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Alzheimer’s Disease II / / edited by Michael S. Wolfe
Alzheimer’s Disease II / / edited by Michael S. Wolfe
Edizione [1st ed. 2017.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017
Descrizione fisica 1 online resource (VII, 202 p. 90 illus., 33 illus. in color.)
Disciplina 616.831
Collana Topics in Medicinal Chemistry
Soggetto topico Medicinal chemistry
Pharmaceutical technology
Proteins 
Neurosciences
Medicinal Chemistry
Pharmaceutical Sciences/Technology
Receptors
ISBN 3-319-59460-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Targets and Strategies Toward the Development of Alzheimer Therapeutics -- The Design, Development, and Evaluation of BACE1 Inhibitors for the Treatment of Alzheimer’s Disease -- γ-Secretase Modulators as Aβ42-Lowering Pharmacological Agents to Treat Alzheimer’s Disease -- Inhibitors of Tau-Phosphorylating Kinases -- Microtubule-Stabilizing Agents for Alzheimer’s and Other Tauopathies -- PET Imaging Agents for Alzheimer’s Disease.
Record Nr. UNINA-9910254160003321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017
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Lo trovi qui: Univ. Federico II
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Arabidopsis BUPS-ANX Receptor Complex Coordinates with RALF Peptides to Regulate Pollen Tube Integrity and Sperm Release [[electronic resource] /] / by Zengxiang Ge
Arabidopsis BUPS-ANX Receptor Complex Coordinates with RALF Peptides to Regulate Pollen Tube Integrity and Sperm Release [[electronic resource] /] / by Zengxiang Ge
Autore Ge Zengxiang
Edizione [1st ed. 2020.]
Pubbl/distr/stampa Singapore : , : Springer Singapore : , : Imprint : Springer, , 2020
Descrizione fisica 1 online resource (85 pages)
Disciplina 575.65
Collana Springer Theses, Recognizing Outstanding Ph.D. Research
Soggetto topico Plant physiology
Cell biology
Proteins 
Plant Physiology
Cell Biology
Protein-Ligand Interactions
Receptors
Reproducció de les plantes
Genètica vegetal
Soggetto genere / forma Llibres electrònics
ISBN 981-15-5491-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction of plant reproduction and cell-cell communication -- Methods and materials -- Results -- Conclusions and discussions.
Record Nr. UNINA-9910409689203321
Ge Zengxiang  
Singapore : , : Springer Singapore : , : Imprint : Springer, , 2020
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Arrestins - Pharmacology and Therapeutic Potential / / edited by Vsevolod V. Gurevich
Arrestins - Pharmacology and Therapeutic Potential / / edited by Vsevolod V. Gurevich
Edizione [1st ed. 2014.]
Pubbl/distr/stampa Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014
Descrizione fisica 1 online resource (441 p.)
Disciplina 572.696
Collana Handbook of Experimental Pharmacology
Soggetto topico Pharmacology
Biochemistry
Proteins 
Gene therapy
Cell physiology
Pharmacology/Toxicology
Biochemistry, general
Protein Structure
Gene Therapy
Cell Physiology
Receptors
ISBN 3-642-41199-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors -- Arrestin-biased GPCR Agonists -- Arrestin-1 Expression Levels, Rod Function and Health -- Protective Functions of Arrestin-1 in Photoreceptors -- Arrestin-4 and Cone Function -- Enhanced Phosphorylation-independent Arrestins and Gene Therapy -- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking -- Arrestins in Ubiquitination and Deubiquitination -- Arrestin Self-association -- Arrestin-dependent Activation of ERK and Src -- Arrestin-dependent Activation of JNK Family Kinases -- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization -- Arrestins in Cell Migration -- Arrestins in Host-pathogen Interactions -- Arrestin Regulation of Small GTPases -- GPCRs and Arrestins in Airways: Implications for Asthma -- Arrestins as Regulatory Signaling Hubs in Cancer Pathways -- Arrestins in Pain and Anesthesia.
Record Nr. UNINA-9910298309403321
Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014
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Biochemical Basis and Therapeutic Implications of Angiogenesis [[electronic resource] /] / edited by Jawahar Mehta, Naranjan S. Dhalla
Biochemical Basis and Therapeutic Implications of Angiogenesis [[electronic resource] /] / edited by Jawahar Mehta, Naranjan S. Dhalla
Edizione [1st ed. 2013.]
Pubbl/distr/stampa New York, NY : , : Springer New York : , : Imprint : Springer, , 2013
Descrizione fisica 1 online resource (532 p.)
Disciplina 612.13
Collana Advances in Biochemistry in Health and Disease
Soggetto topico Human physiology
Cardiology
Cancer research
Proteins 
Molecular biology
Stem cells
Human Physiology
Cancer Research
Receptors
Molecular Medicine
Stem Cells
ISBN 1-4614-5857-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Part A: Molecular Mechanisms of Angiogenesis -- Endothelial Growth Factor Receptors in Angiogenesis -- Role of Transforming Growth Factor Beta in Angiogenesis -- Role of Cytokines in Angiogenesis: Turning it On and Off -- Neuropeptides in Angiogenesis -- The Role of Integrins in Angiogenesis -- Regulation of Angiogenesis by Hypoxia-inducible Factors -- Role of Mast Cells in Angiogenesis -- Vascular Stem Cells in Regulation of Angiogenesis -- Toll-like Receptor-linked Signal Transduction in Angiogenesis -- The Role of Sex Steroids in Angiogenesis -- Biochemical Mechanisms of Exercise-induced Angiogenesis -- Part B: Pathophysiological Aspects of Angiogenesis -- Angiogenesis in Atherosclerosis: An Overview -- Role of Serotonin in Angiogenesis in Diabetes -- Brain Angiogenesis after Stroke -- Angiogenesis in Myocardial Ischemia -- Adipose Tissue-derived Mesenchymal Stem Cell and Angiogenesis in Ischemic Heart Disease -- Trials of Angiogenesis Therapy in Patients with ischemic Heart Disease -- Angiogenesis in Cancer -- Potential Mechanisms Linking Oxidized LDL to Susceptibility to Cancer -- Role of Genetic Polymorphisms in the Angiogenesis Pathway and Non-small Cell Lung Cancer Tumor Behavior -- Part C: Pharmacology and Therapy of Angiogenesis -- Angiogenesis and Arteriogenesis Factors: Their Role in the Treatment of Cancer and Arterial Regeneration -- Physiological Roles and Therapeutic Implications of Hepatocyte Growth Factor for Angiogenesis -- Harnessing Endothelial Progenitor Cells for Therapeutic Angiogenesis -- Microarray and MiRs in Angiogenesis -- MicroRNA and Cardiovascular Disorders, with a Focus on Angiogenesis -- An Overview of Angiogenesis Inhibitors from Natural Sources -- Index.
Record Nr. UNINA-9910437619703321
New York, NY : , : Springer New York : , : Imprint : Springer, , 2013
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Calcium Signaling / / edited by Md. Shahidul Islam
Calcium Signaling / / edited by Md. Shahidul Islam
Edizione [2nd ed. 2020.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020
Descrizione fisica 1 online resource (1,103 pages)
Disciplina 612.8
572.516
Collana Advances in Experimental Medicine and Biology
Soggetto topico Neurosciences
Proteins 
Cell biology
Cell physiology
Receptors
Cell Biology
Cell Physiology
ISBN 3-030-12457-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Preface -- Calcium signaling: from basics to bedside -- Measuring Ca2+ in living cells -- High-throughput fluorescence assays for Ion Channels and GPCRs -- Imaging Native Calcium Currents in Brain Slices -- Molecular diversity of plasma membrane Ca2+ transporting ATPases: their function under normal and pathological conditions -- A role for SERCA pumps in the neurobiology of neuropsychiatric and neurodegenerative disorders -- Cytoplasmic Calcium Buffering: An Integrative Crosstalk -- An update on calcium binding proteins -- Manuel Campos‐Toimil -- New insights in the IP3 receptor and its regulation -- Expression of the inositol 1,4,5-trisphosphate receptor and the ryanodine receptor Ca2+-release channels in the beta-cells and alpha- cells of the human islets of Langerhans -- Evolution of Excitation-Contraction Coupling -- Molecular Insights into Calcium Dependent Regulation of Ryanodine Receptor Calcium Release Channels -- Sarco-endoplasmic reticulum calcium release model based on changes in the luminal calcium content visualized from the luminal side -- Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores -- Calcium Signaling in the Heart -- Molecular basis and regulation of store-operated calcium entry -- Structure and activation mechanisms of CRAC channels -- Canonical Transient Potential Receptor-3 Channels in Normal and Diseased Airway Smooth Muscle Cells -- Pathophysiological significance of store-operated calcium entry in cardiovascular and skeletal muscle disorders and angiogenesis -- Calcium signalling and the regulation of chemosensitivity in cancer cells: role of the Transient Receptor Potential channels -- Targeting Transient Receptor Potential Channels by microRNAs drives tumor development and progression -- Calcium channels and Calcium-regulated channels in human red blood cells -- Regulation of multifunctional calcium/calmodulin stimulated protein kinases by molecular targeting -- Widespread roles of CaMK-II in Developmental Pathways -- Readily releasable stores of calcium in neuronal endolysosomes: Physiological and pathophysiological relevance -- At the crossing of ER stress and MAMs: A key role of Sigma-1 receptor?- ER-mitochondria calcium transfer, organelle contacts and neurodegenerative diseases -- The Role of Mitochondrial Calcium Signaling in the Pathophysiology of Cancer Cells -- Calcium Signaling and Gene Expression -- Simulation Strategies for Calcium Microdomains and Calcium Noise -- A statistical view on calcium oscillations -- Calcium Regulation of Bacterial Virulence -- Ca2+ Signaling in Drosophila Photoreceptor Cells -- Calcium imaging in Drosophila melanogaster -- Calcium imaging in the zebrafish -- Stimulation-secretion coupling in the beta cells: from basic to bedside -- Calcium dynamics and synaptic plasticity -- Calcium signaling during brain aging and its influence on the hippocampal synaptic plasticity -- Calcium Signaling in Endothelial Colony Forming Cells in Health and Disease -- Sensing Extracellular Calcium - An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR) -- Extracellular Ca2+ in bone marrow -- Calcium in Cell-Extracellular Matrix Interactions -- Index.
Record Nr. UNINA-9910367258403321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Cardiac Adaptations [[electronic resource] ] : Molecular Mechanisms / / edited by Bohuslav Ostadal, Naranjan S. Dhalla
Cardiac Adaptations [[electronic resource] ] : Molecular Mechanisms / / edited by Bohuslav Ostadal, Naranjan S. Dhalla
Edizione [1st ed. 2013.]
Pubbl/distr/stampa New York, NY : , : Springer New York : , : Imprint : Springer, , 2013
Descrizione fisica 1 online resource (466 p.)
Disciplina 616.1/05
Collana Advances in Biochemistry in Health and Disease
Soggetto topico Medical biochemistry
Molecular biology
Cardiology
Biochemistry
Proteins 
Human physiology
Medical Biochemistry
Molecular Medicine
Biochemistry, general
Receptors
Human Physiology
ISBN 1-283-69721-1
1-4614-5203-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Comparative Aspects of Cardiac Adaptation -- Molecular Mechanisms in Cardiac Development -- Prenatal Adaptation to Overload -- Hypoxia and Mechanical Factors Drive Coronary Vascular Development -- Cardiac Metabolic Adaptation During Postnatal Development -- Ontogenetic Adaptation to Chronic Hypoxia -- Heart and Arterial Aging -- Differences in Concentric Cardiac Hypertrophy and Eccentric Hypertrophy -- Cardiac Adaptation to Volume Overload -- Functional Adaptation during the Development of Cardiac Hypertrophy and Heart Failure in Females -- Impact of Gender and Exercise on Cardiac Adaptation to Pathological Situations -- Cardiopulmonary Adaptation to High Altitude -- Cardiac Hypertrophy in Hypertension -- Exercise Training and Adverse Cardiac Remodeling and Dysfunction in Mice -- The Athlete’s Heart -- Role of β - Adrenoceptor/Adenylyl Cyclase System in Cardiac Hypertrophy -- Role of Phospholipase C in the α1 - Adrenoceptor Mediated Cardiac Hypertrophy -- Maladaptive Cardiac Remodeling: Signal-dependent Regulation of the Fibrotic Gene Program by CLP-1 in the Hypertrophic Heart -- Role of Sirtuins in Regulation of Cardiac Adaptation Associated with Hypertrophy -- Adaptation of Cardiac and Skeletal Muscle Mitochondria to Endurance Training: Implications for Cardiac Protection -- Adenosine as an Endogenous Adaptive Cardiac Antihypertrophic and Antiremodelling Factor -- Myocardial Adaptation and Autophagy -- Modulatory Role of VEGF in Angiogenesis for Cell Survival -- The Role of CaM Kinase II in Cardiac Function in Health and Disease.
Record Nr. UNINA-9910437825903321
New York, NY : , : Springer New York : , : Imprint : Springer, , 2013
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Cell Death [[electronic resource] ] : Mechanism and Disease / / edited by Hao Wu
Cell Death [[electronic resource] ] : Mechanism and Disease / / edited by Hao Wu
Edizione [1st ed. 2014.]
Pubbl/distr/stampa New York, NY : , : Springer New York : , : Imprint : Springer, , 2014
Descrizione fisica 1 online resource (280 p.)
Disciplina 570
571.6
571.936
572696
Soggetto topico Cell biology
Cell physiology
Proteins 
Apoptosis
Medicine
Cell Biology
Cell Physiology
Receptors
Biomedicine, general
ISBN 1-4614-9302-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto 1. Historical Perspective – the Seven Ages of Cell Death Research -- 2. The Intrinsic Apoptotic Pathway -- 3. Molecular Basis of Cell Death Programs in Mature T Cell Homeostasis -- 4. Bcl-2 family and their therapeutic potential -- 5. IAP proteins and their therapeutic potential -- 6. Cell Death and Cancer -- 7. The DNA damage response mediates apoptosis and tumor suppression -- 8. Neuronal Death Mechanisms in Development and Disease -- 9. The Complex Interplay Between Metabolism and Apoptosis -- 10. Programmed Necrosis/Necroptosis: An Inflammatory Form of Cell Death -- 11. Structural Perspectives on BCL-2 Family of Proteins -- 12. Structural basis of death receptor signaling.
Record Nr. UNINA-9910298334703321
New York, NY : , : Springer New York : , : Imprint : Springer, , 2014
Materiale a stampa
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Chemokines : Chemokines and Their Receptors in Drug Discovery / / edited by Nuska Tschammer
Chemokines : Chemokines and Their Receptors in Drug Discovery / / edited by Nuska Tschammer
Edizione [1st ed. 2015.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015
Descrizione fisica 1 online resource (248 p.)
Disciplina 616.079
Collana Topics in Medicinal Chemistry
Soggetto topico Medicinal chemistry
Proteins 
Pharmaceutical technology
Medicinal Chemistry
Receptors
Pharmaceutical Sciences/Technology
ISBN 3-319-14060-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction -- Insights in the chemokine receptor structures and drug design approaches in chemokine receptors -- Therapeutic targeting of CXCR3 chemokine receptor by small molecules -- Allosteric modulation of chemokine receptors -- Chemokines and their receptors in CNS -- Chemokine receptors in allergy and inflammation.
Record Nr. UNINA-9910298621503321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
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The Discreet Charm of Protein Binding Sites / / by Joseph Yariv
The Discreet Charm of Protein Binding Sites / / by Joseph Yariv
Autore Yariv Joseph
Edizione [1st ed. 2016.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016
Descrizione fisica 1 online resource (71 p.)
Disciplina 572.633
Soggetto topico Proteins 
Biophysics
Biological physics
Bioorganic chemistry
Crystallography
Protein-Ligand Interactions
Biological and Medical Physics, Biophysics
Bioorganic Chemistry
Receptors
Crystallography and Scattering Methods
Protein Science
ISBN 3-319-24996-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction -- Tubulin -- A variety of saccharide binding-sites -- The secret of protein sophistication -- Curious binding-sites – in membrane transport proteins.
Record Nr. UNINA-9910253864703321
Yariv Joseph  
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016
Materiale a stampa
Lo trovi qui: Univ. Federico II
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endoCANNABINOIDS [[electronic resource] ] : Actions at Non-CB1/CB2 Cannabinoid Receptors / / edited by Mary E. Abood, Roger G Sorensen, Nephi Stella
endoCANNABINOIDS [[electronic resource] ] : Actions at Non-CB1/CB2 Cannabinoid Receptors / / edited by Mary E. Abood, Roger G Sorensen, Nephi Stella
Edizione [1st ed. 2013.]
Pubbl/distr/stampa New York, NY : , : Springer New York : , : Imprint : Springer, , 2013
Descrizione fisica 1 online resource (285 p.)
Disciplina 615.7827
Collana The Receptors
Soggetto topico Neurosciences
Human physiology
Proteins 
Animal physiology
Pharmacology
Human Physiology
Receptors
Animal Physiology
Pharmacology/Toxicology
ISBN 1-283-69718-1
1-4614-4669-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Overview of Non-Cannabinoid Receptors.Overview of Non-Classical Cannabinoid Receptors.Overview of Non-Cannabinoid Receptors: Chemistry and Modeling -- G-Protein Coupled Receptors.GPR55 in the CNS.The Role of GPR55 in Bone Biology.The Role of GPR55 in Cancer.GPR18 and NAGly signaling: New members of the endocannabinoid family or distant cousins?.Cannabinoid Signaling Through Non CB1/Non CB2 GPCR Targets in Microglia -- Ion Channels.Temperature-Sensitive Transient Receptor Potential Channels as Ionotropic Cannabinoid Receptors.Nonpsychoactive Cannabinoid Action on 5-HT3 and Glycine Receptors -- Transcription Factors.Peroxisome proliferator-activated receptors and inflammation.Peroxisome proliferator-activated nuclear receptors (PPAR) and drug addiction -- Conclusions/Therapeutic Potential.Conclusions: Therapeutic Potential of Novel Cannabinoid Receptors.
Record Nr. UNINA-9910437855503321
New York, NY : , : Springer New York : , : Imprint : Springer, , 2013
Materiale a stampa
Lo trovi qui: Univ. Federico II
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