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Challenges in pediatric kidney transplantation : a practical guide / / edited by Katherine E. Twombley
| Challenges in pediatric kidney transplantation : a practical guide / / edited by Katherine E. Twombley |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (429 pages) |
| Disciplina | 617.9540083 |
| Soggetto topico |
Pediatric nephrology
Kidneys - Transplantation Transplantation of organs, tissues, etc. in children Trasplantament renal Nefrologia pediàtrica Trasplantament d'òrgans |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-74783-2 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Contents -- Contributors -- Part I: Immunologic Challenges -- 1: Immunologic Challenges Pre-transplant -- Introduction -- What Is Human Leukocyte Antigen (HLA)? -- Pre-transplant -- How Does Sensitization Occur? -- Why Is HLA Compatibility Important? -- Epitope Mismatch -- How Are HLA Antibodies Detected and HLA Matching Performed? -- Antibody Detection -- Cell-Based Assays -- Solid-Phase Assays -- Is Median Fluorescent Intensity (MFI) Signal a Surrogate Measure of the Level of HLA Antibody? -- Peri-transplant -- The Virtual Crossmatch (vXM) in Transplantation -- Unexpected Crossmatch Scenarios -- Clinical Scenarios and Interpretation of Crossmatch Results in Kidney Transplantation -- Conclusion -- Questions and Answers with Explanation -- References -- 2: Challenges in Post-transplant Immunologic Monitoring -- Challenges in Post-transplant Immunologic Monitoring -- Conventional Monitoring Post-Transplant -- Serum Creatinine (Graft Function) -- Drug Monitoring and Variability -- Surveillance Monitoring of Donor-Specific Antibodies -- Non-HLA Antibodies -- Surveillance Biopsies (SBs) -- Innovative Biomarkers for Immunologic Monitoring Post-transplant -- Donor-Derived Cell-Free DNA (dd-cfDNA) -- Urinary Biomarkers -- Molecular Diagnostics -- The Future of Post-transplant Immune Monitoring -- Q& -- A -- Bibliography -- 3: Rejection Challenges: Diagnosis and Management -- A Brief History of Rejection -- An Evolving Paradigm of Rejection: From Discreet Episodic Events to a Fluctuating Continuum of Immune Alloreactivity -- Pathophysiology of Alloimmune Activation and Downstream Processes -- T Cell Development and Activation -- T Cell Migration and Mechanisms of Injury in T Cell-Mediated Rejection with the Allograft -- B Cell Development and Activation -- Alloantibodies and Antibody-Mediated Rejection -- Alloimmune Chronicity.
Detecting Rejection and Monitoring Its Course -- Clinical Monitoring and Biopsy Indication -- Surveillance Biopsies -- Follow-Up Biopsies -- Biomarkers for Rejection -- Gene Expression Signatures -- Chemokines -- Metabolomics -- Cell-Free DNA -- Predisposing Risk Factors for Rejection -- Recipient-Related Risks -- Donor-Recipient Interface -- Donor-Related Risks -- Silent Sensitization -- HLA Mismatch -- Post-transplant Factors -- Hyperacute Rejection -- Acute T Cell-Mediated Rejection (TCMR) -- Clinical and Histological Features -- Treatment of TCMR -- Corticosteroids -- Lymphocyte-Depleting Therapies -- Late Acute TCMR -- B Cell-Rich and Plasma Cell-Rich Acute Rejection -- B Cell-Rich Rejection -- Plasma Cell-Rich Acute Rejection -- Active Antibody-Mediated Rejection (AMR) -- Clinical and Histological Features -- Treatment of AMR -- Plasmapheresis and IVIG -- Rituximab -- Bortezomib -- Emerging Treatments -- Response to Treatment -- Chronic Active TCMR -- Clinical and Histological Features -- Management -- Chronic Active AMR -- Clinical and Histological Features -- Management -- Emerging Therapies -- Post Rejection Infection Prophylaxis -- Special Circumstances: Infection and Rejection -- AGPN and Rejection -- BK Virus and Rejection -- Case Studies -- References -- Part II: Infectious Challenges -- 4: Pretransplant Donor and Recipient Infectious Challenges -- Pretransplant Infectious Disease Evaluation -- Evaluation of the Pediatric Kidney Transplant Candidate -- HIV and Hepatitis Viruses -- Cytomegalovirus/Epstein-Barr Virus Serostatus of Donor and Recipient -- Cytomegalovirus -- Epstein-Barr Virus -- Mycobacterium tuberculosis -- Fungal Infections and Endemic Mycoses -- Parasitic Infections -- COVID-19 -- Urinary Tract Infections -- PHS Increased Risk Donors -- Window Period Duration and the Risk of Virus Transmission. Outcomes of PHS Increased Risk Donors in Pediatric Kidney Transplantation -- Informed Consent -- Posttransplant Testing -- Immunizations -- Preparing the Dialysis Patient for Transplantation -- Vaccine Schedule: Current American Academy of Pediatrics Recommendations -- Summary of recommendations with end stage kidney disease, including transplant candidates [62-64] -- Hepatitis B -- Influenza Vaccine -- Pneumococcal Vaccine [68, 69] -- Special Situations [70, 71] -- Household/Live Donor Vaccination -- Live Vaccines -- Varicella Vaccine -- Measles-Mumps-Rubella Vaccine -- Recombinant and Inactivated ("Killed") Vaccines -- DTaP/Tdap/dT Vaccine -- Poliovirus Vaccine -- Haemophilus Influenzae Type B Vaccine -- Hepatitis A Vaccine -- Hepatitis B Vaccine -- Meningococcal Vaccine -- Human Papillomavirus -- Updating Immunizations for the Dialysis Patient Awaiting Transplant -- Questions -- References -- 5: Post-transplant Recipient Infectious Challenges -- Introduction -- Opportunistic Post-Kidney Transplant Infections (CMV, EBV, and BK Virus and PJP) -- Cytomegalovirus (CMV) -- Risk Factors -- Clinical Presentation -- Screening -- Prophylaxis and Preemptive Therapy -- Treatment -- BK Virus -- Risk Factors -- Clinical Presentation -- Screening -- Treatment -- Epstein-Barr Virus -- Risk Factors -- Clinical Presentation -- Screening -- Treatment -- Pneumocystis jirovecii pneumonia (PJP) -- Resurgent Viral Infection Outbreaks: Measles and Mumps -- Cancer Risks -- Cancer Incidence -- Cancer Risk Factors -- Immunosuppression Burden -- EBV Recipient-Donor Sero-Mismatch -- Time Since Transplant -- HLA Haplotypes -- Pre-transplant Malignancy -- Age -- Gender -- Race -- Donor Source -- Recombinant Growth Hormone (rGH) Use -- Cancer Prevention Strategies -- Cancer Treatment -- Cancer Outcomes -- Urinary Tract Infections (UTI) -- Prevalence -- Risk Factors. Prevention -- Treatment -- Asymptomatic Bacteriuria -- Outcomes -- MOC Questions -- References -- Part III: Disease Challenges -- 6: Urological Considerations for Pediatric Renal Transplantation: CAKUT Challenges -- Urological Complications Post-transplant -- References -- 7: Rheumatologic Challenges -- Systemic Lupus Erythematosus -- Introduction -- Clinical Course of Renal Involvement and Outcomes -- Renal Transplantation in Lupus Nephritis -- Recurrence of Lupus Nephritis Post-transplantation -- Health Disparities in Systemic Lupus Erythematosus and Lupus Nephritis -- Conclusion -- IgA Vasculitis -- Introduction -- Clinical Course of Renal Involvement and Outcomes -- Renal Transplantation in IgAV Nephritis and Outcomes -- ANCA-Associated Vasculitis -- Introduction -- Clinical Course of Renal Involvement and Outcomes -- Renal Transplantation in Childhood AAV and Outcomes -- Conclusion -- References -- 8: Recurrent Disease Challenges in Pediatric Kidney Transplantation -- Introduction -- Atypical Hemolytic Uremic Syndrome (aHUS) -- Nature and Frequency of Primary Disease -- Considerations for Transplant Planning -- Risk Factors for Recurrence and Treatment of Recurrence -- Risk of Disease Recurrence in the Era of Eculizumab -- Additional Post-transplant Considerations -- C3 Glomerulopathy (C3G) -- Nature and Frequency of C3G -- Considerations for Transplant Planning -- Risk Factors for Recurrence and Treatment of C3G Recurrence -- IgA Nephropathy -- Nature and Frequency of IgA Nephropathy (IgAN) -- Risk Factors for Recurrence -- Considerations for Transplant Planning -- Treatment of IgAN Recurrence -- Impact of IgAN on Graft Function and Survival -- IgA Vasculitis (Henoch-Schonlein Purpura) -- Lupus Nephritis -- Nature and Frequency of Disease -- Risk for Disease Recurrence -- Considerations for Transplant Planning. Impact of RLN on Graft Function and Survival -- Other Diseases -- Primary Hyperoxaluria Type 1 (Oxalosis) -- Membranous Nephropathy -- Conclusion -- References -- 9: Nephrotic Syndrome Challenges: An Old Recurring Problem -- APOL1 -- Mechanism of Renal Injury -- Second Hit Modifiers -- Clinical Implications -- Pre-transplant Nephrectomy -- Proteinuria -- WT1 Mutation -- Disease Recurrence -- Genetic Mutations -- Living vs Deceased Donation -- Clinical Features Predictive of DR -- Circulating Factor and DR -- Treatment of Disease Recurrence -- Plasmapheresis -- Immunoadsorption -- Rituximab -- Cyclosporine -- Lipid Apheresis -- Questions -- Bibliography -- 10: Challenges of Maintaining Adequate Health and Well-Being, Growth, Nutrition, and Development in Pediatric Transplant Recipients -- Vaccinations -- Pre-transplant -- Post-transplant -- Vaccines and Travel -- Nutritional Challenges -- Pre-transplant -- CKD 2-5 Pre-dialysis -- Hemodialysis -- Peritoneal Dialysis -- Nutritional Management in CKD and Dialysis -- Enteral Nutrition Support -- Post-transplant -- Appetite and Weight -- Transition from Enteral to Oral Feeding -- Medication Effects -- Nutritional Management Post-transplant -- Food Safety -- Growth Challenges -- Growth Hormone Physiology -- Growth and CKD -- Growth After Kidney Transplant -- Outcomes -- Growth Hormone Utilization -- Indications and Contraindications for Growth Hormone -- Work-Up, Treatment, and Monitoring -- Work-Up -- Treatment -- Monitoring -- Safety of Growth Hormone in Transplant Recipients -- Metabolic Bone Disease -- Pathophysiology of CKD-BMD -- Bone Mineral Monitoring -- Post-transplant Bone Metabolism -- PTH, FGF-23, and Hypophosphatemia -- Hypomagnesemia -- Vitamin D -- Immunosuppression -- Role of Sex Hormones -- Prevention Strategies -- Steroid Minimization -- Diet and Physical Activity -- Treatment. Pharmacologic Therapies. |
| Record Nr. | UNINA-9910488710503321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Childhood kidney diseases
| Childhood kidney diseases |
| Pubbl/distr/stampa | Gyeonggi-do, Republic of Korea : , : Korean Society of Pediatric Nephrology, , [2015]- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Pediatric nephrology
Kidneys - Diseases Kidney Diseases Child |
| Soggetto genere / forma | Periodicals. |
| ISSN | 2384-0250 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | ChiKD |
| Record Nr. | UNISA-996475751403316 |
| Gyeonggi-do, Republic of Korea : , : Korean Society of Pediatric Nephrology, , [2015]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Childhood kidney diseases
| Childhood kidney diseases |
| Pubbl/distr/stampa | Gyeonggi-do, Republic of Korea : , : Korean Society of Pediatric Nephrology, , [2015]- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Pediatric nephrology
Kidneys - Diseases Kidney Diseases Child |
| Soggetto genere / forma | Periodicals. |
| ISSN | 2384-0250 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | ChiKD |
| Record Nr. | UNINA-9910571780503321 |
| Gyeonggi-do, Republic of Korea : , : Korean Society of Pediatric Nephrology, , [2015]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Critical care nephrology and renal replacement therapy in children / / Akash Deep, Stuart L. Goldstein, editors
| Critical care nephrology and renal replacement therapy in children / / Akash Deep, Stuart L. Goldstein, editors |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , [2018] |
| Descrizione fisica | 1 online resource (xii, 456 pages) : illustrations (chiefly color), portraits |
| Disciplina | 616.028 |
| Soggetto topico |
Renal intensive care
Pediatric nephrology Acute renal failure Critical care medicine Kidneys - Diseases Pediatrics Nephrology Acute Kidney Injury Critical Care Kidney Diseases Renal Replacement Therapy Adolescent Child Infant |
| ISBN | 3-319-90281-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Foreword -- Preface -- Part I. Acute Kidney Injury -- Evolution of Acute Kidney Injury in the last 2 decades -- Renal function monitoring in a critically sick patient -- Acute Kidney Injury-Definitions and Epidemiology -- Biomarkers in AKI -- Neonatal AKI including new devices -- Sepsis Associated AKI -- Acute Kidney Injury in a child after cardiopulmonary -- Bypass, post cardiac surgery and Cardio-renal Syndromes -- Acute Kidney Injury in stem cell transplant recipients -- Hemolytic Uremic Syndrome -- Acute Kidney Injury in liver disease -- Renal emergencies in PICU – electrolyte, acid base and blood pressure issues -- Nutrition in a child with Acute Kidney Injury and on CRRT -- Outcomes and Renal Recovery -- Part II. Renal Replacement Therpay -- Continuous Renal Replacement Therapy – Technology and Basic concepts -- Timing of initiation of CRRT -- Management considerations for the delivery of CRRT in children -- Anticoagulation in CRRT -- Haemodialysis -- Sustained Low Efficiency Dialysis (SLED) and hybrid therapies – Principles and Management -- Peritoneal Dialysis -- Plasmapheresis and Total plasma exchange in the PICU -- Tandem Therapies in Extracorporeal support -- Pharmacology of drugs in critically ill patient with AKI and renal replacement therapy -- CRRT nursing programme Development -- Future of Paediatric AKI and CRRT -- Part III. CRRT in Specific Disease States -- CRRT in a child in cardiac ICU -- CRRT in a child with sepsis and multi-organ failure -- Hyperammonaemia and Inborn Errors of metabolism (IEM) -- CRRT in Exogenous Intoxications -- CRRT in Liver Failure and other liver assist devices. |
| Record Nr. | UNINA-9910300447303321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , [2018] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Growth failure in children with kidney disease
| Growth failure in children with kidney disease |
| Pubbl/distr/stampa | [Bethesda, MD] : , : U.S. Dept. of Health and Human Services, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Disease, National Kidney and Urologic Diseases Information Clearinghouse, , [2009] |
| Descrizione fisica | 1 online resource (3 pages) : illustrations |
| Collana | NIH publication |
| Soggetto topico |
Pediatric nephrology
Child development deviations Kidneys - Diseases - Health aspects Children - Growth |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910700818703321 |
Is my child at risk for kidney disease?
| Is my child at risk for kidney disease? |
| Edizione | [Rev. October 2011.] |
| Pubbl/distr/stampa | [Bethesda, Md.] : , : National Kidney Disease Education Program, , 2011 |
| Descrizione fisica | 1 online resource (6 unnumbered pages) : color illustrations |
| Collana | NIH publication |
| Soggetto topico |
Pediatric nephrology - United States
Pediatric nephrology |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910704494403321 |
| [Bethesda, Md.] : , : National Kidney Disease Education Program, , 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Is your child at risk for kidney disease?
| Is your child at risk for kidney disease? |
| Edizione | [Revised October 2011.] |
| Pubbl/distr/stampa | Bethesda, MD : , : U.S. Department of Health and Human Services, National Institute of Diabetes and Digestive and Kidney Diseases, National Kidney Disease Education Program, , 2011 |
| Descrizione fisica | 1 online resource (1 page) : illustrations |
| Collana | NIH publication |
| Soggetto topico | Pediatric nephrology |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910705427603321 |
| Bethesda, MD : , : U.S. Department of Health and Human Services, National Institute of Diabetes and Digestive and Kidney Diseases, National Kidney Disease Education Program, , 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Journal of pediatric nephrology
| Journal of pediatric nephrology |
| Pubbl/distr/stampa | Tehran : , : Shahid Beheshti University of Medical Sciences, , [2013]- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Pediatric nephrology
Kidney Diseases Pediatrics |
| Soggetto genere / forma |
Periodical
Periodicals. |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | JPN |
| Record Nr. | UNISA-996321518603316 |
| Tehran : , : Shahid Beheshti University of Medical Sciences, , [2013]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Journal of pediatric nephrology
| Journal of pediatric nephrology |
| Pubbl/distr/stampa | Tehran : , : Shahid Beheshti University of Medical Sciences, , [2013]- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Pediatric nephrology
Kidney Diseases Pediatrics |
| Soggetto genere / forma |
Periodical
Periodicals. |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | JPN |
| Record Nr. | UNINA-9910139127503321 |
| Tehran : , : Shahid Beheshti University of Medical Sciences, , [2013]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nephrology and fluid/electrolyte physiology / / [edited by] William Oh, Michel Baum ; consulting editor, Richard A. Polin
| Nephrology and fluid/electrolyte physiology / / [edited by] William Oh, Michel Baum ; consulting editor, Richard A. Polin |
| Edizione | [Third edition.] |
| Pubbl/distr/stampa | Philadelphia, PA : , : Elsevier, , [2019] |
| Descrizione fisica | 1 online resource (xi, 277 pages) : illustrations (chiefly color) |
| Collana | Neonatology questions and controversies |
| Soggetto topico |
Pediatric nephrology
Newborn infants - Diseases Infant, Newborn, Diseases Kidney Diseases Infant, Newborn Water-Electrolyte Imbalance |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Section 1. Foreword. Water flux and amniotic fluid volume: understanding fetal water flow -- Body composition of fetus and newborn -- Potassium metabolism -- Section B. Renal aspects of sodium metabolism in the fetus and neonate -- Perinatal calcium and phosphorus metabolism -- Acid-base homeostasis in the fetus -- Section C. Glomerular filtration rate in neonates -- Section D. Renal development and molecular pathogenesis of renal dysplasia -- The developing kidney and the fetal origins of adult cardiovascular disease -- Fluid and electrolyte management of high risk infants -- Renal modulation: the renin-angiotensin-aldosterone system -- Renal modulation: arginine vasopressin and atrial natriuretic peptide -- Acute problems of prematurity: balancing fluid volume and electrolyte replacements in very low birth weight and extremely low birth weight neonates -- Lung fluid balance in developing lungs and its role in neonatal transition -- Use of diuretics in the newborn -- Neonatal hypertension: diagnosis and management -- Edema -- Kidney injury in the neonate -- Hereditary tubulopathies -- Inherited disorders of calcium, phosphate and magnesium. |
| Record Nr. | UNINA-9910583456203321 |
| Philadelphia, PA : , : Elsevier, , [2019] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
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Pediatric nephrology
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- Kidney Diseases (11)
- Child (8)
- Infant (5)
- Nephrology (5)