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Cullin-RING Ligases and Protein Neddylation : Biology and Therapeutics / / edited by Yi Sun, Wenyi Wei, Jianping Jin
Cullin-RING Ligases and Protein Neddylation : Biology and Therapeutics / / edited by Yi Sun, Wenyi Wei, Jianping Jin
Edizione [1st ed. 2020.]
Pubbl/distr/stampa Singapore : , : Springer Singapore : , : Imprint : Springer, , 2020
Descrizione fisica 1 online resource (VIII, 372 p. 119 illus., 68 illus. in color.)
Disciplina 572.8
Collana Advances in Experimental Medicine and Biology
Soggetto topico Molecular biology
Post-translational modification
Cytology
Molecular Medicine
Posttranslational Modification
Cell Biology
ISBN 981-15-1025-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Chapter 1 Introduction of Protein Ubiquitination and Cullin/RING Ubiquitin Ligases: introduce the protein ubiquitination system briefly; discuss the family of Cullin/RING Ubiquitin Ligases -- Chapter 2 Assembly and Regulation of CRL ubiquitin ligases: discuss the assembly process of CRL ubiquitin ligases by CAND1; elaborate the regulation of CRL ubiquitin ligases by neddylation -- Chapter 3 Protein structure of CRL and Neddylation complex -- Chapter 4 The roles of CRL ubiquitin ligases and neddylation in human diseases -- Chapter 5 The roles of CRL ubiquitin ligases in stem cell biology: Briefly introduce concept and potential application of stem cells; analyze a few example for CRL ubiquitin ligases to control stem cell biology -- Chapter 6 The biology of F-box proteins: introduce the history of SCF ubiquitin ligases; discuss the overall functions of F-box proteins (emphasize phospho-degron concept) -- Chapter 7 The roles of Fbxw7 in human diseases: discuss the roles of Fbw7 in cancer; elaborate the roles of Fbxw7 in other diseases -- Chapter 8 Mouse models of CRL1 components to study their biological function -- Chapter 9 Cullin2 and cancer: introduce Cullin2 ubiquitin ligases; discuss VHL ubiquitin ligase and its roles in cancer -- Chapter 10 Cullin3 and tumorigenesis: introduce Cullin3 ubiquitin ligases; discuss a few examples of Cullin3 ubiquitin ligases in control of tumorigenesis -- Chapter 11 Cullin4-DCAF proteins in tumorigenesis: Discovery of DCAF proteins; discuss a few examples of DCAF’s biological functions -- Chapter 12 Cullin4 ubiquitin ligases in DNA damage responses: Introduce Cullin4 ubiquitin ligases; discuss the roles of Cullin4 ubiquitin ligases in DNA damage responses -- Chapter 13 Coordinating the roles of Cullin5 ubiquitin ligases by SAG and UBE2F: introduce Cullin5 ubiquitin ligases; discuss how SGA and UBE2F mediates the functions of Cullin5 -- Chapter 14 Cullin5 in anti-virus infection: mechanism and drug target -- Chapter 15 The roles of Cul7 in cancer biology: introduce Cullin7 ubiquitin ligase7; discuss a few examples of Cullin7 ubiquitin ligases in cancer -- Chapter 16 Coordinating functions of p97 and CRL ubiquitin ligases in protein turnover: introduce the interactions between p97 and CRL ubiquitin ligases; discuss the coordinating roles between p97 and CRL ubiquitin ligases in protein turnover -- Chapter 17 Interaction between CRL ubiquitin ligases and COP9 Signalosome: introduce Cop9 signalosome; discuss how Cop9 signalosome regulates CRL ubiquitin ligases -- Chapter 18 Drug discovery effort to target Cullin-3 neddylation: discuss inhibitor of Cullin3 neddylation and its application -- Chapter 19 Targeting neddylation modification: Briefly introduce protein neddylation; discuss the roles of neddylation in cancer -- Chapter 20 Targeting CRL ubiquitin ligases: discuss current progress in targeting CRL ubiquitin ligases; discuss the application of CRL ubiquitin ligases in Protac drug development.
Record Nr. UNINA-9910373936803321
Singapore : , : Springer Singapore : , : Imprint : Springer, , 2020
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Epigenetics in Allergy and Autoimmunity / / edited by Christopher Chang, Qianjin Lu
Epigenetics in Allergy and Autoimmunity / / edited by Christopher Chang, Qianjin Lu
Edizione [1st ed. 2020.]
Pubbl/distr/stampa Singapore : , : Springer Singapore : , : Imprint : Springer, , 2020
Descrizione fisica 1 online resource (408 pages)
Disciplina 572.865
Collana Advances in Experimental Medicine and Biology
Soggetto topico Immunology
Post-translational modification
Rheumatology
Allergy
Posttranslational Modification
Allergology
Epigenètica
Al·lèrgia
Sistema immunitari
Soggetto genere / forma Llibres electrònics
ISBN 981-15-3449-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Epigenetics in health and disease -- The development of epigenetics in the study of disease pathogenesis -- Epigenetic methods and twin studies -- The role of genetics, the environment and epigenetics in atopic dermatitis -- The epigenetics of food allergy -- Epigenetics and the Environment in allergy and asthma: asthma and allergic rhinitis -- Epigenetics of lupus erythematosus -- Epigenetics of psoriasis -- The role of epigenetics in type 1 diabetes -- Epigenetics of Primary Biliary Cholangitis -- Epigenetics in primary Sjogren’s syndrome -- Epigenetics in Multiple Sclerosis -- The epigenetic regulation of Scleroderma and its clinical application.
Record Nr. UNINA-9910409692603321
Singapore : , : Springer Singapore : , : Imprint : Springer, , 2020
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Lo trovi qui: Univ. Federico II
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Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders / / by Shabir Ahmad Ganai
Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders / / by Shabir Ahmad Ganai
Autore Ganai Shabir Ahmad
Edizione [1st ed. 2019.]
Pubbl/distr/stampa Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019
Descrizione fisica 1 online resource (XVII, 93 p. 8 illus., 5 illus. in color.)
Disciplina 612.8
Soggetto topico Neurosciences
Pharmacology
Genetics
Proteins 
Posttranslational modification
Pharmacology/Toxicology
Genetics and Genomics
Protein Science
Posttranslational Modification
ISBN 981-13-8019-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Chapter 1. Role of Epigenetics in neurological diseases -- Chapter 2. Epigenetic enzymes and the drawbacks of conventional therapeutic regimens -- Chapter 3. Distinct classes of HDACs -- Chapter 4. HDAC implications in neurological diseases -- Chapter 5. HDAC inhibitors and their structurally distinct groups -- Chapter 6. HDAC inhibitors as novel therapeutic option against therapeutically challenging neurological disorders -- Chapter 7. Current Challenges with HDAC inhibitor based therapeutic intervention against neurological maladies -- Chapter 8. Escalating need of isoform selective inhibitors for enhanced therapeutic efficacy -- Chapter 9. Combinatorial therapeutic regimens using HDAC inhibitors in conjunction with conventional therapeutic agents -- Chapter 10. Future directions of epigenetic research in tackling neurological complications.
Record Nr. UNINA-9910350356103321
Ganai Shabir Ahmad  
Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019
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Histone Recognition / / edited by Ming-Ming Zhou
Histone Recognition / / edited by Ming-Ming Zhou
Edizione [1st ed. 2015.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015
Descrizione fisica 1 online resource (284 p.)
Disciplina 572.6
610
611.01816
Soggetto topico Gene expression
Posttranslational modification
Proteins 
Medical genetics
Gene Expression
Posttranslational Modification
Protein-Ligand Interactions
Gene Function
ISBN 3-319-18102-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto The Bromodomain as the Acetyl-Lysine Binding Domain in Gene Transcription -- PHD Fingers as Histone Readers -- Methyl-Lysine Recognition by the Royal Family Modules: Chromo, Tudor, MBT, Chromo Barrel, and PWWP Domains -- Histone Recognition by WD40 Proteins -- Methyl-Lys Recognition by Ankyrin Repeat Proteins -- Methyl-Arginine Recognition by Tudor Domains -- Histone Recognition by Tandem Modules and Modulation by Multiple PTMs -- Genome-Wide Profiling of Molecular Recognition of Histone PTMs -- BET Bromodomain Inhibition as a Therapeutic Approach in Hematological Malignancies -- Anti-Inflammatory Effects of BET Protein Inhibition Through Modulation of Gene Transcription -- Activating Latent HIV by Inhibiting Bromodomain Proteins -- Small Molecule Modulation of Methyl-Lysine Mediated Interactions.
Record Nr. UNINA-9910298296503321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Immune Metabolism in Health and Tumor / / edited by Bin Li, Fan Pan
Immune Metabolism in Health and Tumor / / edited by Bin Li, Fan Pan
Edizione [1st ed. 2017.]
Pubbl/distr/stampa Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2017
Descrizione fisica 1 online resource (V, 223 p. 24 illus., 23 illus. in color.)
Disciplina 616.079
Collana Advances in Experimental Medicine and Biology
Soggetto topico Immunology
Posttranslational modification
Medical microbiology
Cancer research
Posttranslational Modification
Medical Microbiology
Cancer Research
ISBN 94-024-1170-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Metabolism in Immune Cell Differentiation and Function -- Metabolic Regulation of T cell Immunity -- Transcriptional regulation of T cell metabolism reprograming -- Adipose tissue-resident regulatory T cells -- Immune cell metabolism in tumor microenvironment -- Regulation of Metabolism across Different Subsets of T Cells in Cancer -- Immunometabolism in Tumour Microenvironment .
Record Nr. UNINA-9910253938603321
Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2017
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Insights into Human Neurodegeneration: Lessons Learnt from Drosophila / / edited by Mousumi Mutsuddi, Ashim Mukherjee
Insights into Human Neurodegeneration: Lessons Learnt from Drosophila / / edited by Mousumi Mutsuddi, Ashim Mukherjee
Edizione [1st ed. 2019.]
Pubbl/distr/stampa Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019
Descrizione fisica 1 online resource (470 pages)
Disciplina 595.774
Soggetto topico Neurosciences
Developmental biology
Animal models in research
Stem cells
Post-translational modification
Developmental Biology
Animal Models
Stem Cells
Posttranslational Modification
Neurociències
Soggetto genere / forma Llibres electrònics
ISBN 981-13-2218-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Chapter 1. Introduction to Drosophila as a model organism -- Chapter 2. Methods for creating fly models in order to understand molecular mechanism of neurological diseases -- Chapter 3. Neurodegeneration: Lessons learnt from forward genetic screens in Drosophila -- Chapter 4. Drosophila neural stem cells, a primer for understanding mammalian neurobiology -- Chapter 5. Understanding motor disorders using flies -- Chapter 6. Metabolic alterations amalgamated with neurodegenerative diseases -- Chapter 7. Notch signalling in neurodegenerative disease -- Chapter 8. Drosophila model of neurofibrillar tangles -- Chapter 9. Unraveling Alzheimer's disease using Drosophila -- Chapter 10. Modelling Human Parkinson's disease in fly -- Chapter 11. Post-translational modifications: A mystery to unravel Huntington’s disease -- Chapter 12. Understanding the pathogenicity of non-coding RNA expansion associated neurodegenerative disorders -- Chapter 13. Expanding roles of RNA binding proteins in neurodegeneration -- Chapter 14. Hereditary Spastic Paraplegia Disease in Drosophila -- Chapter 15. Drosophila as a model system for the identification of pharmacological therapies in neurodegenerative diseases.
Record Nr. UNINA-9910373907803321
Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Lipid Hydroperoxide-Derived Modification of Biomolecules / / edited by Yoji Kato
Lipid Hydroperoxide-Derived Modification of Biomolecules / / edited by Yoji Kato
Edizione [1st ed. 2014.]
Pubbl/distr/stampa Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2014
Descrizione fisica 1 online resource (203 p.)
Disciplina 572.57
Collana Subcellular Biochemistry
Soggetto topico Cancer research
Posttranslational modification
Food—Biotechnology
Cancer Research
Posttranslational Modification
Food Science
ISBN 94-007-7920-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Preface. I Lipid peroxidation and small molecule adducts -- Lipid hydroperoxides as a source of singlet molecular oxygen -- The formation of lipid hydroperoxide-derived amide-type lysine adducts on proteins: a review of current knowledge -- Lipid hydroperoxide-derived adduction to amino-phospholipid in biomembrane -- Amide-type adduct of dopamine - Plausible cause of Parkinson diseases -- Determination of HEL (hexanoyl-lysine adduct): a novel biomarker for omega-6 PUFA oxidation -- Hexanoyl-lysine as a deterioration marker for rice during storage -- Cholesterol hydroperoxides and their degradation mechanism. II Pathophysiological consequences -- Amide-adducts in atherosclerosis -- Oxidative Modification of Lipoproteins -- Immunochemical Detection of Lipid Hydroperoxide- and Aldehyde-Modified Proteins in Diseases -- Role of Lipid Peroxide in the Neurodegenerative Disorders -- Lipid Hydroperoxide-Derived Modification of Proteins in Gastrointestinal Tract. III Applications for diagnosis and development of functional food -- Low-cost and easy-to-use "on-chip ELISA" for developing health-promoting foods -- Hexanoyl-lysine as an oxidative-injured marker - application of development of functional food -- Potential role of oxidative protein modification in energy metabolism in exercise -- Suppressive effects of cacao polyphenols on the development of atherosclerosis in apolipoprotein E-deficient mice -- Index.
Record Nr. UNINA-9910298306103321
Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2014
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions / / edited by Seyed Ehtesham Hasnain, Nasreen Z. Ehtesham, Sonam Grover
Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions / / edited by Seyed Ehtesham Hasnain, Nasreen Z. Ehtesham, Sonam Grover
Edizione [1st ed. 2019.]
Pubbl/distr/stampa Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019
Descrizione fisica 1 online resource (xxii, 514 pages) : illustrations
Disciplina 616.2
Soggetto topico Parasitology
Infectious diseases
Post-translational modification
Immunology
Vaccines
Infectious Diseases
Posttranslational Modification
Vaccine
Mycobacterium tuberculosis
Malalties per micobacteris
Soggetto genere / forma Llibres electrònics
ISBN 981-329-413-2
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Chapter 1. Challenges and Advances in TB drug discovery -- Chapter 2. Biofilms: A Phenotypic mechanism of bacteria conferring tolerance against stress and antibiotics -- Chapter 3. History of TB- Robert Koch and Beyond -- Chapter 4. Clinical Aspects and Principles of Management of Tuberculosis -- Chapter 5. Toxin-Antitoxin (TA) systems in stress survival and pathogenesis -- Chapter 6. Infections with Nontuberculous Mycobacteria: Increased awareness and recent developments -- Chapter 7. Heat Shock Proteins in the Pathogenesis of Mycobacterium tuberculosis -- Chapter 8. Tuberculosis vaccine: past experiences and future prospects -- Chapter 9. TB Diagnostics: Journey from Smear Microscopy to Whole Genome Sequencing -- Chapter 10. Nucleotide excision repair pathway in mycobacteria -- Chapter 11. Intrinsically disordered regions in PE/PPE protein family of Mycobacterium tuberculosis: Moonlighting function -- Chapter 12. Best Practices in Mycobacterial Research Laboratories -- Chapter 13. Cellular stress responses and immunological regulations during Mycobacterium tuberculosis infection -- Chapter 14. Repurposing of Carbapenems for the treatment of Drug-Resistant Tuberculosis -- Chapter 15. Mesenchymal stem cells: A hidden arsenal for Mtb persistence, resuscitation and reactivation -- Chapter 16. Importance of cell wall-associated Poly-α-L-glutamine in the biology of pathogenic mycobacteria -- Chapter 17. Breaking the transmission of TB: a roadmap to bridge the gaps in controlling TB in endemic settings -- Chapter 18. Mycobacterial Methyltransferases: Significance in Pathogenesis and Virulence -- Chapter 19. Tuberculosis as an underlying etiological factor for other human respiratory diseases -- Chapter 20. Tuberculosis in New Zealand: Historical Overview to Modern Epidemiology -- Chapter 21. The PE and PPE family proteins of Mycobacterium tuberculosis: What they are upto? -- Chapter 22. Endoplasmic Reticulum stress: Importance in Pathogenesis of Mycobacterium tuberculosis -- Chapter 23. Comparative in silico analyses reveal crucial factors for virulence, antigenicity and evolution in M.tb -- Chapter 24. Host Factors in Tuberculosis -- Chapter 25. Extrapulmonary Tuberculosis -- Chapter 26. Immunotherapeutic potential of Mycobacterium indicus pranii against tuberculosis.
Record Nr. UNINA-9910373911603321
Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Non-coding RNAs and Cancer / / edited by Muller Fabbri
Non-coding RNAs and Cancer / / edited by Muller Fabbri
Edizione [1st ed. 2014.]
Pubbl/distr/stampa New York, NY : , : Springer New York : , : Imprint : Springer, , 2014
Descrizione fisica 1 online resource (287 p.)
Disciplina 571.6
572
572.6
599935
Soggetto topico Cancer research
Cell biology
Biochemistry
Posttranslational modification
Gene expression
Human genetics
Cancer Research
Cell Biology
Biochemistry, general
Posttranslational Modification
Gene Expression
Human Genetics
ISBN 1-4614-8444-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction -- Biogenesis and Physiology of microRNAs.-Detecting non-coding RNA expression: from arrays to next generation sequencing -- MicroRNAs in Solid Tumors.-MicroRNAs in hematologic malignancies -- miRNAs as Cancer Biomarkers -- Unraveling the complex network of interactions between non-coding RNAs and epigenetics in cancer -- MicroRNA SNPs in Cancer -- Bioinformatics Approaches to the study of microRNAs -- Beyond miRNAs: role of other non-coding RNAs in cancer -- Translational Implications for non-coding RNA in Cancer -- Index.
Record Nr. UNINA-9910298337703321
New York, NY : , : Springer New York : , : Imprint : Springer, , 2014
Materiale a stampa
Lo trovi qui: Univ. Federico II
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PlantOmics: The Omics of Plant Science [[electronic resource] /] / edited by Debmalya Barh, Muhammad Sarwar Khan, Eric Davies
PlantOmics: The Omics of Plant Science [[electronic resource] /] / edited by Debmalya Barh, Muhammad Sarwar Khan, Eric Davies
Edizione [1st ed. 2015.]
Pubbl/distr/stampa New Delhi : , : Springer India : , : Imprint : Springer, , 2015
Descrizione fisica 1 online resource (839 p.)
Disciplina 570
572.6
580
660.6
Soggetto topico Plant science
Botany
Biotechnology
Posttranslational modification
Proteins 
Plant Sciences
Posttranslational Modification
Protein Science
ISBN 81-322-2172-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Chapter-1: Omics of Model Plants -- Chapter-2:Instrumental techniques and methods: their role in plant omics -- Chapter-3:Next generation sequencing and assembly of plant genomes -- Chapter-4: Functional genomics: applications in plant science -- Chapter-5: Cytogenomics and mutagenomics in plant functional biology and breeding -- Chapter-6: Plant Epigenetics and Crop Improvement -- Chapter-7: Plant miRNomics: novel insights in gene expression and regulation -- Chapter-8:Plant Proteomics: Technologies and applications -- Chapter-9: Plant Metabolomics: An overview of technology platforms for applications in metabolism -- Chapter-10:Plant Glycomics: advances and applications -- Chapter-11: Plant Lipidomics: Signalling and Analytical Strategies -- Chapter-12: Plant secretomics: unique initiatives -- Chapter-13: Phenomics: Technologies and applications in plant and agriculture -- Chapter-14: Plant Cytomics: Novel Methods to View Molecules on the Move -- Chapter-15:Plant Physiomics: Photo-electro-chemical and molecular retrograde signaling in plant acclimatory and defence responses -- Chapter-16: Signalomics: diversity and methods of analysis of systemic signals in plants -- Chapter-17: Signalome in salt stress -- Chapter-18: Thiolomics: Molecular mechanisms of thiol-cascade in plant growth and nutrition -- Chapter-19: Chloroplast Omics: global strategies for study of plastid biology -- Chapter-20: Transplastomics: A convergence of genomics and biotechnology -- Chapter-21:Plant Mitochondrial Omics: state of the art knowledge -- Chapter-22: Micromorphomics: a morphological dissection to unveil environmental stress -- Chapter-23: Microbiomics: An approach to community microbiology -- Chapter-24: Cryobionomics: evaluating the concept in plant cryopreservation -- Chapter-25: Nanobiotechnology: applications in plant and agriculture -- Chapter-26: Plant pharmacogenomics: from drug discovery to personalized ethnomedicine -- Chapter-27: Machine learning approaches in plant biology -- Chapter-28: Applications of bioinformatics in plant and agriculture -- Chapter-29: Plant system biology: insights and advancements -- Chapter-30: Plantomics and Futuromics.
Record Nr. UNINA-9910298286103321
New Delhi : , : Springer India : , : Imprint : Springer, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
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