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Advanced Dairy Chemistry : Volume 1B: Proteins: Applied Aspects / / edited by Paul L. H. McSweeney, James A. O'Mahony
| Advanced Dairy Chemistry : Volume 1B: Proteins: Applied Aspects / / edited by Paul L. H. McSweeney, James A. O'Mahony |
| Edizione | [4th ed. 2016.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2016 |
| Descrizione fisica | 1 online resource (508 p.) |
| Disciplina | 540 |
| Soggetto topico |
Food—Biotechnology
Proteins Microbiology Food Science Protein Science Applied Microbiology |
| ISBN | 1-4939-2800-7 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface -- 1. Manufacture and properties of dairy powders -- 2. Functional milk proteins production and utilization: casein-based ingredients -- 3. Functional Milk Proteins: Production and Utilization. Whey-Based Ingredients -- 4. Rehydration and solubility characteristics of high-protein dairy powders -- 5. Emulsions and foams stabilised by milk proteins -- 6. Heat-induced denaturation, aggregation and gelation of whey proteins -- 7. Heat stability of milk -- 8. Sensory Properties of Milk Protein Ingredients -- 9. Ethanol Stability and Milk Composition -- 10. Protein stability in sterilised milk and milk products -- 11. Enzymatic Coagulation of Milk -- 12. Acid coagulation of milk -- 13. Milk Proteins in Ice Cream -- 14. Protein in cheese and cheese products: structure-function relationships -- 15. Milk protein hydrolysates and bioactive peptides -- Index. |
| Record Nr. | UNINA-9910254054203321 |
| New York, NY : , : Springer New York : , : Imprint : Springer, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advanced Technologies for Protein Complex Production and Characterization / / edited by M. Cristina Vega
| Advanced Technologies for Protein Complex Production and Characterization / / edited by M. Cristina Vega |
| Edizione | [1st ed. 2016.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
| Descrizione fisica | 1 online resource (XIII, 382 p. 87 illus., 71 illus. in color.) |
| Disciplina | 660.63 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Proteins
Systems biology Protein Science Protein Structure Systems Biology |
| ISBN | 3-319-27216-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Protein complex production from the drug discovery standpoint -- Choose a suitable expression host: a survey of available protein production platforms -- ACEMBL Tool-Kits for High-Throughput Multigene Delivery and Expression in Prokaryotic and Eukaryotic Hosts -- Complex reconstitution and characterization by combining co-expression techniques in Escherichia coli with high-throughput -- Membrane protein production in E. coli for applications in drug discovery -- Cell-free Synthesis of Macromolecular Complexes -- A Bacillus megaterium system for the production of recombinant proteins and protein complexes -- Protein complex production in alternative prokaryotic hosts -- Production of Protein Complexes in Non-methylotrophic and Methylotrophic Yeasts -- Leishmania tarentolae for the Production of Multi-Subunit Complexes -- Alternative Eukaryotic Expression Systems for the Production of Proteins and Protein Complexes -- Fundamentals of baculovirus expression and applications -- The MultiBac Baculovirus / Insect Cell Expression Vector System for Producing Complex Protein Biologics -- Fundamentals of expression in mammalian cells -- Assembling multi-subunit complexes using mammalian expression -- Microalgae as solar-powered protein factories -- Strategies and methodologies for the co-expression of multiple proteins in plants -- Transient expression systems in plants—potentialities and constraints -- Complex reconstitution from individual protein modules -- Structural reconstruction of protein-protein complexes involved in intracellular signaling -- The use of small-angle scattering for the characterization of multi subunit complexes -- Application of nuclear magnetic resonance and hybrid methods to structure determination of complex systems. . |
| Record Nr. | UNINA-9910253889603321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advances in Chemical Bioanalysis / / edited by Frank-Michael Matysik
| Advances in Chemical Bioanalysis / / edited by Frank-Michael Matysik |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (269 p.) |
| Disciplina | 615.1901 |
| Collana | Bioanalytical Reviews |
| Soggetto topico |
Analytical chemistry
Laboratory medicine Proteins Analytical Chemistry Laboratory Medicine Protein Science |
| ISBN | 3-319-00182-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Indicators for optical oxygen sensors -- Electron transfer mechanisms between microorganisms and electrodes in bioelectrochemical systems -- Synthesis and application of monodisperse polymeric nano- and micro-particles -- Upconverting phosphor labels for bioanalytical assays -- Biosensors based on periplasmatic binding proteins -- Periplasmic binding proteins in biosensing applications -- Hyphenation of electrochemistry with mass spectrometry for bioanalytical studies. |
| Record Nr. | UNINA-9910298651503321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Advances in GAPDH Protein Analysis: A Functional and Biochemical Approach / / by Shanmugasundaram Ganapathy-Kanniappan
| Advances in GAPDH Protein Analysis: A Functional and Biochemical Approach / / by Shanmugasundaram Ganapathy-Kanniappan |
| Autore | Ganapathy-Kanniappan Shanmugasundaram |
| Edizione | [1st ed. 2017.] |
| Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2017 |
| Descrizione fisica | 1 online resource (XIV, 115 p. 35 illus., 12 illus. in color.) |
| Disciplina | 572.6 |
| Soggetto topico |
Proteins
Protein Science |
| ISBN | 981-10-7342-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction -- Analysis of GAPDH enzyme activity: A quantitative and qualitative approach -- Analysis of GAPDH - Native protein -- Analysis of GAPDH under Denaturing Conditions -- Analysis of GAPDH and Protein Interaction -- Analysis of GAPDH and Nucleic acid Interaction -- Analysis of Subcellular and Extracellular GAPDH -- Analysis of GAPDH posttranslational modifications -- Analysis of GAPDH by Mass Spectrometry -- Purification of GAPDH. |
| Record Nr. | UNINA-9910255451103321 |
Ganapathy-Kanniappan Shanmugasundaram
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| Singapore : , : Springer Singapore : , : Imprint : Springer, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Advances in Membrane Proteins : Building, Signaling and Malfunction / / edited by Yu Cao
| Advances in Membrane Proteins : Building, Signaling and Malfunction / / edited by Yu Cao |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (132 pages) |
| Disciplina | QP552.M44 |
| Soggetto topico |
Proteins
Pharmaceutical technology Protein Science Pharmaceutical Sciences/Technology Protein Structure |
| ISBN | 981-13-9077-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. Cell adhesion molecules and development -- 2. Receptors and signal transduction -- 3. Single-transmembrane proteins and antibody drugs -- 4. Viral membrane proteins -- 5. Biosynthesis and folding of oily peptide chains -- 6. Quality control in producing membrane proteins. |
| Record Nr. | UNINA-9910350349503321 |
| Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Advances in Membrane Proteins : Part I: Mass Processing and Transportation / / edited by Yu Cao
| Advances in Membrane Proteins : Part I: Mass Processing and Transportation / / edited by Yu Cao |
| Edizione | [1st ed. 2018.] |
| Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018 |
| Descrizione fisica | 1 online resource (183 pages) |
| Disciplina | 572.696 |
| Soggetto topico |
Proteins
Pharmaceutical technology Protein Science Pharmaceutical Sciences/Technology Protein Structure |
| ISBN |
978-981-13-0532-0
981-13-0532-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chapter 1: Membrane Proteins as Critical Molecules -- Chapter 2: Channels -- Chapter 3: Solute Transporters. Chapter 4. Cytoplasmic Membrane Proteins -- Chapter 5: Nuclear Membrane Proteins: the transportation of genetic materials -- Chapter 6. Membrane Embedded Enzymes and Hydrophobic bio-catalysis. |
| Record Nr. | UNINA-9910298421903321 |
| Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Agricultural Bioinformatics [[electronic resource] /] / edited by Kavi Kishor P.B., Rajib Bandopadhyay, Prashanth Suravajhala
| Agricultural Bioinformatics [[electronic resource] /] / edited by Kavi Kishor P.B., Rajib Bandopadhyay, Prashanth Suravajhala |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | New Delhi : , : Springer India : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (296 p.) |
| Disciplina | 631 |
| Soggetto topico |
Bioinformatics
Agriculture Proteomics Systems biology Proteins Biostatistics Systems Biology Protein Science |
| ISBN | 81-322-1880-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. Preface -- 2. Foreword -- 3.Association Mapping – A new Paradigm for Dissection of Complex traits in crops -- 4. The silent Assassins – Informatics of plant Viral Silencing Suppressors.5. Tackling the Heat Stress Tolerance in crop Plants: a Bioinformatics Approach -- 6. Comparative Genomics of Cereal Crops: Status and Future Prospects -- 7. A Comprehensive Overview on Application of Bioinformatics and Computational Statistics in Rice Genomics Towards an Amalgamated Approach for Improving Acquaintance Base -- 8. Contribution of Bioinformatics to Gene Discovery in Salt Stress Responses in Plants -- 9. Peanut Bioinformatics: Tools and Applications for Developing more Effective Immunotherapies for Peanut Allergy and Improving Food Safety -- 10. Plant MicroRNAs - An Overview -- 11. ESTs in plants: Where are we heading? -- 12. Bioinformatics Strategies Associated with Important Ethnic Medicinal Plants -- 13. Mining Knowledge from Omics Data -- 14. Cloud Computing in Agriculture -- 15. Bioinformatic Tools in the Analysis of Determinants of Pathogenicity and Ecology of Entomopathogenic Fungi used as Microbial Insecticides in Crop Protection -- 16. Exploring the Genomes of Symbiotic Diazotrophs with Relevance to Biological Nitrogen Fixation -- 17. Plant-Microbial Interaction: A Dialogue between two Dynamic Bioentities -- 18. Machine Learning with Special Emphasis on Support Vector Machines (SVMs) in Systems Biology: A Plant Perspective -- 19. Xanthine Derivatives: A molecular Modeling perspective. . |
| Record Nr. | UNINA-9910298349703321 |
| New Delhi : , : Springer India : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Algorithms in Bioinformatics [[electronic resource] ] : 15th International Workshop, WABI 2015, Atlanta, GA, USA, September 10-12, 2015, Proceedings / / edited by Mihai Pop, Hélène Touzet
| Algorithms in Bioinformatics [[electronic resource] ] : 15th International Workshop, WABI 2015, Atlanta, GA, USA, September 10-12, 2015, Proceedings / / edited by Mihai Pop, Hélène Touzet |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (XX, 328 p. 85 illus.) |
| Disciplina | 572.80285 |
| Collana | Lecture Notes in Bioinformatics |
| Soggetto topico |
Bioinformatics
Algorithms Computer science—Mathematics Data mining Proteins Computational Biology/Bioinformatics Algorithm Analysis and Problem Complexity Discrete Mathematics in Computer Science Data Mining and Knowledge Discovery Protein Structure |
| ISBN | 3-662-48221-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Organization -- Abstracts -- Reference-free Compression of High Throughput Sequencing Data with a Probabilistic de Bruijn Graph -- Genome Scaffolding with PE-Contaminated Mate-Pair Libraries -- Network Properties of the Ensemble of RNA Structures -- Contents -- BicNET: Efficient Biclustering of Biological Networks to Unravel Non-Trivial Modules -- 1 Introduction -- 2 Background -- 3 Solution -- 3.1 Network Modules with Flexible Coherency -- 3.2 BicNET: Efficient Biclustering of Biological Networks -- 4 Results and Discussion -- 4.1 Results on Synthetic Data -- 4.2 Results on Real Data -- 5 Conclusions and Future Work -- References -- Simultaneous Optimization of both Node and Edge Conservation in Network Alignment via WAVE -- 1 Introduction -- 1.1 Motivation -- 1.2 Related Work -- 1.3 Our Contributions and Significance -- 2 Methods -- 2.1 Data -- 2.2 Combining Topological and Sequence Information Within NCF -- 2.3 Evaluation of Alignment Quality -- 2.4 Our Methodology -- 3 Results and Discussion -- 3.1 Comparison of Edge-Weighted and Edge-Unweighted Versions of WAVE -- 3.2 Comparison of Different Parameter Values Within WAVE -- 3.3 Comparison of Five NCF-AS Methods -- 3.4 Comparison of WAVE with Very Recent Methods -- 4 Concluding Remarks -- A Appendix -- A.1 Appendix Figures -- References -- The Topological Profile of a Model of Protein Network Evolution Can Direct Model Improvement -- 1 Introduction -- 2 Methods -- 2.1 The Evolutionary Model -- 2.2 The Empirical Network -- 2.3 Topological Measures Assessed -- 3 Results -- 3.1 Success of Driving Properties Towards the Empirical Topology -- 3.2 Non-Optimized Topological Properties that Trend Towards Empirical Values -- 3.3 Variability of Topological Measures -- 3.4 Correlation Among Topological Characteristics -- 3.5 Improving the Evolutionary Model -- 4 Conclusion.
References -- Algorithms for Regular Tree Grammar Network Search and Their Application to Mining Human-Viral Infection Patterns -- 1 Introduction -- 2 Regular Tree Grammars and Curry-Encoding -- 3 The RTG Network Parse-and-Search Problem -- 4 Algorithms for Solving Problem 2 -- 4.1 Stage 1: Hypergraph Construction and Its Optimal Derivation -- 4.2 Stage 2: Computing K-Best Scoring Trees -- 5 Results -- 6 Discussion -- References -- Orthology Relation and Gene Tree Correction: Complexity Results -- 1 Introduction -- 2 Trees and Orthology Relations -- 2.1 Evolution of a Gene Family -- 2.2 Relation Graph -- 3 Relation Correction Problems -- 3.1 The Minimum Edge-Removal Consistency Problem -- 3.2 The Minimum Node-Removal Consistency Problem -- 4 Gene Tree Correction Problems -- 4.1 The Maximum Homology Correction Problem -- 4.2 The Maximum Clade Correction Problem -- 5 Algorithmic Avenues -- 6 Conclusion -- References -- Finding a Perfect Phylogeny from Mixed Tumor Samples -- 1 Introduction -- 2 Problem Formulation -- 3 A Characterization of Row-Conflict Graphs -- 4 Complexity Results -- 5 An Algorithm for the Case When No Column Is Contained in both Columns of a Pair of Conflicting Columns -- 6 Discussion -- References -- A Sub-quadratic Time and Space Complexity Solution for the Dated Tree Reconciliation Problem for Select Tree Topologies -- 1 Background -- 2 Methodology -- 2.1 The Number of Mapping Sites Required for Each Parasite Node -- 2.2 Space Complexity Reduction -- 2.3 Time Complexity Reduction -- 3 Results and Discussion -- 3.1 Analysis of Space Complexity Improvements (Synthetic Data) -- 3.2 Analysis of Time Complexity Improvements (Synthetic Data) -- 3.3 Time and Space Complexity Improvements for Biological Data -- References -- Maximum Parsimony Analysis of Gene Copy Number Changes -- 1 Introduction -- 2 Methods. 2.1 The Rectilinear Steiner Minimum Tree (RSMT) Problem -- 2.2 The Maximum Parsimony Tree (MPT) Problem -- 2.3 From MPT to RSMT -- 3 Experimental Results -- 3.1 Real Cancer Datasets -- 3.2 Simulated Cancer Data -- 4 Discussion -- References -- Multiple-Ancestor Localization for Recently Admixed Individuals -- 1 Introduction -- 2 Materials and Methods -- 2.1 Estimation of Spatial Parameters from Training Data -- 2.2 Localization of Individuals of 1-Generation Admixture -- 2.3 A Spatial Model for Individuals of g-generations Admixture -- 2.4 Simulation Setup -- 2.5 Method Comparison -- 3 Results -- 3.1 Localization of Simulated 1-Generation Admixed Individuals -- 3.2 Localization of Real Europeans from the POPRES Dataset -- 3.3 Localization of Simulated g-generation Admixed Individuals -- 4 Discussion -- References -- Association Mapping for Compound Heterozygous Traits Using Phenotypic Distance and Integer Programming -- 1 Biological Background and CH-Model -- 1.1 A Formal Model of a CH-trait at a Single Gene -- 2 The Phenotypic Distance Problem -- 2.1 An ILP Formulation for the Phenotypic Distance Problem -- 3 Simulated Data -- 4 The Most Striking and Positive Empirical Results -- 4.1 Speeding Up the Computations for Non-causal Genes and Permuted Data -- References -- Semi-nonparametric Modeling of Topological Domain Formation from Epigenetic Data -- 1 Introduction -- 1.1 Additional Related Work -- 2 The nTDP Model -- 2.1 The Likelihood Function -- 2.2 Nonparametric Form of the Effect Functions -- 3 Optimal Algorithms for Training and Inference -- 3.1 Training -- 3.2 Training Extensions -- 3.3 Inferring Domains Using the Trained Model -- 4 Results -- 4.1 Experimental Setup -- 4.2 nTDP Finds a Small Subset of Modifications Predictive of TADs -- 4.3 Predicting TADs from Histone Marks in Human -- 4.4 Multiscale Analysis of the Predicted TADs. 5 Conclusion -- References -- Scrible: Ultra-Accurate Error-Correction of Pooled Sequenced Reads -- 1 Introduction -- 2 Preliminaries -- 2.1 Pooling Design -- 2.2 Read Decoding -- 3 Methods -- 3.1 Indexing k-mers -- 3.2 Identification and Correction of Sequencing Errors -- 4 Experimental Results -- 4.1 Results on Synthetic Reads for the Rice Genome -- 4.2 Results on Real Reads from the Barley Genome -- References -- Jabba: Hybrid Error Correction for Long Sequencing Reads Using Maximal Exact Matches -- 1 Introduction -- 1.1 Related Work -- 2 Methods -- 2.1 Overview -- 2.2 Correction of the de Bruijn Graph -- 2.3 Aligning Reads to a de Bruijn Graph -- 3 Results Concerning Maximal Exact Matches -- 3.1 Coverage by Exact Regions -- 3.2 Occurrence of Exact Regions -- 3.3 Applications -- 4 Results -- 4.1 Data -- 4.2 Parameters -- 4.3 Evaluation Metrics -- 4.4 Evaluation -- References -- Optimizing Read Reversals for Sequence Compression -- 1 Introduction -- 2 Problem Taxonomy -- 3 Hardness Results -- 4 Approximation Algorithms -- 4.1 Approximations Based on TSP -- 4.2 Ordering with Reversals for Palindromic Value Functions -- 5 Experimental Results -- References -- Circular Sequence Comparison with q-grams -- 1 Introduction -- 2 Definitions and Properties -- 3 Algorithms -- 3.1 Algorithm hCSC: a Heuristic Algorithm -- 3.2 Algorithm saCSC: an Exact Suffix-Array-based Algorithm -- 4 Experimental Results -- 4.1 Accuracy -- 4.2 Time Performance -- 4.3 Application to Real Data -- 5 Final Remarks -- References -- Bloom Filter Trie -- A Data Structure for Pan-Genome Storage -- 1 Introduction -- 2 Existing Approaches -- 2.1 Data Structures -- 2.2 Software for Pan-Genome Storage -- 3 The Bloom Filter Trie -- 3.1 Uncompressed Container -- 3.2 Compressed Container -- 4 Operations Supported by the Bloom Filter Trie -- 4.1 Look-Up -- 4.2 Insertion. 4.3 Color Compression -- 5 Traversing Successors and Predecessors -- 6 Evaluation -- 7 Conclusion -- References -- A Filtering Approach for Alignment-Free Biosequences Comparison with Mismatches -- 1 Introduction -- 2 Preliminaries -- 2.1 Related Work -- 3 The MissMax Algorithm -- 3.1 Initial Set Up: MaxCork(1) -- 3.2 Minimum MaxCork from the Previous Step -- 3.3 Potential Candidates from the Previous Step -- 3.4 Theoretical and Practical Considerations -- 4 Preliminary Experimental Analysis -- 5 Concluding Remarks -- References -- Models and Algorithms for Genome Rearrangement with Positional Constraints -- 1 Introduction -- 1.1 Genomes as Sets of Signed Integers -- 1.2 DCJ and Sorting DCJs -- 1.3 The Minimum Weighted Rearrangements Problem -- 1.4 Positional Constraints as Colored Adjacencies -- 1.5 Locality and the Adjacency Graph -- 1.6 A Positional Weight Function -- 2 Minimum Local Parsimonious Scenario -- 2.1 Colored Partitions -- 2.2 Even-length Paths -- 3 Conclusion -- References -- Sparse RNA Folding Revisited: Space-Efficient Minimum Free Energy Prediction -- 1 Introduction -- 2 Time and Space Efficient Computation of the MFE -- 2.1 Time and Space Efficient Bp-Based Folding -- 2.2 Time and Space Efficient Calculation of the MFE -- 2.3 The Difficulty of MFE Fold Reconstruction Compared to Bp-Based Folding -- 3 MFE Folding with Fold Reconstruction -- 3.1 Adding Trace Arrows -- 3.2 Avoiding Trace Arrows -- 3.3 Garbage Collecting Trace Arrows -- 3.4 Algorithm Summary -- 3.5 Complexity -- 4 Empirical Results -- 5 Conclusion and Future Work -- References -- A Sparsified Four-Russian Algorithm for RNA Folding -- 1 Introduction -- 2 Problem Definition and Basic Algorithm -- 2.1 Extending the Notation and Moving Towards a Vector by Vector Computation of -- 3 Sparsification of the SSF Algorithm -- 3.1 OCT and STEP Sub-instances of Sequence. 4 On-demand Four Russians Speedup. |
| Record Nr. | UNISA-996200356903316 |
| Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Algorithms in Bioinformatics : 15th International Workshop, WABI 2015, Atlanta, GA, USA, September 10-12, 2015, Proceedings / / edited by Mihai Pop, Hélène Touzet
| Algorithms in Bioinformatics : 15th International Workshop, WABI 2015, Atlanta, GA, USA, September 10-12, 2015, Proceedings / / edited by Mihai Pop, Hélène Touzet |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (XX, 328 p. 85 illus.) |
| Disciplina | 572.80285 |
| Collana | Lecture Notes in Bioinformatics |
| Soggetto topico |
Bioinformatics
Algorithms Computer science—Mathematics Data mining Proteins Computational Biology/Bioinformatics Algorithm Analysis and Problem Complexity Discrete Mathematics in Computer Science Data Mining and Knowledge Discovery Protein Structure |
| ISBN | 3-662-48221-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Organization -- Abstracts -- Reference-free Compression of High Throughput Sequencing Data with a Probabilistic de Bruijn Graph -- Genome Scaffolding with PE-Contaminated Mate-Pair Libraries -- Network Properties of the Ensemble of RNA Structures -- Contents -- BicNET: Efficient Biclustering of Biological Networks to Unravel Non-Trivial Modules -- 1 Introduction -- 2 Background -- 3 Solution -- 3.1 Network Modules with Flexible Coherency -- 3.2 BicNET: Efficient Biclustering of Biological Networks -- 4 Results and Discussion -- 4.1 Results on Synthetic Data -- 4.2 Results on Real Data -- 5 Conclusions and Future Work -- References -- Simultaneous Optimization of both Node and Edge Conservation in Network Alignment via WAVE -- 1 Introduction -- 1.1 Motivation -- 1.2 Related Work -- 1.3 Our Contributions and Significance -- 2 Methods -- 2.1 Data -- 2.2 Combining Topological and Sequence Information Within NCF -- 2.3 Evaluation of Alignment Quality -- 2.4 Our Methodology -- 3 Results and Discussion -- 3.1 Comparison of Edge-Weighted and Edge-Unweighted Versions of WAVE -- 3.2 Comparison of Different Parameter Values Within WAVE -- 3.3 Comparison of Five NCF-AS Methods -- 3.4 Comparison of WAVE with Very Recent Methods -- 4 Concluding Remarks -- A Appendix -- A.1 Appendix Figures -- References -- The Topological Profile of a Model of Protein Network Evolution Can Direct Model Improvement -- 1 Introduction -- 2 Methods -- 2.1 The Evolutionary Model -- 2.2 The Empirical Network -- 2.3 Topological Measures Assessed -- 3 Results -- 3.1 Success of Driving Properties Towards the Empirical Topology -- 3.2 Non-Optimized Topological Properties that Trend Towards Empirical Values -- 3.3 Variability of Topological Measures -- 3.4 Correlation Among Topological Characteristics -- 3.5 Improving the Evolutionary Model -- 4 Conclusion.
References -- Algorithms for Regular Tree Grammar Network Search and Their Application to Mining Human-Viral Infection Patterns -- 1 Introduction -- 2 Regular Tree Grammars and Curry-Encoding -- 3 The RTG Network Parse-and-Search Problem -- 4 Algorithms for Solving Problem 2 -- 4.1 Stage 1: Hypergraph Construction and Its Optimal Derivation -- 4.2 Stage 2: Computing K-Best Scoring Trees -- 5 Results -- 6 Discussion -- References -- Orthology Relation and Gene Tree Correction: Complexity Results -- 1 Introduction -- 2 Trees and Orthology Relations -- 2.1 Evolution of a Gene Family -- 2.2 Relation Graph -- 3 Relation Correction Problems -- 3.1 The Minimum Edge-Removal Consistency Problem -- 3.2 The Minimum Node-Removal Consistency Problem -- 4 Gene Tree Correction Problems -- 4.1 The Maximum Homology Correction Problem -- 4.2 The Maximum Clade Correction Problem -- 5 Algorithmic Avenues -- 6 Conclusion -- References -- Finding a Perfect Phylogeny from Mixed Tumor Samples -- 1 Introduction -- 2 Problem Formulation -- 3 A Characterization of Row-Conflict Graphs -- 4 Complexity Results -- 5 An Algorithm for the Case When No Column Is Contained in both Columns of a Pair of Conflicting Columns -- 6 Discussion -- References -- A Sub-quadratic Time and Space Complexity Solution for the Dated Tree Reconciliation Problem for Select Tree Topologies -- 1 Background -- 2 Methodology -- 2.1 The Number of Mapping Sites Required for Each Parasite Node -- 2.2 Space Complexity Reduction -- 2.3 Time Complexity Reduction -- 3 Results and Discussion -- 3.1 Analysis of Space Complexity Improvements (Synthetic Data) -- 3.2 Analysis of Time Complexity Improvements (Synthetic Data) -- 3.3 Time and Space Complexity Improvements for Biological Data -- References -- Maximum Parsimony Analysis of Gene Copy Number Changes -- 1 Introduction -- 2 Methods. 2.1 The Rectilinear Steiner Minimum Tree (RSMT) Problem -- 2.2 The Maximum Parsimony Tree (MPT) Problem -- 2.3 From MPT to RSMT -- 3 Experimental Results -- 3.1 Real Cancer Datasets -- 3.2 Simulated Cancer Data -- 4 Discussion -- References -- Multiple-Ancestor Localization for Recently Admixed Individuals -- 1 Introduction -- 2 Materials and Methods -- 2.1 Estimation of Spatial Parameters from Training Data -- 2.2 Localization of Individuals of 1-Generation Admixture -- 2.3 A Spatial Model for Individuals of g-generations Admixture -- 2.4 Simulation Setup -- 2.5 Method Comparison -- 3 Results -- 3.1 Localization of Simulated 1-Generation Admixed Individuals -- 3.2 Localization of Real Europeans from the POPRES Dataset -- 3.3 Localization of Simulated g-generation Admixed Individuals -- 4 Discussion -- References -- Association Mapping for Compound Heterozygous Traits Using Phenotypic Distance and Integer Programming -- 1 Biological Background and CH-Model -- 1.1 A Formal Model of a CH-trait at a Single Gene -- 2 The Phenotypic Distance Problem -- 2.1 An ILP Formulation for the Phenotypic Distance Problem -- 3 Simulated Data -- 4 The Most Striking and Positive Empirical Results -- 4.1 Speeding Up the Computations for Non-causal Genes and Permuted Data -- References -- Semi-nonparametric Modeling of Topological Domain Formation from Epigenetic Data -- 1 Introduction -- 1.1 Additional Related Work -- 2 The nTDP Model -- 2.1 The Likelihood Function -- 2.2 Nonparametric Form of the Effect Functions -- 3 Optimal Algorithms for Training and Inference -- 3.1 Training -- 3.2 Training Extensions -- 3.3 Inferring Domains Using the Trained Model -- 4 Results -- 4.1 Experimental Setup -- 4.2 nTDP Finds a Small Subset of Modifications Predictive of TADs -- 4.3 Predicting TADs from Histone Marks in Human -- 4.4 Multiscale Analysis of the Predicted TADs. 5 Conclusion -- References -- Scrible: Ultra-Accurate Error-Correction of Pooled Sequenced Reads -- 1 Introduction -- 2 Preliminaries -- 2.1 Pooling Design -- 2.2 Read Decoding -- 3 Methods -- 3.1 Indexing k-mers -- 3.2 Identification and Correction of Sequencing Errors -- 4 Experimental Results -- 4.1 Results on Synthetic Reads for the Rice Genome -- 4.2 Results on Real Reads from the Barley Genome -- References -- Jabba: Hybrid Error Correction for Long Sequencing Reads Using Maximal Exact Matches -- 1 Introduction -- 1.1 Related Work -- 2 Methods -- 2.1 Overview -- 2.2 Correction of the de Bruijn Graph -- 2.3 Aligning Reads to a de Bruijn Graph -- 3 Results Concerning Maximal Exact Matches -- 3.1 Coverage by Exact Regions -- 3.2 Occurrence of Exact Regions -- 3.3 Applications -- 4 Results -- 4.1 Data -- 4.2 Parameters -- 4.3 Evaluation Metrics -- 4.4 Evaluation -- References -- Optimizing Read Reversals for Sequence Compression -- 1 Introduction -- 2 Problem Taxonomy -- 3 Hardness Results -- 4 Approximation Algorithms -- 4.1 Approximations Based on TSP -- 4.2 Ordering with Reversals for Palindromic Value Functions -- 5 Experimental Results -- References -- Circular Sequence Comparison with q-grams -- 1 Introduction -- 2 Definitions and Properties -- 3 Algorithms -- 3.1 Algorithm hCSC: a Heuristic Algorithm -- 3.2 Algorithm saCSC: an Exact Suffix-Array-based Algorithm -- 4 Experimental Results -- 4.1 Accuracy -- 4.2 Time Performance -- 4.3 Application to Real Data -- 5 Final Remarks -- References -- Bloom Filter Trie -- A Data Structure for Pan-Genome Storage -- 1 Introduction -- 2 Existing Approaches -- 2.1 Data Structures -- 2.2 Software for Pan-Genome Storage -- 3 The Bloom Filter Trie -- 3.1 Uncompressed Container -- 3.2 Compressed Container -- 4 Operations Supported by the Bloom Filter Trie -- 4.1 Look-Up -- 4.2 Insertion. 4.3 Color Compression -- 5 Traversing Successors and Predecessors -- 6 Evaluation -- 7 Conclusion -- References -- A Filtering Approach for Alignment-Free Biosequences Comparison with Mismatches -- 1 Introduction -- 2 Preliminaries -- 2.1 Related Work -- 3 The MissMax Algorithm -- 3.1 Initial Set Up: MaxCork(1) -- 3.2 Minimum MaxCork from the Previous Step -- 3.3 Potential Candidates from the Previous Step -- 3.4 Theoretical and Practical Considerations -- 4 Preliminary Experimental Analysis -- 5 Concluding Remarks -- References -- Models and Algorithms for Genome Rearrangement with Positional Constraints -- 1 Introduction -- 1.1 Genomes as Sets of Signed Integers -- 1.2 DCJ and Sorting DCJs -- 1.3 The Minimum Weighted Rearrangements Problem -- 1.4 Positional Constraints as Colored Adjacencies -- 1.5 Locality and the Adjacency Graph -- 1.6 A Positional Weight Function -- 2 Minimum Local Parsimonious Scenario -- 2.1 Colored Partitions -- 2.2 Even-length Paths -- 3 Conclusion -- References -- Sparse RNA Folding Revisited: Space-Efficient Minimum Free Energy Prediction -- 1 Introduction -- 2 Time and Space Efficient Computation of the MFE -- 2.1 Time and Space Efficient Bp-Based Folding -- 2.2 Time and Space Efficient Calculation of the MFE -- 2.3 The Difficulty of MFE Fold Reconstruction Compared to Bp-Based Folding -- 3 MFE Folding with Fold Reconstruction -- 3.1 Adding Trace Arrows -- 3.2 Avoiding Trace Arrows -- 3.3 Garbage Collecting Trace Arrows -- 3.4 Algorithm Summary -- 3.5 Complexity -- 4 Empirical Results -- 5 Conclusion and Future Work -- References -- A Sparsified Four-Russian Algorithm for RNA Folding -- 1 Introduction -- 2 Problem Definition and Basic Algorithm -- 2.1 Extending the Notation and Moving Towards a Vector by Vector Computation of -- 3 Sparsification of the SSF Algorithm -- 3.1 OCT and STEP Sub-instances of Sequence. 4 On-demand Four Russians Speedup. |
| Record Nr. | UNINA-9910484594803321 |
| Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Alzheimer’s Disease II / / edited by Michael S. Wolfe
| Alzheimer’s Disease II / / edited by Michael S. Wolfe |
| Edizione | [1st ed. 2017.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 |
| Descrizione fisica | 1 online resource (VII, 202 p. 90 illus., 33 illus. in color.) |
| Disciplina | 616.831 |
| Collana | Topics in Medicinal Chemistry |
| Soggetto topico |
Medicinal chemistry
Pharmaceutical technology Proteins Neurosciences Medicinal Chemistry Pharmaceutical Sciences/Technology Receptors |
| ISBN | 3-319-59460-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Targets and Strategies Toward the Development of Alzheimer Therapeutics -- The Design, Development, and Evaluation of BACE1 Inhibitors for the Treatment of Alzheimer’s Disease -- γ-Secretase Modulators as Aβ42-Lowering Pharmacological Agents to Treat Alzheimer’s Disease -- Inhibitors of Tau-Phosphorylating Kinases -- Microtubule-Stabilizing Agents for Alzheimer’s and Other Tauopathies -- PET Imaging Agents for Alzheimer’s Disease. |
| Record Nr. | UNINA-9910254160003321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Proteins
(213)
- Protein Science (134)
- Protein Structure (60)
- Protein-Ligand Interactions (32)
- Biological and Medical Physics, Biophysics (30)