Autore	Singh Vijai
Edizione	[2nd ed. 2024.]
Pubbl/distr/stampa	Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2024
Descrizione fisica	1 online resource (364 pages)
Disciplina	570.285
Altri autori (Persone)	KumarAjay
Soggetto topico	Bioinformatics Proteins Genomics Chemoinformatics Artificial intelligence Cheminformatics Artificial Intelligence
ISBN	981-9984-01-7
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Ch 1 Revolutionizing Genomics: Exploring the Potential of Next-Generation Sequencing -- Ch 2 Advances in structural bioinformatics -- Ch 3 Functional genomics and network biology -- Ch 4 Bioinformatics in gene and genome analysis -- Ch 5 Role of bioinformatics in non-coding RNA analysis -- Ch 6 Next generation sequencing in healthcare -- Ch 7 Genome scale modelling for novel drug targets -- Ch 8 Role of bioinformatics in genome editing -- Ch 9 Bioinformatics in pathway identification, design, modelling and simulation -- Ch 10 Integration of Metabolomics and Flux Balance Analysis: Applications and Challenges -- Ch 11 Bioinformatics in drug discovery -- Ch 12 Use of bioinformatics in high throughput drug screening -- Ch 13 Bioinformatics in precision medicine and healthcare -- Ch 14 Role of bioinformatics in data mining and big data analysis -- Ch 15 Unveiling the Dynamic Role of Bioinformatics in Automation for Efficient and Accurate Data Processing and Interpretation -- Ch 16 Artificial intelligence and machine learning in bioinformatics -- Ch 17 Bioinformatics in preventive medicine and epidemiology.
Record Nr.	UNINA-9910831020603321

Autore	Brooks Charles L
Pubbl/distr/stampa	Hoboken, : Wiley, 2009
Descrizione fisica	1 online resource (278 p.)
Disciplina	541.305 541/.08 547.75
Altri autori (Persone)	KarplusMartin PettittB. Montgomery
Collana	Advances in chemical physics
Soggetto topico	Chemistry, Physical and theoretical -- Periodicals Chemistry, Physical and theoretical Physics -- Periodicals Physics Proteins
Soggetto genere / forma	Electronic books.
ISBN	0-470-14120-4
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	PROTEINS: A THEORETICAL PERSPECTIVE OF DYNAMICS, STRUCTURE, AND THERMODYNAMICS; CONTENTS; I. INTRODUCTION; II. PROTEIN STRUCTURE AND DYNAMICS-AN OVERVIEW; III. POTENTIAL FUNCTIONS; IV. DYNAMICAL SIMULATION METHODS; V. THERMODYNAMIC METHODS; VI. ATOM AND SIDECHAIN MOTIONS; VII. RIGID-BODY MOTIONS; VIII. LARGER-SCALE MOTIONS; IX. SOLVENT INFLUENCE ON PROTEIN DYNAMICS; X. THERMODYNAMIC ASPECTS; XI. EXPERIMENTAL COMPARISONS AND ANALYSIS; XII. CONCLUDING DISCUSSION; REFERENCES; INDEX
Record Nr.	UNINA-9910144273703321

Pubbl/distr/stampa	Sharjah : , : Bentham Science Publishers, , 2013
Descrizione fisica	1 online resource (911 p.)
Altri autori (Persone)	DunnBen M
Collana	Advances in Protein and Peptide Sciences
Soggetto topico	Proteins Peptides
Soggetto genere / forma	Electronic books.
ISBN	1-60805-487-X
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Cover; Title; EUL; Contents; Foreword; Preface; List of Contributors; Section I; Chapter 01; Chapter 03; Chapter 04; Section II; Chapter 05; Chapter 06; Chapter 07; Section III; Chapter 08; Chapter 09; Chapter 10; Chapter 11; Chapter 12; Section IV; Chapter 13; Chapter 14; Chapter 15; Chapter 16; Chapter 17; Chapter 18; Chapter 19; Index
Record Nr.	UNINA-9910463009803321

Edizione	[1st ed.]
Pubbl/distr/stampa	Sharjah : , : Bentham Science Publishers, , 2013
Descrizione fisica	1 online resource (911 p.)
Disciplina	615.3
Altri autori (Persone)	DunnBen M
Collana	Advances in Protein and Peptide Sciences
Soggetto topico	Proteins Peptides
ISBN	1-60805-487-X
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Cover; Title; EUL; Contents; Foreword; Preface; List of Contributors; Section I; Chapter 01; Chapter 03; Chapter 04; Section II; Chapter 05; Chapter 06; Chapter 07; Section III; Chapter 08; Chapter 09; Chapter 10; Chapter 11; Chapter 12; Section IV; Chapter 13; Chapter 14; Chapter 15; Chapter 16; Chapter 17; Chapter 18; Chapter 19; Index
Record Nr.	UNINA-9910820288303321

Pubbl/distr/stampa	Waltham, Massachusetts ; ; San Diego, California : , : Academic Press, , 2014
Descrizione fisica	1 online resource (174 p.)
Disciplina	572.7
Soggetto topico	Proteins
Soggetto genere / forma	Electronic books.
ISBN	0-12-800012-0 0-12-800788-5
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Front Cover; Metal-Containing Enzymes; Copyright; Contents; Contributors; Preface; Chapter 1: Type-3 Copper Proteins: Recent Advances on Polyphenol Oxidases; 1. Introduction; 2. Primary Structure and Molecular Weights of PPOs; 2.1. General sequence structure; 2.2. Core domain, C-terminal domain, and its proteolytic cleavage site; 2.3. Conserved amino acid motifs in the core domain; 2.4. Conserved amino acid motifs in the C-terminal domain; 2.5. Transit peptide and location of PPOs; 2.6. Sequence homologies within PPOs; 2.7. In vitro activation of PPOs; 2.8. In vivo activation of PPOs 2.9. Mutants of PPOs2.9.1. Mutants of plant PPOs; 2.9.2. Mutants of fungal PPOs; 2.9.3. Mutants of bacterial PPOs; 3. Oxo Complex; 3.1. Oxo complex investigated by UV/vis absorption spectroscopy; 3.2. Oxo complex investigated by CD spectroscopy; 3.3. Oxo complex investigated by resonance Raman spectroscopy; 3.4. Oxo complex of catechol oxidase; 3.5. Oxo complex of tyrosinase; 3.6. Oxo complex of aureusidin synthase; 3.7. Oxo complex of hemocyanin; 4. X-ray Crystallographic Structural Data of PPOs and Hemocyanins; 4.1. Published structures in the protein data bank 4.1.1. Published structures in the PDB of hemocyanins4.1.2. Published structures in the PDB of catechol oxidases; 4.1.3. Published structures in the PDB of tyrosinases; 4.2. Structural differences of tyrosinases and catechol oxidases; 5. Conclusions and Outlook; Acknowledgments; References; Chapter 2: Biophysical Studies of Matrix Metalloproteinase/Triple-Helix Complexes; 1. MMPs and Collagen Hydrolysis; 2. Structures of Full-Length, Collagenolytic MMPs in Solution and in the Solid State; 3. Structural Evaluation of MMP Interactions with Collagen; 4. Mechanism of Collagenolysis 5. Heterogeneity in MMP StructuresAcknowledgment; References; Chapter 3: Catalytic Mechanisms of Metallohydrolases Containing Two Metal Ions; 1. Introduction; 2. Metallo-β-Lactamases, Major Culprits in the Emergence of Antibiotic Resistance; 3. Methionine Aminopeptidase, a Target for Novel Anticancer Drugs; 4. Glycerophosphodiesterase, a Very Promiscuous Potential Bioremediator; 5. PAP, an Alternative Target to Treat Osteoporosis; 6. Conclusions and Outlook: Agmatinase, an Emerging Target for Biotechnological Applications; Acknowledgments; References Chapter 4: Applications of Quantum Mechanical/Molecular Mechanical Methods to the Chemical Insertion Step of DNA and RNA ...1. Introduction; 2. Methods for Describing Reactive Pathways; 3. DNA Polymerase β; 3.1. Abashkin, Erickson, and Burt (2001): A cluster QM calculation at steps along a proposed reaction path; 3.2. Rittenhouse, Apostoluk, Miller, and Straatsma (2003): A cluster QM calculation on the prechemistry complex of Pol β; 3.3. Sawaya et al., 1997); 3.4. Batra et al., 2006); 3.5. Batra et al., 2008) 3.6. Batra et al. (2013): A QM/MM study based on the X-ray crystal structure of the Pol β variant D256E
Record Nr.	UNINA-9910465130003321