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Alzheimer’s Disease II / / edited by Michael S. Wolfe
| Alzheimer’s Disease II / / edited by Michael S. Wolfe |
| Edizione | [1st ed. 2017.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 |
| Descrizione fisica | 1 online resource (VII, 202 p. 90 illus., 33 illus. in color.) |
| Disciplina | 616.831 |
| Collana | Topics in Medicinal Chemistry |
| Soggetto topico |
Pharmaceutical chemistry
Pharmaceutical technology Proteins Neurosciences Medicinal Chemistry Pharmaceutical Sciences/Technology Receptors |
| ISBN | 3-319-59460-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Targets and Strategies Toward the Development of Alzheimer Therapeutics -- The Design, Development, and Evaluation of BACE1 Inhibitors for the Treatment of Alzheimer’s Disease -- γ-Secretase Modulators as Aβ42-Lowering Pharmacological Agents to Treat Alzheimer’s Disease -- Inhibitors of Tau-Phosphorylating Kinases -- Microtubule-Stabilizing Agents for Alzheimer’s and Other Tauopathies -- PET Imaging Agents for Alzheimer’s Disease. |
| Record Nr. | UNINA-9910254160003321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Arabidopsis BUPS-ANX Receptor Complex Coordinates with RALF Peptides to Regulate Pollen Tube Integrity and Sperm Release / / by Zengxiang Ge
| Arabidopsis BUPS-ANX Receptor Complex Coordinates with RALF Peptides to Regulate Pollen Tube Integrity and Sperm Release / / by Zengxiang Ge |
| Autore | Ge Zengxiang |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (85 pages) |
| Disciplina | 575.65 |
| Collana | Springer Theses, Recognizing Outstanding Ph.D. Research |
| Soggetto topico |
Plant physiology
Cytology Proteins Plant Physiology Cell Biology Protein-Ligand Interactions Receptors Reproducció de les plantes Genètica vegetal |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 981-15-5491-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction of plant reproduction and cell-cell communication -- Methods and materials -- Results -- Conclusions and discussions. |
| Record Nr. | UNINA-9910409689203321 |
Ge Zengxiang
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| Singapore : , : Springer Singapore : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Arrestins - Pharmacology and Therapeutic Potential / / edited by Vsevolod V. Gurevich
| Arrestins - Pharmacology and Therapeutic Potential / / edited by Vsevolod V. Gurevich |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (441 p.) |
| Disciplina | 572.696 |
| Collana | Handbook of Experimental Pharmacology |
| Soggetto topico |
Pharmacology
Biochemistry Proteins Gene therapy Cell physiology Pharmacology/Toxicology Biochemistry, general Protein Structure Gene Therapy Cell Physiology Receptors |
| ISBN | 3-642-41199-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors -- Arrestin-biased GPCR Agonists -- Arrestin-1 Expression Levels, Rod Function and Health -- Protective Functions of Arrestin-1 in Photoreceptors -- Arrestin-4 and Cone Function -- Enhanced Phosphorylation-independent Arrestins and Gene Therapy -- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking -- Arrestins in Ubiquitination and Deubiquitination -- Arrestin Self-association -- Arrestin-dependent Activation of ERK and Src -- Arrestin-dependent Activation of JNK Family Kinases -- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization -- Arrestins in Cell Migration -- Arrestins in Host-pathogen Interactions -- Arrestin Regulation of Small GTPases -- GPCRs and Arrestins in Airways: Implications for Asthma -- Arrestins as Regulatory Signaling Hubs in Cancer Pathways -- Arrestins in Pain and Anesthesia. |
| Record Nr. | UNINA-9910298309403321 |
| Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Calcium Signaling / / edited by Md. Shahidul Islam
| Calcium Signaling / / edited by Md. Shahidul Islam |
| Edizione | [2nd ed. 2020.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (1,103 pages) |
| Disciplina |
612.8
572.516 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Neurosciences
Proteins Cytology Cell physiology Receptors Cell Biology Cell Physiology |
| ISBN | 3-030-12457-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface -- Calcium signaling: from basics to bedside -- Measuring Ca2+ in living cells -- High-throughput fluorescence assays for Ion Channels and GPCRs -- Imaging Native Calcium Currents in Brain Slices -- Molecular diversity of plasma membrane Ca2+ transporting ATPases: their function under normal and pathological conditions -- A role for SERCA pumps in the neurobiology of neuropsychiatric and neurodegenerative disorders -- Cytoplasmic Calcium Buffering: An Integrative Crosstalk -- An update on calcium binding proteins -- Manuel Campos‐Toimil -- New insights in the IP3 receptor and its regulation -- Expression of the inositol 1,4,5-trisphosphate receptor and the ryanodine receptor Ca2+-release channels in the beta-cells and alpha- cells of the human islets of Langerhans -- Evolution of Excitation-Contraction Coupling -- Molecular Insights into Calcium Dependent Regulation of Ryanodine Receptor Calcium Release Channels -- Sarco-endoplasmic reticulum calcium release model based on changes in the luminal calcium content visualized from the luminal side -- Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores -- Calcium Signaling in the Heart -- Molecular basis and regulation of store-operated calcium entry -- Structure and activation mechanisms of CRAC channels -- Canonical Transient Potential Receptor-3 Channels in Normal and Diseased Airway Smooth Muscle Cells -- Pathophysiological significance of store-operated calcium entry in cardiovascular and skeletal muscle disorders and angiogenesis -- Calcium signalling and the regulation of chemosensitivity in cancer cells: role of the Transient Receptor Potential channels -- Targeting Transient Receptor Potential Channels by microRNAs drives tumor development and progression -- Calcium channels and Calcium-regulated channels in human red blood cells -- Regulation of multifunctional calcium/calmodulin stimulated protein kinases by molecular targeting -- Widespread roles of CaMK-II in Developmental Pathways -- Readily releasable stores of calcium in neuronal endolysosomes: Physiological and pathophysiological relevance -- At the crossing of ER stress and MAMs: A key role of Sigma-1 receptor?- ER-mitochondria calcium transfer, organelle contacts and neurodegenerative diseases -- The Role of Mitochondrial Calcium Signaling in the Pathophysiology of Cancer Cells -- Calcium Signaling and Gene Expression -- Simulation Strategies for Calcium Microdomains and Calcium Noise -- A statistical view on calcium oscillations -- Calcium Regulation of Bacterial Virulence -- Ca2+ Signaling in Drosophila Photoreceptor Cells -- Calcium imaging in Drosophila melanogaster -- Calcium imaging in the zebrafish -- Stimulation-secretion coupling in the beta cells: from basic to bedside -- Calcium dynamics and synaptic plasticity -- Calcium signaling during brain aging and its influence on the hippocampal synaptic plasticity -- Calcium Signaling in Endothelial Colony Forming Cells in Health and Disease -- Sensing Extracellular Calcium - An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR) -- Extracellular Ca2+ in bone marrow -- Calcium in Cell-Extracellular Matrix Interactions -- Index. |
| Record Nr. | UNINA-9910367258403321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cell Death : Mechanism and Disease / / edited by Hao Wu
| Cell Death : Mechanism and Disease / / edited by Hao Wu |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (280 p.) |
| Disciplina |
570
571.6 571.936 572696 |
| Soggetto topico |
Cytology
Cell physiology Proteins Apoptosis Medicine Cell Biology Cell Physiology Receptors Biomedicine, general |
| ISBN | 1-4614-9302-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. Historical Perspective – the Seven Ages of Cell Death Research -- 2. The Intrinsic Apoptotic Pathway -- 3. Molecular Basis of Cell Death Programs in Mature T Cell Homeostasis -- 4. Bcl-2 family and their therapeutic potential -- 5. IAP proteins and their therapeutic potential -- 6. Cell Death and Cancer -- 7. The DNA damage response mediates apoptosis and tumor suppression -- 8. Neuronal Death Mechanisms in Development and Disease -- 9. The Complex Interplay Between Metabolism and Apoptosis -- 10. Programmed Necrosis/Necroptosis: An Inflammatory Form of Cell Death -- 11. Structural Perspectives on BCL-2 Family of Proteins -- 12. Structural basis of death receptor signaling. |
| Record Nr. | UNINA-9910298334703321 |
| New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Chemokines : Chemokines and Their Receptors in Drug Discovery / / edited by Nuska Tschammer
| Chemokines : Chemokines and Their Receptors in Drug Discovery / / edited by Nuska Tschammer |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (248 p.) |
| Disciplina | 616.079 |
| Collana | Topics in Medicinal Chemistry |
| Soggetto topico |
Pharmaceutical chemistry
Proteins Pharmaceutical technology Medicinal Chemistry Receptors Pharmaceutical Sciences/Technology |
| ISBN | 3-319-14060-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction -- Insights in the chemokine receptor structures and drug design approaches in chemokine receptors -- Therapeutic targeting of CXCR3 chemokine receptor by small molecules -- Allosteric modulation of chemokine receptors -- Chemokines and their receptors in CNS -- Chemokine receptors in allergy and inflammation. |
| Record Nr. | UNINA-9910298621503321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Discreet Charm of Protein Binding Sites / / by Joseph Yariv
| The Discreet Charm of Protein Binding Sites / / by Joseph Yariv |
| Autore | Yariv Joseph |
| Edizione | [1st ed. 2016.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
| Descrizione fisica | 1 online resource (71 p.) |
| Disciplina | 572.633 |
| Soggetto topico |
Proteins
Biophysics Bioorganic chemistry Crystallography Protein-Ligand Interactions Biological and Medical Physics, Biophysics Bioorganic Chemistry Receptors Crystallography and Scattering Methods Protein Science |
| ISBN | 3-319-24996-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction -- Tubulin -- A variety of saccharide binding-sites -- The secret of protein sophistication -- Curious binding-sites – in membrane transport proteins. |
| Record Nr. | UNINA-9910253864703321 |
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Yariv Joseph
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| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Extracellular Matrix in Tumor Biology / / edited by Rolf A. Brekken, Dwayne Stupack
| Extracellular Matrix in Tumor Biology / / edited by Rolf A. Brekken, Dwayne Stupack |
| Edizione | [1st ed. 2017.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 |
| Descrizione fisica | 1 online resource (115 pages) |
| Disciplina | 611.0182 |
| Collana | Biology of Extracellular Matrix |
| Soggetto topico |
Cancer - Research
Immunology Molecular biology Oncology Proteins Cytology Cancer Research Molecular Medicine Receptors Cell Biology |
| ISBN | 3-319-60907-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. The extracellular matrix of tumors: a focus on fibronectin and fibulin-5 -- 2. Internalization of collagen: an important matrix turnover pathway in cancer -- 3. Lumican, a Small Leucine-Rich Proteoglycan, and Its Biological Function in Tumor Progression -- 4. Versican: Role in Cancer Tumorigenesis -- 5. Engineering advanced models of the glioblastoma microenvironment using biomaterials -- 6. Breaching and opening basement membrane barriers: the anchor cell leads the way. |
| Record Nr. | UNINA-9910253940203321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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G Protein Signaling Mechanisms in the Retina / / edited by Kirill A. Martemyanov, Alapakkam P. Sampath
| G Protein Signaling Mechanisms in the Retina / / edited by Kirill A. Martemyanov, Alapakkam P. Sampath |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (197 p.) |
| Disciplina |
572696
573.8 610 612.8 |
| Collana | Springer Series in Vision Research |
| Soggetto topico |
Neurosciences
Neurobiology Proteins Receptors |
| ISBN | 1-4939-1218-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. Introduction: G-protein Signaling in the Retina -- Part One- Phototransduction in Rods and Cones -- 2. G-protein Deactivation Mechanisms in Vertebrate Phototransduction -- 3. Signaling by Rod and Cone Photoreceptors: Opsin Properties, G-protein Assembly and Mechanisms of Activation -- 4. G-protein–effector Coupling in the Vertebrate Phototransduction Cascade -- Part II- Inner Retinal GPCR Signaling Pathways -- 5. Interdependence among Members of the mGluR6 G-protein Mediated Signalplex of Retinal Depolarizing Bipolar Cells -- 6. Mechanistic Basis for G-protein Function in ON Bipolar Cells -- 7. Modulation of Trpm1 and the mGluR6 cascade in ON Bipolar Cells -- 8. The Role of Dopamine in Fine-tuning Cone- and Rod-driven Vision -- 9. Regulation of Electrical Synaptic Plasticity in the Retina by G-protein Coupled Receptors -- Part III- Signaling by Photosensitive Ganglion Cells -- 10. The Functional Properties of the G-protein-coupled Receptor melanopsin in Intrinsically Photosensitive Retinal Ganglion Cells. |
| Record Nr. | UNINA-9910298340903321 |
| New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Genomics of pattern recognition receptors : applications in oncology and cardiovascular diseases / / Anton G. Kutikhin, Arseniy E. Yuzhalin
| Genomics of pattern recognition receptors : applications in oncology and cardiovascular diseases / / Anton G. Kutikhin, Arseniy E. Yuzhalin |
| Autore | Kutikhin Anton G |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | New York, : Springer, 2013 |
| Descrizione fisica | 1 online resource (190 p.) |
| Disciplina |
570
572696 574.87 599935 |
| Altri autori (Persone) | YuzhalinArseniy E |
| Soggetto topico |
Cell receptors
Genetics Receptors Immunology Cancer - Research Human genetics |
| ISBN | 3-0348-0688-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | The Biology of Toll-like Receptors and NOD-like Receptors: Toggles of Inflammation -- Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword -- Structural Genomic Variation in Toll-Like Receptor 4 and Cancer -- Structural Genomic Variation in Other Toll-like Receptors and Cancer -- Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer -- Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer -- Structural Genomic Variation in NOD-Like Receptors and Cancer -- Structural Genomic Variation in Pattern Recognition Receptors and Cardiovascular Diseases -- Hot Spots In the Field: Where Should We Go. |
| Record Nr. | UNINA-9910437623603321 |
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Kutikhin Anton G
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| New York, : Springer, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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