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Analysis and function of amino acids and peptides [[electronic resource] /] / edited by Andrew B. Hughes
| Analysis and function of amino acids and peptides [[electronic resource] /] / edited by Andrew B. Hughes |
| Pubbl/distr/stampa | Weinheim, Germany, : Wiley-VCH, 2012 |
| Descrizione fisica | 1 online resource (510 p.) |
| Disciplina | 547.7 |
| Altri autori (Persone) | HughesAndrew B |
| Collana | Amino acids, peptides and proteins in organic chemistry |
| Soggetto topico |
Amino acids - Analysis
Peptides - Analysis Proteins - Analysis |
| ISBN |
1-299-24119-0
3-527-63185-2 3-527-63184-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Amino Acids, Peptides and Proteins in Organic Chemistry:Volume 5 - Analysis and Function of Amino Acids and Peptides; Contents; List of Contributors; 1 Mass Spectrometry of Amino Acids and Proteins; 1.1 Introduction; 1.1.1 Mass Terminology; 1.1.2 Components of a Mass Spectrometer; 1.1.3 Resolution and Mass Accuracy; 1.1.4 Accurate Analysis of ESI Multiply Charged Ions; 1.1.5 Fragment Ions; 1.2 Basic Protein Chemistry and How it Relates to MS; 1.2.1 Mass Properties of the Polypeptide Chain; 1.2.2 In Vivo Protein Modifications; 1.2.3 Ex Vivo Protein Modifications
1.3 Sample Preparation and Data Acquisition 1.3.1 Top-Down Versus Bottom-Up Proteomics; 1.3.2 Shotgun Versus Targeted Proteomics; 1.3.3 Enzymatic Digestion for Bottom-Up Proteomics; 1.3.4 Liquid Chromatography and Capillary Electrophoresis for Mixtures in Bottom-Up; 1.4 Data Analysis of LC-MS/MS (or CE-MS/MS) of Mixtures; 1.4.1 Identification of Proteins from MS/MS Spectra of Peptides; 1.4.2 De Novo Sequencing; 1.5 MS of Protein Structure, Folding, and Interactions; 1.5.1 Methods to Mass-Tag Structural Features; 1.6 Conclusions and Perspectives; References 2 X-Ray Structure Determination of Proteins and Peptides 2.1 Introduction; 2.1.1 Light Microscopy; 2.1.2 X-Rays and Crystallography at the Start; 2.1.3 X-Ray Crystallography Today; 2.1.4 Limitations of X-Ray Crystallography; 2.2 Growing Crystals; 2.2.1 Why Crystals?; 2.2.2 Basic Methods of Growing Protein Crystals; 2.2.3 Protein Sample; 2.2.4 Preliminary Crystal Analysis; 2.2.5 Mounting Crystals for X-Ray Analysis; 2.3 Symmetry and Space Groups; 2.3.1 Crystals and the Unit Cell; 2.3.2 Point Groups; 2.3.3 Space Groups; 2.3.4 Asymmetric Unit; 2.4 X-Ray Scattering and Diffraction 2.4.1 X-Rays and Mathematical Representation of Waves 2.4.2 Interaction of X-Rays with Matter; 2.4.3 Crystal Lattice, Miller Indices, and the Reciprocal Space; 2.4.4 X-Ray Diffraction from a Crystal: Bragg.s Law; 2.4.5 Bragg.s Law in Reciprocal Space; 2.4.6 Fourier Transform Equation from a Lattice; 2.4.7 Friedel' s Law and the Electron Density Equation; 2.5 Collecting and Processing Diffraction Data; 2.5.1 Data Collection Strategy; 2.5.2 Symmetry and Scaling Data; 2.6 Solving the Structure (Determining Phases); 2.6.1 Molecular Replacement; 2.6.2 Isomorphous Replacement; 2.6.3 MAD 2.7 Analyzing and Refining the Structure 2.7.1 Electron Density Interpretation and Model Building; 2.7.2 Protein Structure Refinement; 2.7.3 Protein Structure Validation; References; 3 Nuclear Magnetic Resonance of Amino Acids, Peptides, and Proteins; 3.1 Introduction; 3.1.1 Active Nuclei in NMR; 3.1.2 Energy Levels and Spin States; 3.1.3 Main NMR Parameters (Glossary); 3.1.3.1 Chemical Shift; 3.1.3.2 Scalar Coupling Constants; 3.1.3.3 NOE; 3.1.3.4 RDC; 3.2 Amino Acids; 3.2.1 Historical Significance; 3.2.2 Amino Acids Structure; 3.2.3 Random Coil Chemical Shift; 3.2.4 Spin Systems 3.2.5 Labile Protons |
| Record Nr. | UNINA-9910138033703321 |
| Weinheim, Germany, : Wiley-VCH, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Analysis and function of amino acids and peptides / / edited by Andrew B. Hughes
| Analysis and function of amino acids and peptides / / edited by Andrew B. Hughes |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Weinheim, Germany, : Wiley-VCH, 2012 |
| Descrizione fisica | 1 online resource (510 p.) |
| Disciplina | 547.7 |
| Altri autori (Persone) | HughesAndrew B |
| Collana | Amino acids, peptides and proteins in organic chemistry |
| Soggetto topico |
Amino acids - Analysis
Peptides - Analysis Proteins - Analysis |
| ISBN |
1-299-24119-0
3-527-63185-2 3-527-63184-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Amino Acids, Peptides and Proteins in Organic Chemistry:Volume 5 - Analysis and Function of Amino Acids and Peptides; Contents; List of Contributors; 1 Mass Spectrometry of Amino Acids and Proteins; 1.1 Introduction; 1.1.1 Mass Terminology; 1.1.2 Components of a Mass Spectrometer; 1.1.3 Resolution and Mass Accuracy; 1.1.4 Accurate Analysis of ESI Multiply Charged Ions; 1.1.5 Fragment Ions; 1.2 Basic Protein Chemistry and How it Relates to MS; 1.2.1 Mass Properties of the Polypeptide Chain; 1.2.2 In Vivo Protein Modifications; 1.2.3 Ex Vivo Protein Modifications
1.3 Sample Preparation and Data Acquisition 1.3.1 Top-Down Versus Bottom-Up Proteomics; 1.3.2 Shotgun Versus Targeted Proteomics; 1.3.3 Enzymatic Digestion for Bottom-Up Proteomics; 1.3.4 Liquid Chromatography and Capillary Electrophoresis for Mixtures in Bottom-Up; 1.4 Data Analysis of LC-MS/MS (or CE-MS/MS) of Mixtures; 1.4.1 Identification of Proteins from MS/MS Spectra of Peptides; 1.4.2 De Novo Sequencing; 1.5 MS of Protein Structure, Folding, and Interactions; 1.5.1 Methods to Mass-Tag Structural Features; 1.6 Conclusions and Perspectives; References 2 X-Ray Structure Determination of Proteins and Peptides 2.1 Introduction; 2.1.1 Light Microscopy; 2.1.2 X-Rays and Crystallography at the Start; 2.1.3 X-Ray Crystallography Today; 2.1.4 Limitations of X-Ray Crystallography; 2.2 Growing Crystals; 2.2.1 Why Crystals?; 2.2.2 Basic Methods of Growing Protein Crystals; 2.2.3 Protein Sample; 2.2.4 Preliminary Crystal Analysis; 2.2.5 Mounting Crystals for X-Ray Analysis; 2.3 Symmetry and Space Groups; 2.3.1 Crystals and the Unit Cell; 2.3.2 Point Groups; 2.3.3 Space Groups; 2.3.4 Asymmetric Unit; 2.4 X-Ray Scattering and Diffraction 2.4.1 X-Rays and Mathematical Representation of Waves 2.4.2 Interaction of X-Rays with Matter; 2.4.3 Crystal Lattice, Miller Indices, and the Reciprocal Space; 2.4.4 X-Ray Diffraction from a Crystal: Bragg.s Law; 2.4.5 Bragg.s Law in Reciprocal Space; 2.4.6 Fourier Transform Equation from a Lattice; 2.4.7 Friedel' s Law and the Electron Density Equation; 2.5 Collecting and Processing Diffraction Data; 2.5.1 Data Collection Strategy; 2.5.2 Symmetry and Scaling Data; 2.6 Solving the Structure (Determining Phases); 2.6.1 Molecular Replacement; 2.6.2 Isomorphous Replacement; 2.6.3 MAD 2.7 Analyzing and Refining the Structure 2.7.1 Electron Density Interpretation and Model Building; 2.7.2 Protein Structure Refinement; 2.7.3 Protein Structure Validation; References; 3 Nuclear Magnetic Resonance of Amino Acids, Peptides, and Proteins; 3.1 Introduction; 3.1.1 Active Nuclei in NMR; 3.1.2 Energy Levels and Spin States; 3.1.3 Main NMR Parameters (Glossary); 3.1.3.1 Chemical Shift; 3.1.3.2 Scalar Coupling Constants; 3.1.3.3 NOE; 3.1.3.4 RDC; 3.2 Amino Acids; 3.2.1 Historical Significance; 3.2.2 Amino Acids Structure; 3.2.3 Random Coil Chemical Shift; 3.2.4 Spin Systems 3.2.5 Labile Protons |
| Record Nr. | UNINA-9910825812403321 |
| Weinheim, Germany, : Wiley-VCH, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Analytical characterization of biotherapeutics / / edited by Jennie R. Lill, Wendy N. Sandoval
| Analytical characterization of biotherapeutics / / edited by Jennie R. Lill, Wendy N. Sandoval |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2017 |
| Descrizione fisica | 1 online resource |
| Disciplina | 615.7 |
| Soggetto topico |
Proteins - Therapeutic use
Proteins - Analysis |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-119-38440-0
1-119-38442-7 1-119-38443-5 |
| Classificazione | SCI013010 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: Dedication Chapter 1: Introduction to Biotherapeutics Jennie R. Lill Chapter 2: Mass Spectrometric Characterization of Recombinant Proteins Corey E Bakalarski, Wendy N Sandoval & Jennie R Lill Chapter 3: Characterizing the Termini of Recombinant Proteins Nestor Solis, Christopher M. Overall Chapter 4: Assessing activity & conformation of recombinant proteins Diego Ellerman, Till Maurer, Justin M. Scheer Chapter 5: Structural Characterization of Recombinant Proteins & Antibodies Paola Di Lello and Patrick Lupardus Chapter 6: Antibody de novo sequencing Natalie Castellana, Adrian Guthals Chapter 7: Characterization of Antibody Drug Conjugates Yichin Liu Chapter 8: Characterization of Bi-Specific or other Hybrid molecules T. Noelle Lombana and Christoph Spiess Chapter 9: Bio-Repository Anne Baldwin, Kurt Schroeder, Lovejit Singh, Karen Billeci Chapter 10: Characterization of Manufacturing Host-Cell Contaminant Proteins Denise Krawitz, Jason Rouse, Justin Sperry, Wendy Sandoval, Martin Vanderlaan Chapter 11: Analytical Tools for Biologics Molecular Assessment Wilson Phung , Wendy Sandoval, Robert F Kelley & Jennie R Lill Chapter 12: Glycan Characterization: Determining the Structure, Distribution, and Localization of Glycoprotein Glycans John Briggs INDEX. |
| Record Nr. | UNINA-9910271008203321 |
| Hoboken, New Jersey : , : Wiley, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Analytical characterization of biotherapeutics / / edited by Jennie R. Lill, Wendy N. Sandoval
| Analytical characterization of biotherapeutics / / edited by Jennie R. Lill, Wendy N. Sandoval |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2017 |
| Descrizione fisica | 1 online resource |
| Disciplina | 615.7 |
| Soggetto topico |
Proteins - Therapeutic use
Proteins - Analysis |
| ISBN |
1-119-38440-0
1-119-38442-7 1-119-38443-5 |
| Classificazione | SCI013010 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: Dedication Chapter 1: Introduction to Biotherapeutics Jennie R. Lill Chapter 2: Mass Spectrometric Characterization of Recombinant Proteins Corey E Bakalarski, Wendy N Sandoval & Jennie R Lill Chapter 3: Characterizing the Termini of Recombinant Proteins Nestor Solis, Christopher M. Overall Chapter 4: Assessing activity & conformation of recombinant proteins Diego Ellerman, Till Maurer, Justin M. Scheer Chapter 5: Structural Characterization of Recombinant Proteins & Antibodies Paola Di Lello and Patrick Lupardus Chapter 6: Antibody de novo sequencing Natalie Castellana, Adrian Guthals Chapter 7: Characterization of Antibody Drug Conjugates Yichin Liu Chapter 8: Characterization of Bi-Specific or other Hybrid molecules T. Noelle Lombana and Christoph Spiess Chapter 9: Bio-Repository Anne Baldwin, Kurt Schroeder, Lovejit Singh, Karen Billeci Chapter 10: Characterization of Manufacturing Host-Cell Contaminant Proteins Denise Krawitz, Jason Rouse, Justin Sperry, Wendy Sandoval, Martin Vanderlaan Chapter 11: Analytical Tools for Biologics Molecular Assessment Wilson Phung , Wendy Sandoval, Robert F Kelley & Jennie R Lill Chapter 12: Glycan Characterization: Determining the Structure, Distribution, and Localization of Glycoprotein Glycans John Briggs INDEX. |
| Record Nr. | UNINA-9910830599403321 |
| Hoboken, New Jersey : , : Wiley, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Applications of monolithic column and isotope dimethylation labeling in shotgun proteome analysis / / Fangjun Wang
| Applications of monolithic column and isotope dimethylation labeling in shotgun proteome analysis / / Fangjun Wang |
| Autore | Wang Fangjun |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | Heidelberg, Germany : , : Springer, , 2014 |
| Descrizione fisica | 1 online resource (xiii, 94 pages) : illustrations (some color) |
| Disciplina | 543.65 |
| Collana | Springer Theses, Recognizing Outstanding Ph.D. Research |
| Soggetto topico |
Proteins - Analysis
Proteomics |
| ISBN | 3-642-42008-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction -- Online sample injection and multidimensional chromatography separation by using strong cation exchange monolithic column -- Development of polymer-based hydrophobic monolithic columns and their applications in proteome analysis -- Large-scale proteome and phosphoproteome quantification by using dimethylation isotope labeling. |
| Record Nr. | UNINA-9910298640103321 |
Wang Fangjun
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| Heidelberg, Germany : , : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemical modification of proteins. Separation methods for nucleic acids and oligonucleotides / A. N. Glazer, R. J. Delange and D. S. Sigman, Hannah Gould and H. R. Matthews
| Chemical modification of proteins. Separation methods for nucleic acids and oligonucleotides / A. N. Glazer, R. J. Delange and D. S. Sigman, Hannah Gould and H. R. Matthews |
| Autore | Glazer, Alexander N. |
| Pubbl/distr/stampa | Amsterdam : North Holland |
| Descrizione fisica | viii, 491 p. : ill. ; 21 cm |
| Disciplina | 572 |
| Altri autori (Persone) |
Delange, Robert J.
Sigman, D. S. Gould, Hannah Matthews, Harry Roy |
| Collana | Laboratory techniques in biochemistry and molecular biology ; 4 Pt.1 |
| Soggetto topico |
Proteins - Analysis
Separation (Technology) Nucleic acids - Analysis Nucleotides - Analysis |
| ISBN | 0444109854 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISALENTO-991002189119707536 |
|
Glazer, Alexander N.
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| Amsterdam : North Holland | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. del Salento | ||
| ||
From genome to proteome : advances in the practice and application of proteomics / / edited by Michael J. Dunn
| From genome to proteome : advances in the practice and application of proteomics / / edited by Michael J. Dunn |
| Pubbl/distr/stampa | Weinheim, [Germany] : , : Wiley-VCH, , 2000 |
| Descrizione fisica | 1 online resource (556 p.) |
| Disciplina | 572.6 |
| Soggetto topico |
Proteins - Analysis
Proteins - Structure Proteomics |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-01041-7
9786612010415 3-527-61348-X 3-527-61349-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | From Genome to Proteome; Contents; Reviews; Sample preparation and solubilization; Developments in electrophoresis; Detection and quantitation; Mass spectrometry; Proteome data analysis and management; Prokaryotes and yeast; Biological Fluids; Eukaryotic cells and tissue; Oncology; Plants; Index |
| Record Nr. | UNINA-9910144734103321 |
| Weinheim, [Germany] : , : Wiley-VCH, , 2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
From genome to proteome : advances in the practice and application of proteomics / / edited by Michael J. Dunn
| From genome to proteome : advances in the practice and application of proteomics / / edited by Michael J. Dunn |
| Pubbl/distr/stampa | Weinheim, [Germany] : , : Wiley-VCH, , 2000 |
| Descrizione fisica | 1 online resource (556 p.) |
| Disciplina | 572.6 |
| Soggetto topico |
Proteins - Analysis
Proteins - Structure Proteomics |
| ISBN |
1-282-01041-7
9786612010415 3-527-61348-X 3-527-61349-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | From Genome to Proteome; Contents; Reviews; Sample preparation and solubilization; Developments in electrophoresis; Detection and quantitation; Mass spectrometry; Proteome data analysis and management; Prokaryotes and yeast; Biological Fluids; Eukaryotic cells and tissue; Oncology; Plants; Index |
| Record Nr. | UNINA-9910829973503321 |
| Weinheim, [Germany] : , : Wiley-VCH, , 2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Functional analysis of the nuclear basket and protein Tpr / / Haruki Iino
| Functional analysis of the nuclear basket and protein Tpr / / Haruki Iino |
| Autore | Iino Haruki |
| Edizione | [1. Auflage.] |
| Pubbl/distr/stampa | Gottingen, [Germany] : , : Cuvillier Verlag, , 2017 |
| Descrizione fisica | 1 online resource (153 pages) : illustrations (some color), tables |
| Disciplina | 574.19245 |
| Soggetto topico |
Proteins - Analysis
Functional analysis |
| ISBN | 3-7369-8589-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910796375403321 |
|
Iino Haruki
|
||
| Gottingen, [Germany] : , : Cuvillier Verlag, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Functional analysis of the nuclear basket and protein Tpr / / Haruki Iino
| Functional analysis of the nuclear basket and protein Tpr / / Haruki Iino |
| Autore | Iino Haruki |
| Edizione | [1. Auflage.] |
| Pubbl/distr/stampa | Gottingen, [Germany] : , : Cuvillier Verlag, , 2017 |
| Descrizione fisica | 1 online resource (153 pages) : illustrations (some color), tables |
| Disciplina | 574.19245 |
| Soggetto topico |
Proteins - Analysis
Functional analysis |
| ISBN | 3-7369-8589-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910806925603321 |
|
Iino Haruki
|
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| Gottingen, [Germany] : , : Cuvillier Verlag, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
