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Advances in Protein Kinases / / edited by Gabriela Da Silva Xavier
| Advances in Protein Kinases / / edited by Gabriela Da Silva Xavier |
| Pubbl/distr/stampa | London, England : , : IntechOpen, , 2012 |
| Descrizione fisica | 1 online resource (388 pages) : illustrations |
| Disciplina | 572.62 |
| Soggetto topico | Protein kinases |
| ISBN | 953-51-5301-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910317588103321 |
| London, England : , : IntechOpen, , 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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AMPK-S6K1 signaling pathway as a target for treating hepatic insulin resistance [[electronic resource] /] / Sang Geon Kim, Il Je Cho and Hee Yeon Kay
| AMPK-S6K1 signaling pathway as a target for treating hepatic insulin resistance [[electronic resource] /] / Sang Geon Kim, Il Je Cho and Hee Yeon Kay |
| Autore | Kim Sang Geon |
| Pubbl/distr/stampa | New York, : Nova Science Publishers, c2010 |
| Descrizione fisica | 1 online resource (69 p.) |
| Disciplina | 616.3/6207 |
| Altri autori (Persone) |
ChoIl Je
KayHee Yeon |
| Collana | Hepatology research and clinical developments series |
| Soggetto topico |
Insulin resistance - Molecular aspecsts
Liver - Diseases - Molecular aspecsts Protein kinases |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-61761-457-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction: Insulin signaling in hepatocytes -- Clinical and preclinical drugs for the treatment of hepatic insulin resistance. |
| Record Nr. | UNINA-9910452412003321 |
Kim Sang Geon
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| New York, : Nova Science Publishers, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
AMPK-S6K1 signaling pathway as a target for treating hepatic insulin resistance [[electronic resource] /] / Sang Geon Kim, Il Je Cho and Hee Yeon Kay
| AMPK-S6K1 signaling pathway as a target for treating hepatic insulin resistance [[electronic resource] /] / Sang Geon Kim, Il Je Cho and Hee Yeon Kay |
| Autore | Kim Sang Geon |
| Pubbl/distr/stampa | New York, : Nova Science Publishers, c2010 |
| Descrizione fisica | 1 online resource (69 p.) |
| Disciplina | 616.3/6207 |
| Altri autori (Persone) |
ChoIl Je
KayHee Yeon |
| Collana | Hepatology research and clinical developments series |
| Soggetto topico |
Insulin resistance - Molecular aspecsts
Liver - Diseases - Molecular aspecsts Protein kinases |
| ISBN | 1-61761-457-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction: Insulin signaling in hepatocytes -- Clinical and preclinical drugs for the treatment of hepatic insulin resistance. |
| Record Nr. | UNINA-9910779634203321 |
|
Kim Sang Geon
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| New York, : Nova Science Publishers, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
AMPK-S6K1 signaling pathway as a target for treating hepatic insulin resistance [[electronic resource] /] / Sang Geon Kim, Il Je Cho and Hee Yeon Kay
| AMPK-S6K1 signaling pathway as a target for treating hepatic insulin resistance [[electronic resource] /] / Sang Geon Kim, Il Je Cho and Hee Yeon Kay |
| Autore | Kim Sang Geon |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | New York, : Nova Science Publishers, c2010 |
| Descrizione fisica | 1 online resource (69 p.) |
| Disciplina | 616.3/6207 |
| Altri autori (Persone) |
ChoIl Je
KayHee Yeon |
| Collana | Hepatology research and clinical developments series |
| Soggetto topico |
Insulin resistance - Molecular aspecsts
Liver - Diseases - Molecular aspecsts Protein kinases |
| ISBN | 1-61761-457-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction: Insulin signaling in hepatocytes -- Clinical and preclinical drugs for the treatment of hepatic insulin resistance. |
| Record Nr. | UNINA-9910824238303321 |
|
Kim Sang Geon
|
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| New York, : Nova Science Publishers, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Kinomics : approaches and applications / / edited by Heinz-Bernhard Kraatz and Sanela Martic
| Kinomics : approaches and applications / / edited by Heinz-Bernhard Kraatz and Sanela Martic |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , [2015] |
| Descrizione fisica | 1 online resource (365 p.) |
| Disciplina | 616.109283746 |
| Soggetto topico | Protein kinases |
| ISBN |
3-527-68305-4
3-527-68303-8 3-527-68304-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; List of Contributors; Preface; Part I Protein Kinases Cell Signaling; Chapter 1 Global Approaches to Understanding Protein Kinase Functions; 1.1 A Brief History of the Structure of the Human Kinome; 1.1.1 AGC Kinases; 1.1.2 The CaMK Family; 1.1.3 CMGC Family Kinases; References; 1.1.4 STE Family Kinases; 1.1.5 Tyrosine Kinases; 1.1.6 Casein Kinases; 1.1.7 Tyrosine Kinase-Like Family; 1.1.8 RGC Kinases; 1.1.9 Atypical/Other Protein Kinases; 1.2 Why Study Protein Kinases - Their Roles in Disease; 1.2.1 Neurodegenerative Disease; 1.2.2 Hallmarks of Cancer
1.3 Methodology for Assessment of Protein Kinase Functions1.3.1 Mass Spectrometry; 1.3.2 Fluorescence Resonance Energy Transfer; 1.3.3 Assessment of Kinase Functions in vitro: Genetic and Chemical; 1.3.4 Functional Assessment of Kinase Function in vivo: Animal Models; 1.3.5 CRISPR/Cas9 Genomic Recombineering; 1.4 Final Thoughts; Acknowledgments; Chapter 2 ""Genuine"" Casein Kinase (Fam20C): The Mother of the Phosphosecretome; 2.1 Introduction; 2.2 Early Detection of the pS-x-E Motif in Secreted Phosphoproteins; 2.3 CK1 and CK2 are Not Genuine Casein Kinases 2.4 Polo-Like Kinases: Newcomers in the Club of False ""Casein Kinases""2.5 Characterization of an Orphan Enzyme: The Spectacular Performance of a Peptide Substrate; 2.6 Catalytic Activity of Fam20C: Mechanistic Aspects; 2.7 A Kinase in Need of Control; 2.7.1 Constitutively Active or Inactive?; 2.7.2 A Potential Mediator of Sphingosine Signaling; 2.7.3 Fam20c as a Novel Regulator of Blood Phosphate Homeostasis; 2.7.4 Does it Make Sense to Develop Fam20C Inhibitors?; 2.8 Outlook; Funding; References; Chapter 3 Chemical Biology of Protein Kinases; 3.1 The Basis of Chemical Genetics 4.2.2 Caspase-Dependent Intrinsic Apoptosis3.2 Protein Kinase Chemical Genetics; 3.3 Applications for AS Kinases; 3.3.1 Substrate Identification: General Phosphoproteomics; 3.3.2 Substrate Identification: Refinements through the Use of AS Kinases; 3.3.3 Substrate Identification in Action: What Have We Learned?; 3.3.4 Use of Specific Inhibitors for AS Kinases; 3.4 Current Challenges; 3.5 Conclusions; Acknowledgments; References; Chapter 4 Protein Kinases and Caspases: Bidirectional Interactions in Apoptosis; 4.1 Introduction; 4.2 Apoptosis: Caspase-Dependent Pathways; 4.2.1 Extrinsic Apoptosis 4.3 Functional Crosstalk between Protein Kinases and Caspases4.3.1 Direct Phosphorylation of Caspases by Protein Kinases; 4.3.1.1 Initiator Caspases; 4.3.1.2 Executioner Caspases; 4.3.2 Cleavage of Caspase Substrates is Positively and Negatively Regulated by Protein Kinase Phosphorylation; 4.3.3 Caspase-Mediated Degradation of Kinases and Apoptotic Progression; 4.3.3.1 Rho-Associated Coiled-Coil-Containing Protein 1 (ROCK1); 4.3.3.2 p21-Activated Protein Kinase 2 (PAK2); 4.3.3.3 Focal Adhesion Kinase (FAK); 4.3.3.4 Protein Kinase Akt; 4.3.3.5 Protein Kinase Cδ (PKCδ) 4.4 Strategies to Investigate Global Crosstalk between Protein Kinases and Caspases |
| Record Nr. | UNINA-9910131606403321 |
| Weinheim, Germany : , : Wiley-VCH, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Kinomics : approaches and applications / / edited by Heinz-Bernhard Kraatz and Sanela Martic
| Kinomics : approaches and applications / / edited by Heinz-Bernhard Kraatz and Sanela Martic |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , [2015] |
| Descrizione fisica | 1 online resource (365 p.) |
| Disciplina | 616.109283746 |
| Soggetto topico | Protein kinases |
| ISBN |
3-527-68305-4
3-527-68303-8 3-527-68304-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; List of Contributors; Preface; Part I Protein Kinases Cell Signaling; Chapter 1 Global Approaches to Understanding Protein Kinase Functions; 1.1 A Brief History of the Structure of the Human Kinome; 1.1.1 AGC Kinases; 1.1.2 The CaMK Family; 1.1.3 CMGC Family Kinases; References; 1.1.4 STE Family Kinases; 1.1.5 Tyrosine Kinases; 1.1.6 Casein Kinases; 1.1.7 Tyrosine Kinase-Like Family; 1.1.8 RGC Kinases; 1.1.9 Atypical/Other Protein Kinases; 1.2 Why Study Protein Kinases - Their Roles in Disease; 1.2.1 Neurodegenerative Disease; 1.2.2 Hallmarks of Cancer
1.3 Methodology for Assessment of Protein Kinase Functions1.3.1 Mass Spectrometry; 1.3.2 Fluorescence Resonance Energy Transfer; 1.3.3 Assessment of Kinase Functions in vitro: Genetic and Chemical; 1.3.4 Functional Assessment of Kinase Function in vivo: Animal Models; 1.3.5 CRISPR/Cas9 Genomic Recombineering; 1.4 Final Thoughts; Acknowledgments; Chapter 2 ""Genuine"" Casein Kinase (Fam20C): The Mother of the Phosphosecretome; 2.1 Introduction; 2.2 Early Detection of the pS-x-E Motif in Secreted Phosphoproteins; 2.3 CK1 and CK2 are Not Genuine Casein Kinases 2.4 Polo-Like Kinases: Newcomers in the Club of False ""Casein Kinases""2.5 Characterization of an Orphan Enzyme: The Spectacular Performance of a Peptide Substrate; 2.6 Catalytic Activity of Fam20C: Mechanistic Aspects; 2.7 A Kinase in Need of Control; 2.7.1 Constitutively Active or Inactive?; 2.7.2 A Potential Mediator of Sphingosine Signaling; 2.7.3 Fam20c as a Novel Regulator of Blood Phosphate Homeostasis; 2.7.4 Does it Make Sense to Develop Fam20C Inhibitors?; 2.8 Outlook; Funding; References; Chapter 3 Chemical Biology of Protein Kinases; 3.1 The Basis of Chemical Genetics 4.2.2 Caspase-Dependent Intrinsic Apoptosis3.2 Protein Kinase Chemical Genetics; 3.3 Applications for AS Kinases; 3.3.1 Substrate Identification: General Phosphoproteomics; 3.3.2 Substrate Identification: Refinements through the Use of AS Kinases; 3.3.3 Substrate Identification in Action: What Have We Learned?; 3.3.4 Use of Specific Inhibitors for AS Kinases; 3.4 Current Challenges; 3.5 Conclusions; Acknowledgments; References; Chapter 4 Protein Kinases and Caspases: Bidirectional Interactions in Apoptosis; 4.1 Introduction; 4.2 Apoptosis: Caspase-Dependent Pathways; 4.2.1 Extrinsic Apoptosis 4.3 Functional Crosstalk between Protein Kinases and Caspases4.3.1 Direct Phosphorylation of Caspases by Protein Kinases; 4.3.1.1 Initiator Caspases; 4.3.1.2 Executioner Caspases; 4.3.2 Cleavage of Caspase Substrates is Positively and Negatively Regulated by Protein Kinase Phosphorylation; 4.3.3 Caspase-Mediated Degradation of Kinases and Apoptotic Progression; 4.3.3.1 Rho-Associated Coiled-Coil-Containing Protein 1 (ROCK1); 4.3.3.2 p21-Activated Protein Kinase 2 (PAK2); 4.3.3.3 Focal Adhesion Kinase (FAK); 4.3.3.4 Protein Kinase Akt; 4.3.3.5 Protein Kinase Cδ (PKCδ) 4.4 Strategies to Investigate Global Crosstalk between Protein Kinases and Caspases |
| Record Nr. | UNINA-9910830933303321 |
| Weinheim, Germany : , : Wiley-VCH, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Protein kinase-mediated decisions between life and death / / Ayse Basak Engin, Atilla Engin, editors
| Protein kinase-mediated decisions between life and death / / Ayse Basak Engin, Atilla Engin, editors |
| Edizione | [1st ed. 2021.] |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (VIII, 415 p. 30 illus., 23 illus. in color.) |
| Disciplina | 572.62 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Protein kinases
Proteomics |
| ISBN | 3-030-49844-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Protein kinase-mediated decision between life and death -- Aging, cellular senescence and protein kinases -- Oxidative stress-related endothelial cell death and protein kinases -- Signal transduction in immune cells and protein kinases -- Role of protein kinase C in immune cell activation and its implication chemical-induced immunotoxicity -- Metabolic stress and immunity -- Activation of tropomyosin-related kinase receptor B by N-acetyl-serotonin: implications for neuroprotection -- Protein kinase inhibitors in traumatic brain injury and repair -- Amyloid beta toxicity in Alzheimer’s Disease and neuronal death-associated protein kinases -- Glucolipotoxicity-related beta cell death and protein kinases -- Protein kinases and cell death in hematological disorders -- A crosstalk between dual-specific phosphatases and dual-specific protein kinases can be a potential therapeutic target for anti-cancer therapy -- Bile acid toxicity and protein kinases -- Nanoparticle toxicity: Protein kinases and cell death -- Two-component signal transduction systems in antibiotic resistance -- ERK1/2 MAP kinase, its regulation and role in cellular activities including apoptosis and cell survival. . |
| Record Nr. | UNINA-9910483204603321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Protein kinases : promising targets for anticancer drug research / / edited by Rajesh Singh
| Protein kinases : promising targets for anticancer drug research / / edited by Rajesh Singh |
| Pubbl/distr/stampa | London, England : , : IntechOpen, , [2021] |
| Descrizione fisica | 1 online resource (162 pages) |
| Disciplina | 572.62 |
| Collana | Biochemistry |
| Soggetto topico | Protein kinases |
| ISBN | 1-83880-907-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Protein Kinases |
| Record Nr. | UNINA-9910586670103321 |
| London, England : , : IntechOpen, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Protein kinases / / edited by Gabriela Da Silva Xavier
| Protein kinases / / edited by Gabriela Da Silva Xavier |
| Pubbl/distr/stampa | Rijeka, Croatia : , : InTech, , [2012] |
| Descrizione fisica | 1 online resource (vi, 484 pages) : illustrations |
| Disciplina | 572.62 |
| Soggetto topico | Protein kinases |
| ISBN | 953-51-5302-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910137691103321 |
| Rijeka, Croatia : , : InTech, , [2012] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Protein kinases as drug targets [[electronic resource] /] / edited by Bert Klebl, Gerhard Müller, and Michael Hamacher
| Protein kinases as drug targets [[electronic resource] /] / edited by Bert Klebl, Gerhard Müller, and Michael Hamacher |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Weinheim, Germany, : Wiley-VCH, 2011 |
| Descrizione fisica | 1 online resource (398 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) |
MüllerGerhard
KleblBert HamacherMichael |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Protein kinases
Drugs - Design |
| Soggetto genere / forma | Electronic books. |
| ISBN |
3-527-63349-9
1-283-28324-7 9786613283245 3-527-63347-2 3-527-63348-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. 1. Hit finding and profiling for protein kinases : assay development and screening, libraries -- pt. 2. Medicinal chemistry -- pt. 3. Application of kinase inhibitors to therapeutic indication areas. |
| Record Nr. | UNINA-9910139601103321 |
| Weinheim, Germany, : Wiley-VCH, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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