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The Molecular basis of smell and taste transduction [[electronic resource] /] / [editors, Derek Chadwick, Joan Marsh, and Jamie Goode]
| The Molecular basis of smell and taste transduction [[electronic resource] /] / [editors, Derek Chadwick, Joan Marsh, and Jamie Goode] |
| Pubbl/distr/stampa | Chichester ; ; New York, : Wiley, 1993 |
| Descrizione fisica | 1 online resource (304 p.) |
| Disciplina |
591.1
591.1826 |
| Altri autori (Persone) |
ChadwickDerek
MarshJoan GoodeJamie |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Smell - Molecular aspects
Taste - Molecular aspects Cellular signal transduction Second messengers (Biochemistry) G proteins |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-34787-X
9786612347870 0-470-51451-5 0-470-51452-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
THE MOLECULAR BASIS OF SMELL AND TASTE TRANSDUCTION; Contents; Participants; Introduction; From genotype to olfactory neuron phenotype: the role of the Olf-I-binding site; Mucous domains: microchemical heterogeneity in the mucociliary complex of the olfactory epithelium; Receptor diversity and spatial patterning in the mammalian olfactory system; Molecular mechanisms of olfactory neuronal gene regulation; A new tool for investigating G protein-coupled receptors; General discussion I; Second messenger signalling in olfaction; Membrane currents and mechanisms of olfactory transduction
Olfactory receptors: transduction, diversity, human psychophysics and genome analysisGeneral discussion II; MolecuIar genetics of Drosophila olfaction; Perireceptor events in taste; Gustducin and transduci n: a tale of two G proteins; Role of apical ion channels in sour taste t ransduction; Ion pathways in the taste bud and their significance for transduction; The cellular and genetic basis of olfactory responses in Caenorhabditis elegans; Genetic and pathological taste variation: what can we learn from animal models and human disease?; General discussion Ill; Summing-up Index of contributorsSubject Index |
| Record Nr. | UNINA-9910144742303321 |
| Chichester ; ; New York, : Wiley, 1993 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The Molecular basis of smell and taste transduction / / [editors, Derek Chadwick, Joan Marsh, and Jamie Goode]
| The Molecular basis of smell and taste transduction / / [editors, Derek Chadwick, Joan Marsh, and Jamie Goode] |
| Pubbl/distr/stampa | Chichester ; ; New York, : Wiley, 1993 |
| Descrizione fisica | 1 online resource (304 p.) |
| Disciplina | 591.1/826 |
| Altri autori (Persone) |
ChadwickDerek
MarshJoan GoodeJamie |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Smell - Molecular aspects
Taste - Molecular aspects Cellular signal transduction Second messengers (Biochemistry) G proteins |
| ISBN |
1-282-34787-X
9786612347870 0-470-51451-5 0-470-51452-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
THE MOLECULAR BASIS OF SMELL AND TASTE TRANSDUCTION; Contents; Participants; Introduction; From genotype to olfactory neuron phenotype: the role of the Olf-I-binding site; Mucous domains: microchemical heterogeneity in the mucociliary complex of the olfactory epithelium; Receptor diversity and spatial patterning in the mammalian olfactory system; Molecular mechanisms of olfactory neuronal gene regulation; A new tool for investigating G protein-coupled receptors; General discussion I; Second messenger signalling in olfaction; Membrane currents and mechanisms of olfactory transduction
Olfactory receptors: transduction, diversity, human psychophysics and genome analysisGeneral discussion II; MolecuIar genetics of Drosophila olfaction; Perireceptor events in taste; Gustducin and transduci n: a tale of two G proteins; Role of apical ion channels in sour taste t ransduction; Ion pathways in the taste bud and their significance for transduction; The cellular and genetic basis of olfactory responses in Caenorhabditis elegans; Genetic and pathological taste variation: what can we learn from animal models and human disease?; General discussion Ill; Summing-up Index of contributorsSubject Index |
| Record Nr. | UNINA-9910877226703321 |
| Chichester ; ; New York, : Wiley, 1993 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Progress in molecular biology and translational science . Volume 130 Molecular basis of olfaction / / edited by Richard Glatz
| Progress in molecular biology and translational science . Volume 130 Molecular basis of olfaction / / edited by Richard Glatz |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Waltham, Massachusetts : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (147 p.) |
| Disciplina | 591.1826 |
| Collana | Progress in Molecular Biology and Translational Science |
| Soggetto topico |
Olfactory receptor genes
Smell - Molecular aspects Insects - Molecular genetics Vertebrates - Molecular genetics |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-12-802913-7
0-12-802912-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Molecular Basis of Olfaction; Copyright; Contents; Contributors; Preface; Chapter 1: Mammalian Olfactory Receptors: Molecular Mechanisms of Odorant Detection, 3D-Modeling, and Structure-Activity ...; 1. Mammalian Olfactory Receptors: From Genes to Proteins; 1.1. Genes and pseudogenes; 1.2. OR protein expression; 1.3. Olfactory signal transduction; 2. Olfactory Receptor Activity Regulation: Homodimerization, Binding Cooperativity, and Allostery; 3. Olfactory Receptor 3D Modeling and Use for Virtual Screening; 3.1. Model building; 3.2. Ligand virtual screening
3.3. GPCR inverse agonist, antagonist, and agonist ligands4. Odorant Ligands Structure-Activity Relationships; References; Chapter 2: Olfactory Signaling in Insects; 1. Introduction; 2. Insect Olfactory Receptors; 2.1. Structure; 2.2. Function; 2.3. Regulation; 3. Role of Orco; 4. Final Remarks; Acknowledgments; References; Chapter 3: Advances in the Identification and Characterization of Olfactory Receptors in Insects; 1. Introduction: The Molecular Bases of Odor Detection in Insects 2. Identification of Complete Insect OR Repertoires Could Only Be Achieved by Genome and Transcriptome Sequencing2.1. Advances in sequencing technologies and bioinformatic tools; 2.2. Exploitation of insect genomes for OR identification; 2.3. Developing insect antennal transcriptomes for OR identification; 3. Toward the Development of High Throughput Methods for the Functional Characterization of Insect ORs; 3.1. Description of the different methodologies; 3.1.1. In vitro heterologous expression systems; 3.1.2. In vivo heterologous expression systems; 3.2. Large OR repertoire deorphanization 3.3. Future perspective in the functional characterization of insect ORs3.3.1. Automatization for HT screens; 3.3.2. In silico HT screens; 4. Conclusion; References; Chapter 4: Olfactory Disruption: Toward Controlling Important Insect Vectors of Disease; 1. Introduction; 2. Detection of Olfactory Signals by Insect Vectors; 2.1. Odorant-binding and chemosensory proteins; 2.2. Odorant receptors; 2.3. Gustatory receptors; 2.4. Ionotropic receptors; 2.5. Sensory neuron membrane proteins; 2.6. Activation of olfactory receptor neurons; 2.7. Processing of olfactory signals in the brain 2.8. Volatile sensation in GRNs2.9. Interaction of repellents with olfactory receptors; 3. Discovery and Development of New Repellents; 4. Conclusion; References; Chapter 5: Pheromone Reception in Moths: From Molecules to Behaviors; 1. Introduction; 2. Structure of Antennae; 3. Antennal ORNs; 4. Molecular Components of Chemical Reception; 5. Pheromone Receptors; 6. Pheromone-Binding Proteins; 7. General Odorant-Binding Proteins; 8. Sensory Neuron Membrane Proteins; 9. Antennal Lobe; 10. Behavior; Acknowledgments; References; Index; Color Plate |
| Record Nr. | UNINA-9910460499503321 |
| Waltham, Massachusetts : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Progress in molecular biology and translational science . Volume 130 Molecular basis of olfaction / / edited by Richard Glatz
| Progress in molecular biology and translational science . Volume 130 Molecular basis of olfaction / / edited by Richard Glatz |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Waltham, Massachusetts : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (147 p.) |
| Disciplina | 591.1826 |
| Collana | Progress in Molecular Biology and Translational Science |
| Soggetto topico |
Olfactory receptor genes
Smell - Molecular aspects Insects - Molecular genetics Vertebrates - Molecular genetics |
| ISBN |
0-12-802913-7
0-12-802912-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Molecular Basis of Olfaction; Copyright; Contents; Contributors; Preface; Chapter 1: Mammalian Olfactory Receptors: Molecular Mechanisms of Odorant Detection, 3D-Modeling, and Structure-Activity ...; 1. Mammalian Olfactory Receptors: From Genes to Proteins; 1.1. Genes and pseudogenes; 1.2. OR protein expression; 1.3. Olfactory signal transduction; 2. Olfactory Receptor Activity Regulation: Homodimerization, Binding Cooperativity, and Allostery; 3. Olfactory Receptor 3D Modeling and Use for Virtual Screening; 3.1. Model building; 3.2. Ligand virtual screening
3.3. GPCR inverse agonist, antagonist, and agonist ligands4. Odorant Ligands Structure-Activity Relationships; References; Chapter 2: Olfactory Signaling in Insects; 1. Introduction; 2. Insect Olfactory Receptors; 2.1. Structure; 2.2. Function; 2.3. Regulation; 3. Role of Orco; 4. Final Remarks; Acknowledgments; References; Chapter 3: Advances in the Identification and Characterization of Olfactory Receptors in Insects; 1. Introduction: The Molecular Bases of Odor Detection in Insects 2. Identification of Complete Insect OR Repertoires Could Only Be Achieved by Genome and Transcriptome Sequencing2.1. Advances in sequencing technologies and bioinformatic tools; 2.2. Exploitation of insect genomes for OR identification; 2.3. Developing insect antennal transcriptomes for OR identification; 3. Toward the Development of High Throughput Methods for the Functional Characterization of Insect ORs; 3.1. Description of the different methodologies; 3.1.1. In vitro heterologous expression systems; 3.1.2. In vivo heterologous expression systems; 3.2. Large OR repertoire deorphanization 3.3. Future perspective in the functional characterization of insect ORs3.3.1. Automatization for HT screens; 3.3.2. In silico HT screens; 4. Conclusion; References; Chapter 4: Olfactory Disruption: Toward Controlling Important Insect Vectors of Disease; 1. Introduction; 2. Detection of Olfactory Signals by Insect Vectors; 2.1. Odorant-binding and chemosensory proteins; 2.2. Odorant receptors; 2.3. Gustatory receptors; 2.4. Ionotropic receptors; 2.5. Sensory neuron membrane proteins; 2.6. Activation of olfactory receptor neurons; 2.7. Processing of olfactory signals in the brain 2.8. Volatile sensation in GRNs2.9. Interaction of repellents with olfactory receptors; 3. Discovery and Development of New Repellents; 4. Conclusion; References; Chapter 5: Pheromone Reception in Moths: From Molecules to Behaviors; 1. Introduction; 2. Structure of Antennae; 3. Antennal ORNs; 4. Molecular Components of Chemical Reception; 5. Pheromone Receptors; 6. Pheromone-Binding Proteins; 7. General Odorant-Binding Proteins; 8. Sensory Neuron Membrane Proteins; 9. Antennal Lobe; 10. Behavior; Acknowledgments; References; Index; Color Plate |
| Record Nr. | UNINA-9910787449803321 |
| Waltham, Massachusetts : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Progress in molecular biology and translational science . Volume 130 Molecular basis of olfaction / / edited by Richard Glatz
| Progress in molecular biology and translational science . Volume 130 Molecular basis of olfaction / / edited by Richard Glatz |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Waltham, Massachusetts : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (147 p.) |
| Disciplina | 591.1826 |
| Collana | Progress in Molecular Biology and Translational Science |
| Soggetto topico |
Olfactory receptor genes
Smell - Molecular aspects Insects - Molecular genetics Vertebrates - Molecular genetics |
| ISBN |
0-12-802913-7
0-12-802912-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Molecular Basis of Olfaction; Copyright; Contents; Contributors; Preface; Chapter 1: Mammalian Olfactory Receptors: Molecular Mechanisms of Odorant Detection, 3D-Modeling, and Structure-Activity ...; 1. Mammalian Olfactory Receptors: From Genes to Proteins; 1.1. Genes and pseudogenes; 1.2. OR protein expression; 1.3. Olfactory signal transduction; 2. Olfactory Receptor Activity Regulation: Homodimerization, Binding Cooperativity, and Allostery; 3. Olfactory Receptor 3D Modeling and Use for Virtual Screening; 3.1. Model building; 3.2. Ligand virtual screening
3.3. GPCR inverse agonist, antagonist, and agonist ligands4. Odorant Ligands Structure-Activity Relationships; References; Chapter 2: Olfactory Signaling in Insects; 1. Introduction; 2. Insect Olfactory Receptors; 2.1. Structure; 2.2. Function; 2.3. Regulation; 3. Role of Orco; 4. Final Remarks; Acknowledgments; References; Chapter 3: Advances in the Identification and Characterization of Olfactory Receptors in Insects; 1. Introduction: The Molecular Bases of Odor Detection in Insects 2. Identification of Complete Insect OR Repertoires Could Only Be Achieved by Genome and Transcriptome Sequencing2.1. Advances in sequencing technologies and bioinformatic tools; 2.2. Exploitation of insect genomes for OR identification; 2.3. Developing insect antennal transcriptomes for OR identification; 3. Toward the Development of High Throughput Methods for the Functional Characterization of Insect ORs; 3.1. Description of the different methodologies; 3.1.1. In vitro heterologous expression systems; 3.1.2. In vivo heterologous expression systems; 3.2. Large OR repertoire deorphanization 3.3. Future perspective in the functional characterization of insect ORs3.3.1. Automatization for HT screens; 3.3.2. In silico HT screens; 4. Conclusion; References; Chapter 4: Olfactory Disruption: Toward Controlling Important Insect Vectors of Disease; 1. Introduction; 2. Detection of Olfactory Signals by Insect Vectors; 2.1. Odorant-binding and chemosensory proteins; 2.2. Odorant receptors; 2.3. Gustatory receptors; 2.4. Ionotropic receptors; 2.5. Sensory neuron membrane proteins; 2.6. Activation of olfactory receptor neurons; 2.7. Processing of olfactory signals in the brain 2.8. Volatile sensation in GRNs2.9. Interaction of repellents with olfactory receptors; 3. Discovery and Development of New Repellents; 4. Conclusion; References; Chapter 5: Pheromone Reception in Moths: From Molecules to Behaviors; 1. Introduction; 2. Structure of Antennae; 3. Antennal ORNs; 4. Molecular Components of Chemical Reception; 5. Pheromone Receptors; 6. Pheromone-Binding Proteins; 7. General Odorant-Binding Proteins; 8. Sensory Neuron Membrane Proteins; 9. Antennal Lobe; 10. Behavior; Acknowledgments; References; Index; Color Plate |
| Record Nr. | UNINA-9910826903703321 |
| Waltham, Massachusetts : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
