Alzheimer’s Disease II / / edited by Michael S. Wolfe |
Edizione | [1st ed. 2017.] |
Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 |
Descrizione fisica | 1 online resource (VII, 202 p. 90 illus., 33 illus. in color.) |
Disciplina | 616.831 |
Collana | Topics in Medicinal Chemistry |
Soggetto topico |
Medicinal chemistry
Pharmaceutical technology Proteins Neurosciences Medicinal Chemistry Pharmaceutical Sciences/Technology Receptors |
ISBN | 3-319-59460-5 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Targets and Strategies Toward the Development of Alzheimer Therapeutics -- The Design, Development, and Evaluation of BACE1 Inhibitors for the Treatment of Alzheimer’s Disease -- γ-Secretase Modulators as Aβ42-Lowering Pharmacological Agents to Treat Alzheimer’s Disease -- Inhibitors of Tau-Phosphorylating Kinases -- Microtubule-Stabilizing Agents for Alzheimer’s and Other Tauopathies -- PET Imaging Agents for Alzheimer’s Disease. |
Record Nr. | UNINA-9910254160003321 |
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 | ||
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Lo trovi qui: Univ. Federico II | ||
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Arabidopsis BUPS-ANX Receptor Complex Coordinates with RALF Peptides to Regulate Pollen Tube Integrity and Sperm Release [[electronic resource] /] / by Zengxiang Ge |
Autore | Ge Zengxiang |
Edizione | [1st ed. 2020.] |
Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2020 |
Descrizione fisica | 1 online resource (85 pages) |
Disciplina | 575.65 |
Collana | Springer Theses, Recognizing Outstanding Ph.D. Research |
Soggetto topico |
Plant physiology
Cell biology Proteins Plant Physiology Cell Biology Protein-Ligand Interactions Receptors Reproducció de les plantes Genètica vegetal |
Soggetto genere / forma | Llibres electrònics |
ISBN | 981-15-5491-9 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Introduction of plant reproduction and cell-cell communication -- Methods and materials -- Results -- Conclusions and discussions. |
Record Nr. | UNINA-9910409689203321 |
Ge Zengxiang
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Singapore : , : Springer Singapore : , : Imprint : Springer, , 2020 | ||
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Lo trovi qui: Univ. Federico II | ||
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Arrestins - Pharmacology and Therapeutic Potential / / edited by Vsevolod V. Gurevich |
Edizione | [1st ed. 2014.] |
Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014 |
Descrizione fisica | 1 online resource (441 p.) |
Disciplina | 572.696 |
Collana | Handbook of Experimental Pharmacology |
Soggetto topico |
Pharmacology
Biochemistry Proteins Gene therapy Cell physiology Pharmacology/Toxicology Biochemistry, general Protein Structure Gene Therapy Cell Physiology Receptors |
ISBN | 3-642-41199-1 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors -- Arrestin-biased GPCR Agonists -- Arrestin-1 Expression Levels, Rod Function and Health -- Protective Functions of Arrestin-1 in Photoreceptors -- Arrestin-4 and Cone Function -- Enhanced Phosphorylation-independent Arrestins and Gene Therapy -- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking -- Arrestins in Ubiquitination and Deubiquitination -- Arrestin Self-association -- Arrestin-dependent Activation of ERK and Src -- Arrestin-dependent Activation of JNK Family Kinases -- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization -- Arrestins in Cell Migration -- Arrestins in Host-pathogen Interactions -- Arrestin Regulation of Small GTPases -- GPCRs and Arrestins in Airways: Implications for Asthma -- Arrestins as Regulatory Signaling Hubs in Cancer Pathways -- Arrestins in Pain and Anesthesia. |
Record Nr. | UNINA-9910298309403321 |
Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014 | ||
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Lo trovi qui: Univ. Federico II | ||
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Biochemical Basis and Therapeutic Implications of Angiogenesis [[electronic resource] /] / edited by Jawahar Mehta, Naranjan S. Dhalla |
Edizione | [1st ed. 2013.] |
Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 |
Descrizione fisica | 1 online resource (532 p.) |
Disciplina | 612.13 |
Collana | Advances in Biochemistry in Health and Disease |
Soggetto topico |
Human physiology
Cardiology Cancer research Proteins Molecular biology Stem cells Human Physiology Cancer Research Receptors Molecular Medicine Stem Cells |
ISBN | 1-4614-5857-9 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Part A: Molecular Mechanisms of Angiogenesis -- Endothelial Growth Factor Receptors in Angiogenesis -- Role of Transforming Growth Factor Beta in Angiogenesis -- Role of Cytokines in Angiogenesis: Turning it On and Off -- Neuropeptides in Angiogenesis -- The Role of Integrins in Angiogenesis -- Regulation of Angiogenesis by Hypoxia-inducible Factors -- Role of Mast Cells in Angiogenesis -- Vascular Stem Cells in Regulation of Angiogenesis -- Toll-like Receptor-linked Signal Transduction in Angiogenesis -- The Role of Sex Steroids in Angiogenesis -- Biochemical Mechanisms of Exercise-induced Angiogenesis -- Part B: Pathophysiological Aspects of Angiogenesis -- Angiogenesis in Atherosclerosis: An Overview -- Role of Serotonin in Angiogenesis in Diabetes -- Brain Angiogenesis after Stroke -- Angiogenesis in Myocardial Ischemia -- Adipose Tissue-derived Mesenchymal Stem Cell and Angiogenesis in Ischemic Heart Disease -- Trials of Angiogenesis Therapy in Patients with ischemic Heart Disease -- Angiogenesis in Cancer -- Potential Mechanisms Linking Oxidized LDL to Susceptibility to Cancer -- Role of Genetic Polymorphisms in the Angiogenesis Pathway and Non-small Cell Lung Cancer Tumor Behavior -- Part C: Pharmacology and Therapy of Angiogenesis -- Angiogenesis and Arteriogenesis Factors: Their Role in the Treatment of Cancer and Arterial Regeneration -- Physiological Roles and Therapeutic Implications of Hepatocyte Growth Factor for Angiogenesis -- Harnessing Endothelial Progenitor Cells for Therapeutic Angiogenesis -- Microarray and MiRs in Angiogenesis -- MicroRNA and Cardiovascular Disorders, with a Focus on Angiogenesis -- An Overview of Angiogenesis Inhibitors from Natural Sources -- Index. |
Record Nr. | UNINA-9910437619703321 |
New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 | ||
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Lo trovi qui: Univ. Federico II | ||
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Calcium Signaling / / edited by Md. Shahidul Islam |
Edizione | [2nd ed. 2020.] |
Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
Descrizione fisica | 1 online resource (1,103 pages) |
Disciplina |
612.8
572.516 |
Collana | Advances in Experimental Medicine and Biology |
Soggetto topico |
Neurosciences
Proteins Cell biology Cell physiology Receptors Cell Biology Cell Physiology |
ISBN | 3-030-12457-6 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Preface -- Calcium signaling: from basics to bedside -- Measuring Ca2+ in living cells -- High-throughput fluorescence assays for Ion Channels and GPCRs -- Imaging Native Calcium Currents in Brain Slices -- Molecular diversity of plasma membrane Ca2+ transporting ATPases: their function under normal and pathological conditions -- A role for SERCA pumps in the neurobiology of neuropsychiatric and neurodegenerative disorders -- Cytoplasmic Calcium Buffering: An Integrative Crosstalk -- An update on calcium binding proteins -- Manuel Campos‐Toimil -- New insights in the IP3 receptor and its regulation -- Expression of the inositol 1,4,5-trisphosphate receptor and the ryanodine receptor Ca2+-release channels in the beta-cells and alpha- cells of the human islets of Langerhans -- Evolution of Excitation-Contraction Coupling -- Molecular Insights into Calcium Dependent Regulation of Ryanodine Receptor Calcium Release Channels -- Sarco-endoplasmic reticulum calcium release model based on changes in the luminal calcium content visualized from the luminal side -- Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores -- Calcium Signaling in the Heart -- Molecular basis and regulation of store-operated calcium entry -- Structure and activation mechanisms of CRAC channels -- Canonical Transient Potential Receptor-3 Channels in Normal and Diseased Airway Smooth Muscle Cells -- Pathophysiological significance of store-operated calcium entry in cardiovascular and skeletal muscle disorders and angiogenesis -- Calcium signalling and the regulation of chemosensitivity in cancer cells: role of the Transient Receptor Potential channels -- Targeting Transient Receptor Potential Channels by microRNAs drives tumor development and progression -- Calcium channels and Calcium-regulated channels in human red blood cells -- Regulation of multifunctional calcium/calmodulin stimulated protein kinases by molecular targeting -- Widespread roles of CaMK-II in Developmental Pathways -- Readily releasable stores of calcium in neuronal endolysosomes: Physiological and pathophysiological relevance -- At the crossing of ER stress and MAMs: A key role of Sigma-1 receptor?- ER-mitochondria calcium transfer, organelle contacts and neurodegenerative diseases -- The Role of Mitochondrial Calcium Signaling in the Pathophysiology of Cancer Cells -- Calcium Signaling and Gene Expression -- Simulation Strategies for Calcium Microdomains and Calcium Noise -- A statistical view on calcium oscillations -- Calcium Regulation of Bacterial Virulence -- Ca2+ Signaling in Drosophila Photoreceptor Cells -- Calcium imaging in Drosophila melanogaster -- Calcium imaging in the zebrafish -- Stimulation-secretion coupling in the beta cells: from basic to bedside -- Calcium dynamics and synaptic plasticity -- Calcium signaling during brain aging and its influence on the hippocampal synaptic plasticity -- Calcium Signaling in Endothelial Colony Forming Cells in Health and Disease -- Sensing Extracellular Calcium - An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR) -- Extracellular Ca2+ in bone marrow -- Calcium in Cell-Extracellular Matrix Interactions -- Index. |
Record Nr. | UNINA-9910367258403321 |
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
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Lo trovi qui: Univ. Federico II | ||
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Cardiac Adaptations [[electronic resource] ] : Molecular Mechanisms / / edited by Bohuslav Ostadal, Naranjan S. Dhalla |
Edizione | [1st ed. 2013.] |
Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 |
Descrizione fisica | 1 online resource (466 p.) |
Disciplina | 616.1/05 |
Collana | Advances in Biochemistry in Health and Disease |
Soggetto topico |
Medical biochemistry
Molecular biology Cardiology Biochemistry Proteins Human physiology Medical Biochemistry Molecular Medicine Biochemistry, general Receptors Human Physiology |
ISBN |
1-283-69721-1
1-4614-5203-1 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Comparative Aspects of Cardiac Adaptation -- Molecular Mechanisms in Cardiac Development -- Prenatal Adaptation to Overload -- Hypoxia and Mechanical Factors Drive Coronary Vascular Development -- Cardiac Metabolic Adaptation During Postnatal Development -- Ontogenetic Adaptation to Chronic Hypoxia -- Heart and Arterial Aging -- Differences in Concentric Cardiac Hypertrophy and Eccentric Hypertrophy -- Cardiac Adaptation to Volume Overload -- Functional Adaptation during the Development of Cardiac Hypertrophy and Heart Failure in Females -- Impact of Gender and Exercise on Cardiac Adaptation to Pathological Situations -- Cardiopulmonary Adaptation to High Altitude -- Cardiac Hypertrophy in Hypertension -- Exercise Training and Adverse Cardiac Remodeling and Dysfunction in Mice -- The Athlete’s Heart -- Role of β - Adrenoceptor/Adenylyl Cyclase System in Cardiac Hypertrophy -- Role of Phospholipase C in the α1 - Adrenoceptor Mediated Cardiac Hypertrophy -- Maladaptive Cardiac Remodeling: Signal-dependent Regulation of the Fibrotic Gene Program by CLP-1 in the Hypertrophic Heart -- Role of Sirtuins in Regulation of Cardiac Adaptation Associated with Hypertrophy -- Adaptation of Cardiac and Skeletal Muscle Mitochondria to Endurance Training: Implications for Cardiac Protection -- Adenosine as an Endogenous Adaptive Cardiac Antihypertrophic and Antiremodelling Factor -- Myocardial Adaptation and Autophagy -- Modulatory Role of VEGF in Angiogenesis for Cell Survival -- The Role of CaM Kinase II in Cardiac Function in Health and Disease. |
Record Nr. | UNINA-9910437825903321 |
New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 | ||
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Lo trovi qui: Univ. Federico II | ||
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Cell Death [[electronic resource] ] : Mechanism and Disease / / edited by Hao Wu |
Edizione | [1st ed. 2014.] |
Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 |
Descrizione fisica | 1 online resource (280 p.) |
Disciplina |
570
571.6 571.936 572696 |
Soggetto topico |
Cell biology
Cell physiology Proteins Apoptosis Medicine Cell Biology Cell Physiology Receptors Biomedicine, general |
ISBN | 1-4614-9302-1 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | 1. Historical Perspective – the Seven Ages of Cell Death Research -- 2. The Intrinsic Apoptotic Pathway -- 3. Molecular Basis of Cell Death Programs in Mature T Cell Homeostasis -- 4. Bcl-2 family and their therapeutic potential -- 5. IAP proteins and their therapeutic potential -- 6. Cell Death and Cancer -- 7. The DNA damage response mediates apoptosis and tumor suppression -- 8. Neuronal Death Mechanisms in Development and Disease -- 9. The Complex Interplay Between Metabolism and Apoptosis -- 10. Programmed Necrosis/Necroptosis: An Inflammatory Form of Cell Death -- 11. Structural Perspectives on BCL-2 Family of Proteins -- 12. Structural basis of death receptor signaling. |
Record Nr. | UNINA-9910298334703321 |
New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 | ||
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Lo trovi qui: Univ. Federico II | ||
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Chemokines : Chemokines and Their Receptors in Drug Discovery / / edited by Nuska Tschammer |
Edizione | [1st ed. 2015.] |
Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 |
Descrizione fisica | 1 online resource (248 p.) |
Disciplina | 616.079 |
Collana | Topics in Medicinal Chemistry |
Soggetto topico |
Medicinal chemistry
Proteins Pharmaceutical technology Medicinal Chemistry Receptors Pharmaceutical Sciences/Technology |
ISBN | 3-319-14060-4 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Introduction -- Insights in the chemokine receptor structures and drug design approaches in chemokine receptors -- Therapeutic targeting of CXCR3 chemokine receptor by small molecules -- Allosteric modulation of chemokine receptors -- Chemokines and their receptors in CNS -- Chemokine receptors in allergy and inflammation. |
Record Nr. | UNINA-9910298621503321 |
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 | ||
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Lo trovi qui: Univ. Federico II | ||
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The Discreet Charm of Protein Binding Sites / / by Joseph Yariv |
Autore | Yariv Joseph |
Edizione | [1st ed. 2016.] |
Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
Descrizione fisica | 1 online resource (71 p.) |
Disciplina | 572.633 |
Soggetto topico |
Proteins
Biophysics Biological physics Bioorganic chemistry Crystallography Protein-Ligand Interactions Biological and Medical Physics, Biophysics Bioorganic Chemistry Receptors Crystallography and Scattering Methods Protein Science |
ISBN | 3-319-24996-7 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Introduction -- Tubulin -- A variety of saccharide binding-sites -- The secret of protein sophistication -- Curious binding-sites – in membrane transport proteins. |
Record Nr. | UNINA-9910253864703321 |
Yariv Joseph
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 | ||
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Lo trovi qui: Univ. Federico II | ||
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endoCANNABINOIDS [[electronic resource] ] : Actions at Non-CB1/CB2 Cannabinoid Receptors / / edited by Mary E. Abood, Roger G Sorensen, Nephi Stella |
Edizione | [1st ed. 2013.] |
Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 |
Descrizione fisica | 1 online resource (285 p.) |
Disciplina | 615.7827 |
Collana | The Receptors |
Soggetto topico |
Neurosciences
Human physiology Proteins Animal physiology Pharmacology Human Physiology Receptors Animal Physiology Pharmacology/Toxicology |
ISBN |
1-283-69718-1
1-4614-4669-4 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Overview of Non-Cannabinoid Receptors.Overview of Non-Classical Cannabinoid Receptors.Overview of Non-Cannabinoid Receptors: Chemistry and Modeling -- G-Protein Coupled Receptors.GPR55 in the CNS.The Role of GPR55 in Bone Biology.The Role of GPR55 in Cancer.GPR18 and NAGly signaling: New members of the endocannabinoid family or distant cousins?.Cannabinoid Signaling Through Non CB1/Non CB2 GPCR Targets in Microglia -- Ion Channels.Temperature-Sensitive Transient Receptor Potential Channels as Ionotropic Cannabinoid Receptors.Nonpsychoactive Cannabinoid Action on 5-HT3 and Glycine Receptors -- Transcription Factors.Peroxisome proliferator-activated receptors and inflammation.Peroxisome proliferator-activated nuclear receptors (PPAR) and drug addiction -- Conclusions/Therapeutic Potential.Conclusions: Therapeutic Potential of Novel Cannabinoid Receptors. |
Record Nr. | UNINA-9910437855503321 |
New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 | ||
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Lo trovi qui: Univ. Federico II | ||
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