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The Biology of mRNA: Structure and Function / / edited by Marlene Oeffinger, Daniel Zenklusen
The Biology of mRNA: Structure and Function / / edited by Marlene Oeffinger, Daniel Zenklusen
Edizione [1st ed. 2019.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019
Descrizione fisica 1 online resource (318 pages)
Disciplina 572.88
Collana Advances in Experimental Medicine and Biology
Soggetto topico Medicine—Research
Biology—Research
Molecular genetics
Proteins
Neurosciences
Post-translational modification
Biomedical Research
Molecular Genetics
Protein Biochemistry
Neuroscience
Post-translational Modifications
RNA
Soggetto genere / forma Llibres electrònics
ISBN 3-030-31434-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Regulation of co-transcriptional mRNP assembly -- mRNA export through the NPC -- Roles of mRNA modifications in gene regulation -- Studying mRNPs using single molecule approaches -- Difference between mRNPs and lncRNAs? -- RNPs and/or sequence motives in mRNA localization -- mRNP structure -- New RNA binding proteins: mRNP composition -- Aggregation of repeats RNAs in neurodegenerative diseases -- mRNA structural organization and translation -- How to decide to make an mRNA - degradation -- Methods to study mRNP composition -- mRNA-DNA kisses – R-loops -- Forms of mRNA editing and their role in disease.
Record Nr. UNINA-9910373908303321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Cullin-RING Ligases and Protein Neddylation : Biology and Therapeutics / / edited by Yi Sun, Wenyi Wei, Jianping Jin
Cullin-RING Ligases and Protein Neddylation : Biology and Therapeutics / / edited by Yi Sun, Wenyi Wei, Jianping Jin
Edizione [1st ed. 2020.]
Pubbl/distr/stampa Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2020
Descrizione fisica 1 online resource (VIII, 372 p. 119 illus., 68 illus. in color.)
Disciplina 572.8
Collana Advances in Experimental Medicine and Biology
Soggetto topico Medicine - Research
Biology - Research
Post-translational modification
Cytology
Biomedical Research
Post-translational Modifications
Cell Biology
ISBN 981-15-1025-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Chapter 1 Introduction of Protein Ubiquitination and Cullin/RING Ubiquitin Ligases: introduce the protein ubiquitination system briefly; discuss the family of Cullin/RING Ubiquitin Ligases -- Chapter 2 Assembly and Regulation of CRL ubiquitin ligases: discuss the assembly process of CRL ubiquitin ligases by CAND1; elaborate the regulation of CRL ubiquitin ligases by neddylation -- Chapter 3 Protein structure of CRL and Neddylation complex -- Chapter 4 The roles of CRL ubiquitin ligases and neddylation in human diseases -- Chapter 5 The roles of CRL ubiquitin ligases in stem cell biology: Briefly introduce concept and potential application of stem cells; analyze a few example for CRL ubiquitin ligases to control stem cell biology -- Chapter 6 The biology of F-box proteins: introduce the history of SCF ubiquitin ligases; discuss the overall functions of F-box proteins (emphasize phospho-degron concept) -- Chapter 7 The roles of Fbxw7 in human diseases: discuss the roles of Fbw7 in cancer; elaborate the roles of Fbxw7 in other diseases -- Chapter 8 Mouse models of CRL1 components to study their biological function -- Chapter 9 Cullin2 and cancer: introduce Cullin2 ubiquitin ligases; discuss VHL ubiquitin ligase and its roles in cancer -- Chapter 10 Cullin3 and tumorigenesis: introduce Cullin3 ubiquitin ligases; discuss a few examples of Cullin3 ubiquitin ligases in control of tumorigenesis -- Chapter 11 Cullin4-DCAF proteins in tumorigenesis: Discovery of DCAF proteins; discuss a few examples of DCAF’s biological functions -- Chapter 12 Cullin4 ubiquitin ligases in DNA damage responses: Introduce Cullin4 ubiquitin ligases; discuss the roles of Cullin4 ubiquitin ligases in DNA damage responses -- Chapter 13 Coordinating the roles of Cullin5 ubiquitin ligases by SAG and UBE2F: introduce Cullin5 ubiquitin ligases; discuss how SGA and UBE2F mediates the functions of Cullin5 -- Chapter 14 Cullin5 in anti-virus infection: mechanism and drug target -- Chapter 15 The roles of Cul7 in cancerbiology: introduce Cullin7 ubiquitin ligase7; discuss a few examples of Cullin7 ubiquitin ligases in cancer -- Chapter 16 Coordinating functions of p97 and CRL ubiquitin ligases in protein turnover: introduce the interactions between p97 and CRL ubiquitin ligases; discuss the coordinating roles between p97 and CRL ubiquitin ligases in protein turnover -- Chapter 17 Interaction between CRL ubiquitin ligases and COP9 Signalosome: introduce Cop9 signalosome; discuss how Cop9 signalosome regulates CRL ubiquitin ligases -- Chapter 18 Drug discovery effort to target Cullin-3 neddylation: discuss inhibitor of Cullin3 neddylation and its application -- Chapter 19 Targeting neddylation modification: Briefly introduce protein neddylation; discuss the roles of neddylation in cancer -- Chapter 20 Targeting CRL ubiquitin ligases: discuss current progress in targeting CRL ubiquitin ligases; discuss the application of CRL ubiquitin ligases in Protac drug development.
Record Nr. UNINA-9910373936803321
Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2020
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Epigenetics: Development and Disease / / edited by Tapas Kumar Kundu
Epigenetics: Development and Disease / / edited by Tapas Kumar Kundu
Edizione [1st ed. 2013.]
Pubbl/distr/stampa Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2013
Descrizione fisica 1 online resource (697 p.)
Disciplina 572.865
616.042
Altri autori (Persone) KunduTapas K
Collana Subcellular Biochemistry
Soggetto topico Molecular genetics
Post-translational modification
Cancer
Developmental biology
Stem cells
Molecular Genetics
Post-translational Modifications
Cancer Biology
Developmental Biology and Stem Cells
Stem Cell Biology
ISBN 1-283-84976-3
94-007-4525-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto PART I: EPIGENETICS AND EVOLUTION -- 1.1 Chromatin Organization, Epigenetics and Differentiation: An evolutionary perspective -- 1.2 Secondary structures of the core histone N-terminal tails: their role in regulating chromatin structure -- 1.3 Megabase replication domains along the human genome: Relation to chromatin structure and genome organization -- 1.4 Role of DNA methyltransferases in epigenetic regulation in bacteria -- PART II: DEVELOPMENTAL EPIGENETICS -- 2.1 Metabolic aspects of epigenome: Coupling of S-adenosylmethionine synthesis and gene regulation on chromatin by SAMIT module -- 2.2 Epigenetic regulation of male germ cell differentiation -- 2.3 Epigenetic Regulation of Skeletal Muscle Development and Differentiation -- 2.4 Small changes, big effects: chromatin goes aging -- 2.5 Homeotic gene regulation: A paradigm for epigenetic mechanisms underlying organismal development -- PART III: EPIGENETICS AND TRANSCRIPTION REGULATION -- 3.1 Basic mechanisms in RNA Polymerase I transcriptionof the ribosomal RNA genes -- 3.2 The RNA polymerase II transcriptional machinery and its epigenetic context -- 3.3 RNA polymerase III transcriptions - regulated by chromatin structure and regulator of nuclear chromatin organization -- 3.4. The Role of DNA Methylation and Histone Modifications in Transcriptional Regulation in humans -- 3.5 Histone variants and Transcription regulation -- 3.6 Noncoding RNAs in Chromatin Organization and Transcription Regulation: An Epigenetic View -- 3.7 Chromatin structure and organization: the relation with gene expression during development and disease -- PART IV: EPIGENETICS AND DISEASE -- 4.1 Epigenetics and cancer: Development, Differentiation and Pathobiology -- 4.2 Epigenetic Regulation of Cancer Stem Cell Gene Expression -- 4.3 Role of Epigenetic Mechanisms in the Vascular Complications of Diabetes -- 4.4 Epigenetic changes in inflammatory and autoimmune diseases -- 4.5 Epigenetic regulation of HIV-1 persistence and evolving strategies for virus eradication -- 4.6 Epigenetics in Parkinson’s and Alzheimer’s diseases -- 4.7 Cellular Redox, Epigenetics and Diseases -- PART V: UNDERSTANDING OF EPIGENETICS: A CHEMICAL BIOLOGY APPROACH AND EPIGENETIC THERAPY -- 5.1 Stem cell plasticity in development and cancer: Epigenetic origin of cancer stem cells -- 5.2 Histone acetylation as a therapeutic target- Implication of nanodelivery -- 5.3 DNA methylation and Cancer -- 5.4 Role of epigenetics in inflammation-associated diseases -- 5.5 Plasmodium falciparum: Epigenetic control of var gene regulation and disease.
Record Nr. UNINA-9910437829103321
Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2013
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Histone and Non-Histone Reversible Acetylation in Development, Aging and Disease / / edited by Marta Halasa, Anna Wawruszak
Histone and Non-Histone Reversible Acetylation in Development, Aging and Disease / / edited by Marta Halasa, Anna Wawruszak
Autore Halasa Marta
Edizione [1st ed. 2025.]
Pubbl/distr/stampa Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2025
Descrizione fisica 1 online resource (646 pages)
Disciplina 572.645
Altri autori (Persone) WawruszakAnna
Collana Results and Problems in Cell Differentiation
Soggetto topico Post-translational modification
Epigenetics
Proteins
Cell differentiation
Proteins - Synthesis
Tumor suppressor proteins
Antioncogenes
Post-translational Modifications
Protein Biochemistry
Cell Differentiation
Protein Synthesis and Translation
Tumour-suppressor Proteins
ISBN 3-031-91459-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Part I. Introduction to Reversible Acetylation and Its Biological Consequences -- Chapter 1. Histone and Non-Histone Reversible Acetylation in Development, Aging and Disease -- Chapter 2. Acetylation-Mediated Epigenetic Consequences for Biological Control and Cancer -- Part II. Acetylation of Cytoskeleton-Associated Proteins -- Chapter 3. Acetylation and Deacetylation of Cytoskeleton-Associated Proteins -- Chapter 4. Tubulin Acetylation: A Critical Regulator of Microtubule Function -- Chapter 5. Tubulin Acetylation and the Cellular Mechanosensing and Stress Response -- Part III. Acetylation in Development -- Chapter 6. Reversible Histone Acetylation During Preimplantation Embryo Development in Mammals -- Chapter 7. Epigenetic Echoes: Decoding the Acetylation Journey from Neural Crest to Melanocyte -- Part IV. Acetylation in Physiological and Pathological Processes -- Chapter 8. Impact of Histone Acetyltransferases and His-tone Deacetylases on Adult Brain Myelin Plastici-ty -- Chapter 9. Acetylation in Cardiac Aging: Molecular Mechanism and Therapeutic Approaches -- Chapter 10. Regulatory Roles for SIRT1 in Aging and Immunosenescence -- Chapter 11. Repurposing Histone Deacetylase Inhibitors for Management of Solid Organ Transplant Rejection -- Chapter 12. Acetylation in Viral Infection and Disease -- Chapter 13. Reversible Acetylation of Non-Histone Proteins in Human Cancers -- Chapter 14. Lysine Acetyltransferase 6 Complexes in Neurodevelopmental Disorders and Different Types of Cancer -- Chapter 15. Bromodomain and PHD Finger-Containing Protein 1: From Biological Functions to a Developmental Disorder, Cancer and Therapeutics.
Record Nr. UNINA-9911015876103321
Halasa Marta  
Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2025
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Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders / / by Shabir Ahmad Ganai
Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders / / by Shabir Ahmad Ganai
Autore Ganai Shabir Ahmad
Edizione [1st ed. 2019.]
Pubbl/distr/stampa Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2019
Descrizione fisica 1 online resource (XVII, 93 p. 8 illus., 5 illus. in color.)
Disciplina 612.8
Soggetto topico Neurosciences
Pharmacology
Genetics
Proteins
Post-translational modification
Neuroscience
Genetics and Genomics
Protein Biochemistry
Post-translational Modifications
ISBN 981-13-8019-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Chapter 1. Role of Epigenetics in neurological diseases -- Chapter 2. Epigenetic enzymes and the drawbacks of conventional therapeutic regimens -- Chapter 3. Distinct classes of HDACs -- Chapter 4. HDAC implications in neurological diseases -- Chapter 5. HDAC inhibitors and their structurally distinct groups -- Chapter 6. HDAC inhibitors as novel therapeutic option against therapeutically challenging neurological disorders -- Chapter 7. Current Challenges with HDAC inhibitor based therapeutic intervention against neurological maladies -- Chapter 8. Escalating need of isoform selective inhibitors for enhanced therapeutic efficacy -- Chapter 9. Combinatorial therapeutic regimens using HDAC inhibitors in conjunction with conventional therapeutic agents -- Chapter 10. Future directions of epigenetic research in tackling neurological complications.
Record Nr. UNINA-9910350356103321
Ganai Shabir Ahmad  
Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2019
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The Networking of Chaperones by Co-Chaperones / / edited by Adrienne L. Edkins, Gregory L. Blatch
The Networking of Chaperones by Co-Chaperones / / edited by Adrienne L. Edkins, Gregory L. Blatch
Edizione [3rd ed. 2023.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023
Descrizione fisica 1 online resource (436 pages)
Disciplina 780.71
Collana Subcellular Biochemistry
Soggetto topico Protein folding
Proteins
Post-translational modification
Cytology
Biomolecules
Physical biochemistry
Macromolecules
Protein Folding
Protein Biochemistry
Post-translational Modifications
Cell Biology
Structural Biology
ISBN 3-031-14740-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Chapter 1: GrpE, Hsp110/Grp170, HspBP1/Sil1 and BAG domain proteins: Nucleotide exchange factors for Hsp70 molecular chaperones -- Chapter 2: Functions of the Hsp90-Binding FKBP Immunophilins -- Chapter 3: Hsp70/Hsp90 organising protein (Hop): coordinating much more than chaperones -- Chapter 4: Specification of Hsp70 function by Hsp40 Co-Chaperones -- Chapter 5: Cdc37 as a Co-chaperone to Hsp90 -- Chapter 6: p23 and Aha1 – Distinct functions promote client maturation -- Chapter 7: Beyond chaperoning: UCS proteins emerge as regulators of myosin-mediated cellular processes -- Chapter 8: Chaperonin - Co-Chaperonin Interactions -- Chapter 9: Co-chaperones of the human endoplasmic reticulum: an update -- Chapter 10: J Domain Proteins Orchestrate the Multifunctionality of Hsp70s in Mitochondria: Insights from Mechanistic and Evolutionary Analyses -- Chapter 11: Impact of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity -- Chapter 12: CHIP: a co-chaperone for degradation by the proteasome and lysosome -- Chapter 13: HSP70-HSP90 chaperone networking in protein misfolding disease.
Record Nr. UNINA-9910635392803321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023
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Nutrition, Exercise and Epigenetics: Ageing Interventions / / edited by Byung Pal Yu
Nutrition, Exercise and Epigenetics: Ageing Interventions / / edited by Byung Pal Yu
Edizione [1st ed. 2015.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015
Descrizione fisica 1 online resource (279 p.)
Disciplina 305.26
571.6
572.6
610
612.67
616.2
618.97
Collana Healthy Ageing and Longevity
Soggetto topico Medicine - Research
Biology - Research
Geriatrics
Cytology
Nutrition
Aging
Post-translational modification
Biomedical Research
Cell Biology
Ageing
Post-translational Modifications
ISBN 9783319148304
3-319-14829-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Preface -- Epigenetics and Nutrition -- Calorie restriction as a potent epigenetic modifier -- Anti-inflammatory action of calorie restriction for aging intervention -- Hormonal influence and modulation on aging -- Epigenetic modification by exercise -- Physiological bases and underlying mechanisms of exercise -- Sarcopenia and its intervention -- Nutritional impacts on osteopenia and osteoporosis -- Nutritional interventions for cardiac aging and age-related cardiovascular diseases -- Nutritional influence on aging brain -- Mechanistic bases of calorie restriction mimetics -- Lessons learned from calorie restricted non-human primate research.
Record Nr. UNINA-9910298296703321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015
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Transcription factors in blood cell development / / edited by Tilman Borggrefe, Benedetto Daniele Giaimo
Transcription factors in blood cell development / / edited by Tilman Borggrefe, Benedetto Daniele Giaimo
Autore Borggrefe Tilman
Edizione [1st ed. 2024.]
Pubbl/distr/stampa Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2024
Descrizione fisica 1 online resource (457 pages)
Disciplina 572.8845
Altri autori (Persone) GiaimoBenedetto Daniele
Collana Advances in Experimental Medicine and Biology
Soggetto topico Genetic transcription
Cytology
Post-translational modification
Hematopoietic system
Developmental biology
Gene Transcription
Cell Biology
Post-translational Modifications
Haematopoietic System
Developmental Biology and Stem Cells
ISBN 3-031-62731-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Part 1 – Stem/Progenitor Cells -- Chapter 1. MYB - A Key Transcription Factor in the Hematopoietic System Subject to many Levels of Control - Roza Berhanu Lemma, Bettina Maria Fuglerud, Jon Frampton & Odd Stokke Gabrielsen -- Part 2 – T-Cells -- Chapter 2. Ikaros Family Transcription Factors in Lymphocyte Differentiation and Function - Philippe Kastner & Susan Chan -- Chapter 3. The Role of the Transcriptional Co-Activator BOB.1/OBF.1 in Adaptive Immunity - Annika C. Betzler & Cornelia Brunner -- Chapter 4. Key Functions of the Transcription Factor BCL6 during T-Cell Differentiation - Chara Konstantakopoulou & Mihalis Verykokakis -- Part 3 – B-Cells -- Chapter 5. The Function of E2A in B-Cell Development - Masaki Miyazaki & Kazuko Miyazaki -- Chapter 6. Hypoxia and the Hypoxia-Inducible Factors in Lymphocyte Differentiation and Function - Mark Boothby & Sung Hoon Cho -- Chapter 7. Early B-Cell Factor 1: An Archetype for a Lineage-Restricted Transcription Factor Linking Development to Disease - Mikael Sigvardsson -- Part 4 – Myeloid Cells -- Chapter 8. Transcription Factor NRF2 in Shaping Myeloid Cell Differentiation and Function - Marc Pfefferlé & Florence Vallelian -- Part 5 – Erythroid Cells -- Chapter 9. Trancriptional Repressor BCL11A In Erythroid Cells - Ge Zheng & Stuart H. Orkin -- Chapter 10. Erythroid Krüppel-like Factor / KLF1: a Surprisingly Versatile Regulator of Erythroid Differentiation - James J Bieker & Sjaak Philipsen -- Chapter 11. Transcription Factor TAL1 in Erythropoiesis - Johannes Fechner & Jörn Lausen -- Part 6 – Megakaryocytes -- Chapter 12. GATA1 in Normal and Pathologic Megakaryopoiesis and Platelet Development - Kaoru Takasaki & Stella T. Chou -- Part 7 – Leukemia/Lymphoma -- Chapter 13. The Diverse Roles of ETV6 Alterations in B-Lymphoblastic Leukemia and other Hematopoietic Cancers - Alexander C. Monovich, Aishwarya Gurumurthy & Russell J.H. Ryan -- Chapter 14. Function of PML-RARA in Acute Promyelocytic Leukemia - Ugo Testa & Elvira Pelosi -- Cha[ter 15. MYB as a Critical Transcription Factor and Potential Therapeutic Target in AML - Mary Louise Clarke, Odd Stokke Gabrielsen & Jon Frampton -- Chapter 16. ETS1 Function in Leukemia and Lymphoma - Rebecca A. Luchtel -- Chapter 17. The Molecular and Biological Function of MEF2D in Leukemia - Pengcheng Zhang & Rui Lu -- Chapter 18. HOXA9 Regulome and Pharmacological Interventions in Leukemia - Sajesan Aryal & Rui Lu.
Record Nr. UNINA-9910874672003321
Borggrefe Tilman  
Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2024
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Understanding PTMs in Neurodegenerative Diseases / / edited by Victor Corasolla Carregari
Understanding PTMs in Neurodegenerative Diseases / / edited by Victor Corasolla Carregari
Edizione [1st ed. 2022.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022
Descrizione fisica 1 online resource (150 pages)
Disciplina 612.39
616.80471
Collana Proteomics, Metabolomics, Interactomics and Systems Biology
Soggetto topico Post-translational modification
Bioinformatics
Molecular biology
Nervous system - Diseases
Post-translational Modifications
Computational and Systems Biology
Molecular Biology
Neurological Disorders
ISBN 9783031054600
9783031054594
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Protein extraction and sample preparation methods for shotgun proteomics with central nervous system cells and brain tissue -- Phosphopeptide enrichment techniques: a pivotal step for phosphoproteomic studies -- Post-Translational Modifications during Brain Development -- Aberrant protein glycosylation in brain cancers, with emphasis on glioblastoma -- Post-Translational Modification in Muscular Dystrophies -- Post-translational Modifications in Parkinson’s Disease -- Histone Modifications in Neurological Disorders -- Mitochondrial dysregulation and the influence in neurodegenerative diseases -- PTMs: A missing piece for schizophrenia studies -- Post-Translational Modifications in Brain Diseases: A Future for Biomarkers -- Index.
Record Nr. UNINA-9910590080403321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022
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