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Mechanisms of Genome Protection and Repair / / edited by Dmitry O. Zharkov
| Mechanisms of Genome Protection and Repair / / edited by Dmitry O. Zharkov |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (XVI, 220 p. 30 illus., 20 illus. in color.) |
| Disciplina | 575.1 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Human genetics
Cell biology Biochemistry Molecular biology Cancer research Human Genetics Cell Biology Biochemistry, general Molecular Medicine Cancer Research Reparació de l'ADN Genètica humana |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-41283-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface -- Kinetic Milestones of Damage Recognition by DNA Glycosylases of the Helix–Hairpin–Helix Structural Superfamily -- Protein Engineering of DNA-Dependent Enzymes -- A Multifunctional Protein PolDIP2 in DNA Translesion Synthesis -- Impact of PARP1, PARP2 and PARP3 on the Base Excision Repair of Nucleosomal DNA -- Base Excision Repair in Chromatin and the Requirement for Chromatin Remodelling -- DNA Repair and Mutagenesis in Vertebrate Mitochondria: Evidence for Asymmetric DNA Strand Inheritance -- Mystery of Expansion: DNA Metabolism and Unstable Repeats -- The Detection of 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine in Circulating Cell-Free DNA: A Step Towards Longitudinal Monitoring of Health -- Biotransformation and Toxicities of Aristolochic Acids -- Mechanisms of Sugar Beet Response to Biotic and Abiotic Stresses -- Studying ALS: Current Approaches, Effect on Potential Treatment Strategy. |
| Record Nr. | UNINA-9910409695203321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
RNA damage and repair / / Ioly Kotta-Loizou, editor
| RNA damage and repair / / Ioly Kotta-Loizou, editor |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (180 pages) |
| Disciplina | 572.88 |
| Soggetto topico |
RNA
DNA damage ADN Reparació de l'ADN Biomolècules Procariotes |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-76571-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Contents -- Part I: RNA Damage and Repair in Prokaryotes -- Endoribonucleases of the Toxin-Antitoxin Systems Induce Abortive Infection -- 1 Introduction -- 1.1 The Arms Race Between Bacteria and Phages -- 1.2 The Abortive Infection (Abi) System -- 1.3 The Toxin-Antitoxin (TA) System -- 2 Functions, Structures, and Regulation of the MazF Endoribonuclease -- 2.1 The Abortive Infection Induced by the MazF Endoribonuclease -- 2.2 Phage Mechanism to Overcome MazF-Induced Abi -- 3 Functions, Structures, and Regulation of RnlA Endoribonuclease -- 3.1 The Abortive Infection Induced by RnlA Endoribonuclease -- 3.2 Phage Mechanisms to Overcome RnlA-Induced Abi -- 4 Functions, Structures, and Regulations of ToxN Endoribonuclease -- 4.1 The Abortive Infection Induced by ToxN Endoribonuclease -- 4.2 Phage Mechanisms to Overcome ToxN-Induced Abi -- 5 Conclusion -- References -- The Lifecycle of Ribosomal RNA in Bacteria -- 1 Introduction -- 2 Localisation and Copy Number of rDNA Operons in Bacteria -- 3 Organisation of rDNA Operons in Bacteria -- 4 Transcription Regulation of rDNA Genes Along the Microbial Growth Curve -- 4.1 Ribosomal DNA Promoters and Cis-Regulatory Elements -- 4.2 Trans-regulatory Elements -- 4.2.1 Regulation by Transcription Factors -- 4.2.2 Regulation by NTP and (p)ppGpp -- 5 Processing of Premature rRNA into Functional rRNAs -- 5.1 Maturation of 23S rRNA in E. coli -- 5.2 Maturation of 16S rRNA in E. coli -- 5.3 Maturation of 5S rRNA in E. coli -- 6 Bacterial rRNA Fragmentation -- 7 Chemical Modification of rRNA Molecules -- 8 Assembly of rRNAs into Ribosomes -- 9 rRNA Quality Control -- 10 Damage and Repair of Bacterial rRNA -- 11 Conclusion -- References -- The Rtc RNA End Healing and Sealing System -- 1 Introduction -- 2 Biological RNA Damage -- 2.1 CRISPR-Cas Systems -- 3 RNA Repair -- 4 The RtcA and RtcB Enzymes.
4.1 The RtcA RNA Cyclase -- 4.2 The RtcB RNA Ligase -- 4.3 The RtcB RNA Ligase in Prokaryotes -- 4.4 The RtcB RNA Ligase in Metazoans -- 5 The Bacterial Rtc RNA Repair System -- 5.1 Diversity of the rtc Operon in Bacteria -- 5.2 The RtcR Transcriptional Regulator and Its CARF Domain -- 5.3 Expression and Function of the Rtc System in Bacteria -- 6 Conclusions -- References -- Part II: RNA Damage and Repair in Eukaryotes -- Oxidative and Nitrative RNA Modifications in Plants -- 1 Introduction -- 2 Oxidative Modifications of RNA in Plants -- 3 Nitrative Modifications of RNA in Plants -- 4 Conclusions -- References -- The Role of Ribonucleases in RNA Damage, Inactivation and Degradation -- 1 Introduction -- 2 Quality Control Mechanisms to Manage Damaged RNA -- 3 Ribosome Quality Control (RQC) and No-Go-Decay (NGD) -- 4 Xrn1, a 5'-3' Exoribonuclease, and the Exosome, a 3'-5' Exoribonuclease Complex -- 5 Cue2 as a Potential NGD Endonuclease -- 6 The Role of Ribonucleases in Targeting and Inactivating Host and Foreign RNA -- 7 Regulatory RNase 1 (Regnase-1) -- 8 NEDD4-Binding Protein 1 (N4BP1) -- 9 Zinc Finger Antiviral Protein (ZAP) and Co-Factor Nucleases -- 10 ZAP and KHNYN -- 11 ZAP and the Exosome Complex -- 12 The 2',5'-Oligoadenylate Synthetase (OAS)/RNAse L System -- 13 Conclusion -- References -- Cytoplasmic mRNA Recapping: An Unexpected Form of RNA Repair -- 1 The Nature of the Cap and Its Role in mRNA Metabolism -- 2 Decapping and 5' Decay -- 3 Early Evidence for Uncapped and Recapped Transcripts -- 4 The Discovery of Cytoplasmic Capping -- 5 The Proteins of the Cytoplasmic Capping Complex -- 6 Cap Homeostasis as an RNA Repair Mechanism That Modulates Translation, mRNA Decay, and Translational Control -- 7 Is There a Relationship Between Recapped Ends and CAGE Tags? -- 8 Does Cytoplasmic Capping Impact the Proteome?. 9 Conclusion and Future Questions -- References -- Part III: RNA Damage in Human Diseases -- Adenosine-to-Inosine RNA Editing: A Key RNA Processing Step Rewriting Transcriptome in Normal Physiology and Diseases -- 1 Regulatory Mechanisms of A-to-I RNA Editing -- 1.1 Editing Regulation by Altering ADAR Expression and Activity -- 1.2 Editing Regulation by Affecting Subcellular Localization of ADAR -- 1.3 Additional Layers of A-to-I RNA Editing Regulation -- 2 Cross Talk of RNA Editing with Other RNA Processing and Cellular Pathways -- 2.1 Roles of ADARs and RNA Editing in miRNA Targeting and Biogenesis -- 2.2 ADARs and Splicing Regulation -- 2.3 ADAR Directly Promotes Proximal Polyadenylation Site -- 2.4 ADAR and N6-Methyladenosine -- 2.5 ADAR and Apoptosis -- 2.6 ADAR and Innate Immunity -- 2.7 ADAR2 and Circadian Rhythm -- References -- RNA-Mediated Metabolic Defects in Microsatellite Expansion Diseases -- 1 Overview of Microsatellite Expansion Diseases -- 2 RNA Structure and RNA-Mediated Toxicity -- 3 Repeat Associated Non-AUG Translation -- 4 Emerging Pathological Roles of microRNA -- 5 Defects in Nucleocytoplasmic Transport -- 6 Liquid-Liquid Phase Separation (LLPS) and Stress Granules -- 7 Conclusions and Future Perspectives -- References. |
| Record Nr. | UNINA-9910490024403321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Reparació de l'ADN
(2)
- ADN (1)
- Biochemistry (1)
- Biochemistry, general (1)
- Biomolècules (1)