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Airway smooth muscle in asthma and COPD [[electronic resource] ] : biology and pharmacology / / edited by Kian Fan Chung
| Airway smooth muscle in asthma and COPD [[electronic resource] ] : biology and pharmacology / / edited by Kian Fan Chung |
| Pubbl/distr/stampa | Hoboken, N.J. ; ; Chichester, : Wiley, 2008 |
| Descrizione fisica | 1 online resource (332 p.) |
| Disciplina | 616.2 |
| Altri autori (Persone) | ChungK. Fan <1951-> |
| Soggetto topico |
Respiratory muscles - Physiology
Smooth muscle - Physiology Respiratory muscles - Molecular aspects Smooth muscle - Molecular aspects Respiratory agents Respiratory organs - Diseases - Treatment Respiratory therapy |
| ISBN |
1-282-34322-X
9786612343223 0-470-75422-2 0-470-75421-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Airway Smooth Muscle; Contents; List of Contributors; 1 Biophysical basis of airway smooth muscle contraction and hyperresponsiveness in asthma; 1.1 Introduction; 1.2 Airway hyperresponsiveness; 1.3 Classical behaviour of airway smooth muscle and the balance of static forces; 1.4 Shortening velocity and other manifestations of muscle dynamics; 1.5 Biophysical characterization of airway smooth muscle: bronchospasm in culture?; 1.6 Mechanical plasticity: a nonclassical feature of airway smooth muscle; 1.7 Recent observations; 1.8 Future directions; References
2 Dynamics of cytoskeletal and contractile protein organization: an emerging paradigm for airway smooth muscle contraction2.1 Introduction; 2.2 Molecular structure and organization of contractile and cytoskeletal filaments in the airway smooth muscle cell; 2.3 Cytoskeletal dynamics and airway smooth muscle contraction; References; 3 Airway smooth muscle: role in airway constrictor hyperresponsiveness; 3.1 What is airway constrictor hyperresponsiveness (AHR)?; 3.2 Is AHR ever good?; 3.3 Potential mechanisms leading to airflow obstruction 3.4 Potential abnormalities of airway smooth muscle (ASM)3.5 If ASM is dysfunctional, how did it get that way?; 3.6 Summary; Acknowledgements; References; 4 Airway smooth muscle phenotypic and functional plasticity; 4.1 Introduction; 4.2 Historical perspective: smooth muscle phenotype plasticity; 4.3 Features of phenotype plasticity; 4.4 Mechanisms for phenotypic plasticity; 4.5 Functional plasticity of airway smooth muscle: role in asthma pathogenesis; 4.6 Concluding remarks; References; 5 Airway smooth muscle proliferation: insights into mechanisms regulating airway smooth muscle mass 5.1 Increases in airway smooth muscle (ASM) mass and the functional consequences5.2 Growth factors, inflammatory mediators and cytokines modulate ASM proliferation; References; 6 Airway smooth muscle bidirectional interactions with extracellular matrix; 6.1 Overview; 6.2 Introduction; 6.3 Airway extracellular matrix (ECM) in health and disease; 6.4 Integrins; 6.5 Airway smooth muscle (ASM) as a modulator of airway ECM; 6.6 Airway ECM as modulator of ASM function; 6.7 Impact of anti-asthma therapy on ASM-ECM interactions; 6.8 Conclusions; Acknowledgements; References 7 Airway smooth muscle interaction with mast cells7.1 Introduction; 7.2 Mast cell mediators alter smooth muscle function; 7.3 Smooth muscle cells induce mast cell chemotaxis; 7.4 Mast cells can adhere to airway smooth muscle; 7.5 Conclusion; Acknowledgements; References; 8 Airway smooth muscle synthesis of inflammatory mediators; 8.1 Introduction; 8.2 Lipid mediators; 8.3 Chemokines; 8.4 Growth and remodelling factors; 8.5 Conclusions; References; 9 Airway smooth muscle in experimental models; 9.1 Introduction; 9.2 Methods of assessment of airway smooth muscle (ASM) function 9.3 Potential mechanisms by which ASM properties may contribute to airway responsiveness |
| Record Nr. | UNINA-9910144704303321 |
| Hoboken, N.J. ; ; Chichester, : Wiley, 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Airway smooth muscle in asthma and COPD [[electronic resource] ] : biology and pharmacology / / edited by Kian Fan Chung
| Airway smooth muscle in asthma and COPD [[electronic resource] ] : biology and pharmacology / / edited by Kian Fan Chung |
| Pubbl/distr/stampa | Hoboken, N.J. ; ; Chichester, : Wiley, 2008 |
| Descrizione fisica | 1 online resource (332 p.) |
| Disciplina | 616.2 |
| Altri autori (Persone) | ChungK. Fan <1951-> |
| Soggetto topico |
Respiratory muscles - Physiology
Smooth muscle - Physiology Respiratory muscles - Molecular aspects Smooth muscle - Molecular aspects Respiratory agents Respiratory organs - Diseases - Treatment Respiratory therapy |
| ISBN |
1-282-34322-X
9786612343223 0-470-75422-2 0-470-75421-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Airway Smooth Muscle; Contents; List of Contributors; 1 Biophysical basis of airway smooth muscle contraction and hyperresponsiveness in asthma; 1.1 Introduction; 1.2 Airway hyperresponsiveness; 1.3 Classical behaviour of airway smooth muscle and the balance of static forces; 1.4 Shortening velocity and other manifestations of muscle dynamics; 1.5 Biophysical characterization of airway smooth muscle: bronchospasm in culture?; 1.6 Mechanical plasticity: a nonclassical feature of airway smooth muscle; 1.7 Recent observations; 1.8 Future directions; References
2 Dynamics of cytoskeletal and contractile protein organization: an emerging paradigm for airway smooth muscle contraction2.1 Introduction; 2.2 Molecular structure and organization of contractile and cytoskeletal filaments in the airway smooth muscle cell; 2.3 Cytoskeletal dynamics and airway smooth muscle contraction; References; 3 Airway smooth muscle: role in airway constrictor hyperresponsiveness; 3.1 What is airway constrictor hyperresponsiveness (AHR)?; 3.2 Is AHR ever good?; 3.3 Potential mechanisms leading to airflow obstruction 3.4 Potential abnormalities of airway smooth muscle (ASM)3.5 If ASM is dysfunctional, how did it get that way?; 3.6 Summary; Acknowledgements; References; 4 Airway smooth muscle phenotypic and functional plasticity; 4.1 Introduction; 4.2 Historical perspective: smooth muscle phenotype plasticity; 4.3 Features of phenotype plasticity; 4.4 Mechanisms for phenotypic plasticity; 4.5 Functional plasticity of airway smooth muscle: role in asthma pathogenesis; 4.6 Concluding remarks; References; 5 Airway smooth muscle proliferation: insights into mechanisms regulating airway smooth muscle mass 5.1 Increases in airway smooth muscle (ASM) mass and the functional consequences5.2 Growth factors, inflammatory mediators and cytokines modulate ASM proliferation; References; 6 Airway smooth muscle bidirectional interactions with extracellular matrix; 6.1 Overview; 6.2 Introduction; 6.3 Airway extracellular matrix (ECM) in health and disease; 6.4 Integrins; 6.5 Airway smooth muscle (ASM) as a modulator of airway ECM; 6.6 Airway ECM as modulator of ASM function; 6.7 Impact of anti-asthma therapy on ASM-ECM interactions; 6.8 Conclusions; Acknowledgements; References 7 Airway smooth muscle interaction with mast cells7.1 Introduction; 7.2 Mast cell mediators alter smooth muscle function; 7.3 Smooth muscle cells induce mast cell chemotaxis; 7.4 Mast cells can adhere to airway smooth muscle; 7.5 Conclusion; Acknowledgements; References; 8 Airway smooth muscle synthesis of inflammatory mediators; 8.1 Introduction; 8.2 Lipid mediators; 8.3 Chemokines; 8.4 Growth and remodelling factors; 8.5 Conclusions; References; 9 Airway smooth muscle in experimental models; 9.1 Introduction; 9.2 Methods of assessment of airway smooth muscle (ASM) function 9.3 Potential mechanisms by which ASM properties may contribute to airway responsiveness |
| Record Nr. | UNINA-9910829163303321 |
| Hoboken, N.J. ; ; Chichester, : Wiley, 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drugs for the treatment of respiratory diseases / / edited by Domenico Spina [and others] [[electronic resource]]
| Drugs for the treatment of respiratory diseases / / edited by Domenico Spina [and others] [[electronic resource]] |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2003 |
| Descrizione fisica | 1 online resource (xii, 599 pages) : digital, PDF file(s) |
| Disciplina | 616.2/4061 |
| Soggetto topico |
Lungs - Diseases - Chemotherapy
Respiratory agents |
| ISBN |
1-107-12888-9
1-280-16021-7 9786610160211 1-139-14637-8 0-511-11846-5 0-511-06678-3 0-511-06047-5 0-511-30712-8 0-511-54569-X 0-511-06891-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Half-title; Title; Copyright; Contents; Contributors; Preface; 1 Pathology of asthma and COPD: inflammation and structure; 2 Glucocorticosteroids; 3 Beta2-adrenoceptor agonists; 4 Anticholinergic bronchodilators; 5 Antiallergic drugs; 6 Drugs affecting the synthesis and action of leukotrienes; 7 Theophylline and selective phosphodiesterase inhibitors in the treatment of respiratory disease; 8 Potential therapeutic effects of potassium channel openers in respiratory diseases; 9 Tachykinin and kinin antagonists; 10 Drugs affecting IgE (synthesis inhibitors and monoclonal antibodies)
11 Drugs targeting cell signalling12 Current approaches to the treatment of parenchymal lung diseases; 13 Drug treatments of the future in fibrotic lung disease; 14 Current and future management of pneumonia; 15 Current treatment of chronic bronchial suppuration; 16 Current and future treatment of cystic fibrosis; 17 Pathophysiology of pulmonary vascular disease; 18 Current treatment of pulmonary vascular diseases; 19 Future treatment of pulmonary vascular diseases; 20 Molecular pathology of lung cancer; 21 Small cell lung cancer; 22 Mechanisms of cough; 23 Current treatment of cough; Index |
| Record Nr. | UNINA-9910450363603321 |
| Cambridge : , : Cambridge University Press, , 2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drugs for the treatment of respiratory diseases / / edited by Domenico Spina [and others] [[electronic resource]]
| Drugs for the treatment of respiratory diseases / / edited by Domenico Spina [and others] [[electronic resource]] |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2003 |
| Descrizione fisica | 1 online resource (xii, 599 pages) : digital, PDF file(s) |
| Disciplina | 616.2/4061 |
| Soggetto topico |
Lungs - Diseases - Chemotherapy
Respiratory agents |
| ISBN |
1-107-12888-9
1-280-16021-7 9786610160211 1-139-14637-8 0-511-11846-5 0-511-06678-3 0-511-06047-5 0-511-30712-8 0-511-54569-X 0-511-06891-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Half-title; Title; Copyright; Contents; Contributors; Preface; 1 Pathology of asthma and COPD: inflammation and structure; 2 Glucocorticosteroids; 3 Beta2-adrenoceptor agonists; 4 Anticholinergic bronchodilators; 5 Antiallergic drugs; 6 Drugs affecting the synthesis and action of leukotrienes; 7 Theophylline and selective phosphodiesterase inhibitors in the treatment of respiratory disease; 8 Potential therapeutic effects of potassium channel openers in respiratory diseases; 9 Tachykinin and kinin antagonists; 10 Drugs affecting IgE (synthesis inhibitors and monoclonal antibodies)
11 Drugs targeting cell signalling12 Current approaches to the treatment of parenchymal lung diseases; 13 Drug treatments of the future in fibrotic lung disease; 14 Current and future management of pneumonia; 15 Current treatment of chronic bronchial suppuration; 16 Current and future treatment of cystic fibrosis; 17 Pathophysiology of pulmonary vascular disease; 18 Current treatment of pulmonary vascular diseases; 19 Future treatment of pulmonary vascular diseases; 20 Molecular pathology of lung cancer; 21 Small cell lung cancer; 22 Mechanisms of cough; 23 Current treatment of cough; Index |
| Record Nr. | UNINA-9910783128003321 |
| Cambridge : , : Cambridge University Press, , 2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drugs for the treatment of respiratory diseases / / edited by Domenico Spina [and others] [[electronic resource]]
| Drugs for the treatment of respiratory diseases / / edited by Domenico Spina [and others] [[electronic resource]] |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2003 |
| Descrizione fisica | 1 online resource (xii, 599 pages) : digital, PDF file(s) |
| Disciplina | 616.2/4061 |
| Soggetto topico |
Lungs - Diseases - Chemotherapy
Respiratory agents |
| ISBN |
1-107-12888-9
1-280-16021-7 9786610160211 1-139-14637-8 0-511-11846-5 0-511-06678-3 0-511-06047-5 0-511-30712-8 0-511-54569-X 0-511-06891-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Half-title; Title; Copyright; Contents; Contributors; Preface; 1 Pathology of asthma and COPD: inflammation and structure; 2 Glucocorticosteroids; 3 Beta2-adrenoceptor agonists; 4 Anticholinergic bronchodilators; 5 Antiallergic drugs; 6 Drugs affecting the synthesis and action of leukotrienes; 7 Theophylline and selective phosphodiesterase inhibitors in the treatment of respiratory disease; 8 Potential therapeutic effects of potassium channel openers in respiratory diseases; 9 Tachykinin and kinin antagonists; 10 Drugs affecting IgE (synthesis inhibitors and monoclonal antibodies)
11 Drugs targeting cell signalling12 Current approaches to the treatment of parenchymal lung diseases; 13 Drug treatments of the future in fibrotic lung disease; 14 Current and future management of pneumonia; 15 Current treatment of chronic bronchial suppuration; 16 Current and future treatment of cystic fibrosis; 17 Pathophysiology of pulmonary vascular disease; 18 Current treatment of pulmonary vascular diseases; 19 Future treatment of pulmonary vascular diseases; 20 Molecular pathology of lung cancer; 21 Small cell lung cancer; 22 Mechanisms of cough; 23 Current treatment of cough; Index |
| Record Nr. | UNINA-9910827764603321 |
| Cambridge : , : Cambridge University Press, , 2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Therapeutic advances in respiratory disease
| Therapeutic advances in respiratory disease |
| Pubbl/distr/stampa | Los Angeles, : SAGE Publications, ©2007- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Respiratory organs - Diseases
Respiratory agents Pulmonary pharmacology Respiratory Tract Diseases Respiratory System Agents - therapeutic use Respiratory Tract Diseases - drug therapy Lung Diseases - drug therapy Appareil respiratoire - Maladies - Traitement Agents respiratoires Pharmacologie pulmonaire Appareil respiratoire - Maladies |
| Soggetto genere / forma |
Periodical
periodicals. Periodicals. Périodiques. |
| ISSN | 1753-4666 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910265245703321 |
| Los Angeles, : SAGE Publications, ©2007- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Therapeutic advances in respiratory disease
| Therapeutic advances in respiratory disease |
| Pubbl/distr/stampa | Los Angeles, : SAGE Publications, ©2007- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Respiratory organs - Diseases
Respiratory agents Pulmonary pharmacology Respiratory Tract Diseases Respiratory System Agents - therapeutic use Respiratory Tract Diseases - drug therapy Lung Diseases - drug therapy Appareil respiratoire - Maladies - Traitement Agents respiratoires Pharmacologie pulmonaire Appareil respiratoire - Maladies |
| Soggetto genere / forma |
Periodical
periodicals. Periodicals. Périodiques. |
| ISSN | 1753-4666 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996251345103316 |
| Los Angeles, : SAGE Publications, ©2007- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
