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Antisense RNA Design, Delivery, and Analysis / / edited by Virginia Arechavala-Gomeza, Alejandro Garanto
| Antisense RNA Design, Delivery, and Analysis / / edited by Virginia Arechavala-Gomeza, Alejandro Garanto |
| Autore | Arechavala-Gomeza Virginia |
| Edizione | [1st ed. 2022.] |
| Pubbl/distr/stampa | New York, : Springer Nature, 2022 |
| Descrizione fisica | 1 online resource (XVII, 422 p. 69 illus., 59 illus. in color.) |
| Disciplina | 615.5 |
| Collana | Methods in Molecular Biology |
| Soggetto topico |
Therapeutics
Biomaterials Nucleic acids Nucleic Acid Àcids nucleics RNA Teràpia genètica |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 1-0716-2010-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction and History of the Chemistry of Nucleic Acids Therapeutics -- Antisense RNA Therapeutics: A Brief Overview -- Design of Bifunctional Antisense Oligonucleotides for Exon Inclusion -- Design and Delivery of SINEUP: A New Modular Tool to Increase Protein Translation -- How to Design U1 snRNA Molecules for Splicing Rescue -- Conjugation of Nucleic Acids and Drugs to Gold Nanoparticles -- Determination of Optimum Ratio of Cationic Polymers and Small Interfering RNA with Agarose Gel Retardation Assay -- Generation of Protein-Phosphorodiamidate Morpholino Oligomer Conjugates for Efficient Cellular Delivery via Anthrax Protective Antigen -- Development and Use of Cellular Systems to Assess and Correct Splicing Defects -- Modeling Splicing Variants Amenable to Antisense Therapy by Use of CRISPR-Cas9-Based Gene Editing in HepG2 Cells -- In Vitro Models for the Evaluation of Antisense Oligonucleotides in Skin -- In Vitro Delivery of PMOs in Myoblasts by Electroporation -- Rapid Determination of MBNL1 Protein Levels by Quantitative Dot Blot for Evaluation of Antisense Oligonucleotides in Myotonic Dystrophy Myoblasts -- Evaluation of Exon Skipping and Dystrophin Restoration in In Vitro Models of Duchenne Muscular Dystrophy -- Generation of Human iPSC-Derived Myotubes to Investigate RNA-Based Therapies In Vitro -- Eye on a Dish Models to Evaluate Splicing Modulation -- Establishment of In Vitro Brain Models for AON Delivery -- Considerations for Generating Humanized Mouse Models to Test Efficacy of Antisense Oligonucleotides -- Generation of Humanized Zebrafish Models for the In Vivo Assessment of Antisense Oligonucleotide-Based Splice Modulation Therapies -- Use of Small Animal Models for Duchenne and Parameters to Assess Efficiency upon Antisense Treatment -- In Vivo Models for the Evaluation of Antisense Oligonucleotides in Skin -- Delivery of Antisense Oligonucleotides to the Mouse Retina -- Delivery of Antisense Oligonucleotides to the Mouse Brain by Intracerebroventricular Injections -- Intrathecal Delivery of Therapeutic Oligonucleotides for Potent Modulation of Gene Expression in the Central Nervous System -- Preclinical Safety Assessment of Therapeutic Oligonucleotides -- Preclinical Evaluation of the Renal Toxicity of Oligonucleotide Therapeutics in Mice -- Protocol for Isolation and Culture of Mouse Hepatocytes (HCs), Kupffer Cells (KCs), and Liver Sinusoidal Endothelial Cells (LSECs) in Analyses of Hepatic Drug Distribution -- Patent Considerations When Embarking on New Antisense Drug Programs. |
| Record Nr. | UNINA-9910552988503321 |
Arechavala-Gomeza Virginia
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| New York, : Springer Nature, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Applications of RNA-Seq and Omics Strategies : From Microorganisms to Human Health / / edited by Fabio A. Marchi, Priscila D.R. Cirillo and Elvis C. Mateo
| Applications of RNA-Seq and Omics Strategies : From Microorganisms to Human Health / / edited by Fabio A. Marchi, Priscila D.R. Cirillo and Elvis C. Mateo |
| Autore | Elvis C. Mateo |
| Pubbl/distr/stampa | IntechOpen, 2017 |
| Descrizione fisica | 1 online resource (vii, 328 pages) : illustrations(some color) |
| Disciplina | 572.88 |
| Soggetto topico |
Genetics
RNA |
| Soggetto non controllato |
Life Sciences
Microbiology Genetics and Molecular Biology Biochemistry Microbial Genetics |
| ISBN |
953-51-4652-1
953-51-3504-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Applications of RNA-Seq and omics strategies |
| Record Nr. | UNINA-9910251415403321 |
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Elvis C. Mateo
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| IntechOpen, 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Applications of RNA-seq in biology and medicine / / edited by Irina Vaslova-St Louis
| Applications of RNA-seq in biology and medicine / / edited by Irina Vaslova-St Louis |
| Pubbl/distr/stampa | London, England : , : IntechOpen, , [2021] |
| Descrizione fisica | 1 online resource (142 pages) : illustrations |
| Disciplina | 572.8633 |
| Soggetto topico |
Nucleotide sequence
RNA |
| ISBN | 1-83962-815-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910586678103321 |
| London, England : , : IntechOpen, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Applied RNAi : from fundamental research to therapeutic applications / / Edited by Patrick Arbuthnot and Marc S. Weinberg
| Applied RNAi : from fundamental research to therapeutic applications / / Edited by Patrick Arbuthnot and Marc S. Weinberg |
| Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2014] |
| Descrizione fisica | 1 online resource (266 p.) |
| Disciplina | 572.865 |
| Soggetto topico |
Gene silencing
RNA |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-908230-67-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; Preface; Current books of interest; 1: Overview of Biogenesis and Applications of MicroRNA; Introduction; Mammalian microRNA biogenesis; Regulation during normal and potentially pathogenic microRNA biogenesis; Harnessing the RNAi pathway for gene silencing; Augmenting and antagonizing microRNA function; MicroRNA targets as gene regulators and sensors; MicroRNAs as prognostic and diagnostic markers; Conclusion; 2: Non-canonical MicroRNA Biogenesis and Function; Canonical microRNA biogenesis and function; Other small RNA biogenesis pathways
Non-canonical microRNA biogenesisOther RNA modifications; Non-canonical microRNA function; Concluding remarks; 3: Non-coding RNAs and the Epigenetic Control of Gene Expression; Long non-coding RNAs epigenetic regulators in human cells; Disruption of long antisense ncRNA networks; The therapeutic potential of targeting antisense ncRNAs; Issues with using small antisense ncRNAs therapeutically; 4: From Mice to Men: Towards the Clinical Translation of MicroRNA Technologies for Somatic Cell Reprogramming; Introduction; General evidence for a role of miRNAs in pluripotency and differentiation Strategies for the identification of pluripotency-associated miRNAsDelivery or expression of miRNAs as novel tools to improve reprogramming; MiRNA-based systems to monitor or control pluripotency and differentiation; Outlook: the road towards clinical translation of human iPSC technologies; 5: Systems Biology Tools to Understand the Role of Host MicroRNAs in Infection: a Closer Look at HIV; Background information; Systems biology tools to investigate differential miRNA expression in HIV infection; A high-content screening approach to evaluate the role of host miRNAs in HIV infection Conclusions and future prospects6: Synthetic MicroRNA Blocking Agents; Introduction; Anti-miR chemistries; Mechanisms of action and delivery of anti-miRs into cells; Validation of anti-miR activity in cells and assays; Therapeutic anti-miRs and in vivo delivery; MicroRNA sponges for suppression of microRNA activity; Target protectors for inhibition of microRNA-induced mRNA degradation; MicroRNA mimics; Prospects; 7: Exploiting MicroRNAs to Regulate Transgene Expression; Introduction; Using microRNAs avoid immune response to transgene product after gene transfer Using microRNA to improve cell specificity and escape side-effect of gene transferNovel type of expression system using microRNAs; Conclusion; 8: Use of Artificial MicroRNAs for Gene Silencing; Introduction; Evolution of artificial miRNA as therapeutic agents; Application of amiRNA; Challenges using amiRNAs as therapeutic agents; amiRNA progress to clinic; Conclusions; 9: Harnessing RNAi for the Treatment of Viral Infections; Introduction; RNAi to treat viral hepatitis; RNAi for respiratory viruses; RNAi for haemorrhagic fever viruses; Other viruses targeted by RNAi RNAi for the treatment of non-viral infections |
| Record Nr. | UNINA-9910464383103321 |
| Norfolk, England : , : Caister Academic Press, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Applied RNAi : from fundamental research to therapeutic applications / / Edited by Patrick Arbuthnot and Marc S. Weinberg
| Applied RNAi : from fundamental research to therapeutic applications / / Edited by Patrick Arbuthnot and Marc S. Weinberg |
| Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2014] |
| Descrizione fisica | 1 online resource (266 p.) |
| Disciplina | 572.865 |
| Soggetto topico |
Gene silencing
RNA |
| ISBN | 1-908230-67-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; Preface; Current books of interest; 1: Overview of Biogenesis and Applications of MicroRNA; Introduction; Mammalian microRNA biogenesis; Regulation during normal and potentially pathogenic microRNA biogenesis; Harnessing the RNAi pathway for gene silencing; Augmenting and antagonizing microRNA function; MicroRNA targets as gene regulators and sensors; MicroRNAs as prognostic and diagnostic markers; Conclusion; 2: Non-canonical MicroRNA Biogenesis and Function; Canonical microRNA biogenesis and function; Other small RNA biogenesis pathways
Non-canonical microRNA biogenesisOther RNA modifications; Non-canonical microRNA function; Concluding remarks; 3: Non-coding RNAs and the Epigenetic Control of Gene Expression; Long non-coding RNAs epigenetic regulators in human cells; Disruption of long antisense ncRNA networks; The therapeutic potential of targeting antisense ncRNAs; Issues with using small antisense ncRNAs therapeutically; 4: From Mice to Men: Towards the Clinical Translation of MicroRNA Technologies for Somatic Cell Reprogramming; Introduction; General evidence for a role of miRNAs in pluripotency and differentiation Strategies for the identification of pluripotency-associated miRNAsDelivery or expression of miRNAs as novel tools to improve reprogramming; MiRNA-based systems to monitor or control pluripotency and differentiation; Outlook: the road towards clinical translation of human iPSC technologies; 5: Systems Biology Tools to Understand the Role of Host MicroRNAs in Infection: a Closer Look at HIV; Background information; Systems biology tools to investigate differential miRNA expression in HIV infection; A high-content screening approach to evaluate the role of host miRNAs in HIV infection Conclusions and future prospects6: Synthetic MicroRNA Blocking Agents; Introduction; Anti-miR chemistries; Mechanisms of action and delivery of anti-miRs into cells; Validation of anti-miR activity in cells and assays; Therapeutic anti-miRs and in vivo delivery; MicroRNA sponges for suppression of microRNA activity; Target protectors for inhibition of microRNA-induced mRNA degradation; MicroRNA mimics; Prospects; 7: Exploiting MicroRNAs to Regulate Transgene Expression; Introduction; Using microRNAs avoid immune response to transgene product after gene transfer Using microRNA to improve cell specificity and escape side-effect of gene transferNovel type of expression system using microRNAs; Conclusion; 8: Use of Artificial MicroRNAs for Gene Silencing; Introduction; Evolution of artificial miRNA as therapeutic agents; Application of amiRNA; Challenges using amiRNAs as therapeutic agents; amiRNA progress to clinic; Conclusions; 9: Harnessing RNAi for the Treatment of Viral Infections; Introduction; RNAi to treat viral hepatitis; RNAi for respiratory viruses; RNAi for haemorrhagic fever viruses; Other viruses targeted by RNAi RNAi for the treatment of non-viral infections |
| Record Nr. | UNINA-9910786928003321 |
| Norfolk, England : , : Caister Academic Press, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Applied RNAi : from fundamental research to therapeutic applications / / Edited by Patrick Arbuthnot and Marc S. Weinberg
| Applied RNAi : from fundamental research to therapeutic applications / / Edited by Patrick Arbuthnot and Marc S. Weinberg |
| Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2014] |
| Descrizione fisica | 1 online resource (266 p.) |
| Disciplina | 572.865 |
| Soggetto topico |
Gene silencing
RNA |
| ISBN | 1-908230-67-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; Preface; Current books of interest; 1: Overview of Biogenesis and Applications of MicroRNA; Introduction; Mammalian microRNA biogenesis; Regulation during normal and potentially pathogenic microRNA biogenesis; Harnessing the RNAi pathway for gene silencing; Augmenting and antagonizing microRNA function; MicroRNA targets as gene regulators and sensors; MicroRNAs as prognostic and diagnostic markers; Conclusion; 2: Non-canonical MicroRNA Biogenesis and Function; Canonical microRNA biogenesis and function; Other small RNA biogenesis pathways
Non-canonical microRNA biogenesisOther RNA modifications; Non-canonical microRNA function; Concluding remarks; 3: Non-coding RNAs and the Epigenetic Control of Gene Expression; Long non-coding RNAs epigenetic regulators in human cells; Disruption of long antisense ncRNA networks; The therapeutic potential of targeting antisense ncRNAs; Issues with using small antisense ncRNAs therapeutically; 4: From Mice to Men: Towards the Clinical Translation of MicroRNA Technologies for Somatic Cell Reprogramming; Introduction; General evidence for a role of miRNAs in pluripotency and differentiation Strategies for the identification of pluripotency-associated miRNAsDelivery or expression of miRNAs as novel tools to improve reprogramming; MiRNA-based systems to monitor or control pluripotency and differentiation; Outlook: the road towards clinical translation of human iPSC technologies; 5: Systems Biology Tools to Understand the Role of Host MicroRNAs in Infection: a Closer Look at HIV; Background information; Systems biology tools to investigate differential miRNA expression in HIV infection; A high-content screening approach to evaluate the role of host miRNAs in HIV infection Conclusions and future prospects6: Synthetic MicroRNA Blocking Agents; Introduction; Anti-miR chemistries; Mechanisms of action and delivery of anti-miRs into cells; Validation of anti-miR activity in cells and assays; Therapeutic anti-miRs and in vivo delivery; MicroRNA sponges for suppression of microRNA activity; Target protectors for inhibition of microRNA-induced mRNA degradation; MicroRNA mimics; Prospects; 7: Exploiting MicroRNAs to Regulate Transgene Expression; Introduction; Using microRNAs avoid immune response to transgene product after gene transfer Using microRNA to improve cell specificity and escape side-effect of gene transferNovel type of expression system using microRNAs; Conclusion; 8: Use of Artificial MicroRNAs for Gene Silencing; Introduction; Evolution of artificial miRNA as therapeutic agents; Application of amiRNA; Challenges using amiRNAs as therapeutic agents; amiRNA progress to clinic; Conclusions; 9: Harnessing RNAi for the Treatment of Viral Infections; Introduction; RNAi to treat viral hepatitis; RNAi for respiratory viruses; RNAi for haemorrhagic fever viruses; Other viruses targeted by RNAi RNAi for the treatment of non-viral infections |
| Record Nr. | UNINA-9910817216603321 |
| Norfolk, England : , : Caister Academic Press, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Artificial DNA, PNA & XNA
| Artificial DNA, PNA & XNA |
| Pubbl/distr/stampa | Austin, Tex., : Landes Bioscience, ©2010- |
| Disciplina | 660 |
| Soggetto topico |
DNA - Synthesis
DNA RNA Genetic engineering DNA - chemical synthesis DNA, Recombinant Genetic Engineering Antisense Elements (Genetics) |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 1949-0968 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
Artificial DNA, PNA and XNA
Artificial DNA PNA & XNA |
| Record Nr. | UNISA-996202516103316 |
| Austin, Tex., : Landes Bioscience, ©2010- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Artificial DNA, PNA & XNA
| Artificial DNA, PNA & XNA |
| Pubbl/distr/stampa | Austin, Tex., : Landes Bioscience, ©2010- |
| Disciplina | 660 |
| Soggetto topico |
DNA - Synthesis
DNA RNA Genetic engineering DNA - chemical synthesis DNA, Recombinant Genetic Engineering Antisense Elements (Genetics) |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 1949-0968 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
Artificial DNA, PNA and XNA
Artificial DNA PNA & XNA |
| Record Nr. | UNINA-9910146439203321 |
| Austin, Tex., : Landes Bioscience, ©2010- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Biology of mRNA: Structure and Function / / edited by Marlene Oeffinger, Daniel Zenklusen
| The Biology of mRNA: Structure and Function / / edited by Marlene Oeffinger, Daniel Zenklusen |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (318 pages) |
| Disciplina | 572.88 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Medicine—Research
Biology—Research Molecular genetics Proteins Neurosciences Post-translational modification Biomedical Research Molecular Genetics Protein Biochemistry Neuroscience Post-translational Modifications RNA |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-31434-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Regulation of co-transcriptional mRNP assembly -- mRNA export through the NPC -- Roles of mRNA modifications in gene regulation -- Studying mRNPs using single molecule approaches -- Difference between mRNPs and lncRNAs? -- RNPs and/or sequence motives in mRNA localization -- mRNP structure -- New RNA binding proteins: mRNP composition -- Aggregation of repeats RNAs in neurodegenerative diseases -- mRNA structural organization and translation -- How to decide to make an mRNA - degradation -- Methods to study mRNP composition -- mRNA-DNA kisses – R-loops -- Forms of mRNA editing and their role in disease. |
| Record Nr. | UNINA-9910373908303321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Biology. Nucleic acids
| Biology. Nucleic acids |
| Pubbl/distr/stampa | Bozeman, MT : , : Bozeman Science, , 2015 |
| Descrizione fisica | 1 online resource (8 minutes) |
| Collana | Academic Video Online |
| Soggetto topico |
Biology - Study and teaching
Nucleic acids DNA RNA |
| Soggetto genere / forma | Instructional films. |
| Formato | Videoregistrazioni  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Nucleic acids |
| Record Nr. | UNINA-9910887858003321 |
| Bozeman, MT : , : Bozeman Science, , 2015 | ||
| Videoregistrazioni | ||
| Lo trovi qui: Univ. Federico II | ||
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Soggetto topico
-
RNA
(70)
- Gene silencing (7)
- Molecular biology (6)
- DNA (5)
- Non-coding RNA (5)