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Advances in combination therapy for asthma and COPD / / editor, Jan Lötvall
| Advances in combination therapy for asthma and COPD / / editor, Jan Lötvall |
| Edizione | [3rd ed.] |
| Pubbl/distr/stampa | Chichester, West Sussex, : John Wiley & Sons, 2012 |
| Descrizione fisica | 1 online resource (366 p.) |
| Disciplina | 616.2/3061 |
| Altri autori (Persone) |
LötvallJan
BusseW. W (William W.) |
| Soggetto topico |
Lungs - Diseases, Obstructive - Chemotherapy
Asthma - Chemotherapy Polypharmacy Chemotherapy, Combination |
| ISBN |
1-283-40690-X
9786613406903 1-119-99862-X 1-119-99863-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Similarities and differences in the pathophysiology of asthma and COPD / Christian Virchow -- Glucocorticoids : pharmacology and mechanisms / Peter Barnes -- Inhaled corticosteroids ? clinical effects in asthma and COPD / Paul O'Byrne -- LABAS : pharmacology, mechanisms and interaction with anti-inflammatory treatments / Gary Anderson -- Long and ultra-long acting beta-2-agonists / Mario Cazzola -- The safety of long-acting beta agonists and the development of combination therapies for asthma and chronic obstructive pulmonary disease / Eugene Bleecker -- Inhaled combination therapy with glucocorticoids and long-acting beta-2-agonists in asthma and COPD, current and future perspectives / Jan Lotvall -- Novel anti-inflammatory treatments for asthma and COPD / Ian Adcock -- Novel biologicals alone and in combination in asthma and allergy / William Busse -- Anti-infective treatments in asthma and COPD / Jonathan D.R. Macintyre & Sebastian L. Johnston -- Long acting muscarinic antagonists in asthma and COPD / Denis O'Donnell -- Phosphodiesterase inhibitors in obstructive lung disease / Jan Lotvall -- Biological therapies in development for COPD / Riccardo Polosa -- Triple therapy?, in the management of chronic obstructive lung disease (COPD). The value of combination treatment with inhaled steroid, long acting anticholinergicbronchodilator and long acting beta 2 agonist bronchodilator in COPD / Ronald Dahl. |
| Record Nr. | UNINA-9910139738303321 |
| Chichester, West Sussex, : John Wiley & Sons, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Polypharmacology in drug discovery / / edited by Jens-Uwe Peters
| Polypharmacology in drug discovery / / edited by Jens-Uwe Peters |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2012 |
| Descrizione fisica | 1 online resource (544 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) | PetersJens-Uwe |
| Soggetto topico |
Drugs - Design
Polypharmacy |
| ISBN |
1-280-58932-9
9786613619150 1-118-09813-7 1-118-09814-5 1-118-09812-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: List of contributors. Preface.Introduction: the case for polypharmacology Andrew L. Hopkins Part A: Polypharmacology - a safety concern in drug discovery. 1 The relevance of off-target polypharmacology Bruce D. Car 2 Screening for safety-relevant off-target activities Laszlo Urban, Steven Whitebread, Jacques Hamon, Dmitri Mikhailov and Kamal Azzaoui 2.1 Introduction. 2.2 General aspects. 2.3 Selection of off-targets. 2.4 In silico approaches to off-target profiling .2.5 Summary and conclusions. 3 Pharmacological promiscuity and molecular propertiesJens-Uwe Peters 3.1 Introduction: pharmacological promiscuity in the history of drug discovery. 3.2 Lipophilicity. 3.3 Molecular weight. 3.4 Ionisation state. 3.5 Other molecular descriptors and structural motifs. 3.6 Implications for drug discovery. 4 Kinases as antitargets in genotoxicity Stephan Kirchner 4.1 Protein Kinases and inhibitor-binding sites. 4.2 Cyclin-Dependent Kinases (CDKs) controlling unregulated cell proliferation. 4.3 Mitotic kinases as guardians protecting cells from aberrant chromosome segregation. 5 Activity at cardiovascular ion channels: a key issue for drug discoveryIan M. Bell, Mark T. Bilodeau and Armando A. Lagrutta 5.1 Introduction. 5.2 Screening methods. 5.3 Structural insights into the interaction between drugs and CV ion channels. 5.4 Medicinal Chemistry approaches. 5.5 Conclusion. 6 Prediction of side effects based on fingerprint profiling and data mining Jacques Migeon 6.1 Introduction to BioPrint. 6.2 The pharmacological fingerprint. 6.3 Antidepressant example. 6.4 Profile similarity at non-therapeutic targets. 6.5 Interpreting the polypharmacology profile. 6.6 Methods. 6.7 Patterns of activity. 6.8 Integrating function profile data with traditional pharmacological binding data. 6.9 Analysis of the antifungal tioconazole. 6.10 Conclusions. Part B: Polypharmacology - an opportunity for drug discovery. 7 Polypharmacological drugs - "magic shotguns" for psychiatric diseases Wesley K. Kroeze and Bryan L. Roth 7.1 Introduction. 7.2 Definition. 7.3 The discovery and extent of promiscuity among psychiatric drugs. 7.4 Why are so many psychiatric drugs promiscuous? 7.5 Conclusions. 8 Polypharmacological kinase inhibitors: new hopes for the therapy of cancer Annalisa Petrelli 8.1 Targeted therapies: a new era in the treatment of cancer. 8.2 The single-targeted therapy. 8.3 From single to multi-targeted drugs in cancer therapy. 8.4 Polypharmacology kinase inhibitors in clinical practice and under development. 8.5 Concluding remarks. 9 Polypharmacology as an emerging trend in antibacterial discovery Lynn L. Silver 9.1 Introduction. 9.2 Classical antibacterial polypharmacology. 9.3 New approaches to multi-targeted single pharmacophores. 9.4 Synthetic lethals. 9.5 Hybrid molecules. 9.6 Conclusions. 10 A "magic shotgun" perspective on anticonvulsant mechanisms Matt T. Bianchi and Kathy Chuang 10.1 Introduction. 10.2 Anticonvulsant mechanism. 10.3 Defining promiscuity. 10.4 Promiscuity: lessons from endogenous signaling. 10.5 Promiscuity: lessons from anticonvulsant electrophysiology. 10.6 Use of anticonvulsants in disorders other than epilepsy. 10.7 Experimental and theoretical support for a "Magic Shotgun" approach. 10.8 Current multi-target strategies. 10.9 Practical considerations. 10.10 Conclusion. 11 Selective Optimization of Side Activities (SOSA): a promising way for drug discovery Thierry Langer and Camille-Georges Wermuth 11.1 Introduction. 11.2 Definition and principle. 11.3 Rationale of SOSA. 11.4 Establishing the SOSA approach. 11.5 A successful example of the SOSA approach. 11.6 Other examples of SOSA switches. 11.7 Discussion. 11.8 Computer-assisted design using pharmacophores. 11.9 Conclusions. Part C: Selected approaches to polypharmacological drug discovery 12 Selective multi-targeted drugs Richard Morphy 12.1 Introduction. 12.2 Lead Generation. 12.3 Lead optimization. 12.4 Case studies. 12.5 Summary. 13 Computational multitarget drug discovery Jeremy A. Horst, Adrian Laurenzi, Brady Bernard and Ram Samudrala 13.1 Introduction. 13.2 The pharmacologic hunt of yester year. 13.3. Established technological advancements. 13.4. Computational drug discovery. 13.5. Recent technical improvements. 13.6. Emerging concepts. 13.7 Summary. 14 Behavior-based screening as an approach to polypharmacological ligands Dani Brunner, Vadim Alexandrov, Barbara Caldarone, Taleen Hanania, David Lowe, Jeff Schneider and Jayaraman Chandrasekhar 14.1 The Challenges of CNS Drug Discovery. 14.2 In vivo high throughput screening. 14.3 Screening libraries of compounds. 14.4 Relationship between molecular properties and in vivo CNS activity. 14.5 Following screening hits in secondary assays. 14.6 Potential therapeutic value of dual adenosine compounds. 14.7 Summary. 15 Multicomponent Therapeutics Alexis A. Borisy, Grant R. Zimmermann and Joseph Lehar 15.1 Introduction. 15.2 Drug synergies are statistically more context dependent. 15.3 How a synergistic mechanism can lead to therapeutic selectivity. 15.4 Discussion. Part D: Case studies 16 The discovery of sunitinib as a multitarget treatment of cancer Catherine Delbaldo, Camelia Colichi, Marie-Paule Sablin, Chantal Dreyer, Bertrand Billemont, Sandrine Faivre and Eric Raymond 16.1 A brief introduction to tumor angiogenesis. 16.2 The discovery of sunitinib: from drug design to first evidences of clinical activity. 16.3 Pharmacology of sunitinib. 16.4 Safety of sunitinib. 16.5 Activity of Sunitinib. 16.6 Surrogate imaging techniques to capture vascular changes. 16.7 Surrogate biomarkers. 16.8 Conclusion. 17 Antipsychotics Claus Riemer 17.1 Definition and diagnosis of schizophrenia. 17.2 Etiology and pathophysiology of schizophrenia. 17.3 Epidemiology. 17.4 Medical practice and treatment options. 17.5 Case studies. 17.6 CATIE. 17.7 Conclusions. 18 Triple Uptake Inhibitors ("Broad Spectrum" Antidepressants) Phil Skolnick 18.1 Introduction. 18.2 What is the rationale for developing triple uptake inhibitors as antidepressants? 18.3 Preclinical data. 18.4 Clinical data. 18.5 Concluding remarks. 19 Therapeutic potential of small molecules modulating the cyclooxygenase and 5-lipoxygenase pathway Stefan Laufer and Wolfgang Albrecht 19.1 Targets of the eicosanoid pathway. 19.2 Rationale for development of dual inhibitors of the cyclooxygenase and 5-lipoxygenase pathway. 19.3 Dual inhibitors of the cyclooxygenase and 5-lipoxygenase pathway. 19.4 Development of Licofelone. 19.5 Conclusions. 20 Drug research leading to imatinib and beyond to nilotinib Paul W. Manley and Jurg Zimmermann 20.1 Introduction. 20.2 Historical background. 20.3 BCR-ABL1 as the molecular target for CML therapy. 21 Towards antimalarial hybrid drugs Bernard Meunier 22 Multitarget drugs for the treatment of Alzheimer's disease Andrea Cavalli and Maria Laura Bolognesi 22.1 Introduction. 22.2 Case studies. 22.3 Conclusions and perspectives. 23 Carbonic anhydrases: off-targets, add-on activities, or emerging novel targets? Claudiu Supuran 23.1 Introduction. 23.2 Carbonic anhydrase inhibition. 23.3 Topiramate and zonisamide, antiepileptics with potent antiobesity action. 23.4 Sulfonamide coxibs with antitumor activity due to CA IX/XII inhibition. 23.5 Sulfamates with steroid sulfatase and carbonic anhydrase inhibitory action as anticancer agents in clinical development. 23.6 Lacosamide, an antiepileptic with a strange binding mode to Cas. 23.7 The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian CA isoforms. 23.8 Conclusions. |
| Record Nr. | UNINA-9910141339303321 |
| Hoboken, N.J., : Wiley, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Polypharmacy in psychiatry practice . Volume 1 Multiple medication use strategies / / Michael S. Ritsner, editor
| Polypharmacy in psychiatry practice . Volume 1 Multiple medication use strategies / / Michael S. Ritsner, editor |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | Dordrecht, : Springer, 2013 |
| Descrizione fisica | 1 online resource (295 p.) |
| Disciplina |
615.7/88
615.788 616.8918 |
| Altri autori (Persone) | RitsnerMichael S |
| Soggetto topico |
Polypharmacy
Psychopharmacology |
| ISBN |
1-299-40842-7
94-007-5805-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Polypharmacy in Psychiatry Practice Volume I; About the Editor; Preface; Contents; Contributors; Part I: Polypharmacy Treatment Strategies; Chapter 1 : Multiple Psychiatric Medications Use in Psychiatry: How Rational Can It Be?; 1.1 Introduction; 1.2 Rationale for MMU in HIV; 1.3 Rationale for MMU in Cancer; 1.4 Rationale for MMU in Parkinson's Disease; 1.5 The Principles and the Rationale for MPMU; 1.5.1 Pharmacokinetic Drug Interactions; 1.5.2 Pharmacodynamic Drug Interactions; 1.5.3 Interactions Involving both Pharmacokinetic and Pharmacodynamic Mechanisms
1.6 Conclusions and Future DirectionsReferences; Chapter 2: Receptor Binding Targets for Antipsychotic Efficacy; 2.1 Introduction; 2.2 Methods; 2.2.1 Data Analysis; 2.3 Results; 2.4 Discussion; 2.4.1 D3 Dopamine Receptor Provides a Molecular Binding Target for Antipsychotic Efficacy; 2.4.2 Serotonin Receptor Contributions to Antipsychotic Efficacy; 2.5 Limitations; 2.6 Conclusions and Future Directions; References; Chapter 3: Drug Interactions and Polypharmacy; 3.1 Introduction; 3.2 Pharmacodynamic Interactions; 3.2.1 Pharmacodynamic Drug Interaction Classification 3.2.2 Time Course of Pharmacodynamic Interactions3.2.3 Serious Pharmacodynamic Interactions; 3.2.3.1 Hypertension and Hypertensive Crisis; 3.2.3.2 Serotonin Syndrome; 3.2.3.3 Bleeding; 3.2.3.4 Psychosis and Extrapyramidal Side Effects; 3.2.3.5 CNS Depression; 3.2.3.6 Anticholinergic Effects; 3.2.3.7 Arrhythmias/QTc Prolongation; 3.3 Pharmacokinetic Drug Interactions; 3.4 Clinical Effects of Drug Interactions; 3.4.1 Risk Factors; 3.5 Drug Interaction Software; 3.6 Prevention and Management of Drug Interactions; 3.7 Resources for Assessing Drug Interactions; 3.8 Conclusions Appendix. Commonly Encountered Psychotropic Interactions [ 9, 47, 59, 74 ]References; Chapter 4: Preclinical and Clinical Investigation of Antipsychotic Polypharmacy: What Is the Evidence?; 4.1 Introduction; 4.2 What Is the Preclinical Evidence for Antipsychotic Polypharmacy?; 4.3 Antipsychotic Polypharmacy in Clinical Practice; 4.3.1 Prevalence of Antipsychotic Polypharmacy; 4.3.2 Explaining the Differences in Prevalence of Antipsychotic Polypharmacy Among Studies; 4.3.3 Does the Prevalence of Polypharmacy Depend on the Baseline Antipsychotic Agent? 4.3.4 Prevalence of Polypharmacy: Change Over Time4.3.5 Predictors of Polypharmacy; 4.3.5.1 Patient Factors; 4.3.5.2 Setting and Therapists Factors; 4.3.6 Other Factors Associated with Antipsychotic Polypharmacy; 4.3.6.1 Mortality; 4.3.6.2 Increased Total Antipsychotic Dose; 4.3.6.3 Cost; 4.3.6.4 Cognitive Impairment; 4.4 Efficacy of Polypharmacy; 4.4.1 Meta-analyses; 4.4.2 Reviews; 4.4.3 Discontinuation Studies; 4.5 Management of Antipsychotic Polypharmacy; 4.6 Discussing the Evidence; 4.7 Conclusions and Future Directions; References Chapter 5: Should High Dose or Very Long-Term Antipsychotic Monotherapy Be Considered Before Antipsychotic Polypharmacy? |
| Record Nr. | UNINA-9910437844903321 |
| Dordrecht, : Springer, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Polypharmacy in psychiatry practice . Volume 2 Use of polypharmacy in the "Real World" / / edited by Michael S. Ritsner
| Polypharmacy in psychiatry practice . Volume 2 Use of polypharmacy in the "Real World" / / edited by Michael S. Ritsner |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | Dordrecht, : Springer, 2013 |
| Descrizione fisica | 1 online resource (326 p.) |
| Disciplina |
615.7/88
616.8918 |
| Altri autori (Persone) | RitsnerMichael S |
| Soggetto topico |
Polypharmacy
Psychopharmacology |
| ISBN |
1-299-40841-9
94-007-5799-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. Antipsychotic polypharmacy for schizophrenia: 'Secret sauce' or 'wild abandon'? -- Antipsychotic polypharmacy in USA -- Antipsychotic polypharmacy in Czech Republic and in Ukraine -- Antipsychotic polypharmacy in residential facilities in Italy: the gap between recommendations and real world practice -- Antipsychotic polypharmacy and associated phenomena in patients with schizophrenia: Rational or irrational? -- Antipsychotic polypharmacy in schizophrenia. How to counteract this common practice? -- Clozapine combinations in treatment-resistant schizophrenia patients -- Metabolic syndrome and antipsychotic polypharmacy -- Evidence based combination therapy for bipolar disorder -- Antidepressant combination strategies for major depressive disorder -- Herbal remedies and nutraceuticals as augmentation or adjunct for mood and anxiety disorders: evidence for benefit and risk -- Obsessive-compulsive syndromes in schizophrenia: A case for polypharmacy? -- Polypharmacy and potentially inappropriate medication use among elders with dementia -- The role of polypharmacy in bipolar disorder treatment guidelines. |
| Record Nr. | UNINA-9910437842403321 |
| Dordrecht, : Springer, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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