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Applying genomic and proteomic microarray technology in drug discovery / / Robert S. Matson
| Applying genomic and proteomic microarray technology in drug discovery / / Robert S. Matson |
| Autore | Matson Robert S. |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Boca Raton : , : Taylor & Francis, , 2013 |
| Descrizione fisica | 1 online resource (313 p.) |
| Disciplina | 615.1/9 |
| Soggetto topico |
High throughput screening (Drug development)
DNA microarrays Protein microarrays Pharmacogenomics Proteomics |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-429-10783-8
1-4398-5564-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Omics & microarrays revisited -- The commercial microarray -- Supports & surface chemistries -- The arraying process -- Gene expression microarray-based applications -- Protein microarray applications -- Multiplex assays. |
| Record Nr. | UNINA-9910462913103321 |
Matson Robert S.
|
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| Boca Raton : , : Taylor & Francis, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Applying genomic and proteomic microarray technology in drug discovery / / Robert S. Matson
| Applying genomic and proteomic microarray technology in drug discovery / / Robert S. Matson |
| Autore | Matson Robert S. |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Boca Raton : , : Taylor & Francis, , 2013 |
| Descrizione fisica | 1 online resource (313 p.) |
| Disciplina | 615.1/9 |
| Soggetto topico |
High throughput screening (Drug development)
DNA microarrays Protein microarrays Pharmacogenomics Proteomics |
| ISBN |
0-429-10783-8
1-4398-5564-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Omics & microarrays revisited -- The commercial microarray -- Supports & surface chemistries -- The arraying process -- Gene expression microarray-based applications -- Protein microarray applications -- Multiplex assays. |
| Record Nr. | UNINA-9910786247103321 |
|
Matson Robert S.
|
||
| Boca Raton : , : Taylor & Francis, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Applying genomic and proteomic microarray technology in drug discovery / / Robert S. Matson
| Applying genomic and proteomic microarray technology in drug discovery / / Robert S. Matson |
| Autore | Matson Robert S. |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Boca Raton : , : Taylor & Francis, , 2013 |
| Descrizione fisica | 1 online resource (313 p.) |
| Disciplina | 615.1/9 |
| Soggetto topico |
High throughput screening (Drug development)
DNA microarrays Protein microarrays Pharmacogenomics Proteomics |
| ISBN |
0-429-10783-8
1-4398-5564-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Omics & microarrays revisited -- The commercial microarray -- Supports & surface chemistries -- The arraying process -- Gene expression microarray-based applications -- Protein microarray applications -- Multiplex assays. |
| Record Nr. | UNINA-9910800038603321 |
|
Matson Robert S.
|
||
| Boca Raton : , : Taylor & Francis, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Applying genomic and proteomic microarray technology in drug discovery / / Robert S. Matson
| Applying genomic and proteomic microarray technology in drug discovery / / Robert S. Matson |
| Autore | Matson Robert S. |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Boca Raton : , : Taylor & Francis, , 2013 |
| Descrizione fisica | 1 online resource (313 p.) |
| Disciplina | 615.1/9 |
| Soggetto topico |
High throughput screening (Drug development)
DNA microarrays Protein microarrays Pharmacogenomics Proteomics |
| ISBN |
0-429-10783-8
1-4398-5564-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Omics & microarrays revisited -- The commercial microarray -- Supports & surface chemistries -- The arraying process -- Gene expression microarray-based applications -- Protein microarray applications -- Multiplex assays. |
| Record Nr. | UNINA-9910822584903321 |
|
Matson Robert S.
|
||
| Boca Raton : , : Taylor & Francis, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
BioTech
| BioTech |
| Pubbl/distr/stampa | Basel, Switzerland : , : MDPI AG, , [2020]- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
DNA microarrays
Protein microarrays Gene expression Biotechnology Computational Biology |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 2673-6284 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Bio Tech |
| Record Nr. | UNISA-996405547503316 |
| Basel, Switzerland : , : MDPI AG, , [2020]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
BioTech
| BioTech |
| Pubbl/distr/stampa | Basel, Switzerland : , : MDPI AG, , [2020]- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
DNA microarrays
Protein microarrays Gene expression Biotechnology Computational Biology |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 2673-6284 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Bio Tech |
| Record Nr. | UNINA-9910440652603321 |
| Basel, Switzerland : , : MDPI AG, , [2020]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Isolation of RNA from peripheral blood cells [[electronic resource] ] : a validation study for molecular diagnostics by microarray and kinetic RT-PCR assays -- application in aerospace medicine / / Nicole T. Vu ... [and others]
| Isolation of RNA from peripheral blood cells [[electronic resource] ] : a validation study for molecular diagnostics by microarray and kinetic RT-PCR assays -- application in aerospace medicine / / Nicole T. Vu ... [and others] |
| Pubbl/distr/stampa | Washington, DC : , : U.S. Dept. of Transportation, Federal Aviation Administration, Office of Aerospace Medicine, , [2004] |
| Altri autori (Persone) | VuNicole T |
| Soggetto topico |
RNA - Purification
Molecular diagnosis Protein microarrays Polymerase chain reaction Reverse transcriptase Aviation medicine - Technological innovations - United States |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Isolation of RNA from peripheral blood cells |
| Record Nr. | UNINA-9910693276203321 |
| Washington, DC : , : U.S. Dept. of Transportation, Federal Aviation Administration, Office of Aerospace Medicine, , [2004] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Microarrays
| Microarrays |
| Pubbl/distr/stampa | Basel, Switzerland : , : MDPI AG, , [2012]- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
DNA microarrays
Protein microarrays Gene expression Microarray Analysis - methods Microarray Analysis - instrumentation |
| Soggetto genere / forma |
Fulltext
Internet Resources. Periodicals. Periodical |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996210779703316 |
| Basel, Switzerland : , : MDPI AG, , [2012]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Microarrays
| Microarrays |
| Pubbl/distr/stampa | Basel, Switzerland : , : MDPI AG, , [2012]- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
DNA microarrays
Protein microarrays Gene expression Microarray Analysis - methods Microarray Analysis - instrumentation |
| Soggetto genere / forma |
Fulltext
Internet Resources. Periodicals. Periodical |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910141390103321 |
| Basel, Switzerland : , : MDPI AG, , [2012]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Protein microarray technology [[electronic resource] /] / edited by Dev Kambhampati
| Protein microarray technology [[electronic resource] /] / edited by Dev Kambhampati |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2004 |
| Descrizione fisica | 1 online resource (277 p.) |
| Disciplina |
572.636
572.8636 |
| Altri autori (Persone) | KambhampatiDev |
| Soggetto topico |
Protein microarrays
Physiology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-52030-2
9786610520305 3-527-60521-5 3-527-60155-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Protein Microarray Technology; Preface; Contents; List of Authors; Colour Plates; 1 Protein Microarrays: From Fundamental Screening to Clinical Diagnostics; 1.1 Potential Need for Protein Microarrays; 1.1.1 Protein Therapeutics; 1.1.2 Clinical Diagnostics; 1.1.3 National Security; 1.2 Current Applications of Protein Microarrays; 1.3 Problems and Challenges; 1.3.1 Sample Preparation and Handling (Probe and Target); 1.3.2 Microarray Platform; 1.3.3 Detection Technologies; 1.3.4 Data Analysis; 1.4 Potential Solutions: Enabling Technologies and Advancements; References
2 Protein Microarray Surface Chemistry and Coupling Schemes2.1 Introduction; 2.1.1 Background and Current State of Biomolecule Libraries; 2.2 Microarray Based of Class Substrates; 2.2.1 Surface Modification; 2.2.2 Current State of Glass-Based Protein Microarrays; 2.3 Microarrays based of Gold Substrates; 2.3.1 Surface Modifications; 2.3.2 Current State of Gold-based Protein Microarrays; 2.4 Microarrays based on Polymer Substrates; 2.4.1 Surface Modifications; 2.5 Special Formats: Microfluidic Devices and Integrated Semiconductor Chips; 2.6 Chemical Immobilization Techniques for Proteins 2.6.1 Covalent Chemical Coupling2.6.2 Photochemical Cross-Coupling; 2.6.3 Tagged Proteins; 2.6.4 Site-Specific Immobilization of Antibodies; 2.7 Conclusions; References; 3 Optimization of a Protein Microarray Platform Based on a Small-molecule Chemical Affinity System; 3.1 Introduction; 3.2 Experimental; 3.2.1 Reagents and Materials; 3.2.2 Comparison of the Intrinsic Fluorescence and Non-Specific Protein Binding of 2-D and 3-D SHA-Coated Glass Slides; 3.2.2.1 Preparation of 2D SHA-Coated Glass Surfaces; 3.2.2.2 Preparation of PDBA-modified Bovine Serum Albumin 3.2.2.3 Preparation of PDBA-modified Human IgG3.2.2.4 Printing and Development of 2-D and 3-D SHA-coated Glass Slides; 3.2.2.5 Comparison of the Intrinsic Flurescence of Unmodified, 2-D and 3-D SHA-coated Glass Slides; 3.2.2.6 Determination of the Non-Specific Protein Binding of 2-D and 3-D SHA-coated Glass Slides; 3.2.3 Immunoassay Using a 3-D SHA-coated Glass Slide; 3.2.3.1 Preparation of PDBA-Cy3-modified Bovine Serum Albumin, PDBA-Human IgG, PDBA-Goat anti Human IgG; 3.2.3.2 Printing the Array and Analyzing the Data 3.2.4 Stability of the PDBA-Protein Conjugates Immobilized on 3-D-SHA-coated Glass Slides3.2.4.1 Preparation of PDBA-modified Goat Anti-rabbit Fc-specific IgG, PDBA-modified Goat Anti-rabbit Fc-specific F(ab)(2), PDBA-modified Goat Anti-human F(ab)(2), and PDBA-modified Goat Anti-mouse Fcγ-specific F(ab)(2); 3.2.4.2 Printing and Reading the Array; 3.3 Results and Discussion; 3.3.1 Comparison of the Intrinsic Fluorescence and Non-specific Protein Binding of 2-D and 3-D SHA-coated Glass Slides; 3.3.2 Immunoassay on a 3-D SHA-coated Slide 3.3.3 Stability of PDBA-Protein Conjugates Immobilized on 3-D SHA-coated Glass Slides |
| Record Nr. | UNINA-9910146239103321 |
| Weinheim, : Wiley-VCH, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
