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Airway smooth muscle in asthma and COPD [[electronic resource] ] : biology and pharmacology / / edited by Kian Fan Chung
| Airway smooth muscle in asthma and COPD [[electronic resource] ] : biology and pharmacology / / edited by Kian Fan Chung |
| Pubbl/distr/stampa | Hoboken, N.J. ; ; Chichester, : Wiley, 2008 |
| Descrizione fisica | 1 online resource (332 p.) |
| Disciplina | 616.2 |
| Altri autori (Persone) | ChungK. Fan <1951-> |
| Soggetto topico |
Respiratory muscles - Physiology
Smooth muscle - Physiology Respiratory muscles - Molecular aspects Smooth muscle - Molecular aspects Respiratory agents Respiratory organs - Diseases - Treatment Respiratory therapy |
| ISBN |
1-282-34322-X
9786612343223 0-470-75422-2 0-470-75421-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Airway Smooth Muscle; Contents; List of Contributors; 1 Biophysical basis of airway smooth muscle contraction and hyperresponsiveness in asthma; 1.1 Introduction; 1.2 Airway hyperresponsiveness; 1.3 Classical behaviour of airway smooth muscle and the balance of static forces; 1.4 Shortening velocity and other manifestations of muscle dynamics; 1.5 Biophysical characterization of airway smooth muscle: bronchospasm in culture?; 1.6 Mechanical plasticity: a nonclassical feature of airway smooth muscle; 1.7 Recent observations; 1.8 Future directions; References
2 Dynamics of cytoskeletal and contractile protein organization: an emerging paradigm for airway smooth muscle contraction2.1 Introduction; 2.2 Molecular structure and organization of contractile and cytoskeletal filaments in the airway smooth muscle cell; 2.3 Cytoskeletal dynamics and airway smooth muscle contraction; References; 3 Airway smooth muscle: role in airway constrictor hyperresponsiveness; 3.1 What is airway constrictor hyperresponsiveness (AHR)?; 3.2 Is AHR ever good?; 3.3 Potential mechanisms leading to airflow obstruction 3.4 Potential abnormalities of airway smooth muscle (ASM)3.5 If ASM is dysfunctional, how did it get that way?; 3.6 Summary; Acknowledgements; References; 4 Airway smooth muscle phenotypic and functional plasticity; 4.1 Introduction; 4.2 Historical perspective: smooth muscle phenotype plasticity; 4.3 Features of phenotype plasticity; 4.4 Mechanisms for phenotypic plasticity; 4.5 Functional plasticity of airway smooth muscle: role in asthma pathogenesis; 4.6 Concluding remarks; References; 5 Airway smooth muscle proliferation: insights into mechanisms regulating airway smooth muscle mass 5.1 Increases in airway smooth muscle (ASM) mass and the functional consequences5.2 Growth factors, inflammatory mediators and cytokines modulate ASM proliferation; References; 6 Airway smooth muscle bidirectional interactions with extracellular matrix; 6.1 Overview; 6.2 Introduction; 6.3 Airway extracellular matrix (ECM) in health and disease; 6.4 Integrins; 6.5 Airway smooth muscle (ASM) as a modulator of airway ECM; 6.6 Airway ECM as modulator of ASM function; 6.7 Impact of anti-asthma therapy on ASM-ECM interactions; 6.8 Conclusions; Acknowledgements; References 7 Airway smooth muscle interaction with mast cells7.1 Introduction; 7.2 Mast cell mediators alter smooth muscle function; 7.3 Smooth muscle cells induce mast cell chemotaxis; 7.4 Mast cells can adhere to airway smooth muscle; 7.5 Conclusion; Acknowledgements; References; 8 Airway smooth muscle synthesis of inflammatory mediators; 8.1 Introduction; 8.2 Lipid mediators; 8.3 Chemokines; 8.4 Growth and remodelling factors; 8.5 Conclusions; References; 9 Airway smooth muscle in experimental models; 9.1 Introduction; 9.2 Methods of assessment of airway smooth muscle (ASM) function 9.3 Potential mechanisms by which ASM properties may contribute to airway responsiveness |
| Record Nr. | UNINA-9910144704303321 |
| Hoboken, N.J. ; ; Chichester, : Wiley, 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Airway smooth muscle in asthma and COPD : biology and pharmacology / / edited by Kian Fan Chung
| Airway smooth muscle in asthma and COPD : biology and pharmacology / / edited by Kian Fan Chung |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J. ; ; Chichester, : Wiley, 2008 |
| Descrizione fisica | 1 online resource (332 p.) |
| Disciplina | 616.2 |
| Altri autori (Persone) | ChungK. Fan <1951-> |
| Soggetto topico |
Respiratory muscles - Physiology
Smooth muscle - Physiology Respiratory muscles - Molecular aspects Smooth muscle - Molecular aspects Respiratory agents Respiratory organs - Diseases - Treatment Respiratory therapy |
| ISBN |
1-282-34322-X
9786612343223 0-470-75422-2 0-470-75421-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Airway Smooth Muscle; Contents; List of Contributors; 1 Biophysical basis of airway smooth muscle contraction and hyperresponsiveness in asthma; 1.1 Introduction; 1.2 Airway hyperresponsiveness; 1.3 Classical behaviour of airway smooth muscle and the balance of static forces; 1.4 Shortening velocity and other manifestations of muscle dynamics; 1.5 Biophysical characterization of airway smooth muscle: bronchospasm in culture?; 1.6 Mechanical plasticity: a nonclassical feature of airway smooth muscle; 1.7 Recent observations; 1.8 Future directions; References
2 Dynamics of cytoskeletal and contractile protein organization: an emerging paradigm for airway smooth muscle contraction2.1 Introduction; 2.2 Molecular structure and organization of contractile and cytoskeletal filaments in the airway smooth muscle cell; 2.3 Cytoskeletal dynamics and airway smooth muscle contraction; References; 3 Airway smooth muscle: role in airway constrictor hyperresponsiveness; 3.1 What is airway constrictor hyperresponsiveness (AHR)?; 3.2 Is AHR ever good?; 3.3 Potential mechanisms leading to airflow obstruction 3.4 Potential abnormalities of airway smooth muscle (ASM)3.5 If ASM is dysfunctional, how did it get that way?; 3.6 Summary; Acknowledgements; References; 4 Airway smooth muscle phenotypic and functional plasticity; 4.1 Introduction; 4.2 Historical perspective: smooth muscle phenotype plasticity; 4.3 Features of phenotype plasticity; 4.4 Mechanisms for phenotypic plasticity; 4.5 Functional plasticity of airway smooth muscle: role in asthma pathogenesis; 4.6 Concluding remarks; References; 5 Airway smooth muscle proliferation: insights into mechanisms regulating airway smooth muscle mass 5.1 Increases in airway smooth muscle (ASM) mass and the functional consequences5.2 Growth factors, inflammatory mediators and cytokines modulate ASM proliferation; References; 6 Airway smooth muscle bidirectional interactions with extracellular matrix; 6.1 Overview; 6.2 Introduction; 6.3 Airway extracellular matrix (ECM) in health and disease; 6.4 Integrins; 6.5 Airway smooth muscle (ASM) as a modulator of airway ECM; 6.6 Airway ECM as modulator of ASM function; 6.7 Impact of anti-asthma therapy on ASM-ECM interactions; 6.8 Conclusions; Acknowledgements; References 7 Airway smooth muscle interaction with mast cells7.1 Introduction; 7.2 Mast cell mediators alter smooth muscle function; 7.3 Smooth muscle cells induce mast cell chemotaxis; 7.4 Mast cells can adhere to airway smooth muscle; 7.5 Conclusion; Acknowledgements; References; 8 Airway smooth muscle synthesis of inflammatory mediators; 8.1 Introduction; 8.2 Lipid mediators; 8.3 Chemokines; 8.4 Growth and remodelling factors; 8.5 Conclusions; References; 9 Airway smooth muscle in experimental models; 9.1 Introduction; 9.2 Methods of assessment of airway smooth muscle (ASM) function 9.3 Potential mechanisms by which ASM properties may contribute to airway responsiveness |
| Record Nr. | UNINA-9910829163303321 |
| Hoboken, N.J. ; ; Chichester, : Wiley, 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Signal Transduction and Smooth Muscle
| Signal Transduction and Smooth Muscle |
| Autore | Trebak Mohamed |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Milton, : Chapman and Hall/CRC, 2018 |
| Descrizione fisica | 1 online resource (chapter 9, pages 173-190) : charts; digital file(s) |
| Disciplina | 611.018 |
| Altri autori (Persone) | EarleyScott |
| Collana | Methods in Signal Transduction |
| Soggetto topico |
Smooth muscle - Physiology
Cellular signal transduction |
| Soggetto non controllato |
Mitochondria structure and position
local control calcium signals smooth muscle cells |
| ISBN |
1-4987-7423-7
1-351-65061-0 1-315-15458-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Half Title; Title Page; Copyright Page; Table of Contents; Series Preface; Preface; Editors; Contributors; Chapter 1: Elucidation of Vasopressin Signal Transduction Pathways in Vascular Smooth Muscle; Chapter 2: Investigating Chloride Channels in Smooth Muscle; Chapter 3: Methods for the Isolation of and Study of Ca2+ Signaling in Arteriolar Smooth Muscle Cells; Chapter 4: Ion Channel Trafficking in Arterial Smooth Muscle Cells and Functional Significance; Chapter 5: Total Internal Reflection Fluorescence Microscopy in Vascular Smooth Muscle
Chapter 6: T-Type Ca2+ Channels in Vascular Smooth Muscle: Properties, Regulation, and FunctionChapter 7: Calcium Sensitization in Smooth Muscle Involving Regulation of Myosin Light Chain Phosphatase Activity; Chapter 8: Approaches for Investigating the Functional Significance of Transient Receptor Potential Cation Channels in Smooth Muscle Cells; Chapter 9: Mitochondria Structure and Position in the Local Control of Calcium Signals in Smooth Muscle Cells; Chapter 10: ORAI Channels in Vascular Smooth Muscle Chapter 11: G Protein-Coupled Receptors in Airway Smooth Muscle Function and Obstructive Lung DiseaseChapter 12: Brain-Derived Neurotrophic Factor in Airway Smooth Muscle: Contributions to Asthma; Chapter 13: Antibody-Based Approaches for Protein Analysis of Smooth Muscles; Chapter 14: Role of Ion Channels in Urinary Bladder Smooth Muscle Function; Chapter 15: Methods for Investigating the Regulation of Smooth Muscle Excitability by Interstitial Cells; Chapter 16: Electrical Pacemaking in Lymphatic Vessels; Chapter 17: NADPH Oxidase, Redox Signaling, and Vascular Smooth Muscle Function; Index |
| Record Nr. | UNINA-9910765836903321 |
Trebak Mohamed
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| Milton, : Chapman and Hall/CRC, 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
