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ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
Autore Tsaioun Katya
Pubbl/distr/stampa Hoboken, : Wiley, 2012
Descrizione fisica 1 online resource (524 p.)
Disciplina 615.19
615/.19
Altri autori (Persone) KatesSteven A
Soggetto topico Drug Design
Drug Toxicity
Drugs - Testing
Drugs --Testing --Juvenile literature
Pharmaceutical Preparations - chemistry
Pharmacokinetics
Metabolic Phenomena
Drug Discovery
Pharmacological Phenomena
Natural Science Disciplines
Kinetics
Chemicals and Drugs
Poisoning
Biochemical Phenomena
Chemistry, Pharmaceutical
Substance-Related Disorders
Disciplines and Occupations
Investigative Techniques
Physiological Phenomena
Phenomena and Processes
Chemical Phenomena
Diseases
Pharmacology
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Biological Science Disciplines
Chemistry
Pharmaceutical Preparations
Health & Biological Sciences
Pharmacy, Therapeutics, & Pharmacology
ISBN 1-280-59122-6
9786613621054
0-470-91509-9
0-470-91511-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions
2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs
2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods
2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution
4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools
4.5.7 Tools for Studying Drug Excretion
Record Nr. UNINA-9910133588303321
Tsaioun Katya  
Hoboken, : Wiley, 2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
Autore Tsaioun Katya
Pubbl/distr/stampa Hoboken, : Wiley, 2012
Descrizione fisica 1 online resource (524 p.)
Disciplina 615.19
615/.19
Altri autori (Persone) KatesSteven A
Soggetto topico Drug Design
Drug Toxicity
Drugs - Testing
Drugs --Testing --Juvenile literature
Pharmaceutical Preparations - chemistry
Pharmacokinetics
Metabolic Phenomena
Drug Discovery
Pharmacological Phenomena
Natural Science Disciplines
Kinetics
Chemicals and Drugs
Poisoning
Biochemical Phenomena
Chemistry, Pharmaceutical
Substance-Related Disorders
Disciplines and Occupations
Investigative Techniques
Physiological Phenomena
Phenomena and Processes
Chemical Phenomena
Diseases
Pharmacology
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Biological Science Disciplines
Chemistry
Pharmaceutical Preparations
Health & Biological Sciences
Pharmacy, Therapeutics, & Pharmacology
ISBN 1-280-59122-6
9786613621054
0-470-91509-9
0-470-91511-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions
2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs
2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods
2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution
4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools
4.5.7 Tools for Studying Drug Excretion
Record Nr. UNINA-9910830164603321
Tsaioun Katya  
Hoboken, : Wiley, 2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
Autore Tsaioun Katya
Pubbl/distr/stampa Hoboken, : Wiley, 2012
Descrizione fisica 1 online resource (524 p.)
Disciplina 615.19
615/.19
Altri autori (Persone) KatesSteven A
Soggetto topico Drug Design
Drug Toxicity
Drugs - Testing
Drugs --Testing --Juvenile literature
Pharmaceutical Preparations - chemistry
Pharmacokinetics
Metabolic Phenomena
Drug Discovery
Pharmacological Phenomena
Natural Science Disciplines
Kinetics
Chemicals and Drugs
Poisoning
Biochemical Phenomena
Chemistry, Pharmaceutical
Substance-Related Disorders
Disciplines and Occupations
Investigative Techniques
Physiological Phenomena
Phenomena and Processes
Chemical Phenomena
Diseases
Pharmacology
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Biological Science Disciplines
Chemistry
Pharmaceutical Preparations
Health & Biological Sciences
Pharmacy, Therapeutics, & Pharmacology
ISBN 1-280-59122-6
9786613621054
0-470-91509-9
0-470-91511-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions
2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs
2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods
2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution
4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools
4.5.7 Tools for Studying Drug Excretion
Record Nr. UNINA-9910841604803321
Tsaioun Katya  
Hoboken, : Wiley, 2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advanced physiology and pathophysiology : essentials for clinical practice / / Nancy C. Tkacs, PhD, RN, Linda Herrmann, PhD, RN, ACHPN, AGACNP-BC, GNP-BC, FAANP, Randall Johnson, PhD, RN
Advanced physiology and pathophysiology : essentials for clinical practice / / Nancy C. Tkacs, PhD, RN, Linda Herrmann, PhD, RN, ACHPN, AGACNP-BC, GNP-BC, FAANP, Randall Johnson, PhD, RN
Autore Tkacs Nancy C.
Pubbl/distr/stampa New York, New York : , : Springer Publishing Company, , [2021]
Descrizione fisica 1 online resource (841 pages)
Disciplina 612
Soggetto topico Physiology
Physiology, Pathological
Physiological Phenomena
Pathologic Processes
Soggetto genere / forma Electronic books.
ISBN 0-8261-7708-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910481051103321
Tkacs Nancy C.  
New York, New York : , : Springer Publishing Company, , [2021]
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advanced physiology and pathophysiology : essentials for clinical practice / / Nancy C. Tkacs, PhD, RN, Linda Herrmann, PhD, RN, ACHPN, AGACNP-BC, GNP-BC, FAANP, Randall Johnson, PhD, RN
Advanced physiology and pathophysiology : essentials for clinical practice / / Nancy C. Tkacs, PhD, RN, Linda Herrmann, PhD, RN, ACHPN, AGACNP-BC, GNP-BC, FAANP, Randall Johnson, PhD, RN
Autore Tkacs Nancy C.
Pubbl/distr/stampa New York, New York : , : Springer Publishing Company, , [2021]
Descrizione fisica 1 online resource (841 pages)
Disciplina 612
Soggetto topico Physiology
Physiology, Pathological
Physiological Phenomena
Pathologic Processes
Soggetto genere / forma Electronic books.
ISBN 0826177085
9780826177070
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto 1. the foundational concepts of clinical practice 2. chemical and biochemical foundations 3. molecular biology, genetics, and genetic diseases 4. cell physiology and pathophysiology 5. infectious disease 6. the immune system and leukocyte function 7. neoplasia 8. blood and clotting9. circulation 10. heart 11. lungs 12. kidneys 13. gastrointestinal tract 14. liver 15. nervous system 16. musculoskeletal system 17. endocrine system
Record Nr. UNINA-9910526014203321
Tkacs Nancy C.  
New York, New York : , : Springer Publishing Company, , [2021]
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Aesthetic surgery after massive weight loss
Aesthetic surgery after massive weight loss
Pubbl/distr/stampa [Place of publication not identified], : Saunders Elsevier, 2007
Soggetto topico Surgical Procedures, Operative
Obesity
Specialties, Surgical
Body Weight Changes
Overweight
Body Weight
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Medicine
Overnutrition
Signs and Symptoms
Nutrition Disorders
Health Occupations
Body Size
Growth
Nutritional and Metabolic Diseases
Disciplines and Occupations
Pathological Conditions, Signs and Symptoms
Growth and Development
Diseases
Body Weights and Measures
Body Constitution
Physiological Processes
Physiological Phenomena
Physical Examination
Phenomena and Processes
Diagnostic Techniques and Procedures
Diagnosis
Obesity, Morbid
Surgery, Plastic
Reconstructive Surgical Procedures
Weight Loss
ISBN 1-4160-2952-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNISA-996212364203316
[Place of publication not identified], : Saunders Elsevier, 2007
Materiale a stampa
Lo trovi qui: Univ. di Salerno
Opac: Controlla la disponibilità qui
Ageing vulnerability : causes and interventions
Ageing vulnerability : causes and interventions
Pubbl/distr/stampa [Place of publication not identified], : Wiley, 2001
Descrizione fisica 1 online resource (291 pages)
Disciplina 612.67
Collana Novartis Foundation Symposia
Soggetto topico Aging
Growth and Development
Physiological Processes
Physiological Phenomena
Phenomena and Processes
Soggetto genere / forma Electronic books.
ISBN 9786610556106
0-470-86869-4
1-280-55610-2
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910143202303321
[Place of publication not identified], : Wiley, 2001
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Ageing vulnerability : causes and interventions
Ageing vulnerability : causes and interventions
Pubbl/distr/stampa [Place of publication not identified], : Wiley, 2001
Descrizione fisica 1 online resource (291 pages)
Disciplina 612.67
Collana Novartis Foundation Symposia
Soggetto topico Aging
Growth and Development
Physiological Processes
Physiological Phenomena
Phenomena and Processes
ISBN 9786610556106
0-470-86869-4
1-280-55610-2
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910830064503321
[Place of publication not identified], : Wiley, 2001
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Ageing vulnerability : causes and interventions
Ageing vulnerability : causes and interventions
Pubbl/distr/stampa [Place of publication not identified], : Wiley, 2001
Descrizione fisica 1 online resource (291 pages)
Disciplina 612.67
Collana Novartis Foundation Symposia
Soggetto topico Aging
Growth and Development
Physiological Processes
Physiological Phenomena
Phenomena and Processes
ISBN 9786610556106
0-470-86869-4
1-280-55610-2
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910840696203321
[Place of publication not identified], : Wiley, 2001
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Un aliment sain dans un corps sain : perspectives historiques
Un aliment sain dans un corps sain : perspectives historiques
Pubbl/distr/stampa [Place of publication not identified], : Presses universitaires François Rabelais, 2007
Descrizione fisica 1 online resource (344 p.)
Soggetto topico Food and Beverages
Nutritional Physiological Phenomena
Behavior, Animal
Behavior
Investigative Techniques
Physiological Phenomena
Technology, Industry, Agriculture
Behavior and Behavior Mechanisms
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Psychiatry and Psychology
Phenomena and Processes
Feeding Behavior
Diet
Food
ISBN 2-86906-338-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione fre
Record Nr. UNINA-9910495897303321
[Place of publication not identified], : Presses universitaires François Rabelais, 2007
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui