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70 Years of Levothyroxine / / edited by George J. Kahaly
| 70 Years of Levothyroxine / / edited by George J. Kahaly |
| Autore | Kahaly George J |
| Edizione | [1st ed. 2021.] |
| Pubbl/distr/stampa | Springer Nature, 2021 |
| Descrizione fisica | 1 online resource (XVII, 129 p. 37 illus., 34 illus. in color.) |
| Disciplina |
616.4
615.36 |
| Collana | Medicine Series |
| Soggetto topico |
Endocrinology
Pharmacology Pharmacology/Toxicology Hormones tiroides Medicaments Farmacologia Malalties de les glàndules endocrines |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-63277-6 |
| Classificazione | MED027000MED071000 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | History Of Levothyroxine -- Pharmacokinetics Of Levothyroxine -- Pharmacodynamics Of Levothyroxine -- Levothyroxine In Pregnancy -- Levothyroxine In Children -- Levothyroxine In The Elderly -- Levothyroxine And Heart -- Levothyroxine And Bone -- Levothyroxine And Cancer -- Potential Adverse Reactions Of Levothyroxine. |
| Record Nr. | UNINA-9910473450103321 |
Kahaly George J
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| Springer Nature, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Actin Cytoskeleton / / edited by Brigitte M. Jockusch
| The Actin Cytoskeleton / / edited by Brigitte M. Jockusch |
| Edizione | [1st ed. 2017.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 |
| Descrizione fisica | 1 online resource (XII, 352 p. 60 illus., 30 illus. in color.) |
| Disciplina | 571.654072 |
| Collana | Handbook of Experimental Pharmacology |
| Soggetto topico |
Pharmacology
Cell physiology Pharmacology/Toxicology Cell Physiology |
| ISBN | 3-319-46371-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Functional significance of actin isoforms -- Assembly and maintenance of myofibrils in striated muscle cells -- Myosins: Domain organisation, motor properties, physiological roles and cellular functions -- Actin filament structures in migrating vertebrate cells -- Signalling pathways controlling cellular actin organization -- Actin-based endocytosis -- ADP-ribosylation and cross-linking of actin by bacterial protein toxins -- Common themes in cytoskeletal remodeling by intracellular bacterial effectors -- Viruses that exploit actin-based motility for their replication and spread -- Multiscale view of cytoskeletal mechanoregulation of cell and tissue polarity -- Molecular control of actin dynamics in vivo insights from Drosophila -- From cytoskeleton to gene expression – actin in the nucleus. |
| Record Nr. | UNINA-9910158672603321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Actin Cytoskeleton and Bacterial Infection / / edited by Hans Georg Mannherz
| The Actin Cytoskeleton and Bacterial Infection / / edited by Hans Georg Mannherz |
| Edizione | [1st ed. 2017.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 |
| Descrizione fisica | 1 online resource (X, 242 p.) |
| Disciplina | 579.317852 |
| Collana | Current Topics in Microbiology and Immunology |
| Soggetto topico |
Medical microbiology
Pharmacology Medical Microbiology Pharmacology/Toxicology |
| ISBN | 3-319-50047-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Actin structure and dynamics -- Influence of binary actin-depolymerizing toxins on the microtubule system -- ADP-ribosylation of actin by Photorhabdus luminescens TccC3 inhibits interaction with actin binding proteins essential for treadmilling -- Pathogenic mechanisms of actin cross-linking toxins – peeling away the layers -- New concepts on bacterial effectors targeting Rho GTPases -- Interaction of bacterial ADPribosyltransferases with actin -- Yersinia's ways to activate and inactivate actin rearrangements in host cells -- The role of formins in phagocytosis of Borrelia by macrophages. |
| Record Nr. | UNINA-9910163990903321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Adherence to Antipsychotics in Schizophrenia / / by Emilio Sacchetti, Antonio Vita, Alberto Siracusano, Wolfgang Fleischhacker
| Adherence to Antipsychotics in Schizophrenia / / by Emilio Sacchetti, Antonio Vita, Alberto Siracusano, Wolfgang Fleischhacker |
| Autore | Sacchetti Emilio |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | Springer Nature, 2013 |
| Descrizione fisica | 1 online resource (168 p.) |
| Disciplina |
615/.7882
616.89806 |
| Soggetto topico |
Psychiatry
Psychopharmacology Psychotherapy Neurosciences Pharmacology Pharmacology/Toxicology |
| ISBN | 88-470-2679-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1 Poor adherence to antipsychotic medication in people with schizophrenia: diffusion, consequences, and contributing factors -- Premise -- Role of antipsychotics in the treatment of schizophrenia -- Compliance versus adherence -- Assessment of medication adherence -- Frequency of poor adherence to antipsychotics -- Consequences of poor adherence to antipsychotics -- Determinants and moderators of adherence to antipsychotics -- Present and medium-term perspectives -- Closing Remarks -- 2 Pharmacological strategies to enhance adherence in schizophrenia -- Introduction -- Pharmacological factors contributing to non-adherence: efficacy, side effects, regimen, co-therapies -- First vs Second generation antipsychotics: efficacy, tolerability and the adherence issue -- Long-acting injectable antipsychotics -- Conclusion. 3 Non-pharmacological strategies to enhance adherence and continuity of care in schizophrenia -- Introduction -- Factors Influencing (non-)adherence in Schizophrenia -- Interventions to Enhance Adherence. Research and Clinical Evidence -- Comprehensive Review of Psychosocial and Programmatic Interventions to Enhance Adherence to Antipsychotic Medication in Schizophrenia -- Summary of Main Results and Evidences -- Conclusions and Future Directions -- 4 Psychological issues in improving adherence and alliance -- The patient-doctor relationship as a determinant of adherence to treatment -- Alliance and psychodynamic issues -- Towards the concept of concordance of the therapeutic project. |
| Record Nr. | UNINA-9910300331703321 |
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Sacchetti Emilio
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| Springer Nature, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Adhesion G Protein-coupled Receptors : Molecular, Physiological and Pharmacological Principles in Health and Disease / / edited by Tobias Langenhan, Torsten Schöneberg
| Adhesion G Protein-coupled Receptors : Molecular, Physiological and Pharmacological Principles in Health and Disease / / edited by Tobias Langenhan, Torsten Schöneberg |
| Edizione | [1st ed. 2016.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
| Descrizione fisica | 1 online resource (XIV, 403 p. 68 illus., 67 illus. in color.) |
| Disciplina | 613 |
| Collana | Handbook of Experimental Pharmacology |
| Soggetto topico |
Pharmacology
Human physiology Human genetics Cytology Clinical biochemistry Pharmacology/Toxicology Human Physiology Human Genetics Cell Biology Medical Biochemistry |
| ISBN | 3-319-41523-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | PART I. Molecular and Pharmacological Properties of Adhesion GPCRs:-Classification, Nomenclature and Structural Aspects of Adhesion GPCRs -- 7TM Domain Structure of Adhesion GPCRs -- Understanding the Structural Basis of Adhesion GPCR Functions.-Control of Adhesion GPCR Function Through Proteolytic Processing.-Tethered Agonism: A Common Activation Mechanism of Adhesion GPCRs -- Versatile Signaling Activity of Adhesion GPCRs -- Adhesion GPCR-Related Protein Networks.-The Relevance of Genomic Signatures at Adhesion GPCR Loci in Humans -- PART II: Adhesion GPCRs as Pharmakotargets in Organ Function and Development -- Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors -- Adhesion GPCRs Govern Polarity of Epithelia and Cell Migration -- Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination.-Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs -- Adhesion GPCR Function in Pulmonary Development and Disease.-Adhesion GPCRs as Modulators of Immune Cell Function.-Heart Development, Angiogenesis, and Blood-Brain Barrier Function is Modulated by Adhesion GPCRs.-Adhesion GPCRs in Tumorigenesis. |
| Record Nr. | UNINA-9910150457103321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The ADME Encyclopedia : A Comprehensive Guide on Biopharmacy and Pharmacokinetics
| The ADME Encyclopedia : A Comprehensive Guide on Biopharmacy and Pharmacokinetics |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2021 |
| Descrizione fisica | 1 online resource (20 illus., 10 illus. in color.) |
| Disciplina | 570 |
| Soggetto topico |
Life sciences
Pharmacology Pharmaceutical technology Chemistry Biofarmàcia Química farmacèutica Life Sciences, general Pharmacology/Toxicology Pharmaceutical Sciences/Technology Chemistry/Food Science, general |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-51519-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Drug Dissolution and Drug Release -- Drug Absorption -- Drug Distribution -- Drug Metabolism -- Drug Excretion -- Routes of Administration -- next Generation Drug Delivery Systems -- Pharmacogenomics -- Bioavailability and Bioequivalence -- Biopharmaceutical Drug Products -- Drug-Drug and Food-Drug Interactions -- In vitro and In silico ADME Predictions -- Drug Transporters -- Non-linear Pharmacokinetics -- Time Dependent Pharmacokinetics -- Pharmacometrics and Physiological Models. |
| Record Nr. | UNINA-9910484249103321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Advances in Cancer Biomarkers : From biochemistry to clinic for a critical revision / / edited by Roberto Scatena
| Advances in Cancer Biomarkers : From biochemistry to clinic for a critical revision / / edited by Roberto Scatena |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (361 p.) |
| Disciplina | 610.28 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Cancer - Research
Oncology Pharmacology Cancer Research Pharmacology/Toxicology |
| ISBN | 94-017-7215-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Prelims -- I Generality.- II Tumor markers-a critical revision -- Enzymes.- Hormones -- Oncofetal proteins.- Cytokeratins -- Carbohydrate markers -- Blood group antigens.- Genetic markers -- Various protein markers -- III Perspectives.- The role of Circulating tumor Cells as tumor markers -- Index. |
| Record Nr. | UNINA-9910298445503321 |
| Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Advances in Computational Toxicology : Methodologies and Applications in Regulatory Science / / edited by Huixiao Hong
| Advances in Computational Toxicology : Methodologies and Applications in Regulatory Science / / edited by Huixiao Hong |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (416 pages) |
| Disciplina | 025.066159 |
| Collana | Challenges and Advances in Computational Chemistry and Physics |
| Soggetto topico |
Chemoinformatics
Pharmacology Bioinformatics Computational biology Chemistry, Physical and theoretical Bioinformatics Computer Applications in Chemistry Pharmacology/Toxicology Computer Appl. in Life Sciences Theoretical and Computational Chemistry Computational Biology/Bioinformatics |
| ISBN |
3-030-16443-8
9783030164430 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Computational Toxicology Promotes Regulatory Science -- Tasks, Major Challenges and Emerging Modelling Methods for Computational Toxicology -- Xenobiotic Metabolism by Cytochrome P450s: Insights Gained from Molecular Simulations -- Applications of Molecular Modeling to Probe the Mechanism of Endocrine Disruptor Action -- Mixture Toxicity -- Towards reproducible in silico practice via OpenTox -- Combining Machine Learning and Multilayer Networks for Toxicity Prediction -- Matrix and tensor factorization for toxicity modelling -- Network-based In Silico Assessment of Drug Cardiotoxicity -- Mode-of-action-guided chemical toxicity prediction: A novel in silico approach for predictive toxicology -- Machine learning methods for toxicity analysis -- Predictive modeling of Tox21 data -- The NTP DrugMatrix Toxicogenomics Database and Analysis Tool -- Applications of Computational Toxicology for Risk Assessment of Food Ingredients and Indirect Food Additives -- In silico prediction of the point of departure (POD) with high throughput data -- The application of topic modeling on drug safety signal detection and analysis -- Molecular dynamics simulations and applications in computational toxicology -- Computational modeling for prediction of drug-induced liver injury in humans -- Genomics in vitro to in vivo extrapolation (GIVIVE) for drug safety evaluation. |
| Record Nr. | UNINA-9910337929603321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions : Current and Future Trends / / edited by Neil H. Shear, Roni P. Dodiuk-Gad
| Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions : Current and Future Trends / / edited by Neil H. Shear, Roni P. Dodiuk-Gad |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Adis, , 2019 |
| Descrizione fisica | 1 online resource (XII, 314 p. 95 illus., 91 illus. in color.) |
| Disciplina | 353.998 |
| Soggetto topico |
Pharmacy
Pharmacology Drug Safety and Pharmacovigilance Pharmacology/Toxicology |
| ISBN | 981-13-1489-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Section I. Introduction -- 1. Introduction: Classification, Terminology, Epidemiology and Etiology of Cutaneous Adverse Drug Reactions -- Section II. Pathomechanisms of Cutaneous Adverse Drug Reactions -- 2. Immunology of Cutaneous Adverse Drug Reactions -- 3. Pharmacogenomics and Cutaneous Adverse Drug Reactions -- 4 Viral Reactivation in Cutaneous Adverse Drug Reactions -- 5. Using Technology to Learn About Immunology of Cutaneous Adverse Drug Reactions -- Section III. Clinical Perspectives of Cutaneous Adverse Drug Reactions -- 6. Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (Epithelial Necrolysis) -- 7. Drug Reaction with Eosinophilia and Systemic Symptoms -- 8. Acute Generalized Exanthematous Pustulosis -- 9. Urticarial Reactions to Drugs -- 10. Dermatological Adverse Events from Cancer Treatments -- 11. Cutaneous Adverse Drug Reactions in Pediatric Population -- 12. Cutaneous Drug Reactions in the Elderly -- 13. Cutaneous Adverse Drug Reactions in Human Immunodeficiency Virus Patients -- 14. Cutaneous Adverse Drug Reactions from Anti-Tuberculosis Treatment -- Section IV. Approach to the Patient with a Cutaneous Adverse Drug Reaction -- 15. Practical Approach to Diagnosis and Management of Cutaneous Adverse Drug Reactions -- 16. Histopathology of Severe Drug Eruptions -- 17. Evaluation of Drug Safety Literature: A Guide for the Practicing Dermatologist -- 18. In vitro and in vivo tests in Cutaneous Adverse Drug Reactions -- 19. Pharmacovigilance of Cutaneous Adverse Drug Reactions -- Section V. Epilogue -- 20. Future Directions and Unmet Research Needs in Cutaneous Adverse Drug Reactions -- 21. Atlas of Cutaneous Adverse Drug Reactions. |
| Record Nr. | UNINA-9910350239403321 |
| Singapore : , : Springer Singapore : , : Imprint : Adis, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Advances in Tumor Immunology and Immunotherapy / / edited by Joseph D. Rosenblatt, Eckhard R. Podack, Glen N. Barber, Augusto Ochoa
| Advances in Tumor Immunology and Immunotherapy / / edited by Joseph D. Rosenblatt, Eckhard R. Podack, Glen N. Barber, Augusto Ochoa |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (369 p.) |
| Disciplina |
614.5999
616.994079 |
| Collana | Current Cancer Research |
| Soggetto topico |
Cancer - Research
Pharmacology Cancer Research Pharmacology/Toxicology |
| ISBN | 1-4614-8809-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Introduction; Part IImmune Activation, Suppression and Manipulation of the Immune Antitumor Response; Myeloid-Derived Suppressor Cells in Cancer; 1 Introduction; 2 Preclinical Data; 2.1 Phenotype; 2.2 Expansion and Activation of MDSCs in Tumor Models; 2.3 Mechanisms of Immunosuppression of MDSCs in Cancer; 2.3.1 Metabolism of l -Arginine; 2.3.2 ROS and Peroxynitrite; 3 Clinical Data; 4 Pharmacologic Modulation of MDSCs; 5 Conclusions; References; The Role of B Cells in Shaping the Antitumor Immune Response; 1 Introduction; 2 B Cells and Antitumor Immunity
3 Mechanisms of B Cell Modulation of Immune Response3.1 Be1 and Be2 Differentiation and Skewing of T Cell Response; 3.2 B Cells and Antigen Presentation; 3.3 B Cells and Expansion of Tregs; 3.4 B10 Cells and Immune Suppression; 3.5 Other Breg Subsets and Role of TGF-β; 3.6 B Cells and Chronic Inflammation; 4 Effects of B Cell Depletion on Antitumor Immunity; 5 B Cell Infiltration in Human Tumors; 6 Conclusions; References; Heat-Shock Protein-Based Cancer Immunotherapy; 1 Heat-Shock Proteins, Sterile Inflammation, and Immunosurveillance; 2 Autologous Purified HSP Vaccines 3 Allogeneic Cell-Based HSP Vaccines4 Recombinant and Nucleic Acid-Based HSP Vaccines; 5 Conclusions Based on Clinical Evidence; References; Activation of NK Cell Responses and Immunotherapy of Cancer; 1 Background and History of NK Cells; 2 NK Cell Activation; 3 NK Cells and Cancer; 4 Activated NK Cells as a Cancer Immunotherapy; 5 NK Cells and Other Immunotherapeutic Approaches; 6 Conclusion; References; Induction of Tumor Immunity by Targeted Inhibition of Nonsense-Mediated mRNA Decay; 1 Introduction; 2 Nonsense-Mediated mRNA Decay: A Primer; 2.1 Physiological Roles of NMD 2.2 Role of NMD in Cancer3 Tumor-Targeted NMD Inhibition to Express New Antigens in Disseminated Tumor Lesions; 3.1 The Concept and Rationale; 3.2 Preclinical Proof-of-Concept Studies in Murine Tumor Models; 4 Conclusions and Future Directions; 4.1 Cytotoxic Therapy or Immunotherapy?; 4.2 What If?; References; Employing T Cell Homeostasis as an Antitumor Strategy; 1 Introduction; 2 Homeostasis of T Lymphocytes; 3 Lymphopenia-Induced T Cell Proliferation; 4 Lymphopenia-Induced Pathologies; 5 Lymphopenia-Induced Antitumor Immune Responses; 6 Clinical Evidence/The Human Model 7 Adoptive Immunotherapy of Cancer8 Vaccine Augmentation; 9 Lymphopenia-Induced Changes in T reg Percentages; 10 The Dose Makes the Poison; 11 Conclusion; References; Adoptive Cell Therapy of Systemic Metastases Using erbB-2-Specific T Cells Redirected with a Chimeric Antibody-Based Receptor; 1 Introduction; 2 Results and Discussion; 2.1 Phenotypic and Functional Profile of the erbB-2-Specific CAR in Transgenic Mice; 2.2 Naïve TgN29 Mice Reject Renca-erbB-2 Tumors; 2.3 Adoptive Transfer of Naïve Lymphocytes from TgN29 Mice Extends the Survival of Mice with Systemic Lung Metastases 2.4 Redirected Allogeneic T Cells (Allo-T-Bodies) as Potential Universal Donors |
| Record Nr. | UNINA-9910300096003321 |
| New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Soggetto topico
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Pharmacology/Toxicology
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