Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Analytical characterization of biotherapeutics / / edited by Jennie R. Lill, Wendy N. Sandoval
| Analytical characterization of biotherapeutics / / edited by Jennie R. Lill, Wendy N. Sandoval |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2017 |
| Descrizione fisica | 1 online resource |
| Disciplina | 615.7 |
| Soggetto topico |
Proteins - Therapeutic use
Proteins - Analysis |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-119-38440-0
1-119-38442-7 1-119-38443-5 |
| Classificazione | SCI013010 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: Dedication Chapter 1: Introduction to Biotherapeutics Jennie R. Lill Chapter 2: Mass Spectrometric Characterization of Recombinant Proteins Corey E Bakalarski, Wendy N Sandoval & Jennie R Lill Chapter 3: Characterizing the Termini of Recombinant Proteins Nestor Solis, Christopher M. Overall Chapter 4: Assessing activity & conformation of recombinant proteins Diego Ellerman, Till Maurer, Justin M. Scheer Chapter 5: Structural Characterization of Recombinant Proteins & Antibodies Paola Di Lello and Patrick Lupardus Chapter 6: Antibody de novo sequencing Natalie Castellana, Adrian Guthals Chapter 7: Characterization of Antibody Drug Conjugates Yichin Liu Chapter 8: Characterization of Bi-Specific or other Hybrid molecules T. Noelle Lombana and Christoph Spiess Chapter 9: Bio-Repository Anne Baldwin, Kurt Schroeder, Lovejit Singh, Karen Billeci Chapter 10: Characterization of Manufacturing Host-Cell Contaminant Proteins Denise Krawitz, Jason Rouse, Justin Sperry, Wendy Sandoval, Martin Vanderlaan Chapter 11: Analytical Tools for Biologics Molecular Assessment Wilson Phung , Wendy Sandoval, Robert F Kelley & Jennie R Lill Chapter 12: Glycan Characterization: Determining the Structure, Distribution, and Localization of Glycoprotein Glycans John Briggs INDEX. |
| Record Nr. | UNINA-9910271008203321 |
| Hoboken, New Jersey : , : Wiley, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Analytical characterization of biotherapeutics / / edited by Jennie R. Lill, Wendy N. Sandoval
| Analytical characterization of biotherapeutics / / edited by Jennie R. Lill, Wendy N. Sandoval |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2017 |
| Descrizione fisica | 1 online resource |
| Disciplina | 615.7 |
| Soggetto topico |
Proteins - Therapeutic use
Proteins - Analysis |
| ISBN |
1-119-38440-0
1-119-38442-7 1-119-38443-5 |
| Classificazione | SCI013010 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: Dedication Chapter 1: Introduction to Biotherapeutics Jennie R. Lill Chapter 2: Mass Spectrometric Characterization of Recombinant Proteins Corey E Bakalarski, Wendy N Sandoval & Jennie R Lill Chapter 3: Characterizing the Termini of Recombinant Proteins Nestor Solis, Christopher M. Overall Chapter 4: Assessing activity & conformation of recombinant proteins Diego Ellerman, Till Maurer, Justin M. Scheer Chapter 5: Structural Characterization of Recombinant Proteins & Antibodies Paola Di Lello and Patrick Lupardus Chapter 6: Antibody de novo sequencing Natalie Castellana, Adrian Guthals Chapter 7: Characterization of Antibody Drug Conjugates Yichin Liu Chapter 8: Characterization of Bi-Specific or other Hybrid molecules T. Noelle Lombana and Christoph Spiess Chapter 9: Bio-Repository Anne Baldwin, Kurt Schroeder, Lovejit Singh, Karen Billeci Chapter 10: Characterization of Manufacturing Host-Cell Contaminant Proteins Denise Krawitz, Jason Rouse, Justin Sperry, Wendy Sandoval, Martin Vanderlaan Chapter 11: Analytical Tools for Biologics Molecular Assessment Wilson Phung , Wendy Sandoval, Robert F Kelley & Jennie R Lill Chapter 12: Glycan Characterization: Determining the Structure, Distribution, and Localization of Glycoprotein Glycans John Briggs INDEX. |
| Record Nr. | UNINA-9910830599403321 |
| Hoboken, New Jersey : , : Wiley, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biophysics for therapeutic protein development / / Linda O. Narhi, editor
| Biophysics for therapeutic protein development / / Linda O. Narhi, editor |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | New York, : Springer, 2013 |
| Descrizione fisica | 1 online resource (297 p.) |
| Disciplina | 615.58 |
| Altri autori (Persone) | NarhiLinda O |
| Collana | Biophysics for the life sciences |
| Soggetto topico |
Proteins - Biotechnology
Cell culture Proteins - Synthesis Proteins - Therapeutic use Biophysics |
| ISBN |
1-299-40831-1
1-4614-4316-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction -- High Throughput Biophysical Approaches to Therapeutic Protein Development -- Techniques for Higher Order Structure Determination -- Biophysical Techniques for Protein Size Distribution Analysis -- Qualification of biophysical methods for the analysis of protein therapeutics -- Application of Biophysics to the Early Developability Assessment of Therapeutic Candidates and its Application to Enhance Developability Properties -- Application of Biophysics in Formulation, Process and Product Characterization: Selected Case Studies -- Biophysical Analysis in Support of Development of Protein Pharmaceuticals -- Case Studies Applying Biophysical Techniques to Better Characterize Protein Aggregates and Particulates of Varying Size -- Investigation of Non Conformance During Protein Therapeutic Manufacturing -- Higher order structure and protein aggregate characterization of protein therapeutics: perspectives from good manufacturing practices and regulatory guidance -- Index. |
| Record Nr. | UNINA-9910437842603321 |
| New York, : Springer, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Characterization of protein therapeutics using mass spectrometry / / Guodong Chen, editor
| Characterization of protein therapeutics using mass spectrometry / / Guodong Chen, editor |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | New York, : Springer, c2013 |
| Descrizione fisica | 1 online resource (408 p.) |
| Disciplina |
54
543.65 572.6 599935 |
| Altri autori (Persone) | ChenGuodong |
| Soggetto topico |
Mass spectrometry
Proteins - Therapeutic use |
| ISBN | 1-4419-7862-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Characterization of Protein Therapeutics by Mass Spectrometry: Recent Developments and Future Directions -- The Use of Mass Spectrometry to Characterize the Metabolism of Peptide Therapeutics -- Quantitative Analysis of Biologics Using Mass Spectrometry -- Maximizing Structural Information from Whole Protein Tandem Mass Spectrometry -- Disulfide Linkages of an Albumin Fusion Protein -- Detailed Structural Characterization of Monoclonal Antibodies -- Application of Protein Mass Spectrometry in Impurity and Degradant Characterization -- Mass Spectrometry Methods to Analyze Higher Order Structure of Protein Therapeutics by Chemical Footprinting -- Aglycosylations Alters Protein Conformation in Antibodies Engineered with Specific Effector Functions Using HDX-MS -- Characterizing Biotherapeutic Protein 3D Structures by Electrospray Ion-Mobility Mass Spectrometry -- Oxford University, Characterization of Assemblies of Proteins by Mass Spectrometry. . |
| Record Nr. | UNINA-9910437808403321 |
| New York, : Springer, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Marine Proteins and Peptides / / edited by Se-Kwon Kim
| Marine Proteins and Peptides / / edited by Se-Kwon Kim |
| Pubbl/distr/stampa | Basel, Switzerland : , : MDPI - Multidisciplinary Digital Publishing Institute, , [2018] |
| Descrizione fisica | 1 online resource (476 pages) |
| Disciplina | 333.9164 |
| Soggetto topico |
Marine resources
Proteins - Therapeutic use Peptides - Therapeutic use |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | About the Special Issue Editor -- Preface to "Marine Proteins and Peptides" -- Identification of Angiotensin I‐Converting Enzyme Inhibitory Peptides Derived from Enzymatic Hydrolysates of Razor Clam Sinonovacula constricta -- Coral Carbonic Anhydrases: Regulation by Ocean Acidification -- Recombinant Expression of a Modified Shrimp Anti‐Lipopolysaccharide Factor Gene in Pichia pastoris GS115 and Its Characteristic Analysis -- Anticancer Activity of a Hexapeptide from Skate (Raja porosa) Cartilage Protein Hydrolysate in HeLa Cells -- An Overview of the Medical Applications of Marine Skeletal Matrix Proteins -- Marine Microbiological Enzymes: Studies with Multiple Strategies and Prospects -- Purification of Antioxidant Peptides by High Resolution Mass Spectrometry from Simulated Gastrointestinal Digestion Hydrolysates of Alaska Pollock (Theragra chalcogramma) Skin Collagen -- Enzymatic Pre‐Treatment Increases the Protein Bioaccessibility and Extractability in Dulse (Palmaria palmata) -- Natural Proline‐Rich Cyclopolypeptides from Marine Organisms: Chemistry, Synthetic Methodologies and Biological Status -- Preclinical and Clinical Studies on Antioxidative, Antihypertensive and Cardioprotective Effect of Marine Proteins and Peptides-A Review -- Alkynyl‐Containing Peptides of Marine Origin: A Review -- Anti‐Fatigue Effect by Peptide Fraction from Protein Hydrolysate of Croceine Croaker (Pseudosciaena crocea) Swim Bladder through Inhibiting the Oxidative Reactions including DNA Damage -- Antimicrobial and Antitumor Activities of Novel Peptides Derived from the Lipopolysaccharide‐ and β‐1,3‐Glucan Binding Protein of the Pacific Abalone Haliotis discus hannai -- Protective Effects of Hydrolyzed Nucleoproteins from Salmon Milt against Ethanol‐Induced Liver Injury in Rats -- Novel Peptide with Specific Calcium‐Binding Capacity from Schizochytrium sp. Protein Hydrolysates and Calcium Bioavailability in Caco‐2 Cells -- In vitro Anti‐Thrombotic Activity of Extracts from Blacklip Abalone (Haliotis rubra) Processing Waste -- Biochemical and Structural Insights into a Novel Thermostable β‐1,3‐Galactosidase from Marinomonas sp. BSi20414 -- Preparation of Antioxidant Peptides from Salmon Byproducts with Bacterial Extracellular Proteases -- Marine Antifreeze Proteins: Structure, Function, and Application to Cryopreservation as a Potential Cryoprotectant -- Enzyme‐Assisted Discovery of Antioxidant Peptides from Edible Marine Invertebrates: A Review -- Purification and Identification of Antioxidant Peptides from Protein Hydrolysate of Scalloped Hammerhead (Sphyrna lewini) Cartilage -- Bioactive Peptide of Marine Origin for the Prevention and Treatment of Non‐Communicable Diseases -- Marine Peptides as Potential Agents for the Management of Type 2 Diabetes Mellitus-A Prospect -- In Vitro Antioxidant Activities of Enzymatic Hydrolysate from Schizochytrium sp. and Its Hepatoprotective Effects on Acute Alcohol‐Induced Liver Injury In Vivo -- Hydrolysates of Fish Skin Collagen: An Opportunity for Valorizing Fish Industry Byproducts -- Marine Fish Proteins and Peptides for Cosmeceuticals: A Review -- Microbial Diseases of Bivalve Mollusks: Infections, Immunology and Antimicrobial Defense. |
| Record Nr. | UNINA-9910598195203321 |
| Basel, Switzerland : , : MDPI - Multidisciplinary Digital Publishing Institute, , [2018] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Peptide and protein vaccines / / edited by Rossen Donev
| Peptide and protein vaccines / / edited by Rossen Donev |
| Pubbl/distr/stampa | Amsterdam, [Netherlands] : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (192 p.) |
| Disciplina | 572.65 |
| Collana | Advances in Protein Chemistry and Structural Biology |
| Soggetto topico |
Peptides - Therapeutic use
Proteins - Therapeutic use Peptide drugs |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-12-802869-6
0-12-802827-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Peptide and Protein Vaccines; Copyright; Contents; Contributors; Preface; References; Chapter 1: Peptide Immunotherapy in Vaccine Development: From Epitope to Adjuvant; 1. Introduction; 2. Cancer Vaccine; 3. Allergy Vaccine; 4. Alzheimerś Disease Vaccine; 5. Adjuvant and Delivery; 6. Perspectives and Conclusions; References; Chapter 2: The Use of Liposomes to Shape Epitope Structure and Modulate Immunogenic Responses of Peptide Vaccines Against...; 1. Introduction; 2. MPER: ASite of Vulnerability on HIV-1 Env and a Linear Epitope; 3. Structural Organization of MPER
3.1. Hydrophobicity Distribution3.2. MPER Peptide Structure; 4. Lipid Vesicles: Adjuvants and Devices to Shape MPER Structure; 4.1. Liposomes as Adjuvants; 4.2. The Lipid Bilayer as an MPER Scaffold; 5. Immunogenicity Studies of MPER-Derived Peptides in Liposomes; References; Chapter 3: Recombinant Lipoproteins as Novel Vaccines with Intrinsic Adjuvant; 1. Introduction; 2. Establishment of High Expression Recombinant Lipoprotein System; 3. The Lipid Structure of Lipoprotein; 4. Recombinant Lipoprotein with Intrinsic Adjuvant Properties 5. To Engineer Chimeric Lipoproteins with Intrinsic Adjuvant for Novel Vaccine Development6. Recombinant Chimeric Lipoproteins Can Activate BMDCs; 7. A Robustness Up- and Downstream Processes for Lipoprotein Production; 8. Recombinant Lipoprotein-Based Subunit Vaccine Induces High Titers of Neutralizing Antibody and Longer Memory Immune Re...; 9. Recombinant Lipidated Human Papillomavirus E7 Induces Cellular Immune Responses and Protective Immunity Against Cervic...; 10. Conclusion; Acknowledgment; References Chapter 4: Perspective of Peptide Vaccine Composed of Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers1. Introduction; 2. Licensed Adjuvants; 3. CpG-DNA: Adjuvant; 4. Phosphodiester Bond CpG-DNA; 5. Liposomes: Adjuvants; 6. Adjuvants for Peptide Vaccine; 7. Peptide Vaccine Composed of Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers; 7.1. Antibody Production with Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers; 7.2. Prevention of Influenza A Virus Infection; 7.3. Prevention of Respiratory Syncytial Virus Infection 7.4. Cancer Vaccine Composed of Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers8. Perspectives; Acknowledgments; References; Chapter 5: Chemical Platforms for Peptide Vaccine Constructs; 1. Introduction; 2. Multiple Antigenic Peptide System Using a PolyLys Core: ABoon to Synthetic Peptide Vaccines; 3. Synthetic Antigen Carrier Bearing N-(S-acetylmercaptoacetyl)-Glutamyl Residues; 4. Thioester as a Replacement for Natural Peptide Bond (Chemical Ligation): Construction of Proteins; 5. Synthetic Peptide Dendrimer with Thiazolidinyl Pendant 6. Oxime Chemistry for Synthetic Peptide-Based Vaccines |
| Record Nr. | UNINA-9910460999503321 |
| Amsterdam, [Netherlands] : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Peptide and protein vaccines / / edited by Rossen Donev
| Peptide and protein vaccines / / edited by Rossen Donev |
| Pubbl/distr/stampa | Amsterdam, [Netherlands] : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (192 p.) |
| Disciplina | 572.65 |
| Collana | Advances in Protein Chemistry and Structural Biology |
| Soggetto topico |
Peptides - Therapeutic use
Proteins - Therapeutic use Peptide drugs |
| ISBN |
0-12-802869-6
0-12-802827-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Peptide and Protein Vaccines; Copyright; Contents; Contributors; Preface; References; Chapter 1: Peptide Immunotherapy in Vaccine Development: From Epitope to Adjuvant; 1. Introduction; 2. Cancer Vaccine; 3. Allergy Vaccine; 4. Alzheimerś Disease Vaccine; 5. Adjuvant and Delivery; 6. Perspectives and Conclusions; References; Chapter 2: The Use of Liposomes to Shape Epitope Structure and Modulate Immunogenic Responses of Peptide Vaccines Against...; 1. Introduction; 2. MPER: ASite of Vulnerability on HIV-1 Env and a Linear Epitope; 3. Structural Organization of MPER
3.1. Hydrophobicity Distribution3.2. MPER Peptide Structure; 4. Lipid Vesicles: Adjuvants and Devices to Shape MPER Structure; 4.1. Liposomes as Adjuvants; 4.2. The Lipid Bilayer as an MPER Scaffold; 5. Immunogenicity Studies of MPER-Derived Peptides in Liposomes; References; Chapter 3: Recombinant Lipoproteins as Novel Vaccines with Intrinsic Adjuvant; 1. Introduction; 2. Establishment of High Expression Recombinant Lipoprotein System; 3. The Lipid Structure of Lipoprotein; 4. Recombinant Lipoprotein with Intrinsic Adjuvant Properties 5. To Engineer Chimeric Lipoproteins with Intrinsic Adjuvant for Novel Vaccine Development6. Recombinant Chimeric Lipoproteins Can Activate BMDCs; 7. A Robustness Up- and Downstream Processes for Lipoprotein Production; 8. Recombinant Lipoprotein-Based Subunit Vaccine Induces High Titers of Neutralizing Antibody and Longer Memory Immune Re...; 9. Recombinant Lipidated Human Papillomavirus E7 Induces Cellular Immune Responses and Protective Immunity Against Cervic...; 10. Conclusion; Acknowledgment; References Chapter 4: Perspective of Peptide Vaccine Composed of Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers1. Introduction; 2. Licensed Adjuvants; 3. CpG-DNA: Adjuvant; 4. Phosphodiester Bond CpG-DNA; 5. Liposomes: Adjuvants; 6. Adjuvants for Peptide Vaccine; 7. Peptide Vaccine Composed of Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers; 7.1. Antibody Production with Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers; 7.2. Prevention of Influenza A Virus Infection; 7.3. Prevention of Respiratory Syncytial Virus Infection 7.4. Cancer Vaccine Composed of Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers8. Perspectives; Acknowledgments; References; Chapter 5: Chemical Platforms for Peptide Vaccine Constructs; 1. Introduction; 2. Multiple Antigenic Peptide System Using a PolyLys Core: ABoon to Synthetic Peptide Vaccines; 3. Synthetic Antigen Carrier Bearing N-(S-acetylmercaptoacetyl)-Glutamyl Residues; 4. Thioester as a Replacement for Natural Peptide Bond (Chemical Ligation): Construction of Proteins; 5. Synthetic Peptide Dendrimer with Thiazolidinyl Pendant 6. Oxime Chemistry for Synthetic Peptide-Based Vaccines |
| Record Nr. | UNINA-9910797252503321 |
| Amsterdam, [Netherlands] : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Peptide and protein vaccines / / edited by Rossen Donev
| Peptide and protein vaccines / / edited by Rossen Donev |
| Pubbl/distr/stampa | Amsterdam, [Netherlands] : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (192 p.) |
| Disciplina | 572.65 |
| Collana | Advances in Protein Chemistry and Structural Biology |
| Soggetto topico |
Peptides - Therapeutic use
Proteins - Therapeutic use Peptide drugs |
| ISBN |
0-12-802869-6
0-12-802827-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Peptide and Protein Vaccines; Copyright; Contents; Contributors; Preface; References; Chapter 1: Peptide Immunotherapy in Vaccine Development: From Epitope to Adjuvant; 1. Introduction; 2. Cancer Vaccine; 3. Allergy Vaccine; 4. Alzheimerś Disease Vaccine; 5. Adjuvant and Delivery; 6. Perspectives and Conclusions; References; Chapter 2: The Use of Liposomes to Shape Epitope Structure and Modulate Immunogenic Responses of Peptide Vaccines Against...; 1. Introduction; 2. MPER: ASite of Vulnerability on HIV-1 Env and a Linear Epitope; 3. Structural Organization of MPER
3.1. Hydrophobicity Distribution3.2. MPER Peptide Structure; 4. Lipid Vesicles: Adjuvants and Devices to Shape MPER Structure; 4.1. Liposomes as Adjuvants; 4.2. The Lipid Bilayer as an MPER Scaffold; 5. Immunogenicity Studies of MPER-Derived Peptides in Liposomes; References; Chapter 3: Recombinant Lipoproteins as Novel Vaccines with Intrinsic Adjuvant; 1. Introduction; 2. Establishment of High Expression Recombinant Lipoprotein System; 3. The Lipid Structure of Lipoprotein; 4. Recombinant Lipoprotein with Intrinsic Adjuvant Properties 5. To Engineer Chimeric Lipoproteins with Intrinsic Adjuvant for Novel Vaccine Development6. Recombinant Chimeric Lipoproteins Can Activate BMDCs; 7. A Robustness Up- and Downstream Processes for Lipoprotein Production; 8. Recombinant Lipoprotein-Based Subunit Vaccine Induces High Titers of Neutralizing Antibody and Longer Memory Immune Re...; 9. Recombinant Lipidated Human Papillomavirus E7 Induces Cellular Immune Responses and Protective Immunity Against Cervic...; 10. Conclusion; Acknowledgment; References Chapter 4: Perspective of Peptide Vaccine Composed of Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers1. Introduction; 2. Licensed Adjuvants; 3. CpG-DNA: Adjuvant; 4. Phosphodiester Bond CpG-DNA; 5. Liposomes: Adjuvants; 6. Adjuvants for Peptide Vaccine; 7. Peptide Vaccine Composed of Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers; 7.1. Antibody Production with Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers; 7.2. Prevention of Influenza A Virus Infection; 7.3. Prevention of Respiratory Syncytial Virus Infection 7.4. Cancer Vaccine Composed of Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers8. Perspectives; Acknowledgments; References; Chapter 5: Chemical Platforms for Peptide Vaccine Constructs; 1. Introduction; 2. Multiple Antigenic Peptide System Using a PolyLys Core: ABoon to Synthetic Peptide Vaccines; 3. Synthetic Antigen Carrier Bearing N-(S-acetylmercaptoacetyl)-Glutamyl Residues; 4. Thioester as a Replacement for Natural Peptide Bond (Chemical Ligation): Construction of Proteins; 5. Synthetic Peptide Dendrimer with Thiazolidinyl Pendant 6. Oxime Chemistry for Synthetic Peptide-Based Vaccines |
| Record Nr. | UNINA-9910818574903321 |
| Amsterdam, [Netherlands] : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Peptidomimetics in organic and medicinal chemistry / / Andrea Trabocchi and Antonio Guarna
| Peptidomimetics in organic and medicinal chemistry / / Andrea Trabocchi and Antonio Guarna |
| Autore | Guarna Antonio |
| Pubbl/distr/stampa | Chichester, West Sussex, United Kingdom : , : John Wiley & Sons, , 2014 |
| Descrizione fisica | 1 online resource (320 p.) |
| Disciplina | 615.1/9 |
| Soggetto topico |
Peptide drugs
Proteins - Therapeutic use Drugs - Design |
| ISBN |
1-118-68314-5
1-118-68303-X 1-118-68384-6 |
| Classificazione | SCI013050 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; Preface; Abbreviations; Part I The Basics of Peptidomimetics; Chapter 1 The Basics of Peptidomimetics; 1.1 Introduction; 1.2 Definition and Classification; 1.3 Strategic Approaches to Peptidomimetic Design; 1.3.1 Modification of Amino Acids; 1.3.2 Compounds with Global Restrictions; 1.3.3 Molecular Scaffolds Mimicking the Peptidic Backbone; 1.4 Successful Examples of Peptidomimetic Drugs; 1.4.1 ACE Inhibitors; 1.4.2 Thrombin Inhibitors; 1.5 Conclusion; References; Chapter 2 Synthetic Approaches towards Peptidomimetic Design; 2.1 Introduction
2.2 Local Modifications2.2.1 Single Amino Acid Modifications; 2.2.2 Dipeptide Isosteres; 2.2.3 Retro-inverso Peptides; 2.2.4 N-Methylation of Peptides; 2.2.5 Azapeptides; 2.2.6 Peptoids; 2.3 Global Restrictions through Cyclic Peptidomimetics; 2.4 Peptidomimetic Scaffolds; 2.5 Conclusions; References; Part II Synthetic Methods and Molecules; Chapter 3 Peptidomimetic Bioisosteres; 3.1 Introduction; 3.2 Peptide Bond Isosteres; 3.2.1 Thioamides; 3.2.2 Esters; 3.2.3 Alkenes and Fluoroalkenes; 3.2.4 Transition-State Isosteres; 3.3 Side-Chain Isosteres 3.3.1 Guanidine Isosteres in Arginine Peptidomimetics3.3.2 Isosteres of Aspartic Acid and Glutamic Acid; 3.3.3 Tethered α-Amino Acids: Constraining the x-Space; 3.4 Dipeptide Isosteres; 3.4.1 δ-Amino Acids; 3.5 Tripeptide Isosteres; 3.6 Conclusion; References; Chapter 4 Solid-Phase Synthesis and Combinatorial Approaches to Peptidomimetics; 4.1 Introduction; 4.2 Solid-Phase Synthesis of Peptidomimetics; 4.2.1 Scaffolds from α-Amino Acids; 4.2.2 Scaffolds from Amino Aldehyde Intermediates; 4.2.3 Pyrrolidine-Containing Scaffolds; 4.3 Conclusion; References Chapter 5 Click Chemistry: The Triazole Ring as a Privileged Peptidomimetic Scaffold5.1 Introduction; 5.1.1 CuAAC Reaction; 5.1.2 Triazole Ring as a Peptidomimetic Isostere; 5.2 Triazole-Containing Peptidomimetics Elaborated through `Click Chemistry'; 5.2.1 Macrocycles; 5.2.2 Oligomers and Foldamers; 5.3 Relevant Applications in Drug Discovery; 5.3.1 AChE Inhibitors; 5.3.2 HIV Protease Inhibitors; 5.3.3 MMP Inhibitors; 5.3.4 Integrin Ligands; 5.4 Conclusions; Acknowledgements; References; Chapter 6 Peptoids; 6.1 Introduction and Basics of Peptoids; 6.2 Synthetic Methods 6.3 Macrocyclic Peptoids6.4 Conformational Analysis of Folded Peptoids; 6.5 Application of Peptoids as Antimicrobial Peptidomimetics; 6.6 Conclusions; References; Chapter 7 Sugar Amino Acids; 7.1 Introduction; 7.2 α-SAAs; 7.2.1 Furanoid α-SAAs; 7.2.2 Pyranoid α-SAAs; 7.3 β-SAAs; 7.3.1 Furanoid β-SAAs; 7.3.2 Pyranoid β-SAAs; 7.4 r-SAAs1; 7.5 δ-SAAs; 7.5.1 Furanoid δ-SAAs; 7.5.2 Pyranoid δ-SAAs; 7.6 Representative Applications in Medicinal Chemistry; 7.7 Conclusions; References; Chapter 8 Cyclic α-Amino Acids as Proline Mimetics; 8.1 Introduction; 8.2 Cyclic α-Amino Acids 8.2.1 3-Substituted Proline Derivatives |
| Record Nr. | UNINA-9910140270003321 |
Guarna Antonio
|
||
| Chichester, West Sussex, United Kingdom : , : John Wiley & Sons, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Peptidomimetics in organic and medicinal chemistry / / Andrea Trabocchi and Antonio Guarna
| Peptidomimetics in organic and medicinal chemistry / / Andrea Trabocchi and Antonio Guarna |
| Autore | Guarna Antonio |
| Pubbl/distr/stampa | Chichester, West Sussex, United Kingdom : , : John Wiley & Sons, , 2014 |
| Descrizione fisica | 1 online resource (320 p.) |
| Disciplina | 615.1/9 |
| Soggetto topico |
Peptide drugs
Proteins - Therapeutic use Drugs - Design |
| ISBN |
1-118-68314-5
1-118-68303-X 1-118-68384-6 |
| Classificazione | SCI013050 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; Preface; Abbreviations; Part I The Basics of Peptidomimetics; Chapter 1 The Basics of Peptidomimetics; 1.1 Introduction; 1.2 Definition and Classification; 1.3 Strategic Approaches to Peptidomimetic Design; 1.3.1 Modification of Amino Acids; 1.3.2 Compounds with Global Restrictions; 1.3.3 Molecular Scaffolds Mimicking the Peptidic Backbone; 1.4 Successful Examples of Peptidomimetic Drugs; 1.4.1 ACE Inhibitors; 1.4.2 Thrombin Inhibitors; 1.5 Conclusion; References; Chapter 2 Synthetic Approaches towards Peptidomimetic Design; 2.1 Introduction
2.2 Local Modifications2.2.1 Single Amino Acid Modifications; 2.2.2 Dipeptide Isosteres; 2.2.3 Retro-inverso Peptides; 2.2.4 N-Methylation of Peptides; 2.2.5 Azapeptides; 2.2.6 Peptoids; 2.3 Global Restrictions through Cyclic Peptidomimetics; 2.4 Peptidomimetic Scaffolds; 2.5 Conclusions; References; Part II Synthetic Methods and Molecules; Chapter 3 Peptidomimetic Bioisosteres; 3.1 Introduction; 3.2 Peptide Bond Isosteres; 3.2.1 Thioamides; 3.2.2 Esters; 3.2.3 Alkenes and Fluoroalkenes; 3.2.4 Transition-State Isosteres; 3.3 Side-Chain Isosteres 3.3.1 Guanidine Isosteres in Arginine Peptidomimetics3.3.2 Isosteres of Aspartic Acid and Glutamic Acid; 3.3.3 Tethered α-Amino Acids: Constraining the x-Space; 3.4 Dipeptide Isosteres; 3.4.1 δ-Amino Acids; 3.5 Tripeptide Isosteres; 3.6 Conclusion; References; Chapter 4 Solid-Phase Synthesis and Combinatorial Approaches to Peptidomimetics; 4.1 Introduction; 4.2 Solid-Phase Synthesis of Peptidomimetics; 4.2.1 Scaffolds from α-Amino Acids; 4.2.2 Scaffolds from Amino Aldehyde Intermediates; 4.2.3 Pyrrolidine-Containing Scaffolds; 4.3 Conclusion; References Chapter 5 Click Chemistry: The Triazole Ring as a Privileged Peptidomimetic Scaffold5.1 Introduction; 5.1.1 CuAAC Reaction; 5.1.2 Triazole Ring as a Peptidomimetic Isostere; 5.2 Triazole-Containing Peptidomimetics Elaborated through `Click Chemistry'; 5.2.1 Macrocycles; 5.2.2 Oligomers and Foldamers; 5.3 Relevant Applications in Drug Discovery; 5.3.1 AChE Inhibitors; 5.3.2 HIV Protease Inhibitors; 5.3.3 MMP Inhibitors; 5.3.4 Integrin Ligands; 5.4 Conclusions; Acknowledgements; References; Chapter 6 Peptoids; 6.1 Introduction and Basics of Peptoids; 6.2 Synthetic Methods 6.3 Macrocyclic Peptoids6.4 Conformational Analysis of Folded Peptoids; 6.5 Application of Peptoids as Antimicrobial Peptidomimetics; 6.6 Conclusions; References; Chapter 7 Sugar Amino Acids; 7.1 Introduction; 7.2 α-SAAs; 7.2.1 Furanoid α-SAAs; 7.2.2 Pyranoid α-SAAs; 7.3 β-SAAs; 7.3.1 Furanoid β-SAAs; 7.3.2 Pyranoid β-SAAs; 7.4 r-SAAs1; 7.5 δ-SAAs; 7.5.1 Furanoid δ-SAAs; 7.5.2 Pyranoid δ-SAAs; 7.6 Representative Applications in Medicinal Chemistry; 7.7 Conclusions; References; Chapter 8 Cyclic α-Amino Acids as Proline Mimetics; 8.1 Introduction; 8.2 Cyclic α-Amino Acids 8.2.1 3-Substituted Proline Derivatives |
| Record Nr. | UNINA-9910821269603321 |
|
Guarna Antonio
|
||
| Chichester, West Sussex, United Kingdom : , : John Wiley & Sons, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
