Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
| ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide |
| Autore | Tsaioun Katya |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2012 |
| Descrizione fisica | 1 online resource (524 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) | KatesSteven A |
| Soggetto topico |
Drug Design
Drug Toxicity Drugs - Testing Drugs --Testing --Juvenile literature Pharmaceutical Preparations - chemistry Pharmacokinetics Metabolic Phenomena Drug Discovery Pharmacological Phenomena Natural Science Disciplines Kinetics Chemicals and Drugs Poisoning Biochemical Phenomena Chemistry, Pharmaceutical Substance-Related Disorders Disciplines and Occupations Investigative Techniques Physiological Phenomena Phenomena and Processes Chemical Phenomena Diseases Pharmacology Analytical, Diagnostic and Therapeutic Techniques and Equipment Biological Science Disciplines Chemistry Pharmaceutical Preparations Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-280-59122-6
9786613621054 0-470-91509-9 0-470-91511-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions
2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs 2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods 2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution 4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools 4.5.7 Tools for Studying Drug Excretion |
| Record Nr. | UNINA-9910133588303321 |
Tsaioun Katya
|
||
| Hoboken, : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
| ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide |
| Autore | Tsaioun Katya |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2012 |
| Descrizione fisica | 1 online resource (524 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) | KatesSteven A |
| Soggetto topico |
Drug Design
Drug Toxicity Drugs - Testing Drugs --Testing --Juvenile literature Pharmaceutical Preparations - chemistry Pharmacokinetics Metabolic Phenomena Drug Discovery Pharmacological Phenomena Natural Science Disciplines Kinetics Chemicals and Drugs Poisoning Biochemical Phenomena Chemistry, Pharmaceutical Substance-Related Disorders Disciplines and Occupations Investigative Techniques Physiological Phenomena Phenomena and Processes Chemical Phenomena Diseases Pharmacology Analytical, Diagnostic and Therapeutic Techniques and Equipment Biological Science Disciplines Chemistry Pharmaceutical Preparations Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-280-59122-6
9786613621054 0-470-91509-9 0-470-91511-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions
2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs 2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods 2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution 4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools 4.5.7 Tools for Studying Drug Excretion |
| Record Nr. | UNINA-9910830164603321 |
|
Tsaioun Katya
|
||
| Hoboken, : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Asia Pacific journal of medical toxicology
| Asia Pacific journal of medical toxicology |
| Pubbl/distr/stampa | Mashhad, : Mashhad University of Medical Sciences, 2012- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Toxicology
Poisoning |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 2322-4320 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | APJMT |
| Record Nr. | UNISA-996321932403316 |
| Mashhad, : Mashhad University of Medical Sciences, 2012- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Asia Pacific journal of medical toxicology
| Asia Pacific journal of medical toxicology |
| Pubbl/distr/stampa | Mashhad, : Mashhad University of Medical Sciences, 2012- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Toxicology
Poisoning |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 2322-4320 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | APJMT |
| Record Nr. | UNINA-9910141580203321 |
| Mashhad, : Mashhad University of Medical Sciences, 2012- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Caustic acids. April 1, 1926. -- Committed to the Committee of the Whole House on the State of the Union and ordered to be printed
| Caustic acids. April 1, 1926. -- Committed to the Committee of the Whole House on the State of the Union and ordered to be printed |
| Pubbl/distr/stampa | [Washington, D.C.] : , : [U.S. Government Printing Office], , 1926 |
| Descrizione fisica | 1 online resource (3 pages) |
| Altri autori (Persone) | NelsonJohn Edward <1874-1955> (Republican (ME)) |
| Collana |
House report / 69th Congress, 1st session. House
[United States congressional serial set ] |
| Soggetto topico |
Interstate commerce
Labels Poisons Poisoning |
| Soggetto genere / forma | Legislative materials. |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910716349303321 |
| [Washington, D.C.] : , : [U.S. Government Printing Office], , 1926 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
La cocina de los venenos : aspectos de la criminalidad en el Nuevo Reino de Granada, siglos XVII y XVIII / / Juan Sebastián Ariza Martínez
| La cocina de los venenos : aspectos de la criminalidad en el Nuevo Reino de Granada, siglos XVII y XVIII / / Juan Sebastián Ariza Martínez |
| Autore | Ariza Martínez Juan Sebastián |
| Pubbl/distr/stampa | Bogotá : , : Editorial Universidad del Rosario, , [2015] |
| Descrizione fisica | 1 online resource (213 páginas) |
| Disciplina | 364 |
| Collana | Colección Opera Prima |
| Soggetto topico |
Criminology
Criminología Poisoning Envenenamiento |
| Soggetto genere / forma | Libros electronicos. |
| ISBN | 958-738-550-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | spa |
| Record Nr. | UNINA-9910228950303321 |
|
Ariza Martínez Juan Sebastián
|
||
| Bogotá : , : Editorial Universidad del Rosario, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The elements of murder [[electronic resource] /] / John Emsley
| The elements of murder [[electronic resource] /] / John Emsley |
| Autore | Emsley John |
| Pubbl/distr/stampa | Oxford ; ; New York, : Oxford University Press, 2005 |
| Descrizione fisica | 1 online resource (436 p.) |
| Disciplina | 615.9 |
| Collana | Oxford scholarship online |
| Soggetto topico |
Poisoning
Poisons Toxicology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-19-191641-2
0-19-100490-1 0-19-151735-6 9786612268410 0-19-280600-9 1-282-26841-4 1-280-76289-6 9786610762897 1-4356-0532-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Contents; Acknowledgements; Introduction; 1. The poisonous elements of alchemy; MERCURY; ARSENIC; ANTIMONY; LEAD; THALLIUM; Appendix; Glossary; Bibliography; Index; |
| Record Nr. | UNINA-9910450801603321 |
|
Emsley John
|
||
| Oxford ; ; New York, : Oxford University Press, 2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The elements of murder [[electronic resource] /] / John Emsley
| The elements of murder [[electronic resource] /] / John Emsley |
| Autore | Emsley John |
| Pubbl/distr/stampa | Oxford ; ; New York, : Oxford University Press, 2005 |
| Descrizione fisica | 1 online resource (436 p.) |
| Disciplina | 615.9 |
| Collana | Oxford scholarship online |
| Soggetto topico |
Poisoning
Poisons Toxicology |
| ISBN |
0-19-191641-2
0-19-100490-1 0-19-151735-6 9786612268410 0-19-280600-9 1-282-26841-4 1-280-76289-6 9786610762897 1-4356-0532-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Contents; Acknowledgements; Introduction; 1. The poisonous elements of alchemy; MERCURY; ARSENIC; ANTIMONY; LEAD; THALLIUM; Appendix; Glossary; Bibliography; Index; |
| Record Nr. | UNINA-9910777042803321 |
|
Emsley John
|
||
| Oxford ; ; New York, : Oxford University Press, 2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The elements of murder / / John Emsley
| The elements of murder / / John Emsley |
| Autore | Emsley John |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Oxford ; ; New York, : Oxford University Press, 2005 |
| Descrizione fisica | 1 online resource (436 p.) |
| Disciplina |
615.9
615.909 |
| Collana | Oxford scholarship online |
| Soggetto topico |
Poisoning
Poisons Toxicology |
| ISBN |
0-19-191641-2
0-19-100490-1 0-19-151735-6 9786612268410 0-19-280600-9 1-282-26841-4 1-280-76289-6 9786610762897 1-4356-0532-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Contents; Acknowledgements; Introduction; 1. The poisonous elements of alchemy; MERCURY; ARSENIC; ANTIMONY; LEAD; THALLIUM; Appendix; Glossary; Bibliography; Index; |
| Record Nr. | UNINA-9910812235203321 |
|
Emsley John
|
||
| Oxford ; ; New York, : Oxford University Press, 2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Ellen B. Monahan. February 17, 1927. -- Committed to the Committee of the Whole House and ordered to be printed
| Ellen B. Monahan. February 17, 1927. -- Committed to the Committee of the Whole House and ordered to be printed |
| Pubbl/distr/stampa | [Washington, D.C.] : , : [U.S. Government Printing Office], , 1927 |
| Descrizione fisica | 1 online resource (8 pages) |
| Altri autori (Persone) | BoxJohn C <1871-1941> (John Calvin), (Democrat (TX)) |
| Collana |
House report / 69th Congress, 2nd session. House
[United States congressional serial set] |
| Soggetto topico |
Claims
Indoor air pollution Industrial accidents Industrial safety Legislative amendments Poisons Poisoning Civil service |
| Soggetto genere / forma | Legislative materials. |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910716446103321 |
| [Washington, D.C.] : , : [U.S. Government Printing Office], , 1927 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Poisoning
(43)
- Toxicology (21)
- Poisons (15)
- Diseases (8)
- Substance-Related Disorders (8)