid Supports; 1.2 Linkers; 1.3 Reaction Monitoring in Solid-Phase Synthesis; 1.4 Purity and Yield Determination in Solid-Phase Synthesis; References; 2 Solid-Phase Synthesis: Oligomeric Molecules; 2.1 Peptides; 2.2 Oligonucleotides; 2.3 Oligosaccharides; References; 3 Solid-Phase Synthesis: Small Organic Molecules; 3.1 Small Organic Molecules on Solid Phase: Target Selection and Solution Studies; 3.2 Small Organic Molecules on Solid Phase: Solid-Phase Synthesis
3.3 Small Organic Molecules on Solid Phase: From Solid-Phase Synthesis to Synthetic Organic Libraries3.4 An Example: Solid-Phase Synthesis of 1H-[2]Pyrindinones; 3.5 Solid-Phase Synthetic Strategies: Selected Examples; References; 4 Combinatorial Technologies: Basic Principles; 4.1 Combinatorial Technologies; 4.2 Combinatorial Libraries; References; 5 Synthetic Organic Libraries: Library Design and Properties; 5.1 Primary Libraries: Shooting in the Dark?; 5.2 Focused Libraries: High-Throughput Structure--Activity Relationships; 5.3 Biased-Targeted Libraries: Information-Rich Primary Libraries 5.4 Library Design via Computational ToolsReferences; 6 Synthetic Organic Libraries: Solid-Phase Discrete Libraries; 6.1 Synthesis of Solid-Phase Discrete Libraries; 6.2 Structure Determination, Quality Control, and Purification of Solid-Phase Discrete Libraries; 6.3 Examples of Solid-Phase Discrete Library Synthesis; 6.4 New Trends in Solid-Phase Discrete Library Synthesis; References; 7 Synthetic Organic Libraries: Solid-Phase Pool Libraries; 7.1 Synthesis of Solid-Phase Pool Libraries; 7.2 Direct Structure Determination of Positives from Solid-Phase Pool Libraries 7.3 Deconvolution Methods for Solid-Phase Pool Libraries7.4 Encoding Methods for Solid-Phase Pool Libraries; 7.5 New Trends in Solid-Phase Pool Libraries; References; 8 Synthetic Organic Libraries: Solution-Phase Libraries; 8.1 Solution- Versus Solid-Phase Synthetic Libraries: Which Ones to Use?; 8.2 Solution-Phase Discrete Libraries; 8.3 Purification of Solution-Phase Library Intermediates and Final Compounds: Liquid-Liquid and Solid-Phase Extraction Systems; 8.4 Solid-Phase Assisted Solution-Phase Library Synthesis and Purification 8.5 Soluble Supports in Solution-Phase Combinatorial Synthesis8.6 New Trends in Solution-Phase Combinatorial Synthesis; References; 9 Applications of Synthetic Libraries; 9.1 Pharmaceutical Applications; 9.2 Agrochemical and Food-Related Applications; 9.3 Applications to Combinatorial Reaction Optimization; 9.4 Applications to Catalysis; 9.5 Applications to Molecular Recognition; References; 10 Biosynthetic Combinatorial Libraries; 10.1 Biosynthetic Polypeptide Libraries; 10.2 Biosynthetic Oligonucleotide Libraries; 10.3 Combinatorial Biosynthesis of Natural Products 10.4 Combinatorial Biocatalysis |
| Record Nr. | UNINA-9910829959403321 |
|
Seneci Pierfausto <1960->
|
||
| New York, : John Wiley & Sons, c2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
