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Antifreeze Proteins Volume 1 : Environment, Systematics and Evolution / / edited by Hans Ramløv, Dennis Steven Friis
| Antifreeze Proteins Volume 1 : Environment, Systematics and Evolution / / edited by Hans Ramløv, Dennis Steven Friis |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (xiv, 313 pages) : illustrations |
| Disciplina | 572.617 |
| Soggetto topico |
Proteins
Evolutionary biology Biophysics Biological physics Protein Science Evolutionary Biology Biological and Medical Physics, Biophysics Proteïnes Biofísica Termoregulació |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-41929-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction -- Ice and its formation -- Ice formation in living organisms -- Fish antifreeze proteins -- Insect antifreeze proteins -- Plant antifreeze proteins -- Antifreeze proteins in other species -- Molecular origins and mechanisms of fish antifreeze evolution. |
| Record Nr. | UNINA-9910409687703321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antifreeze Proteins Volume 2 : Biochemistry, Molecular Biology and Applications / / edited by Hans Ramløv, Dennis Steven Friis
| Antifreeze Proteins Volume 2 : Biochemistry, Molecular Biology and Applications / / edited by Hans Ramløv, Dennis Steven Friis |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (364 pages) : illustrations |
| Disciplina | 572.6 |
| Soggetto topico |
Proteins
Biotechnology Biophysics Biological physics Protein Science Biological and Medical Physics, Biophysics Proteïnes Termoregulació Biofísica |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-41948-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Contents of volume 2 Antifreeze proteins: Biochemistry, molecular biology and applications -- Characteristics of antifreeze proteins -- Physicochemical properties of antifreeze proteins -- Structure-function of IBPs and their interactions with ice -- Interaction of antifreeze protein with water -- Thermal hysteresis -- Inhibition of recrystallization -- Other protective measures of antifreeze proteins -- Measuring antifreeze protein activity -- Antifreeze proteins in foods -- Cell, tissue and organ preservation with insect-derived antifreeze peptides -- Antifreeze proteins and gas hydrate inhibition -- Antifreeze protein-covered surfaces -- Mutational studies on antifreeze proteins -- Summary and future directions. |
| Record Nr. | UNINA-9910409687603321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Frontiers in Protein Structure, Function, and Dynamics / / edited by Dev Bukhsh Singh, Timir Tripathi
| Frontiers in Protein Structure, Function, and Dynamics / / edited by Dev Bukhsh Singh, Timir Tripathi |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (XII, 452 p. 71 illus., 54 illus. in color.) |
| Disciplina | 378.1662 |
| Soggetto topico |
Proteins
Enzymology Medical genetics Bioinformatics Protein Science Protein Structure Gene Function Proteïnes Bioinformàtica |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 981-15-5530-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chapter 1. Protein Purification, Estimation, Storage and Effect on Structure, Function and Dynamics -- Chapter 2. Experimental and Computational Methods to Determine Protein Structure and Stability -- Chapter 3. Wet-Lab Approaches to Determine Three-Dimensional Structures of Proteins -- Chapter 4. Use of Group Specific Reagents in Active Site Functional Group Elucidation I: Cys, Ser, Tyr and Trp Residues -- Chapter 5. Use of Group Specific Reagents in Active Site Functional Group Elucidation II: Asp, Glu, Arg, Lys and His residues -- Chapter 6. Protein-Protein Interactions Modeling: From Dry to Wet Lab -- Chapter 7. Thermodynamics of Protein-Ligand Binding -- Chapter 8. SynergisticEffects of Hydration Sites in Protein Stability: A Theoretical Water Thermodynamics Approach -- Chapter 9. Molecular Dynamics Simulation: Methods and Application -- Chapter 10. Protein Folding, Dynamics and Aggregation at Single Molecule Resolution -- Chapter 11. Protein Misfolding and Neurodegenerative Diseases -- Chapter 12. Management of Insulin Through Co-Solute Engineering: A Therapeutic Approach -- Chapter 13. Structural and Functional Aspects of Muscarinic Receptors in Correlation with Anticholinergic Drugs -- Chapter 14. Dopamine Β Hydroxylase: An Enzyme with Therapeutic Potential to Combat Neural and Cardiovascular Diseases -- Chapter 15. Molecular Motors: Subdomain Dynamics and Mechanochemistry -- Chapter 16. Structural and Functional Dynamics of Lysosomal Cysteine Proteases with Particular Reference to Cathepsin B and Cathepsin H -- Chapter 17. An Insight into the Importance of Ferritins in the Physiology of Mycobacterium tuberculosis: Unique Structural and Functional Properties. |
| Record Nr. | UNINA-9910416110503321 |
| Singapore : , : Springer Singapore : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Heat Shock Protein 60 in Human Diseases and Disorders / / edited by Alexzander A. A. Asea, Punit Kaur
| Heat Shock Protein 60 in Human Diseases and Disorders / / edited by Alexzander A. A. Asea, Punit Kaur |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (xi, 363 pages) : illustrations |
| Disciplina | 572.6 |
| Collana | Heat Shock Proteins |
| Soggetto topico |
Proteins
Protein Science Proteïnes |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-23154-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | SECTION I: BIOMOLECULAR ASPECTS OF HSP60 -- Chapter 1. HSP60: A Story as Long as Life on the Earth -- Chapter 2. Single-Ring Intermediates in the Catalytic Cycle of the Human Mitochondrial HSP60 -- Chapter 3. HSP60 Inhibitors and Modulators -- Chapter 4. HSP60 as Modulators of Apoptosis -- Chapter 5. Utilizing The Unique Architecture And Abilities of Hsp60 In Drug Development -- Chapter 6. Role of The Post-Translational Modifications of HSP60 In Disease -- SECTION II: HSP60 AND CANCER -- Chapter 7. Evaluation of Heat Shock Protein 60 (HSP60) Chaperonin in Oncology -- Chapter 8. Exosomal Hsp60: a Tumor Biomarker? -- Chapter 9. HSP60 in Cancer Immunity: Biological Basis, Diagnostic Potential and Therapeutic Opportunities -- Chapter 10. Hsp60 Involvement During Carcinogenesis -- SECTION III: HSP60 AND INFLAMMATORY DISEASES AND DISORDERS -- Chapter 11. Anti-Human Hsp60 Autoantibodies in Autoimmune and Inflammatory Rheumatic Diseases -- Chapter 12. Hsp60 In Inflammatory Disorders -- SECTION IV: HSP60 AND CARDIOVASCULAR DISEASES AND DISORDERS -- Chapter 13. HSP60 In Atherosclerosis - Past, Present and Future -- Chapter 14. Cardiac Myopathy In Conditional HSP60 Transgenic Mice -- SECTION V: HSP60 AND NEUROLOGICAL AND NEUROSCIENCES -- Chapter 15. Heat Shock Protein 60: An Effective Target Candidate In Neurological Diseases Treatment -- Chapter 16. Hsp60 In Modifications of Nervous System Homeostasis and Neurodegeneration -- SECTION VI: HSP60 AND SKELETAL MUSCLE DISEASES AND DISORDERS -- Chapter 17. Hsp60 in Skeletal Muscle: From Molecular Anatomy To Pathophysiology -- Chapter 18. Heat Shock Protein 60 (HSP60): Its Role in Skeletal Muscle Diseases and Novel Prospects for Therapy -- Chapter 19. Heat Shock Protein 60 Regulation of Skeletal Tissue Integrity -- SECTION VII: HSP60 IN HUMAN HEALTH -- Chapter 20. Role of HSP60 In The Steroidogenesis and Reproduction -- Chapter 21. Heat Shock Protein 60 in Skin Diseases. |
| Record Nr. | UNINA-9910349438903321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Heat Shock Protein 90 in Human Diseases and Disorders / / edited by Alexzander A. A. Asea, Punit Kaur
| Heat Shock Protein 90 in Human Diseases and Disorders / / edited by Alexzander A. A. Asea, Punit Kaur |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (XI, 607 p. 102 illus., 73 illus. in color.) |
| Disciplina | 572.6 |
| Collana | Heat Shock Proteins |
| Soggetto topico |
Proteins
Protein Science Proteïnes |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-23158-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | SECTION I: ONCOGENIC ASPECTS OF HSP90 -- Chapter 1. Regulatory Roles of HSP90-rich Extracellular Vesicles -- Chapter 2. HSP90-Based Heterocomplex as Essential Regulator for Cancer Disease -- Chapter 3. Therapeutic Potential of Heat Shock Protein 90 Inhibitors in Colorectal Cancer -- Chapter 4. Hsp90 in the Migration of Primordial Germ Cells: A Model to Study Long-Distance Cell Migration and Perhaps Cancer? -- Chapter 5. Role of Heat Shock Protein 90 in Mammary Tumorigenesis -- Chapter 6. Role of HSP90 Inhibitors in the Treatment of Cancer -- Chapter 7. p53-HSP90 Axis in Human Cancer -- Chapter 8. HSP90 and its Inhibitors for Cancer Therapy: Use of Nano-delivery System to Improve its Clinical Application -- Chapter 9. Hsp90 is a Pivotal Player in Retinal Disease and Cancer -- Chapter 10. Targeting Hsp-90 Related Disease Entities for Therapeutic Development -- Chapter 11. HSP90: A Key Player in Metal-Induced Carcinogenesis? -- Section II: Biomolecular Aspects of HSP90 -- Chapter 12. Hsp90 and its Role in Heme-Maturation of Client Proteins: Implications for Human Diseases -- Chapter 13. Moonlighting Functions of Heat Shock Protein 90 -- Chapter 14. Hsp90 as a Member of Dicarboxylate Clamp TPR Protein Interaction Network: Implication in Human Diseases and Prospect as a Drug Target -- Chapter 15. ‘Complex World’ of Hsp90 Co-chaperone R2TP -- Chapter 16. Functions of SGT1, a Co-chaperone -- Chapter 17. Sti1/Hop Plays a Pivotal Role in Hsp90 Regulation beyond Bridging Hsp70 -- Section III: HSP90 in Natural Products Development.-Chapter 18. Hsp90: A Target for Susceptibilities and Substitutions in Biotechnological and Medicinal Application -- Chapter 19. Screening Technique for Heat Shock Protein 90 Inhibitors from Natural Products -- Chapter 20. Therapeutic Effects and Related Molecular Mechanisms of Celastrol, a Triterpenoid Natural Compound and Novel HSP90 Inhibitor Extracted from Plants of the Celastraceae Family -- Section IV: Clinical Aspects of HSP90 -- Chapter 21. Hsp90 Chaperone in Disease -- Chapter 22. Theranostic Implications of Heat Shock Proteins in Idiopathic Pulmonary Fibrosis -- Chapter 23. Heat Shock Protein 90 and Reproduction in Female Animals: Ovary, Oocyte and Early Embryo -- Chapter 24. Heat Shock Protein 90 in Severe Trauma -- Chapter 25. HSP90 - Is there an Unknown Role in Pain Neurobiology -- Chapter 26. Heat Shock Protein 90 in Kidney Stone Disease -- Chapter 27. HSP90 et al. - Chaperome and Proteostasis Deregulation in Human Disease. |
| Record Nr. | UNINA-9910373921403321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Heat shock proteins in human diseases / / Alexzander A. A. Asea and Punit Kaur (editors)
| Heat shock proteins in human diseases / / Alexzander A. A. Asea and Punit Kaur (editors) |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (301 pages) : illustrations |
| Disciplina | 572.6 |
| Collana | Heat Shock Proteins |
| Soggetto topico |
Heat shock proteins - Physiological effect
Proteïnes Neuroimmunologia Malalties |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-62289-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Contents -- About the Editors -- Inter-Relationship Between the Inflammation and Heat Shock Protein in Cancer Development: A Possible Target for Diagnosis and ... -- 1 Introduction -- 2 Cancer, Inflammation and HSP -- 2.1 Role of Inflammation in Cancer Development -- 2.2 Role of Heat Shock Proteins (HSP) in Cancer Development -- 2.3 Relationship Between HSP and Inflammation in Cancer Development -- 3 Role of the Immune System and HSP in Cancer Diagnosis and Prevention -- 3.1 Ingenious Tumour Immune Surveillance Mechanism to Prevent Cancer -- 3.2 HSP as a Biomarker for Cancer Diagnosis -- 3.3 Targeting the HSP-Inflammation Cooperative System as a Target for Cancer Diagnosis Therapeutics -- 3.4 HSP Based Cancer Immunotherapy -- 3.4.1 Vaccines Based on HSP -- 3.4.2 Immune Responses Stimulation Using HSP as an Antigen -- 3.4.3 The Application of HSP as an Adjuvant for the Immune System Stimulation -- 4 Conclusions -- References -- Chaperonin Hsp60 and Cancer Therapies -- 1 Introduction -- 2 Human Hsp60 and Its Bacterial Orthologues -- 2.1 Hsp60 vs. GroEL -- 2.2 Hsp60 and Autoimmune Diseases -- 3 Hsp60 in Carcinogenesis -- 3.1 Chaperonopathy by Mistake -- 3.2 Hsp60 in Cancer -- 4 Hsp60 in Cancer Management -- 4.1 Exosomes: Definition and Biogenesis -- 4.2 Exosomes in Disease: Cancer -- 4.3 Exosomal Hsp60 in Tumorigenesis -- 5 Hsp60 in Cancer Therapy -- 5.1 Hsp and the Immune System -- 5.2 Hsp60-Associated Vaccines in Tumors -- 5.3 Exosomal Hsp60 for Tumor Therapy -- 6 Conclusions -- References -- Combined Thermotherapy and Heat Shock Protein Modulation for Tumor Treatment -- 1 Introduction -- 1.1 Heat Shock Proteins in Cancer Cells -- 1.1.1 Intracellular HSP -- 1.1.2 Extracellular HSP in Cancer -- 1.2 Heat Shock Protein Modulation as a Target for Cancer Therapy -- 1.2.1 Targeting Hsp90 -- 1.2.2 Targeting Hsp70.
1.2.3 Targeting Hsp60 in Cancer -- 1.2.4 Targeting Hsp27 in Cancer -- 1.3 Targeted Cancer Thermotherapy -- 1.3.1 Nanoparticles in Cancer Therapy -- 1.3.2 SPIONs -- 1.3.3 Synthesis Approaches -- 1.3.4 Chemical Synthesis: Co-precipitation -- 1.3.5 SPIONs Enhancement: Surface Functionalization -- 1.3.6 Targeting -- 1.3.7 Magnetic Field-Induced Hyperthermia -- 1.4 Combined HSP Targeting with Hyperthermia -- 2 Conclusions -- References -- Small Molecule Inhibitors Targeting Heat Shock Response Pathways: Lessons from Clinical and Preclinical Studies in Cancer Ther... -- 1 Introduction -- 2 HSR Inhibitors Currently in Human Clinical Studies (Table 1 and Fig. 2) -- 2.1 Quercetin -- 2.2 QC12 (Analog Prodrug of Quercetin) -- 2.3 Triptolide -- 2.4 Minnelide (Analog Prodrug of Triptolide) -- 3 HSR Inhibitors Currently in Preclinical Animal Studies (Table 2 and Fig. 3) -- 3.1 PW3405 -- 3.2 Cantharidin -- 3.3 KNK437 -- 3.4 KRIBB11 -- 3.5 Fisetin -- 3.6 Racoglamide A -- 3.7 CCT251236 -- 4 HSR Inhibitors in Early Preclinical Studies (Cancer Cell Lines, Table 3 and Fig. 4) -- 5 Lessons Learned from Preclinical and Clinical Studies -- 5.1 Improvement of Therapeutic Window by Prodrug Design and Nanoparticle Packaging -- 5.2 Combined Application with Chemotherapy Drugs or Drugs against a Different Cancer Target -- 5.3 Target Validation and Use of RNA Aptamer -- 5.4 HSF1 as a Potential Biomarker for Clinical Trial Design and Prognosis Prediction -- 6 Conclusions -- References -- Multifaceted Roles of Heat Shock Factor 1 (HSF 1) in Cancer -- 1 Introduction -- 2 HSF1 Becomes Constitutively Activated Within Cancer Cells -- 2.1 Activation of HSF1 by the Oncogenic RAS Signaling Pathway -- 2.2 Activation of HSF1 by Other Oncogenic Signaling Pathways -- 2.3 Inactivation of HSF1 by Metabolic Stress Signaling -- 2.4 Other Signaling Pathways Suppress HSF1 Through Phosphorylation. 3 HSF1 Enables Oncogenesis Through Multifaceted Mechanisms -- 3.1 Guarding Proteomic Stability in Cancer -- 3.2 Preventing Cell Senescence and Promoting Survival -- 3.3 Contributing to Genomic Instability and Alleviating Genotoxic Stress -- 4 Enhancing Tumor Cell Invasion and Metastasis -- 4.1 Augmenting Critical Oncogenic Signaling Pathways -- 4.2 Reprogramming Cancer Metabolism -- 4.3 Modulating Tumor Immune Evasion -- 4.4 Promoting Oncogenic Growth Non-cell-autonomously -- 5 HSF1 Is a Potential Therapeutic Target and Prognostic Marker -- 6 Conclusions -- References -- Exploring the Role of Heat Shock Proteins in the Development of Gastric Cancer -- 1 Introduction -- 2 Heat Shock Proteins -- 3 Mode of Action -- 4 HSP27 -- 5 HSP40 -- 6 HSP60 -- 7 HSP70 -- 8 HSP90 -- 9 Differential Expression of Hsp in Gastric Cancer -- 10 HSP70 -- 11 HSP40 -- 12 HSP60 -- 13 Hsp27 -- 14 HSP90 -- 15 Diagnostic and Prognostic Applications of HSP in Gastric Cancer -- 16 HSP70 in H. pylori and EBV Positive Gastric Cancer -- 17 Genetic Polymorphism of HSP70 in Gastric Cancer -- 18 Inhibitors of HSP -- 19 HSP70 Based Vaccines -- 20 Conclusions -- References -- Heat Shock Proteins in Atrial Fibrillation -- 1 Introduction -- 2 HSP and Electrical Remodeling in AF -- 3 HSP and Structural Remodeling in AF -- 4 HSP and Inflammatory Reactions in AF -- 5 HSP and Oxidative Stress in AF -- 6 Clinical Application of HSP -- 7 Conclusions -- References -- Threading Microarrays into Novel Applications -- 1 Introduction -- 1.1 HSP90 as a Stress Marker -- 1.2 HSP90-Oriented Screening of Compound Libraries by the Use of Protein Microarrays (PMA) -- 1.3 Novel Applications by Protein Microarrays (PMA) -- 1.3.1 Quantum Dots as a Sensor for Biomarker -- Studying Mutational Effects by PMA -- 2 Conclusions -- References. Regulation of Kaposi´s Sarcoma-Associated Herpesvirus Biology by Host Molecular Chaperones -- 1 Introduction -- 1.1 KSHV Lifecycle and Biology -- 1.2 KSHV Structure -- 1.3 KSHV Associated Malignancies -- 1.4 KSHV, Protein Folding and Molecular Chaperones -- 1.5 KSHV and Hsp90 -- 1.6 Hsp70 and KSHV -- 1.7 Endoplasmic Reticulum Chaperones and KSHV -- 1.8 KSHV and Nucleophosmin -- 1.9 Putative Candidate KSHV Chaperone Clients Inferred from Proteomics Datasets -- 2 Conclusions -- References -- Role of Heat Shock Factors in Diseases and Immunity -- 1 Introduction -- 1.1 Heat Shock Factors - Functions, Characteristics, Organization and Role in Diseases -- 1.1.1 Heat Shock Response and Importance of HSF -- 1.1.2 Organization and Regulation of HSF -- 1.1.3 PTMs and HSF -- 1.1.4 Importance of Small Molecules in HSF Activation -- 1.1.5 Relationship Between HSF, Diseases and Immunity -- HSF and Cancer -- HSF and Neurodegenerative Diseases -- HSF and Bacterial Infections -- 1.1.6 HSF and Its Turnover Mechanism -- 2 Conclusions -- References -- Heat Shock Proteins and Pain -- 1 Introduction -- 1.1 Inflammation and Pain -- 1.1.1 Pain Signaling -- 1.1.2 Inflammation and Pain -- 1.2 Heat Shock Proteins and Pain -- 1.2.1 Small Heat Shock Proteins(sHsp) -- 1.2.2 Heat Shock Protein 60 (Hsp60) -- 1.2.3 Heat Shock Protein 70 (Hsp70) -- 1.2.4 Heat Shock Protein 90 (Hsp90) -- 1.3 Heat Shock Proteins and Pain Management -- 1.3.1 sHsp -- 1.3.2 Hsp70 -- 1.3.3 Hsp90 -- 2 Conclusions -- References -- HSF1 Regulates Cellular Senescence: Role of the DHRS2-MDM2-p53 Pathway -- 1 Introduction -- 1.1 Cellular Senescence -- 1.2 Acute Depletion of HSF1 Induces Cellular Senescence -- 1.3 Role of HDIS in Tumorigenesis -- 1.3.1 The DHRS2-MDM2-p53 Pathway -- 1.4 Role of HDIS in Age-Related Pathologies -- 2 Conclusions -- References. Huntingtin Yeast Two-Hybrid Protein K (HYPK): An Intrinsically Unstructured Heat Shock Inducible Protein with Diverse Cellular... -- 1 Introduction -- 1.1 Regulation of Heat Shock Proteins by HSF1 -- 1.2 Functions of Heat Shock Proteins -- 1.3 Characteristics of Intrinsically Unstructured/Disordered Protein (IUP/IDP) -- 1.4 Huntingtin Yeast Two-Hybrid Protein K (HYPK) Is an Intrinsically Unstructured/Disordered Protein (IUP/IDP) -- 1.5 In Vitro and In Vivo Chaperone Activity of HYPK -- 1.6 HYPK Binds with Newly Synthesized Peptides/Proteins -- 1.7 HYPK Interacting Proteins -- 1.8 Chaperones Are in Hub of Protein-Protein Interaction Network -- 1.9 HYPK Is Associated with Aggregate Prone Proteins -- 1.10 Thermal Stress, Hypoxia and Proteasome Inhibitor MG132 Enhance Expression of HYPK in Cultured Cells -- 1.11 HSF1 Binds to the Promoter Sequence of HYPK and Regulates the Expression -- 1.12 HYPK Negatively Regulates Heat Shock Response -- 1.13 HSF1 Also Regulate HYPK Conjoined SERF2 Gene -- 1.14 Functions of HYPK -- 1.15 Does HYPK Modify Expression of Other Genes? -- 1.16 Does HYPK Play Any Role Human Disease? -- 2 Conclusions -- References -- Roles of HSP on Antigen Presentation -- 1 Introduction -- 1.1 Mechanisms of Antigen Presentation by Dendritic Cells -- 1.2 Roles of HSP in Antigen Presentation by MHC-I -- 1.3 Roles of HSP in Antigen Presentation by MHC-II -- 2 Conclusions -- References -- Heat Shock Proteins Mediate Anastasis and Plasticity of Thermotolerant Cells -- 1 Introduction -- 2 Apoptosis -- 2.1 The Role of Mitochondria in Apoptosis -- 2.2 The Role of Death Receptors in Apoptosis -- 3 Thermotolernce and Anastasis -- 4 Role of HSP in Anastasis -- 5 Conclusions and Perspectives -- References -- Index. |
| Record Nr. | UNINA-9910484696803321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Heat Shock Proteins in Neuroscience / / edited by Alexzander A. A. Asea, Punit Kaur
| Heat Shock Proteins in Neuroscience / / edited by Alexzander A. A. Asea, Punit Kaur |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (ix, 307 pages) : illustrations |
| Disciplina | 572.6 |
| Collana | Heat Shock Proteins |
| Soggetto topico |
Proteïnes
Neurociències Protein Science |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-24285-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Section I: Neurological Aspects of HSP -- Chapter 1. Hsp60 Friend and Foe of the Nervous System -- Chapter 2. Role of Heat Shock Proteins in Brain Tumors -- Chapter 3. Body Temperature Regulation Determines Immune Reactions and Species Longevity -- Chapter 4. Interaction between Heat Shock Proteins and Components of the Plasminogen Activator System in the Central Nervous System -- Chapter 5. Role of HSP70 in Plasticity and Mem -- Chapter 6. Role of Heat Shock Proteins (HSP) in Neuroprotection for Ischemic Stroke -- Section II: Aspects of HSP in Neurodegenerative Diseases and Disorders -- Chapter 7. Dysregulation of Heat Shock Proteins in Neurodegenerative Diseases: Restorative Roles of Small Molecules and Natural Compounds -- Chapter 8. Molecular Chaperones and Protein Quality Control System in the Canine Model of Brain Aging and Neurodegenerative Diseases -- Chapter 9. Role of Hsp90 Interacting Molecular Chaperones on Tau And Aß Processing in Alzheimer’s Disease -- Section III: Aspects of HSP in Multiple Sclerosis -- Chapter 10. Role of Hsp70 in Multiple Sclerosis: An Overview -- Chapter 11. Protective Role of Glial Heat Shock Proteins in Amyotrophic Lateral Sclerosis -- Section IV: Development of HSP-Based Therapies for Neurological Disorders -- Chapter 12. Therapeutic Drugs and Natural Products: The Effect of Suppressing Hsps in Brain Tumors -- Chapter 13. Can HSP Targeted Gene Therapy be a New Hope for Gliomas? -- Chapter 14. Therapeutic Aspects of Heat Shock Proteins in Glioma: Cementing the Crevasses between Bench and Bedside -- Chapter 15. Engineering Chaperones for Alzheimer’s Disease: Insights from Drosophila Models -- Chapter 16. Role of HSP in the Treatment of Internal Dıseases. |
| Record Nr. | UNINA-9910349438803321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Heat shock proteins of malaria / / edited by Addmore Shonhai, Didier Picard, and Gregory L. Blatch
| Heat shock proteins of malaria / / edited by Addmore Shonhai, Didier Picard, and Gregory L. Blatch |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (256 pages) |
| Disciplina | 614.532 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Parasitology
Protein Science Biochemistry, general Proteïnes Malària Neuroimmunologia |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-78397-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910502997103321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
HSF1 and Molecular Chaperones in Biology and Cancer / / edited by Marc Laurence Mendillo, David Pincus, Ruth Scherz-Shouval
| HSF1 and Molecular Chaperones in Biology and Cancer / / edited by Marc Laurence Mendillo, David Pincus, Ruth Scherz-Shouval |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (VIII, 182 p. 31 illus., 26 illus. in color.) |
| Disciplina | 572.633 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Human genetics
Cancer research Molecular biology Proteomics Proteins Human Genetics Cancer Research Molecular Medicine Protein Science Protein Structure Proteïnes Oncologia |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-40204-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface: Dedication to Susan Lindquist -- Part I: Structure -- Structural and Biochemical properties of Hsp40/Hsp70 chaperone system -- The TRiC/CCT chaperonin and its role in uncontrolled proliferation -- Regulation of Hsf1 and the heat shock response -- Part II: Function -- Challenging proteostasis: Role of the chaperone network to control aggregation-prone proteins in human disease -- The multifaceted role of HSF1 in tumorigenesis -- Chaperome networks – redundancy and implications for cancer treatment -- Chaperones in the tumor microenvironment -- The impact of the ER unfolded protein response on cancer initiation and progression: Therapeutic implications -- Part III: Therapies -- The right tool for the job: an overview of Hsp90 inhibitors -- Lessons learned from proteasome inhibitors, the paradigm for targeting protein homeostasis in cancer -- Reflections and outlook on targeting HSP90, HSP70 and HSF1 in cancer: A personal perspective. |
| Record Nr. | UNINA-9910409698803321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Macromolecular protein complexes IV : structure and function / / edited by J. Robin Harris, Jon Marles-Wright
| Macromolecular protein complexes IV : structure and function / / edited by J. Robin Harris, Jon Marles-Wright |
| Edizione | [1st ed. 2022.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 |
| Descrizione fisica | 1 online resource (viii, 552 pages) : illustrations |
| Disciplina | 541.2242 |
| Collana | Subcellular Biochemistry |
| Soggetto topico |
Complex compounds
Proteins Macromolecules Macromolècules Proteïnes Compostos complexos |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-031-00793-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part 1: Soluble Protein Complexes -- Chapter 1: Fatty Acid Synthase: Structure, Function, and Regulation -- Chapter 2: ATP-binding cassette transporters: Snap-on complexes? -- Chapter 3: The Fork Protection Complex: A regulatory hub at the head of the replisome -- Chapter 4: Ferritin-like Proteins: A Conserved Core for a Myriad of Enzyme Complexes -- Chapter 5: Still no rest for the reductases: Ribonucleotide reductase (RNR) Structure and Function — an update -- Chapter 6: Structure and Dynamics of the Human Multi-tRNA Synthetase Complex -- Chapter 7: On the regulation of mitosis by the kinetochore, a macromolecular complex and organising hub of eukaryotic organisms -- Part 2: Membrane Protein Complexes -- Chapter 8: The conformational dynamics of heterotrimeric G proteins during GPCR-mediated activation -- Chapter 9: Regulation of Lytic Machineries by the FtsEX Complex in the Bacterial Divisome -- Chapter 10 : Structure, Function, and Regulation of the Kainate Receptor -- Chapter 11: Structure, function and variations of the photosystem I-antenna supercomplex from different photosynthetic organisms -- Chapter 12: Structure and Function of Mycobacterial Arabinofuranosyltransferases -- Part 3: Fibrous Protein Complexes -- Chapter 13: Structure and assembly of the bacterial flagellum -- Chapter 14: Actomyosin Complex -- Chapter 15: Structure of motile cilia -- Chapter 16: Segment-Long-Spacing (SLS) and the Polymorphic Structures of Fibrillar Collagen -- Part 4: Virus Protein Complexes -- Chapter 17: Viral Capsid and Polymerase in Reoviridae. |
| Record Nr. | UNINA-9910595042903321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Soggetto topico
-
Proteïnes
(18)
- Protein Science (10)
- Proteins (8)
- Protein Structure (3)
- Biochemistry, general (2)