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Antibiotic Resistant Bacteria: A Challenge to Modern Medicine / / by Sadhana Sagar, Shilpa Kaistha, Amar Jyoti Das, Rajesh Kumar
| Antibiotic Resistant Bacteria: A Challenge to Modern Medicine / / by Sadhana Sagar, Shilpa Kaistha, Amar Jyoti Das, Rajesh Kumar |
| Autore | Sagar Sadhana |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (XVI, 179 p. 57 illus., 45 illus. in color.) |
| Disciplina | 616.9041 |
| Soggetto topico |
Drug resistance
Infectious diseases Bacteriology Pharmaceutical technology Drug Resistance Infectious Diseases Pharmaceutical Sciences/Technology Resistència als medicaments |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 981-13-9879-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Module 1_Emergence of antibiotic resistant bacteria -- Module 2_Impact of antibiotic resistant bacteria on different field -- Module 3_Antibiotic resistance: Pattern and Mechanisms -- Module 4_Novel strategies for overcoming of antibiotic resistant mechanisms -- Module 5_Future Prospects. |
| Record Nr. | UNINA-9910373917603321 |
Sagar Sadhana
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| Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Antimicrobial resistance & infection control
| Antimicrobial resistance & infection control |
| Pubbl/distr/stampa | London, : Biomed Central |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Diagnosis, Laboratory
Infection - Treatment Drug resistance Drug Resistance, Microbial Infection Control Communicable Disease Control Infeccions Malalties infeccioses Microorganismes Resistència als medicaments |
| Soggetto genere / forma |
Periodical
Periodicals. Revistes electròniques. |
| Soggetto non controllato | Pathology |
| ISSN | 2047-2994 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
Antimicrobial resistance and infection control
ARIC |
| Record Nr. | UNISA-996206840303316 |
| London, : Biomed Central | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Antimicrobial resistance & infection control
| Antimicrobial resistance & infection control |
| Pubbl/distr/stampa | London, : Biomed Central |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Diagnosis, Laboratory
Infection - Treatment Drug resistance Drug Resistance, Microbial Infection Control Communicable Disease Control Infeccions Malalties infeccioses Microorganismes Resistència als medicaments |
| Soggetto genere / forma |
Periodical
Periodicals. Revistes electròniques. |
| ISSN | 2047-2994 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
Antimicrobial resistance and infection control
ARIC |
| Record Nr. | UNINA-9910141178503321 |
| London, : Biomed Central | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Beta-lactam resistance in gram-negative bacteria : threats and challenges / / edited by Mohammad Shahid, Anuradha Singh, and Hiba Sami
| Beta-lactam resistance in gram-negative bacteria : threats and challenges / / edited by Mohammad Shahid, Anuradha Singh, and Hiba Sami |
| Pubbl/distr/stampa | Singapore : , : Springer, , [2022] |
| Descrizione fisica | 1 online resource (330 pages) |
| Disciplina | 616.9041 |
| Soggetto topico |
Drug resistance in microorganisms
Resistència als medicaments Malalties bacterianes grampositives Antibiòtics betalactàmics |
| Soggetto genere / forma | Llibres electrònics |
| ISBN |
981-16-9096-0
981-16-9097-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910743218603321 |
| Singapore : , : Springer, , [2022] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cancer, Complexity, Computation [[electronic resource] /] / edited by Igor Balaz, Andrew Adamatzky
| Cancer, Complexity, Computation [[electronic resource] /] / edited by Igor Balaz, Andrew Adamatzky |
| Edizione | [1st ed. 2022.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 |
| Descrizione fisica | 1 online resource (349 pages) |
| Disciplina | 610.28 |
| Collana | Emergence, Complexity and Computation |
| Soggetto topico |
Engineering mathematics
Engineering - Data processing Dynamics Nonlinear theories Cancer - Animal models Mathematical and Computational Engineering Applications Applied Dynamical Systems Cancer Models Enginyeria biomèdica Tumors Resistència als medicaments |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-031-04379-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | What Cancer Is by J. James Frost -- Complementarity, Complexity and the Fokker-Planck Equation; From the Microscale Quantum Stochastic Events to Fractal Dynamics of Cancer -- Quantitative in vivo Imaging to Enable Tumor Forecasting and Treatment Optimization. |
| Record Nr. | UNISA-996485662103316 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Cancer, Complexity, Computation / / edited by Igor Balaz, Andrew Adamatzky
| Cancer, Complexity, Computation / / edited by Igor Balaz, Andrew Adamatzky |
| Edizione | [1st ed. 2022.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 |
| Descrizione fisica | 1 online resource (349 pages) |
| Disciplina |
610.28
616.9940072 |
| Collana | Emergence, Complexity and Computation |
| Soggetto topico |
Engineering mathematics
Engineering - Data processing Dynamics Nonlinear theories Cancer - Animal models Mathematical and Computational Engineering Applications Applied Dynamical Systems Cancer Models Enginyeria biomèdica Tumors Resistència als medicaments |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-031-04379-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | What Cancer Is by J. James Frost -- Complementarity, Complexity and the Fokker-Planck Equation; From the Microscale Quantum Stochastic Events to Fractal Dynamics of Cancer -- Quantitative in vivo Imaging to Enable Tumor Forecasting and Treatment Optimization. |
| Record Nr. | UNINA-9910586588803321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Diagnosis of Mycobacterium / / edited by Amit Singh, Divakar Sharma
| Diagnosis of Mycobacterium / / edited by Amit Singh, Divakar Sharma |
| Edizione | [1st ed. 2023.] |
| Pubbl/distr/stampa | Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023 |
| Descrizione fisica | 1 online resource (274 pages) |
| Disciplina | 616.0142 |
| Soggetto topico |
Microbiology
Diagnosis Diseases Internal medicine Internal Medicine Mycobacterium tuberculosis Micobacteris Microbiologia mèdica Tuberculosi Resistència als medicaments Diagnòstic de laboratori |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 981-9956-24-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chapter 1. Introduction to Diagnosis of Mycobacterium -- Chapter 2. Clinical and Radiological Diagnosis of Tuberculosis -- Chapter 3. Pathology based Diagnosis of Tuberculosis -- Chapter 4. Assessment of Hematological and Biochemical Parameters in the Diagnosis and Prognosis of Tuberculosis -- Chapter 5. Different Methods of Microscopic and Bacteriological Diagnosis of Tuberculosis -- Chapter 6. Molecular Diagnosis of Tuberculosis -- Chapter 7. Diagnosis and Challenges of Pediatric Tuberculosis -- Chapter 8. Diagnosis of Latent Tuberculosis -- Chapter 9. The Future of Serology-Based Diagnosis for Tuberculosis in India -- Chapter 10. Point of Care (POC) Detection Technique for Mycobacterium -- Chapter 11. Recent Advances in the Diagnosis and Treatment of Non-tuberculous Mycobacteria Infection -- Chapter 12. Sensor and Nanotechnology based Diagnostics in the Field of Mycobacteriology -- Chapter 13. Non-tuberculous Mycobacterium Infections in Lung Disease and Medical Interventions -- Chapter 14. Laboratory Diagnosis of Zoonotic Tuberculosis: An Update. |
| Record Nr. | UNINA-9910763597103321 |
| Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The end of an antibiotic era : bacteria's triumph over a universal remedy / / Rinke van den Brink
| The end of an antibiotic era : bacteria's triumph over a universal remedy / / Rinke van den Brink |
| Autore | Brink Rinke van den <1955-> |
| Edizione | [1st ed. 2021.] |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (XIX, 322 p. 4 illus.) |
| Disciplina | 616.9041 |
| Soggetto topico |
Drug resistance in microorganisms
Resistència als medicaments |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-70723-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction -- In the beginning there was antibiotic resistance -- Human and economic costs -- Mega-outbreak at Maasstad Hospital -- A thin layer of faeces on everything you touch -- The beginning of the end -- The end in sight? -- Looking behind the figures -- The role of microbiology -- INTERREG projects: ‘Pathogens don’t recognise any borders’ -- A bottomless well, and other solutions. |
| Record Nr. | UNINA-9910483592303321 |
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Brink Rinke van den <1955->
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| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Resistance to targeted therapies in multiple myeloma / / Silvia Cw Ling, Steven Trieu, editors
| Resistance to targeted therapies in multiple myeloma / / Silvia Cw Ling, Steven Trieu, editors |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (161 pages) |
| Disciplina | 616.994061 |
| Collana | Resistance to Targeted Anti-Cancer Therapeutics |
| Soggetto topico |
Drug resistance in cancer cells
Multiple myeloma - Treatment Mieloma múltiple Resistència als medicaments |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-73440-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Aims and Scope -- Objective -- Preface -- Contents -- Series Editor Biography -- About the Series Editor -- Contributors -- About the Editors -- Chapter 1: The Role of Targeted Therapy in Multiple Myeloma -- 1.1 Multiple Myeloma Overview -- 1.2 Historical Treatment of Multiple Myeloma Until Present -- 1.3 Immunomodulatory Imide Drugs -- 1.4 Proteasome Inhibitors -- 1.5 Monoclonal Antibodies -- 1.6 Histone Deacetylase Inhibitors -- 1.7 Bone Targeted Therapy -- 1.8 New Agents on the Horizon -- 1.9 Conclusion -- References -- Chapter 2: Lenalidomide -- 2.1 Introduction -- 2.2 Indications -- 2.3 Efficacy of Lenalidomide -- 2.3.1 Efficacy in Relapsed or Refractory Multiple Myeloma -- 2.3.1.1 Lenalidomide and Dexamethasone -- 2.3.1.2 Bortezomib, Lenalidomide, and Dexamethasone -- 2.3.1.3 Daratumumab, Lenalidomide, and Dexamethasone -- 2.3.1.4 Carfilzomib, Lenalidomide, and Dexamethasone -- 2.3.2 Efficacy in Newly Diagnosed Multiple Myeloma -- 2.3.2.1 Transplant Ineligible Patients -- Lenalidomide and Dexamethasone -- Cyclophosphamide, Lenalidomide, and Dexamethasone -- Bortezomib, Lenalidomide, and Dexamethasone -- 2.3.2.2 Transplant Eligible Patients -- Bortezomib, Lenalidomide, and Dexamethasone -- 2.4 Mechanisms of Action -- 2.4.1 Cereblon Pathway -- 2.4.2 Effect on Cytokines -- 2.4.3 T Cell Activation -- 2.4.4 Effect on Natural Killer Cells -- 2.4.5 Anti-Angiogenic Activity -- 2.4.6 Direct Antitumor Activity -- 2.4.7 Myeloma Microenvironment -- 2.5 Lenalidomide Resistance -- 2.5.1 Potential Mechanisms of Lenalidomide Resistance -- 2.5.1.1 Decreased Cereblon Expression and Downstream Factors -- 2.5.1.2 Increase in c-Myc -- 2.5.2 Management of Lenalidomide-Resistant Disease -- 2.5.2.1 Pomalidomide-Based Regimes -- 2.5.2.2 Proteasome Inhibitor and Daratumumab-Based Regimes -- 2.6 Conclusion -- References -- Chapter 3: Pomalidomide.
3.1 Introduction -- 3.2 Clinical Indication of Pomalidomide -- 3.3 Efficacy -- 3.3.1 Efficacy in Relapsed and Refractory Multiple Myeloma -- 3.3.1.1 Pomalidomide and Dexamethasone -- 3.3.1.2 Pomalidomide + Dexamethasone + Cyclophosphamide -- 3.3.1.3 Pomalidomide, Bortezomib, and Dexamethasone -- 3.3.1.4 Pomalidomide, Daratumumab, and Dexamethasone -- 3.3.1.5 Pembrolizumab, Pomalidomide, and Dexamethasone -- 3.4 Mechanisms of Pomalidomide Action -- 3.5 Potential Mechanism of Pomalidomide Resistance and Overcoming Resistance -- 3.6 Conclusion -- References -- Chapter 4: Mechanisms Driving Resistance to Proteasome Inhibitors Bortezomib, Carfilzomib, and Ixazomib in Multiple Myeloma -- 4.1 Introduction -- 4.2 The Proteasome -- 4.3 Endoplasmic Reticulum Stress -- 4.4 Proteasome Inhibitors in Multiple Myeloma -- 4.5 Bortezomib Resistance Mechanisms -- 4.5.1 Proteasome Mutation and Overexpression -- 4.5.2 Drug Efflux -- 4.5.3 Plasma Cell Differentiation -- 4.5.4 Upregulation of Heat Shock Proteins -- 4.5.5 Autophagy -- 4.5.6 The Bone Marrow Microenvironment -- 4.6 Resistance Mechanisms to Second Generation Proteasome Inhibitors -- 4.6.1 Carfilzomib Resistance Mechanisms -- 4.6.1.1 Proteasome Mutations -- 4.6.1.2 Drug Efflux -- 4.6.1.3 Autophagy -- 4.6.1.4 Bone Marrow Microenvironment -- 4.6.2 Ixazomib Resistance Mechanisms -- 4.7 Conclusion -- References -- Chapter 5: Daratumumab -- 5.1 Introduction -- 5.2 Mechanism of Action -- 5.3 Mechanisms Behind Daratumumab-Resistance -- 5.3.1 Reduced Cell Surface Expression of Target Antigen CD38 -- 5.3.2 Antibody-Dependent Cell Cytotoxicity Resistance -- 5.3.3 Antibody-Dependent Cellular Phagocytosis Resistance -- 5.3.4 Complement-Dependent Cytotoxicity Resistance -- 5.3.5 Immune Modulated Resistance -- 5.4 Clinical Efficacy of Daratumumab -- 5.4.1 Daratumumab in the Relapsed and Refractory Setting. 5.4.2 Daratumumab in Newly Diagnosed, Transplant Ineligible Patients -- 5.4.3 Daratumumab in Newly Diagnosed, Transplant Eligible Patients -- 5.5 Toxicity Profile -- 5.6 Conclusion -- References -- Chapter 6: Elotuzumab -- 6.1 Introduction -- 6.2 Mechanisms of Action -- 6.2.1 Preclinical Studies -- 6.3 Pharmacological Characteristics of Elotuzumab -- 6.4 Mechanisms of Resistance to Elotuzumab -- 6.4.1 Expression of the Antigen Target of the Monoclonal Antibody -- 6.4.2 CD16a Expression on NK Cells and Associated Polymorphisms -- 6.4.3 Interactions with the Microenvironment -- 6.4.4 Development of Neutralizing Antibodies -- 6.5 Clinical Trials -- 6.5.1 Relapsed and/or Refractory Myeloma -- 6.6 Toxicities of Elotuzumab -- 6.7 Conclusion -- References -- Chapter 7: Histone Deacetylase Inhibitors -- 7.1 Introduction -- 7.2 Histone Deacetylases -- 7.2.1 Class I Histone Deacetylases -- 7.2.2 Class II Histone Deacetylases -- 7.2.3 Class III Histone Deacetylases (Sirtuins) -- 7.2.4 Class IV Histone Deacetylases -- 7.3 Histone Deacetylases in Multiple Myeloma -- 7.3.1 Histone Deacetylases and Protein Clearance -- 7.3.2 Histone Deacetylase Overexpression and Increased Activity in Multiple Myeloma -- 7.4 Histone Deacetylase Inhibitors -- 7.4.1 Types of Histone Deacetylase Inhibitors -- 7.4.2 Mechanisms of Action -- 7.4.2.1 Altered Gene Expression -- 7.4.2.2 Induction of Apoptosis -- 7.4.2.3 Cell Cycle Arrest -- 7.4.2.4 Inhibition of Angiogenesis -- 7.4.2.5 Regulation of Cytokines -- 7.4.2.6 Suppressed DNA Damage Repair -- 7.4.2.7 Ubiquitin Proteasome System -- 7.4.2.8 Aggresome Pathway -- 7.5 Approved Histone Deacetylase Inhibitors -- 7.5.1 Panobinostat -- 7.5.2 Vorinostat -- 7.5.3 Ricolinostat -- 7.6 Immunomodulatory Imide Drugs and Histone Deacetylase Inhibitors -- 7.7 Potential Mechanisms of Resistance to Histone Deacetylase Inhibitors. 7.7.1 Drug Transporters -- 7.7.2 Cell Signaling -- 7.7.3 Antioxidant Pathway -- 7.7.4 Cell Cycle Proteins -- 7.7.5 Nuclear Factor-Kappa B -- 7.7.6 Anti-Apoptotic Proteins -- 7.7.7 Altered Histone Deacetylases -- 7.7.8 Autophagy -- 7.8 Conclusion -- References -- Chapter 8: Bone Targeted Therapies -- 8.1 Myeloma Bone Disease -- 8.1.1 Diagnosis -- 8.1.2 Pathogenesis -- 8.1.3 Osteoclastic Activation -- 8.1.3.1 The RANK/RANKL Pathway -- 8.1.3.2 Interleukins -- 8.1.3.3 Hepatocyte Growth Factor -- 8.1.3.4 Notch Pathway -- 8.1.3.5 Chemokines -- 8.1.3.6 Activin A -- 8.1.3.7 The TNF Superfamily -- 8.1.3.8 BTK and SDF-1α -- 8.1.4 Osteoblastic Suppression -- 8.1.4.1 The WNT Pathway -- 8.1.4.2 Sclerostin -- 8.1.4.3 DKK1 -- 8.1.4.4 Periostin -- 8.1.4.5 RUNX2/CBFA1 and IL-7 -- 8.2 Indications for Bone Targeted Therapies -- 8.3 Utility of Bone Resorption Markers to Guide Therapy -- 8.4 Current Treatments for Myeloma Bone Disease -- 8.4.1 Bisphosphonates -- 8.4.1.1 Mechanism of Action -- 8.4.1.2 Evidence in MBD -- 8.4.1.3 Comparison Between Bisphosphonates -- 8.4.1.4 Adverse Events -- 8.4.1.5 Renal Impairment -- 8.4.1.6 Osteonecrosis of the Jaw -- 8.4.1.7 Subtrochanteric and Other Atypical Femoral Fractures -- 8.4.1.8 Duration, Frequency, and Monitoring of Therapy -- 8.4.1.9 Future of Bisphosphonate Therapy -- 8.4.2 Denosumab -- 8.4.2.1 Mechanism of Action -- 8.4.2.2 Evidence in MBD -- 8.4.2.3 Adverse Events -- 8.4.2.4 Duration and Frequency of Therapy -- 8.4.3 Novel Therapies -- 8.4.3.1 Anti-Sclerostin Antibodies -- 8.4.3.2 Anti-DKK1 Neutralizing Antibodies -- 8.4.3.3 Activin Receptor Ligand Traps -- 8.4.3.4 Bruton's Tyrosine Kinase (BTK) Inhibitors -- 8.4.3.5 B Cell Activating Factor (BAFF) Neutralizing Antibodies -- 8.4.3.6 Transforming Growth Factor-β (TGF-β) Inhibitors -- 8.4.3.7 Parathyroid Hormone -- 8.4.3.8 Proteasome Inhibitors. 8.4.3.9 Immunomodulatory Imide Drugs -- 8.5 Conclusion -- References -- Chapter 9: New Targeted Therapies for Multiple Myeloma Under Clinical Investigation -- 9.1 Introduction -- 9.2 Antibodies -- 9.2.1 Monoclonal Antibodies Directed at Plasma Cells -- 9.2.2 Bispecific Antibodies -- 9.2.3 Checkpoint Inhibitor -- 9.2.4 Cellular Therapies -- 9.2.4.1 Chimeric Antigen Receptor T Cells -- 9.2.4.2 DC Vaccination -- 9.2.5 Small-Molecule Inhibitors -- 9.2.5.1 Targeting Specific Subsets of Patients -- Venetoclax for Patients with Chromosomal Translocation t(11 -- 14) -- Patients with BRAF V600E Mutation -- Potential MEK Inhibition -- 9.2.5.2 Patients with Overexpressed FGFR3 -- 9.2.5.3 Targeting Inherent Weaknesses in MM -- SINE Compounds -- Bromodomain Inhibitors -- Kinesin Spindle Protein Inhibitors -- 9.3 Conclusion and Perspectives -- References -- Index. |
| Record Nr. | UNINA-9910495203303321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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