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ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
| ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide |
| Autore | Tsaioun Katya |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2012 |
| Descrizione fisica | 1 online resource (524 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) | KatesSteven A |
| Soggetto topico |
Drug Design
Drug Toxicity Drugs - Testing Drugs --Testing --Juvenile literature Pharmaceutical Preparations - chemistry Pharmacokinetics Metabolic Phenomena Drug Discovery Pharmacological Phenomena Natural Science Disciplines Kinetics Chemicals and Drugs Poisoning Biochemical Phenomena Chemistry, Pharmaceutical Substance-Related Disorders Disciplines and Occupations Investigative Techniques Physiological Phenomena Phenomena and Processes Chemical Phenomena Diseases Pharmacology Analytical, Diagnostic and Therapeutic Techniques and Equipment Biological Science Disciplines Chemistry Pharmaceutical Preparations Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-280-59122-6
9786613621054 0-470-91509-9 0-470-91511-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions
2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs 2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods 2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution 4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools 4.5.7 Tools for Studying Drug Excretion |
| Record Nr. | UNINA-9910133588303321 |
Tsaioun Katya
|
||
| Hoboken, : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
| ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide |
| Autore | Tsaioun Katya |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2012 |
| Descrizione fisica | 1 online resource (524 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) | KatesSteven A |
| Soggetto topico |
Drug Design
Drug Toxicity Drugs - Testing Drugs --Testing --Juvenile literature Pharmaceutical Preparations - chemistry Pharmacokinetics Metabolic Phenomena Drug Discovery Pharmacological Phenomena Natural Science Disciplines Kinetics Chemicals and Drugs Poisoning Biochemical Phenomena Chemistry, Pharmaceutical Substance-Related Disorders Disciplines and Occupations Investigative Techniques Physiological Phenomena Phenomena and Processes Chemical Phenomena Diseases Pharmacology Analytical, Diagnostic and Therapeutic Techniques and Equipment Biological Science Disciplines Chemistry Pharmaceutical Preparations Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-280-59122-6
9786613621054 0-470-91509-9 0-470-91511-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions
2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs 2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods 2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution 4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools 4.5.7 Tools for Studying Drug Excretion |
| Record Nr. | UNINA-9910830164603321 |
|
Tsaioun Katya
|
||
| Hoboken, : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advanced physiology and pathophysiology : essentials for clinical practice / / Nancy C. Tkacs, PhD, RN, Linda Herrmann, PhD, RN, ACHPN, AGACNP-BC, GNP-BC, FAANP, Randall Johnson, PhD, RN
| Advanced physiology and pathophysiology : essentials for clinical practice / / Nancy C. Tkacs, PhD, RN, Linda Herrmann, PhD, RN, ACHPN, AGACNP-BC, GNP-BC, FAANP, Randall Johnson, PhD, RN |
| Autore | Tkacs Nancy C. |
| Pubbl/distr/stampa | New York, New York : , : Springer Publishing Company, , [2021] |
| Descrizione fisica | 1 online resource (841 pages) |
| Disciplina | 612 |
| Soggetto topico |
Physiology
Physiology, Pathological Physiological Phenomena Pathologic Processes |
| Soggetto genere / forma | Electronic books. |
| ISBN | 0-8261-7708-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910481051103321 |
|
Tkacs Nancy C.
|
||
| New York, New York : , : Springer Publishing Company, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advanced physiology and pathophysiology : essentials for clinical practice / / Nancy C. Tkacs, PhD, RN, Linda Herrmann, PhD, RN, ACHPN, AGACNP-BC, GNP-BC, FAANP, Randall Johnson, PhD, RN
| Advanced physiology and pathophysiology : essentials for clinical practice / / Nancy C. Tkacs, PhD, RN, Linda Herrmann, PhD, RN, ACHPN, AGACNP-BC, GNP-BC, FAANP, Randall Johnson, PhD, RN |
| Autore | Tkacs Nancy C. |
| Pubbl/distr/stampa | New York, New York : , : Springer Publishing Company, , [2021] |
| Descrizione fisica | 1 online resource (841 pages) |
| Disciplina | 612 |
| Soggetto topico |
Physiology
Physiology, Pathological Physiological Phenomena Pathologic Processes |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0826177085
9780826177070 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. the foundational concepts of clinical practice 2. chemical and biochemical foundations 3. molecular biology, genetics, and genetic diseases 4. cell physiology and pathophysiology 5. infectious disease 6. the immune system and leukocyte function 7. neoplasia 8. blood and clotting9. circulation 10. heart 11. lungs 12. kidneys 13. gastrointestinal tract 14. liver 15. nervous system 16. musculoskeletal system 17. endocrine system |
| Record Nr. | UNINA-9910526014203321 |
|
Tkacs Nancy C.
|
||
| New York, New York : , : Springer Publishing Company, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Aesthetic surgery after massive weight loss
| Aesthetic surgery after massive weight loss |
| Pubbl/distr/stampa | [Place of publication not identified], : Saunders Elsevier, 2007 |
| Soggetto topico |
Surgical Procedures, Operative
Obesity Specialties, Surgical Body Weight Changes Overweight Body Weight Analytical, Diagnostic and Therapeutic Techniques and Equipment Medicine Overnutrition Signs and Symptoms Nutrition Disorders Health Occupations Body Size Growth Nutritional and Metabolic Diseases Disciplines and Occupations Pathological Conditions, Signs and Symptoms Growth and Development Diseases Body Weights and Measures Body Constitution Physiological Processes Physiological Phenomena Physical Examination Phenomena and Processes Diagnostic Techniques and Procedures Diagnosis Obesity, Morbid Surgery, Plastic Reconstructive Surgical Procedures Weight Loss |
| ISBN | 1-4160-2952-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996212364203316 |
| [Place of publication not identified], : Saunders Elsevier, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Ageing vulnerability : causes and interventions
| Ageing vulnerability : causes and interventions |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley, 2001 |
| Descrizione fisica | 1 online resource (291 pages) |
| Disciplina | 612.67 |
| Collana | Novartis Foundation Symposia |
| Soggetto topico |
Aging
Growth and Development Physiological Processes Physiological Phenomena Phenomena and Processes |
| Soggetto genere / forma | Electronic books. |
| ISBN |
9786610556106
0-470-86869-4 1-280-55610-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910143202303321 |
| [Place of publication not identified], : Wiley, 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Ageing vulnerability : causes and interventions
| Ageing vulnerability : causes and interventions |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley, 2001 |
| Descrizione fisica | 1 online resource (291 pages) |
| Disciplina | 612.67 |
| Collana | Novartis Foundation Symposia |
| Soggetto topico |
Aging
Growth and Development Physiological Processes Physiological Phenomena Phenomena and Processes |
| ISBN |
9786610556106
0-470-86869-4 1-280-55610-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910830064503321 |
| [Place of publication not identified], : Wiley, 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Ageing vulnerability : causes and interventions
| Ageing vulnerability : causes and interventions |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley, 2001 |
| Descrizione fisica | 1 online resource (291 pages) |
| Disciplina | 612.67 |
| Collana | Novartis Foundation Symposia |
| Soggetto topico |
Aging
Growth and Development Physiological Phenomena Phenomena and Processes |
| ISBN |
9786610556106
0-470-86869-4 1-280-55610-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910876587003321 |
| [Place of publication not identified], : Wiley, 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Un aliment sain dans un corps sain : perspectives historiques
| Un aliment sain dans un corps sain : perspectives historiques |
| Pubbl/distr/stampa | [Place of publication not identified], : Presses universitaires François Rabelais, 2007 |
| Descrizione fisica | 1 online resource (344 p.) |
| Soggetto topico |
Food and Beverages
Nutritional Physiological Phenomena Behavior, Animal Behavior Investigative Techniques Physiological Phenomena Technology, Industry, Agriculture Behavior and Behavior Mechanisms Analytical, Diagnostic and Therapeutic Techniques and Equipment Psychiatry and Psychology Phenomena and Processes Feeding Behavior Diet Food |
| ISBN | 2-86906-338-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | fre |
| Record Nr. | UNINA-9910495897303321 |
| [Place of publication not identified], : Presses universitaires François Rabelais, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Alimentazione e studenti nella Bologna medievale e moderna [[electronic resource] /] / Alberto Malfitano ; prefazione di Angelo Varni
| Alimentazione e studenti nella Bologna medievale e moderna [[electronic resource] /] / Alberto Malfitano ; prefazione di Angelo Varni |
| Autore | Malfitano Alberto |
| Pubbl/distr/stampa | Bologna, : CLUEB, 1998 |
| Descrizione fisica | 118 p |
| Disciplina | 378 |
| Soggetto topico |
Investigative Techniques
Education, Nonprofessional Habits Persons Feeding Behavior Education Nutritional Physiological Phenomena Named Groups Anthropology, Education, Sociology and Social Phenomena Analytical, Diagnostic and Therapeutic Techniques and Equipment Physiological Phenomena Behavior Phenomena and Processes Behavior and Behavior Mechanisms Psychiatry and Psychology Food Habits Students Diet |
| ISBN | 88-491-1049-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ita |
| Nota di contenuto | (http://www.ilibri.casalini.it/toc/98320939.pdf) |
| Record Nr. | UNINA-9910132986603321 |
|
Malfitano Alberto
|
||
| Bologna, : CLUEB, 1998 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
