Cullin-RING Ligases and Protein Neddylation [[electronic resource] ] : Biology and Therapeutics / / edited by Yi Sun, Wenyi Wei, Jianping Jin |
Edizione | [1st ed. 2020.] |
Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2020 |
Descrizione fisica | 1 online resource (VIII, 372 p. 119 illus., 68 illus. in color.) |
Disciplina | 572.8 |
Collana | Advances in Experimental Medicine and Biology |
Soggetto topico |
Molecular biology
Posttranslational modification Cell biology Molecular Medicine Posttranslational Modification Cell Biology |
ISBN | 981-15-1025-3 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Chapter 1 Introduction of Protein Ubiquitination and Cullin/RING Ubiquitin Ligases: introduce the protein ubiquitination system briefly; discuss the family of Cullin/RING Ubiquitin Ligases -- Chapter 2 Assembly and Regulation of CRL ubiquitin ligases: discuss the assembly process of CRL ubiquitin ligases by CAND1; elaborate the regulation of CRL ubiquitin ligases by neddylation -- Chapter 3 Protein structure of CRL and Neddylation complex -- Chapter 4 The roles of CRL ubiquitin ligases and neddylation in human diseases -- Chapter 5 The roles of CRL ubiquitin ligases in stem cell biology: Briefly introduce concept and potential application of stem cells; analyze a few example for CRL ubiquitin ligases to control stem cell biology -- Chapter 6 The biology of F-box proteins: introduce the history of SCF ubiquitin ligases; discuss the overall functions of F-box proteins (emphasize phospho-degron concept) -- Chapter 7 The roles of Fbxw7 in human diseases: discuss the roles of Fbw7 in cancer; elaborate the roles of Fbxw7 in other diseases -- Chapter 8 Mouse models of CRL1 components to study their biological function -- Chapter 9 Cullin2 and cancer: introduce Cullin2 ubiquitin ligases; discuss VHL ubiquitin ligase and its roles in cancer -- Chapter 10 Cullin3 and tumorigenesis: introduce Cullin3 ubiquitin ligases; discuss a few examples of Cullin3 ubiquitin ligases in control of tumorigenesis -- Chapter 11 Cullin4-DCAF proteins in tumorigenesis: Discovery of DCAF proteins; discuss a few examples of DCAF’s biological functions -- Chapter 12 Cullin4 ubiquitin ligases in DNA damage responses: Introduce Cullin4 ubiquitin ligases; discuss the roles of Cullin4 ubiquitin ligases in DNA damage responses -- Chapter 13 Coordinating the roles of Cullin5 ubiquitin ligases by SAG and UBE2F: introduce Cullin5 ubiquitin ligases; discuss how SGA and UBE2F mediates the functions of Cullin5 -- Chapter 14 Cullin5 in anti-virus infection: mechanism and drug target -- Chapter 15 The roles of Cul7 in cancer biology: introduce Cullin7 ubiquitin ligase7; discuss a few examples of Cullin7 ubiquitin ligases in cancer -- Chapter 16 Coordinating functions of p97 and CRL ubiquitin ligases in protein turnover: introduce the interactions between p97 and CRL ubiquitin ligases; discuss the coordinating roles between p97 and CRL ubiquitin ligases in protein turnover -- Chapter 17 Interaction between CRL ubiquitin ligases and COP9 Signalosome: introduce Cop9 signalosome; discuss how Cop9 signalosome regulates CRL ubiquitin ligases -- Chapter 18 Drug discovery effort to target Cullin-3 neddylation: discuss inhibitor of Cullin3 neddylation and its application -- Chapter 19 Targeting neddylation modification: Briefly introduce protein neddylation; discuss the roles of neddylation in cancer -- Chapter 20 Targeting CRL ubiquitin ligases: discuss current progress in targeting CRL ubiquitin ligases; discuss the application of CRL ubiquitin ligases in Protac drug development. |
Record Nr. | UNINA-9910373936803321 |
Singapore : , : Springer Singapore : , : Imprint : Springer, , 2020 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
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Epigenetics in Allergy and Autoimmunity [[electronic resource] /] / edited by Christopher Chang, Qianjin Lu |
Edizione | [1st ed. 2020.] |
Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2020 |
Descrizione fisica | 1 online resource (408 pages) |
Disciplina | 572.865 |
Collana | Advances in Experimental Medicine and Biology |
Soggetto topico |
Immunology
Posttranslational modification Rheumatology Allergy Posttranslational Modification Allergology Epigenètica Al·lèrgia Sistema immunitari |
Soggetto genere / forma | Llibres electrònics |
ISBN | 981-15-3449-7 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Epigenetics in health and disease -- The development of epigenetics in the study of disease pathogenesis -- Epigenetic methods and twin studies -- The role of genetics, the environment and epigenetics in atopic dermatitis -- The epigenetics of food allergy -- Epigenetics and the Environment in allergy and asthma: asthma and allergic rhinitis -- Epigenetics of lupus erythematosus -- Epigenetics of psoriasis -- The role of epigenetics in type 1 diabetes -- Epigenetics of Primary Biliary Cholangitis -- Epigenetics in primary Sjogren’s syndrome -- Epigenetics in Multiple Sclerosis -- The epigenetic regulation of Scleroderma and its clinical application. |
Record Nr. | UNINA-9910409692603321 |
Singapore : , : Springer Singapore : , : Imprint : Springer, , 2020 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
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Epigenetics: Development and Disease [[electronic resource] /] / edited by Tapas Kumar Kundu |
Edizione | [1st ed. 2013.] |
Pubbl/distr/stampa | Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2013 |
Descrizione fisica | 1 online resource (697 p.) |
Disciplina |
572.865
616.042 |
Collana | Subcellular Biochemistry |
Soggetto topico |
Gene expression
Posttranslational modification Cancer research Developmental biology Stem cells Gene Expression Posttranslational Modification Cancer Research Developmental Biology Stem Cells |
ISBN |
1-283-84976-3
94-007-4525-7 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | PART I: EPIGENETICS AND EVOLUTION -- 1.1 Chromatin Organization, Epigenetics and Differentiation: An evolutionary perspective -- 1.2 Secondary structures of the core histone N-terminal tails: their role in regulating chromatin structure -- 1.3 Megabase replication domains along the human genome: Relation to chromatin structure and genome organization -- 1.4 Role of DNA methyltransferases in epigenetic regulation in bacteria -- PART II: DEVELOPMENTAL EPIGENETICS -- 2.1 Metabolic aspects of epigenome: Coupling of S-adenosylmethionine synthesis and gene regulation on chromatin by SAMIT module -- 2.2 Epigenetic regulation of male germ cell differentiation -- 2.3 Epigenetic Regulation of Skeletal Muscle Development and Differentiation -- 2.4 Small changes, big effects: chromatin goes aging -- 2.5 Homeotic gene regulation: A paradigm for epigenetic mechanisms underlying organismal development -- PART III: EPIGENETICS AND TRANSCRIPTION REGULATION -- 3.1 Basic mechanisms in RNA Polymerase I transcription of the ribosomal RNA genes -- 3.2 The RNA polymerase II transcriptional machinery and its epigenetic context -- 3.3 RNA polymerase III transcriptions - regulated by chromatin structure and regulator of nuclear chromatin organization -- 3.4. The Role of DNA Methylation and Histone Modifications in Transcriptional Regulation in humans -- 3.5 Histone variants and Transcription regulation -- 3.6 Noncoding RNAs in Chromatin Organization and Transcription Regulation: An Epigenetic View -- 3.7 Chromatin structure and organization: the relation with gene expression during development and disease -- PART IV: EPIGENETICS AND DISEASE -- 4.1 Epigenetics and cancer: Development, Differentiation and Pathobiology -- 4.2 Epigenetic Regulation of Cancer Stem Cell Gene Expression -- 4.3 Role of Epigenetic Mechanisms in the Vascular Complications of Diabetes -- 4.4 Epigenetic changes in inflammatory and autoimmune diseases -- 4.5 Epigenetic regulation of HIV-1 persistence and evolving strategies for virus eradication -- 4.6 Epigenetics in Parkinson’s and Alzheimer’s diseases -- 4.7 Cellular Redox, Epigenetics and Diseases -- PART V: UNDERSTANDING OF EPIGENETICS: A CHEMICAL BIOLOGY APPROACH AND EPIGENETIC THERAPY -- 5.1 Stem cell plasticity in development and cancer: Epigenetic origin of cancer stem cells -- 5.2 Histone acetylation as a therapeutic target- Implication of nanodelivery -- 5.3 DNA methylation and Cancer -- 5.4 Role of epigenetics in inflammation-associated diseases -- 5.5 Plasmodium falciparum: Epigenetic control of var gene regulation and disease. |
Record Nr. | UNINA-9910437829103321 |
Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2013 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
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Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders [[electronic resource] /] / by Shabir Ahmad Ganai |
Autore | Ganai Shabir Ahmad |
Edizione | [1st ed. 2019.] |
Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019 |
Descrizione fisica | 1 online resource (XVII, 93 p. 8 illus., 5 illus. in color.) |
Disciplina | 612.8 |
Soggetto topico |
Neurosciences
Pharmacology Genetics Proteins Posttranslational modification Pharmacology/Toxicology Genetics and Genomics Protein Science Posttranslational Modification |
ISBN | 981-13-8019-8 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Chapter 1. Role of Epigenetics in neurological diseases -- Chapter 2. Epigenetic enzymes and the drawbacks of conventional therapeutic regimens -- Chapter 3. Distinct classes of HDACs -- Chapter 4. HDAC implications in neurological diseases -- Chapter 5. HDAC inhibitors and their structurally distinct groups -- Chapter 6. HDAC inhibitors as novel therapeutic option against therapeutically challenging neurological disorders -- Chapter 7. Current Challenges with HDAC inhibitor based therapeutic intervention against neurological maladies -- Chapter 8. Escalating need of isoform selective inhibitors for enhanced therapeutic efficacy -- Chapter 9. Combinatorial therapeutic regimens using HDAC inhibitors in conjunction with conventional therapeutic agents -- Chapter 10. Future directions of epigenetic research in tackling neurological complications. |
Record Nr. | UNINA-9910350356103321 |
Ganai Shabir Ahmad | ||
Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
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Histone Recognition [[electronic resource] /] / edited by Ming-Ming Zhou |
Edizione | [1st ed. 2015.] |
Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 |
Descrizione fisica | 1 online resource (284 p.) |
Disciplina |
572.6
610 611.01816 |
Soggetto topico |
Gene expression
Posttranslational modification Proteins Medical genetics Gene Expression Posttranslational Modification Protein-Ligand Interactions Gene Function |
ISBN | 3-319-18102-5 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | The Bromodomain as the Acetyl-Lysine Binding Domain in Gene Transcription -- PHD Fingers as Histone Readers -- Methyl-Lysine Recognition by the Royal Family Modules: Chromo, Tudor, MBT, Chromo Barrel, and PWWP Domains -- Histone Recognition by WD40 Proteins -- Methyl-Lys Recognition by Ankyrin Repeat Proteins -- Methyl-Arginine Recognition by Tudor Domains -- Histone Recognition by Tandem Modules and Modulation by Multiple PTMs -- Genome-Wide Profiling of Molecular Recognition of Histone PTMs -- BET Bromodomain Inhibition as a Therapeutic Approach in Hematological Malignancies -- Anti-Inflammatory Effects of BET Protein Inhibition Through Modulation of Gene Transcription -- Activating Latent HIV by Inhibiting Bromodomain Proteins -- Small Molecule Modulation of Methyl-Lysine Mediated Interactions. |
Record Nr. | UNINA-9910298296503321 |
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
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Immune Metabolism in Health and Tumor [[electronic resource] /] / edited by Bin Li, Fan Pan |
Edizione | [1st ed. 2017.] |
Pubbl/distr/stampa | Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2017 |
Descrizione fisica | 1 online resource (V, 223 p. 24 illus., 23 illus. in color.) |
Disciplina | 616.079 |
Collana | Advances in Experimental Medicine and Biology |
Soggetto topico |
Immunology
Posttranslational modification Medical microbiology Cancer research Posttranslational Modification Medical Microbiology Cancer Research |
ISBN | 94-024-1170-4 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Metabolism in Immune Cell Differentiation and Function -- Metabolic Regulation of T cell Immunity -- Transcriptional regulation of T cell metabolism reprograming -- Adipose tissue-resident regulatory T cells -- Immune cell metabolism in tumor microenvironment -- Regulation of Metabolism across Different Subsets of T Cells in Cancer -- Immunometabolism in Tumour Microenvironment . |
Record Nr. | UNINA-9910253938603321 |
Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2017 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
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Insights into Human Neurodegeneration: Lessons Learnt from Drosophila [[electronic resource] /] / edited by Mousumi Mutsuddi, Ashim Mukherjee |
Edizione | [1st ed. 2019.] |
Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019 |
Descrizione fisica | 1 online resource (470 pages) |
Disciplina | 595.774 |
Soggetto topico |
Neurosciences
Developmental biology Animal models in research Stem cells Posttranslational modification Developmental Biology Animal Models Stem Cells Posttranslational Modification Neurociències |
Soggetto genere / forma | Llibres electrònics |
ISBN | 981-13-2218-X |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Chapter 1. Introduction to Drosophila as a model organism -- Chapter 2. Methods for creating fly models in order to understand molecular mechanism of neurological diseases -- Chapter 3. Neurodegeneration: Lessons learnt from forward genetic screens in Drosophila -- Chapter 4. Drosophila neural stem cells, a primer for understanding mammalian neurobiology -- Chapter 5. Understanding motor disorders using flies -- Chapter 6. Metabolic alterations amalgamated with neurodegenerative diseases -- Chapter 7. Notch signalling in neurodegenerative disease -- Chapter 8. Drosophila model of neurofibrillar tangles -- Chapter 9. Unraveling Alzheimer's disease using Drosophila -- Chapter 10. Modelling Human Parkinson's disease in fly -- Chapter 11. Post-translational modifications: A mystery to unravel Huntington’s disease -- Chapter 12. Understanding the pathogenicity of non-coding RNA expansion associated neurodegenerative disorders -- Chapter 13. Expanding roles of RNA binding proteins in neurodegeneration -- Chapter 14. Hereditary Spastic Paraplegia Disease in Drosophila -- Chapter 15. Drosophila as a model system for the identification of pharmacological therapies in neurodegenerative diseases. |
Record Nr. | UNINA-9910373907803321 |
Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
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Lipid Hydroperoxide-Derived Modification of Biomolecules [[electronic resource] /] / edited by Yoji Kato |
Edizione | [1st ed. 2014.] |
Pubbl/distr/stampa | Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2014 |
Descrizione fisica | 1 online resource (203 p.) |
Disciplina | 572.57 |
Collana | Subcellular Biochemistry |
Soggetto topico |
Cancer research
Posttranslational modification Food—Biotechnology Cancer Research Posttranslational Modification Food Science |
ISBN | 94-007-7920-8 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Preface. I Lipid peroxidation and small molecule adducts -- Lipid hydroperoxides as a source of singlet molecular oxygen -- The formation of lipid hydroperoxide-derived amide-type lysine adducts on proteins: a review of current knowledge -- Lipid hydroperoxide-derived adduction to amino-phospholipid in biomembrane -- Amide-type adduct of dopamine - Plausible cause of Parkinson diseases -- Determination of HEL (hexanoyl-lysine adduct): a novel biomarker for omega-6 PUFA oxidation -- Hexanoyl-lysine as a deterioration marker for rice during storage -- Cholesterol hydroperoxides and their degradation mechanism. II Pathophysiological consequences -- Amide-adducts in atherosclerosis -- Oxidative Modification of Lipoproteins -- Immunochemical Detection of Lipid Hydroperoxide- and Aldehyde-Modified Proteins in Diseases -- Role of Lipid Peroxide in the Neurodegenerative Disorders -- Lipid Hydroperoxide-Derived Modification of Proteins in Gastrointestinal Tract. III Applications for diagnosis and development of functional food -- Low-cost and easy-to-use "on-chip ELISA" for developing health-promoting foods -- Hexanoyl-lysine as an oxidative-injured marker - application of development of functional food -- Potential role of oxidative protein modification in energy metabolism in exercise -- Suppressive effects of cacao polyphenols on the development of atherosclerosis in apolipoprotein E-deficient mice -- Index. |
Record Nr. | UNINA-9910298306103321 |
Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2014 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
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Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions [[electronic resource] /] / edited by Seyed Ehtesham Hasnain, Nasreen Z. Ehtesham, Sonam Grover |
Edizione | [1st ed. 2019.] |
Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019 |
Descrizione fisica | 1 online resource (xxii, 514 pages) : illustrations |
Disciplina | 616.2 |
Soggetto topico |
Parasitology
Infectious diseases Posttranslational modification Immunology Vaccines Infectious Diseases Posttranslational Modification Vaccine Mycobacterium tuberculosis Malalties per micobacteris |
Soggetto genere / forma | Llibres electrònics |
ISBN | 981-329-413-2 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Chapter 1. Challenges and Advances in TB drug discovery -- Chapter 2. Biofilms: A Phenotypic mechanism of bacteria conferring tolerance against stress and antibiotics -- Chapter 3. History of TB- Robert Koch and Beyond -- Chapter 4. Clinical Aspects and Principles of Management of Tuberculosis -- Chapter 5. Toxin-Antitoxin (TA) systems in stress survival and pathogenesis -- Chapter 6. Infections with Nontuberculous Mycobacteria: Increased awareness and recent developments -- Chapter 7. Heat Shock Proteins in the Pathogenesis of Mycobacterium tuberculosis -- Chapter 8. Tuberculosis vaccine: past experiences and future prospects -- Chapter 9. TB Diagnostics: Journey from Smear Microscopy to Whole Genome Sequencing -- Chapter 10. Nucleotide excision repair pathway in mycobacteria -- Chapter 11. Intrinsically disordered regions in PE/PPE protein family of Mycobacterium tuberculosis: Moonlighting function -- Chapter 12. Best Practices in Mycobacterial Research Laboratories -- Chapter 13. Cellular stress responses and immunological regulations during Mycobacterium tuberculosis infection -- Chapter 14. Repurposing of Carbapenems for the treatment of Drug-Resistant Tuberculosis -- Chapter 15. Mesenchymal stem cells: A hidden arsenal for Mtb persistence, resuscitation and reactivation -- Chapter 16. Importance of cell wall-associated Poly-α-L-glutamine in the biology of pathogenic mycobacteria -- Chapter 17. Breaking the transmission of TB: a roadmap to bridge the gaps in controlling TB in endemic settings -- Chapter 18. Mycobacterial Methyltransferases: Significance in Pathogenesis and Virulence -- Chapter 19. Tuberculosis as an underlying etiological factor for other human respiratory diseases -- Chapter 20. Tuberculosis in New Zealand: Historical Overview to Modern Epidemiology -- Chapter 21. The PE and PPE family proteins of Mycobacterium tuberculosis: What they are upto? -- Chapter 22. Endoplasmic Reticulum stress: Importance in Pathogenesis of Mycobacterium tuberculosis -- Chapter 23. Comparative in silico analyses reveal crucial factors for virulence, antigenicity and evolution in M.tb -- Chapter 24. Host Factors in Tuberculosis -- Chapter 25. Extrapulmonary Tuberculosis -- Chapter 26. Immunotherapeutic potential of Mycobacterium indicus pranii against tuberculosis. |
Record Nr. | UNINA-9910373911603321 |
Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
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Non-coding RNAs and Cancer [[electronic resource] /] / edited by Muller Fabbri |
Edizione | [1st ed. 2014.] |
Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 |
Descrizione fisica | 1 online resource (287 p.) |
Disciplina |
571.6
572 572.6 599935 |
Soggetto topico |
Cancer research
Cell biology Biochemistry Posttranslational modification Gene expression Human genetics Cancer Research Cell Biology Biochemistry, general Posttranslational Modification Gene Expression Human Genetics |
ISBN | 1-4614-8444-8 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Introduction -- Biogenesis and Physiology of microRNAs.-Detecting non-coding RNA expression: from arrays to next generation sequencing -- MicroRNAs in Solid Tumors.-MicroRNAs in hematologic malignancies -- miRNAs as Cancer Biomarkers -- Unraveling the complex network of interactions between non-coding RNAs and epigenetics in cancer -- MicroRNA SNPs in Cancer -- Bioinformatics Approaches to the study of microRNAs -- Beyond miRNAs: role of other non-coding RNAs in cancer -- Translational Implications for non-coding RNA in Cancer -- Index. |
Record Nr. | UNINA-9910298337703321 |
New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
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