Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Antisense-Based Drugs and Therapeutics: Preclinical and Clinical Considerations for Development
| Antisense-Based Drugs and Therapeutics: Preclinical and Clinical Considerations for Development |
| Edizione | [1st] |
| Pubbl/distr/stampa | John Wiley & Sons, Inc |
| Descrizione fisica | 1 online resource (1 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) |
FerrariNicolay
SeguinRosanne |
| Soggetto topico |
Antisense nucleic acids
Drug development Oligonucleotides |
| ISBN |
1-119-07030-9
1-119-07029-5 1-119-07015-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Mechanisms of oligonucleotide actions -- The medicinal chemistry of antisense oligonucleotides -- Cellular pharmacology of antisense oligonucleotides -- Pharmacokinetics and pharmacodynamics of antisense oligonucleotides -- Tissue distribution, metabolism and clearance -- Hybridization-independent effects : principles and specific considerations for oligonucleotide drugs -- Hybridization-dependent effects : the prediction, evaluation and consequences of unintended target hybridization -- Class-related proinflammatory effects -- Exaggerated pharmacology -- Genotoxicity tests for novel oligonucleotide-based therapeutics -- Reproductive and developmental toxicity testing strategies for oligonucleotide-based therapeutics -- Specific considerations for preclinical development of inhaled oligonucleotides -- Lessons learned in oncology programs -- Inhaled antisense for treatment of respiratory disease -- Antisense oligonucleotides for treatment of neurology diseases -- Nucleic acids as adjuvants -- Splice-switching oligonucleotides -- CMC aspects for the clinical development of spiegelmers. |
| Record Nr. | UNINA-9910876788103321 |
| John Wiley & Sons, Inc | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The aptamer handbook [[electronic resource] ] : functional oligonucleotides and their applications / / edited by Sven Klussmann
| The aptamer handbook [[electronic resource] ] : functional oligonucleotides and their applications / / edited by Sven Klussmann |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2006 |
| Descrizione fisica | 1 online resource (520 p.) |
| Disciplina | 572.85 |
| Altri autori (Persone) | KlussmannSven |
| Soggetto topico | Oligonucleotides |
| ISBN |
1-280-72339-4
9786610723393 3-527-60819-2 3-527-60791-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
The Aptamer Handbook; Contents; Preface; Foreword; List of Contributors; Part 1 History and Theoretical Background; 1 In Vitro Selection of Functional Oligonucleotides and the Origins of Biochemical Activity; 1.1 Introduction; 1.2 A Brief History of In Vitro Selection; 1.3 Lessons from the Aptamers, Ribozymes, Deoxyribozymes Generated by In Vitro Selection; 1.4 Synthetic Approaches to Understanding the Natural Origins of Function; 1.5 Recent Technological Developments and Future Directions; 1.6 Conclusion; Acknowledgments; References
2 Mathematical Models on RNA Evolution, Simulations In Silico, and Concepts for In Vitro Selection2.1 From Early Experiments and Theories to the Concept of Neutral Networks; 2.1.1 Evolution in the Test Tube; 2.1.2 Kinetic Theory of the Evolution of Molecules; 2.1.3 Sequence Space and Shape Space; 2.2 RNA Structures, Thermodynamics and Kinetic Folding; 2.2.1 Secondary Structures of Minimum Free Energies; 2.2.2 Inverse Folding; 2.2.3 Suboptimal Conformations and Kinetic Folding; 2.2.4 Cofolding and DNA Parameters; 2.3 Neutral Networks and In Silico Evolution of Molecules 2.3.1 Neutral Networks in Sequence Space2.3.2 RNA Evolution In Silico; 2.3.3 Lessons from Evolution In Silico; 2.4 Designed and Natural RNA Switches; 2.5 Outlook on Future Problems in RNA Design; Acknowledgments; References; 3 Fitness Landscapes, Error Thresholds, and Cofactors in Aptamer Evolution; 3.1 Introduction; 3.2 Functionality Landscapes Inferred from Examples; 3.2.1 Fitness Landscape; 3.2.2 Damage Selection Experiments with Ribozymes; 3.2.3 Construction of the Fitness Landscape; 3.2.3.1 Compatible Structure; 3.2.3.2 Mispairs; 3.2.3.3 Critical Sites; 3.2.3.4 Predicted Structure 3.2.4 Case Study: The Fitness Landscape of the Neurospora VS Ribozyme3.2.4.1 Compatible Structure of the VS Ribozyme; 3.2.4.2 Allowed Mispairs in the VS Ribozyme; 3.2.4.3 Critical Sites in the VS Ribozyme; 3.2.4.4 Predicted Structure for the VS Ribozyme; 3.2.4.5 Properties of the Estimated Fitness Landscape for the VS Ribozyme; 3.3 Error Thresholds Inferred from Functional Landscapes: The "Realistic" Error Threshold of the Neurospora VS Ribozyme; 3.4 Looking for Catalytic Partners: Cofactors and Aptamers; 3.4.1 Co-ribozymes (cofactor-assisted ribozymes); 3.4.2 Aptazymes 3.5 The Use of Coenzymes: From the RNA World to the Protein World via Translation and the Genetic Code3.6 Outlook; Acknowledgments; References; Part 2 In Vitro Selection of Target-binding Oligonucleotides; 4 Aptamers to Small Molecules; 4.1 Introduction; 4.2 Aptamers to Nucleotides/Nucleosides/Nucleobases; 4.3 Aptamers to Cofactors; 4.4 Aptamers to Amino Acids; 4.5 Aptamers to Carbohydrates; 4.6 Aptamers to Natural Products; 4.7 Aptamers to Organic or Fluorescent Dyes; 4.8 The Chimeric Approach for Aptamer Selection; 4.9 Conclusion; Acknowledgments; References; 5 Aptamers to Antibiotics 5.1 Introduction |
| Record Nr. | UNINA-9910830024003321 |
| Weinheim, : Wiley-VCH, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The aptamer handbook : functional oligonucleotides and their applications / / edited by Sven Klussmann
| The aptamer handbook : functional oligonucleotides and their applications / / edited by Sven Klussmann |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2006 |
| Descrizione fisica | 1 online resource (520 p.) |
| Disciplina | 572.8/5 |
| Altri autori (Persone) | KlussmannSven |
| Soggetto topico | Oligonucleotides |
| ISBN |
1-280-72339-4
9786610723393 3-527-60819-2 3-527-60791-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
The Aptamer Handbook; Contents; Preface; Foreword; List of Contributors; Part 1 History and Theoretical Background; 1 In Vitro Selection of Functional Oligonucleotides and the Origins of Biochemical Activity; 1.1 Introduction; 1.2 A Brief History of In Vitro Selection; 1.3 Lessons from the Aptamers, Ribozymes, Deoxyribozymes Generated by In Vitro Selection; 1.4 Synthetic Approaches to Understanding the Natural Origins of Function; 1.5 Recent Technological Developments and Future Directions; 1.6 Conclusion; Acknowledgments; References
2 Mathematical Models on RNA Evolution, Simulations In Silico, and Concepts for In Vitro Selection2.1 From Early Experiments and Theories to the Concept of Neutral Networks; 2.1.1 Evolution in the Test Tube; 2.1.2 Kinetic Theory of the Evolution of Molecules; 2.1.3 Sequence Space and Shape Space; 2.2 RNA Structures, Thermodynamics and Kinetic Folding; 2.2.1 Secondary Structures of Minimum Free Energies; 2.2.2 Inverse Folding; 2.2.3 Suboptimal Conformations and Kinetic Folding; 2.2.4 Cofolding and DNA Parameters; 2.3 Neutral Networks and In Silico Evolution of Molecules 2.3.1 Neutral Networks in Sequence Space2.3.2 RNA Evolution In Silico; 2.3.3 Lessons from Evolution In Silico; 2.4 Designed and Natural RNA Switches; 2.5 Outlook on Future Problems in RNA Design; Acknowledgments; References; 3 Fitness Landscapes, Error Thresholds, and Cofactors in Aptamer Evolution; 3.1 Introduction; 3.2 Functionality Landscapes Inferred from Examples; 3.2.1 Fitness Landscape; 3.2.2 Damage Selection Experiments with Ribozymes; 3.2.3 Construction of the Fitness Landscape; 3.2.3.1 Compatible Structure; 3.2.3.2 Mispairs; 3.2.3.3 Critical Sites; 3.2.3.4 Predicted Structure 3.2.4 Case Study: The Fitness Landscape of the Neurospora VS Ribozyme3.2.4.1 Compatible Structure of the VS Ribozyme; 3.2.4.2 Allowed Mispairs in the VS Ribozyme; 3.2.4.3 Critical Sites in the VS Ribozyme; 3.2.4.4 Predicted Structure for the VS Ribozyme; 3.2.4.5 Properties of the Estimated Fitness Landscape for the VS Ribozyme; 3.3 Error Thresholds Inferred from Functional Landscapes: The "Realistic" Error Threshold of the Neurospora VS Ribozyme; 3.4 Looking for Catalytic Partners: Cofactors and Aptamers; 3.4.1 Co-ribozymes (cofactor-assisted ribozymes); 3.4.2 Aptazymes 3.5 The Use of Coenzymes: From the RNA World to the Protein World via Translation and the Genetic Code3.6 Outlook; Acknowledgments; References; Part 2 In Vitro Selection of Target-binding Oligonucleotides; 4 Aptamers to Small Molecules; 4.1 Introduction; 4.2 Aptamers to Nucleotides/Nucleosides/Nucleobases; 4.3 Aptamers to Cofactors; 4.4 Aptamers to Amino Acids; 4.5 Aptamers to Carbohydrates; 4.6 Aptamers to Natural Products; 4.7 Aptamers to Organic or Fluorescent Dyes; 4.8 The Chimeric Approach for Aptamer Selection; 4.9 Conclusion; Acknowledgments; References; 5 Aptamers to Antibiotics 5.1 Introduction |
| Record Nr. | UNINA-9910876887003321 |
| Weinheim, : Wiley-VCH, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Aptamers in bioanalysis [[electronic resource] /] / edited by Marco Mascini
| Aptamers in bioanalysis [[electronic resource] /] / edited by Marco Mascini |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley, c2009 |
| Descrizione fisica | 1 online resource (346 p.) |
| Disciplina | 572.85 |
| Altri autori (Persone) | MasciniMarco |
| Soggetto topico |
Oligonucleotides
Biochemistry |
| ISBN |
1-282-11267-8
9786612112676 0-470-38077-2 0-470-38076-4 |
| Classificazione |
CHE 808f
CHE 860f WC 4150 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
APTAMERS IN BIOANALYSIS; CONTENTS; PREFACE; CONTRIBUTORS; I INTRODUCTION; 1 APTAMERS: LIGANDS FOR ALL REASONS; 1.1 Introduction; 1.2 The Power of Selection and Aptamer Refinement; 1.3 The Chemistry Drives the Shape; 1.4 Aptaregulators; 1.5 Aptasensors; 1.6 Prospects; References; 2 SELEX AND ITS RECENT OPTIMIZATIONS; 2.1 Introduction; 2.2 Aptamers and Their Selection by SELEX; 2.3 Modifications of SELEX Technology; 2.4 Advantages and Limitations of Aptamers and Their Selection Technology; 2.5 Applications of Aptamers Being Developed for the Market; 2.6 Future Perspectives; References
II BIOSENSORS3 ELECTROCHEMICAL APTASENSORS; 3.1 Introduction; 3.2 Electrochemical Aptasensor Based on Redox-Active Aptamer Monolayers Linked to Electrodes; 3.3 Enzyme-Based Amplified Electrochemical Aptasensors; 3.4 Amplified Electrochemical Aptasensors Based on Nanoparticles; 3.5 Label-Free Electrochemical Aptasensors; 3.6 Field-Effect Transistor-Based Aptasensors; 3.7 Conclusions and Perspectives; References; 4 APTAMERS: HYBRIDS BETWEEN NATURE AND TECHNOLOGY; 4.1 Introduction; 4.2 Specific Features of Aptamers; 4.3 Electrochemical Detection of Nucleic Acids 4.4 Cytochrome c Binding by Aptamers4.5 DNA Machines and Aptamers; References; 5 DETECTION OF PROTEIN-APTAMER INTERACTIONS BY MEANS OF ELECTROCHEMICAL INDICATORS AND TRANSVERSE SHEAR MODE METHOD; 5.1 Introduction; 5.2 Immobilization of Aptamers on a Solid Support; 5.3 Detection of Aptamer-Ligand Interactions; 5.3.1 Electrochemical Methods; 5.3.2 Acoustic Methods; 5.4 Conclusions; References; 6 BIOSENSORS USING THE APTAMERIC ENZYME SUBUNIT: THE USE OF APTAMERS IN THE ALLOSTERIC CONTROL OF ENZYMES; 6.1 Aptamers as Molecular Recognition Elements of Biosensors 6.1.1 Comparing Aptamers to Antibodies6.1.2 Signaling Aptamers; 6.2 Homogeneous Sensing; 6.2.1 Biosensor Systems That Do Not Require Bound-Free Separation; 6.2.2 Aptameric Enzyme Subunit; 6.3 Evolution-mimicking Algorithm for the Improvement of Aptamers; References; 7 NANOMATERIAL-BASED LABEL-FREE APTASENSORS; 7.1 Introduction; 7.2 Label-Free Electrochemical Aptasensors; 7.3 Field-Effect Transistor-Based Aptasensors; 7.4 Label-Free Aptasensors Based on Localized Surface Plasmon Resonance; 7.5 Forthcoming Challenges and Concluding Remarks; References 8 APTAMER-BASED BIOANALYTICAL ASSAYS: AMPLIFICATION STRATEGIES8.1 Introduction; 8.2 Bioanalytical Assays Based on Aptamer-Functionalized Nanoparticles; 8.3 Aptamers and Quantum Dot-Based Assays; 8.4 Aptazymes and Aptamer-Based Machines; 8.5 Polymerase Chain Reaction as an Amplification Method in Aptamer-Based Assays; 8.6 Conclusions; References; III APPLICATIONS; 9 KINETIC CAPILLARY ELECTROPHORESIS FOR SELECTION, CHARACTERIZATION, AND ANALYTICAL UTILIZATION OF APTAMERS; 9.1 Introduction; 9.1.1 Kinetic Capillary Electrophoresis; 9.1.2 The Concept of NECEEM and ECEEM 9.2 Selection of Aptamers Using KCE Methods for Partitioning and Affinity Control |
| Record Nr. | UNINA-9910146399103321 |
| Hoboken, NJ, : Wiley, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Aptamers in bioanalysis / / edited by Marco Mascini
| Aptamers in bioanalysis / / edited by Marco Mascini |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley, c2009 |
| Descrizione fisica | 1 online resource (346 p.) |
| Disciplina | 572.85 |
| Altri autori (Persone) | MasciniMarco |
| Soggetto topico |
Oligonucleotides
Biochemistry |
| ISBN |
1-282-11267-8
9786612112676 0-470-38077-2 0-470-38076-4 |
| Classificazione |
CHE 808f
CHE 860f WC 4150 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
APTAMERS IN BIOANALYSIS; CONTENTS; PREFACE; CONTRIBUTORS; I INTRODUCTION; 1 APTAMERS: LIGANDS FOR ALL REASONS; 1.1 Introduction; 1.2 The Power of Selection and Aptamer Refinement; 1.3 The Chemistry Drives the Shape; 1.4 Aptaregulators; 1.5 Aptasensors; 1.6 Prospects; References; 2 SELEX AND ITS RECENT OPTIMIZATIONS; 2.1 Introduction; 2.2 Aptamers and Their Selection by SELEX; 2.3 Modifications of SELEX Technology; 2.4 Advantages and Limitations of Aptamers and Their Selection Technology; 2.5 Applications of Aptamers Being Developed for the Market; 2.6 Future Perspectives; References
II BIOSENSORS3 ELECTROCHEMICAL APTASENSORS; 3.1 Introduction; 3.2 Electrochemical Aptasensor Based on Redox-Active Aptamer Monolayers Linked to Electrodes; 3.3 Enzyme-Based Amplified Electrochemical Aptasensors; 3.4 Amplified Electrochemical Aptasensors Based on Nanoparticles; 3.5 Label-Free Electrochemical Aptasensors; 3.6 Field-Effect Transistor-Based Aptasensors; 3.7 Conclusions and Perspectives; References; 4 APTAMERS: HYBRIDS BETWEEN NATURE AND TECHNOLOGY; 4.1 Introduction; 4.2 Specific Features of Aptamers; 4.3 Electrochemical Detection of Nucleic Acids 4.4 Cytochrome c Binding by Aptamers4.5 DNA Machines and Aptamers; References; 5 DETECTION OF PROTEIN-APTAMER INTERACTIONS BY MEANS OF ELECTROCHEMICAL INDICATORS AND TRANSVERSE SHEAR MODE METHOD; 5.1 Introduction; 5.2 Immobilization of Aptamers on a Solid Support; 5.3 Detection of Aptamer-Ligand Interactions; 5.3.1 Electrochemical Methods; 5.3.2 Acoustic Methods; 5.4 Conclusions; References; 6 BIOSENSORS USING THE APTAMERIC ENZYME SUBUNIT: THE USE OF APTAMERS IN THE ALLOSTERIC CONTROL OF ENZYMES; 6.1 Aptamers as Molecular Recognition Elements of Biosensors 6.1.1 Comparing Aptamers to Antibodies6.1.2 Signaling Aptamers; 6.2 Homogeneous Sensing; 6.2.1 Biosensor Systems That Do Not Require Bound-Free Separation; 6.2.2 Aptameric Enzyme Subunit; 6.3 Evolution-mimicking Algorithm for the Improvement of Aptamers; References; 7 NANOMATERIAL-BASED LABEL-FREE APTASENSORS; 7.1 Introduction; 7.2 Label-Free Electrochemical Aptasensors; 7.3 Field-Effect Transistor-Based Aptasensors; 7.4 Label-Free Aptasensors Based on Localized Surface Plasmon Resonance; 7.5 Forthcoming Challenges and Concluding Remarks; References 8 APTAMER-BASED BIOANALYTICAL ASSAYS: AMPLIFICATION STRATEGIES8.1 Introduction; 8.2 Bioanalytical Assays Based on Aptamer-Functionalized Nanoparticles; 8.3 Aptamers and Quantum Dot-Based Assays; 8.4 Aptazymes and Aptamer-Based Machines; 8.5 Polymerase Chain Reaction as an Amplification Method in Aptamer-Based Assays; 8.6 Conclusions; References; III APPLICATIONS; 9 KINETIC CAPILLARY ELECTROPHORESIS FOR SELECTION, CHARACTERIZATION, AND ANALYTICAL UTILIZATION OF APTAMERS; 9.1 Introduction; 9.1.1 Kinetic Capillary Electrophoresis; 9.1.2 The Concept of NECEEM and ECEEM 9.2 Selection of Aptamers Using KCE Methods for Partitioning and Affinity Control |
| Record Nr. | UNINA-9910825105103321 |
| Hoboken, NJ, : Wiley, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Electrochemical modification of glassy carbon [[electronic resource] /] / Amethist S. Finch and James J. Sumner
| Electrochemical modification of glassy carbon [[electronic resource] /] / Amethist S. Finch and James J. Sumner |
| Autore | Finch Amethist S |
| Pubbl/distr/stampa | Adelphi, MD : , : Army Research Laboratory, , [2011] |
| Descrizione fisica | 1 online resource (vi, 14 pages) : color illustrations |
| Altri autori (Persone) | SumnerJames J |
| Collana | ARL-TR |
| Soggetto topico |
DNA - Synthesis
Oligonucleotides Organic electrochemistry |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910701395003321 |
Finch Amethist S
|
||
| Adelphi, MD : , : Army Research Laboratory, , [2011] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Oligonucleotides
| Oligonucleotides |
| Pubbl/distr/stampa | New Rochelle, NY, : Mary Ann Liebert, Inc., [2003]-2011 |
| Disciplina | 572 |
| Soggetto topico |
Oligonucleotides
Oligonucleotides, Antisense |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 1557-8526 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996206432903316 |
| New Rochelle, NY, : Mary Ann Liebert, Inc., [2003]-2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Oligonucleotides
| Oligonucleotides |
| Pubbl/distr/stampa | New Rochelle, NY, : Mary Ann Liebert, Inc., [2003]-2011 |
| Disciplina | 572 |
| Soggetto topico |
Oligonucleotides
Oligonucleotides, Antisense Oligonucléotides |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 1557-8526 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910142637803321 |
| New Rochelle, NY, : Mary Ann Liebert, Inc., [2003]-2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
