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Drugs of abuse : chemistry, pharmacology, immunology, and AIDS / / editors: Phuong Thi Kim Pham, Kenner Rice
| Drugs of abuse : chemistry, pharmacology, immunology, and AIDS / / editors: Phuong Thi Kim Pham, Kenner Rice |
| Pubbl/distr/stampa | Rockville, MD : , : U.S. Department of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, , 1990 |
| Descrizione fisica | 1 online resource (vi, 243 pages) : illustrations |
| Collana |
NIDA research monograph
DHHS publication |
| Soggetto topico |
Drug abuse - United States
Drugs of abuse - Physiological effect - United States AIDS (Disease) - United States Opioids - Receptors AIDS (Disease) Drug abuse Drugs of abuse - Physiological effect |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Drugs of abuse |
| Record Nr. | UNINA-9910712023203321 |
| Rockville, MD : , : U.S. Department of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, , 1990 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Emerging technologies and new directions in drug abuse research / / editors: Rao S. Rapaka, Alexandros Makriyannis, Michael J. Kuhar
| Emerging technologies and new directions in drug abuse research / / editors: Rao S. Rapaka, Alexandros Makriyannis, Michael J. Kuhar |
| Pubbl/distr/stampa | Rockville, MD : , : U.S. Department of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, , 1991 |
| Descrizione fisica | 1 online resource (vii, 335 pages) : illustrations |
| Collana |
Research monograph
DHHS publication |
| Soggetto topico |
Psychopharmacology - Technological innovations - United States
Opioids - Receptors Drug abuse - Treatment - United States Drugs - United States - Design Drug abuse - Treatment - Research |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910712095103321 |
| Rockville, MD : , : U.S. Department of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, , 1991 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Enhancing identification of opioid-involved health outcomes using National Hospital Care Survey data
| Enhancing identification of opioid-involved health outcomes using National Hospital Care Survey data |
| Pubbl/distr/stampa | Hyattsville, Maryland : , : U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics, , 2021 |
| Descrizione fisica | 1 online resource (vi, 23 pages) : color illustrations |
| Collana | Vital and Health statistics. Series 2, Data evaluation and methods research |
| Soggetto topico |
Opioids - Overdose - United States
Opioids - Receptors Opioids - Physiological effect - United States Medical care - United States Opioid abuse - United States |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910717201003321 |
| Hyattsville, Maryland : , : U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics, , 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The kappa opioid receptor / / Lee-Yuan Liu-Chen, Saadet Inan, editors
| The kappa opioid receptor / / Lee-Yuan Liu-Chen, Saadet Inan, editors |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2022] |
| Descrizione fisica | 1 online resource (574 pages) |
| Disciplina | 615.7822 |
| Collana | Handbook of experimental pharmacology |
| Soggetto topico |
Opioids - Receptors
Pharmacology |
| ISBN | 3-030-89074-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Contents -- Part I: Basics -- Fundamentals of the Dynorphins/Kappa Opioid Receptor System: From Distribution to Signaling and Function -- 1 Historical Perspectives -- 2 Dynorphin Peptides -- 3 Cloning of the KOR -- 4 Neuroanatomy of the KOR -- 5 KOR Signaling at the Cellular Level -- 6 Agonist-Promoted KOR Phosphorylation and Regulation -- 7 X-ray Crystal Structures of the KOR -- 8 In Vivo Pharmacology of the DYNs/KOR System -- 9 Conclusion -- References -- Considerations on Using Antibodies for Studying the Dynorphins/Kappa Opioid Receptor System -- 1 Introduction -- 2 General Considerations for Validation of Specificity of Antibodies -- 2.1 Unique Issues Associated with Antibodies Against G Protein-Coupled Receptors (GPCRs) -- 2.2 Validation of Specificity of Antibodies -- 3 Antibodies for IHC of the KOR -- 3.1 Characterization of KT2 Antibody and KOR1 Antibodies for IHC -- 3.2 IHC of the KOR in the Brain -- 3.3 Generation of a Mouse Line Expressing a Fusion Protein of the KOR Conjugated with tdTomato (KOR-tdT) -- 4 KOR Antibodies for IB -- 4.1 Detection of KOR Expressed in Cells -- 4.2 Detection of the KOR in Mouse Brains -- 5 Antibodies for IB of Phosphorylated KOR -- 5.1 Detection of Phosphorylated KOR in Cells -- 5.2 Detection of Phosphorylated KOR in Mouse Brains -- 5.3 U50,488H Promoted KOR Phosphorylation at T363 and S369 in Mouse Brains in a Dose-Dependent Manner -- 6 KOR Antibodies from Commercial Sources -- 7 Antibodies against Dynorphins: Some Considerations -- 8 Conclusion -- References -- Part II: In Vitro Studies -- Structural Characterization of KOR Inactive and Active States for 3D Pharmacology and Drug Discovery -- 1 Introduction -- 2 Structure Determination of KOR -- 2.1 KOR-JDTic Structure in Inactive State -- 2.2 KOR-MP1104 Structure in Active State -- 2.3 JDTic-KOR-Nb6 Structure in Inactive State.
3 Overall Architecture of the KOR in Inactive and Active States -- 4 Structural Determinants of Long-Acting Antagonist JDTic Binding in Inactive Structure -- 5 Structural Determinants of Agonist MP1104 Binding in the Active-State Structure -- 6 Large-Scale Conformational Changes in KOR as a Part of the Activation Mechanism -- 7 Structure-Based Insights into KOR 3D Pharmacology -- 7.1 KOR Antagonists: Long-Acting and Short-Acting -- 7.2 KOR Agonists -- 7.3 Determinants of Opioid Ligand Selectivity at KOR -- 8 Applications of KOR Structure to Computer-Assisted Ligand Discovery -- 8.1 Understanding KOR Dynamics by MD Simulations -- 8.2 Discovery of New KOR Chemotypes by Structure-Based Virtual Screening -- 8.3 Rational Design for KOR Selectivity Over MOR and DOR -- 8.4 Rational Design for KOR Functional Selectivity -- 9 Conclusions and Outlook -- References -- Biosensors Monitor Ligand-Selective Effects at Kappa Opioid Receptors -- 1 Introduction: Ligand-Selective Effects at the Kappa Opioid Receptor -- 2 Nanobodies and Mini-G Proteins Act as Conformation-Specific KOR Binders -- 2.1 Active State Binding Nanobodies Nb39 and Nb33 -- 2.2 Inactive State Binding Nanobody Nb6 -- 2.3 Active State Binding Mini-G Protein Mini-Gsi -- 3 Biosensors Robustly and Rapidly Report on KOR Activation and Deactivation -- 4 Biosensors Reveal Ligand-Selective Effects at KOR -- 4.1 Ligand-Selective Recruitment of Distinct Biosensors to KOR -- 4.2 Agonist-Selective Activation of KOR at Distinct Cellular Locations -- 5 Conclusions and Outlook -- References -- Does GEC1 Enhance Expression and Forward Trafficking of the Kappa Opioid Receptor (KOR) via Its Ability to Interact with NSF D... -- 1 Introduction -- 2 Experimental Procedures -- 2.1 Pull-Down Assays Using Purified Recombinant Proteins Expressed in E. coli -- 3 Results -- 4 Discussion -- References. Kappa Opioid Receptor Mediated Differential Regulation of Serotonin and Dopamine Transporters in Mood and Substance Use Disord... -- 1 Introduction -- 2 KOR and the Serotonergic System -- 2.1 KOR Interaction with Serotonergic System and Its Relevance to Psychiatric Disorders -- 2.2 KOR Signaling in the Regulation of Serotonin Clearance: Modulation of Serotonin Transporter Function, Trafficking, and Pho... -- 3 KOR and the Dopaminergic System -- 3.1 KOR Interaction with Dopaminergic System and Its Relevance to Cocaine Use Disorder -- 3.2 KOR Signaling in the Regulation of Dopamine Clearance: Modulation of Dopamine Transporter Function and Trafficking -- 4 Dynorphin/KOR System as a Therapeutic Target -- 5 Conclusions -- References -- Part III: Preclinical Drug Development -- Biased Ligands at the Kappa Opioid Receptor: Fine-Tuning Receptor Pharmacology -- 1 Introduction: Biased Signaling and the Kappa Opioid Receptor -- 2 Signaling Cascades Downstream of the Kappa Opioid Receptor -- 2.1 G Proteins -- 2.2 βarrestin2 Activation -- 3 Physiological Implications of Signaling Pathways Downstream of the Kappa Opioid Receptor -- 4 Biased Ligands at the Kappa Opioid Receptor -- 5 Conclusions -- References -- Preclinical Studies on Nalfurafine (TRK-820), a Clinically Used KOR Agonist -- 1 Introduction -- 2 In Vitro Pharmacological Characterization of Nalfurafine -- 2.1 Bioassays -- 2.2 Binding Affinity and Selectivity Profile of Nalfurafine at MOR, DOR, KOR and NOR -- 2.3 No Significant Binding to Targets Other Than Opioid Receptors -- 2.4 Efficacies and Potencies of Nalfurafine in Activating MOR, DOR, KOR and NOR: Inhibition of Adenylate Cyclase and Enhanceme... -- 2.5 Functional Selectivity of Nalfurafine in KOR-Mediated Activation of G Proteins and β-Arrestins -- 2.6 KOR Internalization and Down-Regulation -- 3 In Vivo Pharmacological Effects of Nalfurafine. 3.1 Antipruritic Effects -- 3.2 Anti-nociceptive Effects -- 3.3 Anti-allodynic and Anti-hyperalgesic Effects -- 3.4 Inhibition of Neurogenic Inflammation -- 3.5 Aversive Effects or Lack Thereof -- 3.6 Effects on Locomotor Activity and Motor Coordination -- 3.7 Water Diuretic Effects -- 3.8 Nalfurafine and U50,488H Induced Different Phosphoproteomic Changes in Mouse Brains -- 3.9 Effect of Nalfurafine on Pharmacological Actions of Morphine -- 3.9.1 Effects on Morphine-Induced Itch -- 3.9.2 Effect on Morphine-Induced Antinociception -- 3.9.3 Effects on Rewarding Properties of Morphine and Oxycodone -- 3.9.4 Effects on Morphine-Induced Tolerance and Dependence -- 3.9.5 Effects on Morphine-Induced Hyperlocomotion -- 4 Nalfurafine as an Abuse-Deterring Agent for Prescription Opioid Abuse -- 4.1 Translational Significance of Contingent vs. Non-contingent Administration of KOR Agonists -- 4.2 Behavioral Pharmacology of Nalfurafine/Oxycodone Combinations -- 4.2.1 Studies in Rats -- 4.2.2 Studies in Nonhuman Primates -- 5 Effects of Nalfurafine on Alcohol Drinking -- 5.1 The Dynorphins/KOR System in Alcohol-Related Behaviors -- 5.2 Development of Nalfurafine as a Potential Therapeutic Agent for Alcoholism -- 6 Effect of Nalfurafine on CPP and Discriminative Stimulus Effects of Cocaine -- 7 Other Effects -- 8 Conclusion -- References -- Kappa Opioid Receptor Ligands and Pharmacology: Diphenethylamines, a Class of Structurally Distinct, Selective Kappa Opioid Li... -- 1 Introduction -- 2 KOR Ligands and Their Pharmacology -- 2.1 Natural Ligands -- 2.2 Synthetic Ligands -- 2.3 Diphenethylamines, a New Class of Selective KOR Ligands -- 2.3.1 Agonists and Partial Agonists -- 2.3.2 Biased Agonists -- 2.3.3 Antagonists -- 2.3.4 In Vivo Pharmacology -- 3 Conclusion -- References -- Peptide Kappa Opioid Receptor Ligands and Their Potential for Drug Development. 1 Introduction -- 1.1 Actions of the Endogenous Kappa Opioid System and Resultant Potential Therapeutic Applications of Ligands for Kappa Opioid... -- 1.2 Review of Key Non-Peptidic Kappa Opioid Receptor-Selective Ligands -- 2 Peptide Ligands for Kappa Opioid Receptors -- 2.1 Dynorphin A Analogs -- 2.2 Tetrapeptide KOR Ligands -- 2.2.1 All-D-Amino Acid Peptides -- 2.2.2 Endomorphin-1 Derivative -- 2.2.3 Macrocyclic Tetrapeptides -- 3 Conclusions -- References -- Part IV: Preclinical Studies: In Vivo Pharmacology -- Dynorphin/Kappa-Opioid Receptor System Modulation of Cortical Circuitry -- 1 Introduction -- 1.1 Cortical Circuits -- 1.2 Anatomy of the Cortical DYN/KOR System -- 1.3 Function of the DYN/KOR System in the Cortex -- 1.4 Behavioral Effects of the DYN/KOR System in the Cortex -- 1.5 Implication for Human Health and Diseases -- 1.6 Unknowns and Future Directions for the Field -- 1.6.1 DYN/KOR Regulation of Dendritic Integration -- 1.6.2 Conservation Across Species -- 1.6.3 Site of Psychotomimetic Effects -- 1.6.4 Interactions with Other Stress-Related Peptides/Systems -- 1.6.5 Novel Approaches to Study the DYN/KOR System -- 2 Conclusions -- References -- Molecular Genetics of Kappa Opioids in Pain and Itch Sensations -- 1 The Kappa Opioid System in Pain -- 1.1 Peripheral Effects of Dynorphins (DRG and TG Neurons) -- 1.2 Dynorphin Neurons in the Spinal Cord -- 1.3 Functions of the Dynorphin/KOR System in the Parabrachial Nucleus -- 1.4 Role of Kappa Opioids in Pain-Induced Stress Responses in the Dorsal Raphe Nucleus, Amygdala, Rostral Ventral Medulla, and... -- 1.5 Summary and Future Direction of Kappa Signaling in Control of Pain -- 2 Kappa Opioids in Itch -- 2.1 Dynorphin Spinal Cord Interneurons Inhibit Itch -- 2.2 Neuronal Circuits for Itch -- 2.3 Summary and Future Direction for Itch Research. 3 Common Mechanisms of Action of the Kappa Opioid System. |
| Record Nr. | UNINA-9910523003103321 |
| Cham, Switzerland : , : Springer, , [2022] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mechanisms of tolerance and dependence / / editor: Charles Wm. Sharp
| Mechanisms of tolerance and dependence / / editor: Charles Wm. Sharp |
| Pubbl/distr/stampa | Rockville, Maryland : , : Department of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, , 1988 |
| Descrizione fisica | 1 online resource (xiii, 375 pages) : illustrations |
| Collana |
NIDA research monograph
DHHS publication |
| Soggetto topico |
Neuropsychopharmacology - United States
Drug tolerance - United States Neuropharmacology - United States Drug abuse - United States - Physiological aspects Opioids - Receptors |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910712031503321 |
| Rockville, Maryland : , : Department of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, , 1988 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular approaches to drug abuse research / / editor: Theresa N. H. Lee
| Molecular approaches to drug abuse research / / editor: Theresa N. H. Lee |
| Pubbl/distr/stampa | Rockville, MD : , : U.S. Department of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, , 1991-1996 |
| Descrizione fisica | 1 online resource (3 volumes) : illustrations |
| Collana |
DHHS publication
Research monograph NIDA research monograph NIH publication |
| Soggetto topico |
Drug abuse - Research - United States - Methodology
Neural receptors Neurotransmitter receptors Gene expression Opioids - Receptors |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | V. 1. Receptor cloning, neurotransmitter expression, and molecular genetics -- v. 2. Structure, function, and expression -- v. 3. Recent advances and emerging strategies. |
| Record Nr. | UNINA-9910712032603321 |
| Rockville, MD : , : U.S. Department of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, , 1991-1996 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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New non-opioid analgesics : understanding molecular mechanisms on the basis of patch-clamp and quantum-chemical studies / / authored by Boris V. Krylov [and four others]
| New non-opioid analgesics : understanding molecular mechanisms on the basis of patch-clamp and quantum-chemical studies / / authored by Boris V. Krylov [and four others] |
| Pubbl/distr/stampa | Sharjah, United Arab Emirates : , : Bentham Science Publishers, , 2017 |
| Descrizione fisica | 1 online resource (204 pages) : illustrations |
| Disciplina | 615.7822 |
| Collana | Frontiers in Pain Science |
| Soggetto topico | Opioids - Receptors |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-60805-930-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910467362703321 |
| Sharjah, United Arab Emirates : , : Bentham Science Publishers, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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New non-opioid analgesics : understanding molecular mechanisms on the basis of patch-clamp and quantum-chemical studies / / authored by Boris V. Krylov [and four others]
| New non-opioid analgesics : understanding molecular mechanisms on the basis of patch-clamp and quantum-chemical studies / / authored by Boris V. Krylov [and four others] |
| Pubbl/distr/stampa | Sharjah, United Arab Emirates : , : Bentham Science Publishers, , 2017 |
| Descrizione fisica | 1 online resource (204 pages) : illustrations |
| Disciplina | 615.7822 |
| Collana | Frontiers in Pain Science |
| Soggetto topico | Opioids - Receptors |
| ISBN | 1-60805-930-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910796527203321 |
| Sharjah, United Arab Emirates : , : Bentham Science Publishers, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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New non-opioid analgesics : understanding molecular mechanisms on the basis of patch-clamp and quantum-chemical studies / / authored by Boris V. Krylov [and four others]
| New non-opioid analgesics : understanding molecular mechanisms on the basis of patch-clamp and quantum-chemical studies / / authored by Boris V. Krylov [and four others] |
| Pubbl/distr/stampa | Sharjah, United Arab Emirates : , : Bentham Science Publishers, , 2017 |
| Descrizione fisica | 1 online resource (204 pages) : illustrations |
| Disciplina | 615.7822 |
| Collana | Frontiers in Pain Science |
| Soggetto topico | Opioids - Receptors |
| ISBN | 1-60805-930-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910820498503321 |
| Sharjah, United Arab Emirates : , : Bentham Science Publishers, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Opiate receptor subtypes and brain function / / editors: Roger M. Brown, Doris H. Clouet, David P. Friedman
| Opiate receptor subtypes and brain function / / editors: Roger M. Brown, Doris H. Clouet, David P. Friedman |
| Pubbl/distr/stampa | Rockville, Maryland : , : U.S. Department of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, , 1986 |
| Descrizione fisica | 1 online resource (xiii, 195 pages) : illustrations |
| Collana |
DHHS publication
NIDA research monograph |
| Soggetto topico |
Opioids - Receptors
Narcotics - United States - Receptors Endorphins - United States - Receptors Neurophysiology Neurochemistry Brain Endorphins - Receptors |
| Soggetto genere / forma | Conference papers and proceedings. |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910712029803321 |
| Rockville, Maryland : , : U.S. Department of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, , 1986 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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