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The cancer degradome [[electronic resource] ] : proteases and cancer biology / / edited by Dylan Edwards ... [et al.]
| The cancer degradome [[electronic resource] ] : proteases and cancer biology / / edited by Dylan Edwards ... [et al.] |
| Edizione | [1st ed. 2008.] |
| Pubbl/distr/stampa | New York, : Springer, c2008 |
| Descrizione fisica | 1 online resource (946 p.) |
| Disciplina | 616.994 |
| Altri autori (Persone) | EdwardsDylan R |
| Soggetto topico |
Cancer - Molecular aspects
Proteolytic enzymes |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-79189-X
9786611791896 0-387-69057-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | The Degradome and Its Analysis -- Protease Genomics and the Cancer Degradome -- The CLIP-CHIP™: A Focused Oligonucleotide Microarray Platform for Transcriptome Analysis of the Complete Human and Murine Cancer Degradomes -- The Hu/Mu ProtIn Chip: A Custom Dual-Species Oligonucleotide Microarray for Profiling Degradome Gene Expression in Tumors and Their Microenvironment -- Quantitative Real-Time PCR Analysis of Degradome Gene Expression -- Identification of Protease Substrates by Mass Spectrometry Approaches-1 -- Identification of Protease Substrates by Mass Spectrometry Approaches-2 -- Activity-Based Imaging and Biochemical Profiling Tools for Analysis of the Cancer Degradome -- Images of Cleavage: Tumor Proteases in Action -- Insights into Protease Function -- Proteolytic Pathways: Intersecting Cascades in Cancer Development -- Physiological Functions of Plasminogen Activation: Effects of Gene Deficiencies in Humans and Mice -- The Plasminogen Activation System in Tissue Remodeling and Cancer Invasion -- The Urokinase Plasminogen Activator Receptor as a Target for Cancer Therapy -- The Endocytic Collagen Receptor, uPARAP/Endo180, in Cancer Invasion and Tissue Remodeling -- Physiological and Pathological Functions of Type II Transmembrane Serine Proteases: Lessons from Transgenic Mouse Models and Human Disease-Associated Mutations -- Roles of Cysteine Proteases in Tumor Progression: Analysis of Cysteine Cathepsin Knockout Mice in Cancer Models -- In Vitro and In Vivo Models of Angiogenesis to Dissect MMP Functions -- The Surface Transplantation Model to Study the Tumor–Host Interface -- Unravelling the Roles of Proteinases in Cell Migration In Vitro and In Vivo -- New Insights into MMP function in Adipogenesis -- TIMPs: Extracellular Modifiers in Cancer Development -- The Interface Between Proteolysis and Cell Signalling -- Invadopodia: Interface for Invasion -- uPAR and Proteases in Mobilization of Hematopoietic Stem Cells -- The Urokinase Receptor and Integrins Constitute a Cell Migration Signalosome -- Measuring uPAR Dynamics in Live Cells -- Janus-Faced Effects of Broad-Spectrum and Specific MMP Inhibition on Metastasis -- Cytokine Substrates: MMP Regulation of Inflammatory Signaling Molecules -- Matrix Metalloproteinases as Key Regulators of Tumor–Bone Interaction -- The Degradome as Source of Cancer Diagnostic and Markers -- The Plasminogen Activation System as a Source of Prognostic Markers in Cancer -- Cysteine Cathepsins and Cystatins as Cancer Biomarkers -- Novel Degradome Markers in Breast Cancer -- Meta-Analysis of Gene Expression Microarray Data: Degradome Genes in Healthy and Cancer Tissues -- Degradome Gene Polymorphisms -- TIMP-1 as a Prognostic Marker in Colorectal Cancer -- Novel Therapeutic Strategies -- Structure and Inhibition of the Urokinase-Type Plasminogen Activator Receptor -- Engineered Antagonists of uPA and PAI-1 -- MMP Inhibitor Clinical Trials – The Past, Present, and Future -- Tailoring TIMPs for Selective Metalloproteinase Inhibition -- Third-Generation MMP Inhibitors: Recent Advances in the Development of Highly Selective Inhibitors -- Protease-Activated Delivery and Imaging Systems -- Development of Tumour-Selective and Endoprotease-Activated Anticancer Therapeutics -- Targeting Degradome Genes via Engineered Viral Vectors. |
| Record Nr. | UNINA-9910451695603321 |
| New York, : Springer, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The cancer degradome [[electronic resource] ] : proteases and cancer biology / / edited by Dylan Edwards ... [et al.]
| The cancer degradome [[electronic resource] ] : proteases and cancer biology / / edited by Dylan Edwards ... [et al.] |
| Edizione | [1st ed. 2008.] |
| Pubbl/distr/stampa | New York, : Springer, c2008 |
| Descrizione fisica | 1 online resource (946 p.) |
| Disciplina | 616.994 |
| Altri autori (Persone) | EdwardsDylan R |
| Soggetto topico |
Cancer - Molecular aspects
Proteolytic enzymes |
| ISBN |
1-281-79189-X
9786611791896 0-387-69057-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | The Degradome and Its Analysis -- Protease Genomics and the Cancer Degradome -- The CLIP-CHIP™: A Focused Oligonucleotide Microarray Platform for Transcriptome Analysis of the Complete Human and Murine Cancer Degradomes -- The Hu/Mu ProtIn Chip: A Custom Dual-Species Oligonucleotide Microarray for Profiling Degradome Gene Expression in Tumors and Their Microenvironment -- Quantitative Real-Time PCR Analysis of Degradome Gene Expression -- Identification of Protease Substrates by Mass Spectrometry Approaches-1 -- Identification of Protease Substrates by Mass Spectrometry Approaches-2 -- Activity-Based Imaging and Biochemical Profiling Tools for Analysis of the Cancer Degradome -- Images of Cleavage: Tumor Proteases in Action -- Insights into Protease Function -- Proteolytic Pathways: Intersecting Cascades in Cancer Development -- Physiological Functions of Plasminogen Activation: Effects of Gene Deficiencies in Humans and Mice -- The Plasminogen Activation System in Tissue Remodeling and Cancer Invasion -- The Urokinase Plasminogen Activator Receptor as a Target for Cancer Therapy -- The Endocytic Collagen Receptor, uPARAP/Endo180, in Cancer Invasion and Tissue Remodeling -- Physiological and Pathological Functions of Type II Transmembrane Serine Proteases: Lessons from Transgenic Mouse Models and Human Disease-Associated Mutations -- Roles of Cysteine Proteases in Tumor Progression: Analysis of Cysteine Cathepsin Knockout Mice in Cancer Models -- In Vitro and In Vivo Models of Angiogenesis to Dissect MMP Functions -- The Surface Transplantation Model to Study the Tumor–Host Interface -- Unravelling the Roles of Proteinases in Cell Migration In Vitro and In Vivo -- New Insights into MMP function in Adipogenesis -- TIMPs: Extracellular Modifiers in Cancer Development -- The Interface Between Proteolysis and Cell Signalling -- Invadopodia: Interface for Invasion -- uPAR and Proteases in Mobilization of Hematopoietic Stem Cells -- The Urokinase Receptor and Integrins Constitute a Cell Migration Signalosome -- Measuring uPAR Dynamics in Live Cells -- Janus-Faced Effects of Broad-Spectrum and Specific MMP Inhibition on Metastasis -- Cytokine Substrates: MMP Regulation of Inflammatory Signaling Molecules -- Matrix Metalloproteinases as Key Regulators of Tumor–Bone Interaction -- The Degradome as Source of Cancer Diagnostic and Markers -- The Plasminogen Activation System as a Source of Prognostic Markers in Cancer -- Cysteine Cathepsins and Cystatins as Cancer Biomarkers -- Novel Degradome Markers in Breast Cancer -- Meta-Analysis of Gene Expression Microarray Data: Degradome Genes in Healthy and Cancer Tissues -- Degradome Gene Polymorphisms -- TIMP-1 as a Prognostic Marker in Colorectal Cancer -- Novel Therapeutic Strategies -- Structure and Inhibition of the Urokinase-Type Plasminogen Activator Receptor -- Engineered Antagonists of uPA and PAI-1 -- MMP Inhibitor Clinical Trials – The Past, Present, and Future -- Tailoring TIMPs for Selective Metalloproteinase Inhibition -- Third-Generation MMP Inhibitors: Recent Advances in the Development of Highly Selective Inhibitors -- Protease-Activated Delivery and Imaging Systems -- Development of Tumour-Selective and Endoprotease-Activated Anticancer Therapeutics -- Targeting Degradome Genes via Engineered Viral Vectors. |
| Record Nr. | UNINA-9910782094903321 |
| New York, : Springer, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The cancer degradome : proteases and cancer biology / / edited by Dylan Edwards ... [et al.]
| The cancer degradome : proteases and cancer biology / / edited by Dylan Edwards ... [et al.] |
| Edizione | [1st ed. 2008.] |
| Pubbl/distr/stampa | New York, : Springer, c2008 |
| Descrizione fisica | 1 online resource (946 p.) |
| Disciplina | 616.994 |
| Altri autori (Persone) | EdwardsDylan R |
| Soggetto topico |
Cancer - Molecular aspects
Proteolytic enzymes |
| ISBN |
1-281-79189-X
9786611791896 0-387-69057-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | The Degradome and Its Analysis -- Protease Genomics and the Cancer Degradome -- The CLIP-CHIP™: A Focused Oligonucleotide Microarray Platform for Transcriptome Analysis of the Complete Human and Murine Cancer Degradomes -- The Hu/Mu ProtIn Chip: A Custom Dual-Species Oligonucleotide Microarray for Profiling Degradome Gene Expression in Tumors and Their Microenvironment -- Quantitative Real-Time PCR Analysis of Degradome Gene Expression -- Identification of Protease Substrates by Mass Spectrometry Approaches-1 -- Identification of Protease Substrates by Mass Spectrometry Approaches-2 -- Activity-Based Imaging and Biochemical Profiling Tools for Analysis of the Cancer Degradome -- Images of Cleavage: Tumor Proteases in Action -- Insights into Protease Function -- Proteolytic Pathways: Intersecting Cascades in Cancer Development -- Physiological Functions of Plasminogen Activation: Effects of Gene Deficiencies in Humans and Mice -- The Plasminogen Activation System in Tissue Remodeling and Cancer Invasion -- The Urokinase Plasminogen Activator Receptor as a Target for Cancer Therapy -- The Endocytic Collagen Receptor, uPARAP/Endo180, in Cancer Invasion and Tissue Remodeling -- Physiological and Pathological Functions of Type II Transmembrane Serine Proteases: Lessons from Transgenic Mouse Models and Human Disease-Associated Mutations -- Roles of Cysteine Proteases in Tumor Progression: Analysis of Cysteine Cathepsin Knockout Mice in Cancer Models -- In Vitro and In Vivo Models of Angiogenesis to Dissect MMP Functions -- The Surface Transplantation Model to Study the Tumor–Host Interface -- Unravelling the Roles of Proteinases in Cell Migration In Vitro and In Vivo -- New Insights into MMP function in Adipogenesis -- TIMPs: Extracellular Modifiers in Cancer Development -- The Interface Between Proteolysis and Cell Signalling -- Invadopodia: Interface for Invasion -- uPAR and Proteases in Mobilization of Hematopoietic Stem Cells -- The Urokinase Receptor and Integrins Constitute a Cell Migration Signalosome -- Measuring uPAR Dynamics in Live Cells -- Janus-Faced Effects of Broad-Spectrum and Specific MMP Inhibition on Metastasis -- Cytokine Substrates: MMP Regulation of Inflammatory Signaling Molecules -- Matrix Metalloproteinases as Key Regulators of Tumor–Bone Interaction -- The Degradome as Source of Cancer Diagnostic and Markers -- The Plasminogen Activation System as a Source of Prognostic Markers in Cancer -- Cysteine Cathepsins and Cystatins as Cancer Biomarkers -- Novel Degradome Markers in Breast Cancer -- Meta-Analysis of Gene Expression Microarray Data: Degradome Genes in Healthy and Cancer Tissues -- Degradome Gene Polymorphisms -- TIMP-1 as a Prognostic Marker in Colorectal Cancer -- Novel Therapeutic Strategies -- Structure and Inhibition of the Urokinase-Type Plasminogen Activator Receptor -- Engineered Antagonists of uPA and PAI-1 -- MMP Inhibitor Clinical Trials – The Past, Present, and Future -- Tailoring TIMPs for Selective Metalloproteinase Inhibition -- Third-Generation MMP Inhibitors: Recent Advances in the Development of Highly Selective Inhibitors -- Protease-Activated Delivery and Imaging Systems -- Development of Tumour-Selective and Endoprotease-Activated Anticancer Therapeutics -- Targeting Degradome Genes via Engineered Viral Vectors. |
| Record Nr. | UNINA-9910824397203321 |
| New York, : Springer, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Colloquium on Proteolytic Processing and Physiological Regulation [[electronic resource] /] / [edited by Hans Neurath and Charles S. Craik]
| Colloquium on Proteolytic Processing and Physiological Regulation [[electronic resource] /] / [edited by Hans Neurath and Charles S. Craik] |
| Pubbl/distr/stampa | Washington, D.C., : National Academy of Sciences, 1999 |
| Descrizione fisica | 1 online resource (107 p.) |
| Altri autori (Persone) |
NeurathHans <1909-2002.>
CraikCharles S |
| Collana | National Academy of Sciences colloquium series |
| Soggetto topico |
Proteolytic enzymes
Cell physiology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-20990-9
9786610209903 0-309-56942-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910455385203321 |
| Washington, D.C., : National Academy of Sciences, 1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Colloquium on Proteolytic Processing and Physiological Regulation [[electronic resource] /] / [edited by Hans Neurath and Charles S. Craik]
| Colloquium on Proteolytic Processing and Physiological Regulation [[electronic resource] /] / [edited by Hans Neurath and Charles S. Craik] |
| Pubbl/distr/stampa | Washington, D.C., : National Academy of Sciences, 1999 |
| Descrizione fisica | 1 online resource (107 p.) |
| Altri autori (Persone) |
NeurathHans <1909-2002.>
CraikCharles S |
| Collana | National Academy of Sciences colloquium series |
| Soggetto topico |
Proteolytic enzymes
Cell physiology |
| ISBN |
1-280-20990-9
9786610209903 0-309-56942-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910778616503321 |
| Washington, D.C., : National Academy of Sciences, 1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Colloquium on Proteolytic Processing and Physiological Regulation [[electronic resource] /] / [edited by Hans Neurath and Charles S. Craik]
| Colloquium on Proteolytic Processing and Physiological Regulation [[electronic resource] /] / [edited by Hans Neurath and Charles S. Craik] |
| Pubbl/distr/stampa | Washington, D.C., : National Academy of Sciences, 1999 |
| Descrizione fisica | 1 online resource (107 p.) |
| Altri autori (Persone) |
NeurathHans <1909-2002.>
CraikCharles S |
| Collana | National Academy of Sciences colloquium series |
| Soggetto topico |
Proteolytic enzymes
Cell physiology |
| ISBN |
1-280-20990-9
9786610209903 0-309-56942-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910828719303321 |
| Washington, D.C., : National Academy of Sciences, 1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of proteolytic enzymes [[electronic resource] ] . Volume 1 / / edited by, Neil D. Rawlings, Guy Salvesen
| Handbook of proteolytic enzymes [[electronic resource] ] . Volume 1 / / edited by, Neil D. Rawlings, Guy Salvesen |
| Edizione | [3rd ed.] |
| Pubbl/distr/stampa | Oxford, : Academic, 2012 |
| Descrizione fisica | 1 online resource (3987 p.) |
| Disciplina | 572.76 |
| Altri autori (Persone) |
RawlingsNeil D
SalvesenG |
| Soggetto topico |
Proteolytic enzymes
Cellular control mechanisms |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-283-73425-7
0-12-382220-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Handbook of Proteolytic Enzymes; Copyright Page; Contents; Editor Biographies; Contributors; Preface; Introduction; Terminology; Organization of the Handbook; Special forms of information in the Handbook; Links to the MEROPS database; Molecular images; Alignments; Secondary structure; Description of substrate specificity; References; Aspartic Peptidases; 1 Introduction: Aspartic and Glutamic Peptidases and Their Clans; Clan AA; Family A1; Other Families in Clan AA; Clan AF; Clan AC; Clan AD; Clan AE; Other Families; Glutamic Peptidases; Asparagine Peptide Lyases
Clans NA, NC and NEInteins; Autotransporters; References; 2 Catalytic Pathways of Aspartic Peptidases; Introduction; Enzymatic Mechanism of Aspartic Peptidases; Enzymatic Mechanism of Glutamic Peptidases; References; 3 Pepsin A; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Pepsinogen; Preparation; Biological Aspects; Related Peptidases; Further Reading; References; 4 Pepsin B; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects; Further Reading; References; 5 Chymosin; Databanks; Name and History Activity and SpecificityStructural Chemistry; Preparation; Biological Aspects; Distinguishing Features; Related Proteinases; Further Reading; References; 6 Cathepsin E; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects; Tissue Distribution and Subcellular Localization; Regulation of Gene Expression; Processing, Maturation and Intracellular Trafficking Of Cathepsin E; Physiological Roles of Cathepsin E; Distinguishing Features; Further Reading; References; 7 Gastricsin; Databanks; Name and History; Activity and Specificity Structural ChemistryProgastricsin; Preparation; Biological Aspects; References; 8 Cathepsin D; Databanks; Name and History; Activity and Specificity; Assay Methods; Specificity; Inhibition and Activation; Structural Chemistry; Three-dimensional Structure; Preparation; Biological Aspects; Gene and Expression Control; Knock-out Model; Organ Distribution and Cellular Localization; Apoptosis; Involvement in Cancer; Neurodegeneration; Other Biological Functions; Distinguishing Features; Related Peptidases; Acknowledgment; Further Reading; References; 9 Nothepsin; Databanks; Name and History Activity and SpecificityStructural Chemistry; Primary Structure Analysis; Distinguishing Features of This New Class of Aspartic Proteinases; Retrieval and Sequencing of Nothepsin Enzymes; Presence of a Nothepsin Enzyme in Non-Antarctic Fish; Nothepsin in Organisms Other Than Fish; Preparation; Biological Aspects; Expression Pattern of the Nothepsin in Fish and Lizard; Phylogenetic Analysis, Adaptive Evolution and Role of Nothepsin; Further Reading; References; 10 Napsin A; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects Further Reading |
| Record Nr. | UNINA-9910462131003321 |
| Oxford, : Academic, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of proteolytic enzymes [[electronic resource] ] . Volume 1 / / edited by, Neil D. Rawlings, Guy Salvesen
| Handbook of proteolytic enzymes [[electronic resource] ] . Volume 1 / / edited by, Neil D. Rawlings, Guy Salvesen |
| Edizione | [3rd ed.] |
| Pubbl/distr/stampa | Oxford, : Academic, 2012 |
| Descrizione fisica | 1 online resource (3987 p.) |
| Disciplina | 572.76 |
| Altri autori (Persone) |
RawlingsNeil D
SalvesenG |
| Soggetto topico |
Proteolytic enzymes
Cellular control mechanisms |
| ISBN |
1-283-73425-7
0-12-382220-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Handbook of Proteolytic Enzymes; Copyright Page; Contents; Editor Biographies; Contributors; Preface; Introduction; Terminology; Organization of the Handbook; Special forms of information in the Handbook; Links to the MEROPS database; Molecular images; Alignments; Secondary structure; Description of substrate specificity; References; Aspartic Peptidases; 1 Introduction: Aspartic and Glutamic Peptidases and Their Clans; Clan AA; Family A1; Other Families in Clan AA; Clan AF; Clan AC; Clan AD; Clan AE; Other Families; Glutamic Peptidases; Asparagine Peptide Lyases
Clans NA, NC and NEInteins; Autotransporters; References; 2 Catalytic Pathways of Aspartic Peptidases; Introduction; Enzymatic Mechanism of Aspartic Peptidases; Enzymatic Mechanism of Glutamic Peptidases; References; 3 Pepsin A; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Pepsinogen; Preparation; Biological Aspects; Related Peptidases; Further Reading; References; 4 Pepsin B; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects; Further Reading; References; 5 Chymosin; Databanks; Name and History Activity and SpecificityStructural Chemistry; Preparation; Biological Aspects; Distinguishing Features; Related Proteinases; Further Reading; References; 6 Cathepsin E; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects; Tissue Distribution and Subcellular Localization; Regulation of Gene Expression; Processing, Maturation and Intracellular Trafficking Of Cathepsin E; Physiological Roles of Cathepsin E; Distinguishing Features; Further Reading; References; 7 Gastricsin; Databanks; Name and History; Activity and Specificity Structural ChemistryProgastricsin; Preparation; Biological Aspects; References; 8 Cathepsin D; Databanks; Name and History; Activity and Specificity; Assay Methods; Specificity; Inhibition and Activation; Structural Chemistry; Three-dimensional Structure; Preparation; Biological Aspects; Gene and Expression Control; Knock-out Model; Organ Distribution and Cellular Localization; Apoptosis; Involvement in Cancer; Neurodegeneration; Other Biological Functions; Distinguishing Features; Related Peptidases; Acknowledgment; Further Reading; References; 9 Nothepsin; Databanks; Name and History Activity and SpecificityStructural Chemistry; Primary Structure Analysis; Distinguishing Features of This New Class of Aspartic Proteinases; Retrieval and Sequencing of Nothepsin Enzymes; Presence of a Nothepsin Enzyme in Non-Antarctic Fish; Nothepsin in Organisms Other Than Fish; Preparation; Biological Aspects; Expression Pattern of the Nothepsin in Fish and Lizard; Phylogenetic Analysis, Adaptive Evolution and Role of Nothepsin; Further Reading; References; 10 Napsin A; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects Further Reading |
| Record Nr. | UNINA-9910785913503321 |
| Oxford, : Academic, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of proteolytic enzymes . Volume 1 / / edited by, Neil D. Rawlings, Guy Salvesen
| Handbook of proteolytic enzymes . Volume 1 / / edited by, Neil D. Rawlings, Guy Salvesen |
| Edizione | [3rd ed.] |
| Pubbl/distr/stampa | Oxford, : Academic, 2012 |
| Descrizione fisica | 1 online resource (3987 p.) |
| Disciplina | 572.76 |
| Altri autori (Persone) |
RawlingsNeil D
SalvesenG |
| Soggetto topico |
Proteolytic enzymes
Cellular control mechanisms |
| ISBN |
1-283-73425-7
0-12-382220-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Handbook of Proteolytic Enzymes; Copyright Page; Contents; Editor Biographies; Contributors; Preface; Introduction; Terminology; Organization of the Handbook; Special forms of information in the Handbook; Links to the MEROPS database; Molecular images; Alignments; Secondary structure; Description of substrate specificity; References; Aspartic Peptidases; 1 Introduction: Aspartic and Glutamic Peptidases and Their Clans; Clan AA; Family A1; Other Families in Clan AA; Clan AF; Clan AC; Clan AD; Clan AE; Other Families; Glutamic Peptidases; Asparagine Peptide Lyases
Clans NA, NC and NEInteins; Autotransporters; References; 2 Catalytic Pathways of Aspartic Peptidases; Introduction; Enzymatic Mechanism of Aspartic Peptidases; Enzymatic Mechanism of Glutamic Peptidases; References; 3 Pepsin A; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Pepsinogen; Preparation; Biological Aspects; Related Peptidases; Further Reading; References; 4 Pepsin B; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects; Further Reading; References; 5 Chymosin; Databanks; Name and History Activity and SpecificityStructural Chemistry; Preparation; Biological Aspects; Distinguishing Features; Related Proteinases; Further Reading; References; 6 Cathepsin E; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects; Tissue Distribution and Subcellular Localization; Regulation of Gene Expression; Processing, Maturation and Intracellular Trafficking Of Cathepsin E; Physiological Roles of Cathepsin E; Distinguishing Features; Further Reading; References; 7 Gastricsin; Databanks; Name and History; Activity and Specificity Structural ChemistryProgastricsin; Preparation; Biological Aspects; References; 8 Cathepsin D; Databanks; Name and History; Activity and Specificity; Assay Methods; Specificity; Inhibition and Activation; Structural Chemistry; Three-dimensional Structure; Preparation; Biological Aspects; Gene and Expression Control; Knock-out Model; Organ Distribution and Cellular Localization; Apoptosis; Involvement in Cancer; Neurodegeneration; Other Biological Functions; Distinguishing Features; Related Peptidases; Acknowledgment; Further Reading; References; 9 Nothepsin; Databanks; Name and History Activity and SpecificityStructural Chemistry; Primary Structure Analysis; Distinguishing Features of This New Class of Aspartic Proteinases; Retrieval and Sequencing of Nothepsin Enzymes; Presence of a Nothepsin Enzyme in Non-Antarctic Fish; Nothepsin in Organisms Other Than Fish; Preparation; Biological Aspects; Expression Pattern of the Nothepsin in Fish and Lizard; Phylogenetic Analysis, Adaptive Evolution and Role of Nothepsin; Further Reading; References; 10 Napsin A; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects Further Reading |
| Record Nr. | UNINA-9910810488803321 |
| Oxford, : Academic, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Protein degradation in health and disease
| Protein degradation in health and disease |
| Pubbl/distr/stampa | Amsterdam ; ; New York : , : Excerpta Medica, , 1980 |
| Descrizione fisica | 1 online resource (430 pages) : illustrations |
| Disciplina | 616.3/995 |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Proteins - Metabolism
Proteolytic enzymes Physiology, Pathological |
| ISBN |
1-280-78393-1
9786613694324 0-470-72058-1 0-470-71826-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Protein Degradation in Health and Disease; Contents; Discussion; Introduction: the classification of proteinases; Discussion; Lysosomal cysteine proteinases; Discussion; Cathepsin D: the lysosomal aspartic proteinase; Discussion; Human leucocyte elastase and cathepsin G: structural and functional characteristics; Discussion; Human collagenases: comparative and immunolocalization studies; Discussion; Proteinases in connective tissue breakdown; Discussion; Cellular mechanisms of proteinase release from inflammatory cells and the degradation of extracellular proteins; Discussion
Inactivation of cytosol enzymes by a liver membrane protein; Discussion; Lysosomes and protein degradation; Discussion; Insights into mechanisms of intracellular protein turnover from studies on pinocytosis; Discussion; Turnover and degradation of mitochondria and their proteins; Discussion; Protein degradation in cells in culture; Discussion; Regulation of protein breakdown in hepatocyte monolayers; Discussion; A possible role for neutral proteolysis in the degradation of intracellular proteins; Discussion; Studies of the ATP dependence of protein degradation in cells and cell extracts Discussion; Coordination of protein synthesis and degradation; Discussion; General discussion Sites of protein degradation; Application of liver perfusion as an in vitro model in studies of intracellular protein degradation; Protein degradation and the regulation of protein balance in muscle; Discussion; Protein degradation in metabolic and nutritional disorders; Discussion; Proteinase inhibitors in severe inflammatory processes (septic shock and experimental endotoxaemia): biochemical, pathophysiological and therapeutic aspects; Discussion; Neutral proteinases of leucocytes and the inflammatory process; Discussion; Final general discussion; Concluding remarks; Index of contributors; Subject index |
| Record Nr. | UNINA-9910144657103321 |
| Amsterdam ; ; New York : , : Excerpta Medica, , 1980 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
