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Advanced organic chemistry of nucleic acids [[electronic resource] /] / Z. Shabarova, A. Bogdanov
Advanced organic chemistry of nucleic acids [[electronic resource] /] / Z. Shabarova, A. Bogdanov
Autore Shabarova Z (Zoe)
Pubbl/distr/stampa Weinheim ; ; New York, : VCH, c1994
Descrizione fisica 1 online resource (606 p.)
Disciplina 547.79
574.87328
Altri autori (Persone) BogdanovA (Alexey)
Soggetto topico Nucleic acids
Chemistry, Organic
Soggetto genere / forma Electronic books.
ISBN 1-281-75881-7
9786611758813
3-527-61593-8
3-527-61592-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Advanced Organic Chemistry of Nucleic Acids; Contents; 1 Structure of Nucleosides; 1.1 Introduction; 1.2 Pyrimidine and Purine Bases; 1.2.1 Pyrimidines; 1.2.2 Purines; 1.2.3 Nomenclature of Pyrimidines and Purines; 1.2.4 Abbreviations; 1.3 Carbohydrate Moieties of Nucleosides; 1.4 Bonding Between Carbohydrate Moiety and Heterocyclic Base; 1.4.1 Purine Nucleosides; 1.4.2 Pyrimidine Nucleosides; 1.5 Size of the Oxide Ring in the Sugar; 1.6 Configuration of the Glycoside (Anomeric) Center; 1.7 Nomenclature and Abridged Formulas of Nucleosides; 1.8 Minor Nucleosides; 1.9 Pseudouridine
1.10 Nucleoside Antibiotics1.10.1 Purine Nucleosides; 1.10.2 Pyrimidine Nucleosides; 1.11 Other Nucleosides; References; 2 Properties of Nucleosides; 2.1 Heterocyclic Bases; 2.1.1 General Concepts; 2.1.2 Tautomerism; 2.1.3 Reactions with Electrophilic Reagents; 2.1.4 Reactions with Nucleophilic Reagents; 2.1.5 Addition Reactions; 2.1.6 Reactions Involving Exocyclic Amino Groups; 2.2 Reactions at the Carbohydrate Moiety; 2.2.1 Substitution for Hydrogen Atoms in Hydroxyl Groups; 2.2.2 Oxidation; 2.3 Reactions Involving Heterocyclic Bases and the Carbohydrate Moiety
2.4 Stability of N-Glycosidic Bonds2.4.1 Effect of the Heterocyclic Base Species; 2.4.2 Effect of Substituents in the Carbohydrate Moiety; 2.4.3 Mechanism of Hydrolysis of N-Glycosidic Bonds; 2.5 Properties of Pseudouridine; References; 3 Structure of Nucleotides; 3.1 Introduction; 3.2 Nomenclature and Isomerism; 3.3 Structure of Nucleotides; 3.3.1 Nucleoside 5'-Phosphates; 3.3.2 Nucleoside 3'- and 2'-Phosphates; 3.3.3 Nucleoside Cyclic Phosphates; 3.3.4 Nucleoside 3'(2').5'-Diphosphates; 3.4 General Comments Regarding the Structure of Monomer Units in Nucleic Acids; References
4 Properties of Nucleotides4.1 Acid-Base Behavior; 4.1.1 Ionization of Bases; 4.1.2 Ionization of Hydroxyl Groups in Pentose; 4.1.3 Ionization of the Phosphate Group; 4.2 Formation of Derivatives with Metals; 4.3 Reactions at Heterocyclic Bases and Pentose; 4.4 Some Properties of the Phosphate Group (General Concepts); 4.4.1 Structure of the Phosphate Group and the Mechanism of Nucleophilic Substitution at the Phosphorus Atom; 4.4.2 Catalysis of Nucleophilic Substitution at the Phosphorus Atom; 4.4.3 Hydrolysis of Alkyl Phosphates; 4.4.4 Cyclic Phosphates; 4.4.5 B-Elimination Reactions
4.5 Reactions of Nucleotides Involving the Phosphate Group4.5.1 Chemical and Enzymatic Dephosphorylation; 4.5.2 Migration of the Phosphate Group; 4.5.3 Alkylation of the Phosphate Group; 4.5.4 Activation of the Phosphate Group in Nucleotides . Synthesis of Some Derivatives with Respect to the Phosphate Group; 4.5.5 Acylation of the Phosphate Group; 4.6 Properties of Nucleotide Derivatives with Substituents in the Phosphate Group; 4.6.1 Nucleoside Cyclic Phosphates; 4.6.2 Alkyl Esters of Nucleotides; 4.6.3 Mixed Anhydrides of Nucleotides; 4.6.4 Amides of Nucleotides
4.7 Hydrolysis of N-Glycosidic Bonds
Record Nr. UNINA-9910144008903321
Shabarova Z (Zoe)  
Weinheim ; ; New York, : VCH, c1994
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advanced organic chemistry of nucleic acids / / Z. Shabarova, A. Bogdanov, translated by Vladimir Vopyan
Advanced organic chemistry of nucleic acids / / Z. Shabarova, A. Bogdanov, translated by Vladimir Vopyan
Autore Shabarova Z (Zoe)
Pubbl/distr/stampa Weinheim, Germany ; ; New York, New York : , : VCH, , [1994]
Descrizione fisica 1 online resource (606 p.)
Disciplina 574.87328
Soggetto topico Nucleic acids
ISBN 1-281-75881-7
9786611758813
3-527-61593-8
3-527-61592-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Advanced Organic Chemistry of Nucleic Acids; Contents; 1 Structure of Nucleosides; 1.1 Introduction; 1.2 Pyrimidine and Purine Bases; 1.2.1 Pyrimidines; 1.2.2 Purines; 1.2.3 Nomenclature of Pyrimidines and Purines; 1.2.4 Abbreviations; 1.3 Carbohydrate Moieties of Nucleosides; 1.4 Bonding Between Carbohydrate Moiety and Heterocyclic Base; 1.4.1 Purine Nucleosides; 1.4.2 Pyrimidine Nucleosides; 1.5 Size of the Oxide Ring in the Sugar; 1.6 Configuration of the Glycoside (Anomeric) Center; 1.7 Nomenclature and Abridged Formulas of Nucleosides; 1.8 Minor Nucleosides; 1.9 Pseudouridine
1.10 Nucleoside Antibiotics1.10.1 Purine Nucleosides; 1.10.2 Pyrimidine Nucleosides; 1.11 Other Nucleosides; References; 2 Properties of Nucleosides; 2.1 Heterocyclic Bases; 2.1.1 General Concepts; 2.1.2 Tautomerism; 2.1.3 Reactions with Electrophilic Reagents; 2.1.4 Reactions with Nucleophilic Reagents; 2.1.5 Addition Reactions; 2.1.6 Reactions Involving Exocyclic Amino Groups; 2.2 Reactions at the Carbohydrate Moiety; 2.2.1 Substitution for Hydrogen Atoms in Hydroxyl Groups; 2.2.2 Oxidation; 2.3 Reactions Involving Heterocyclic Bases and the Carbohydrate Moiety
2.4 Stability of N-Glycosidic Bonds2.4.1 Effect of the Heterocyclic Base Species; 2.4.2 Effect of Substituents in the Carbohydrate Moiety; 2.4.3 Mechanism of Hydrolysis of N-Glycosidic Bonds; 2.5 Properties of Pseudouridine; References; 3 Structure of Nucleotides; 3.1 Introduction; 3.2 Nomenclature and Isomerism; 3.3 Structure of Nucleotides; 3.3.1 Nucleoside 5'-Phosphates; 3.3.2 Nucleoside 3'- and 2'-Phosphates; 3.3.3 Nucleoside Cyclic Phosphates; 3.3.4 Nucleoside 3'(2').5'-Diphosphates; 3.4 General Comments Regarding the Structure of Monomer Units in Nucleic Acids; References
4 Properties of Nucleotides4.1 Acid-Base Behavior; 4.1.1 Ionization of Bases; 4.1.2 Ionization of Hydroxyl Groups in Pentose; 4.1.3 Ionization of the Phosphate Group; 4.2 Formation of Derivatives with Metals; 4.3 Reactions at Heterocyclic Bases and Pentose; 4.4 Some Properties of the Phosphate Group (General Concepts); 4.4.1 Structure of the Phosphate Group and the Mechanism of Nucleophilic Substitution at the Phosphorus Atom; 4.4.2 Catalysis of Nucleophilic Substitution at the Phosphorus Atom; 4.4.3 Hydrolysis of Alkyl Phosphates; 4.4.4 Cyclic Phosphates; 4.4.5 B-Elimination Reactions
4.5 Reactions of Nucleotides Involving the Phosphate Group4.5.1 Chemical and Enzymatic Dephosphorylation; 4.5.2 Migration of the Phosphate Group; 4.5.3 Alkylation of the Phosphate Group; 4.5.4 Activation of the Phosphate Group in Nucleotides . Synthesis of Some Derivatives with Respect to the Phosphate Group; 4.5.5 Acylation of the Phosphate Group; 4.6 Properties of Nucleotide Derivatives with Substituents in the Phosphate Group; 4.6.1 Nucleoside Cyclic Phosphates; 4.6.2 Alkyl Esters of Nucleotides; 4.6.3 Mixed Anhydrides of Nucleotides; 4.6.4 Amides of Nucleotides
4.7 Hydrolysis of N-Glycosidic Bonds
Record Nr. UNISA-996197616303316
Shabarova Z (Zoe)  
Weinheim, Germany ; ; New York, New York : , : VCH, , [1994]
Materiale a stampa
Lo trovi qui: Univ. di Salerno
Opac: Controlla la disponibilità qui
Advanced organic chemistry of nucleic acids / / Z. Shabarova, A. Bogdanov, translated by Vladimir Vopyan
Advanced organic chemistry of nucleic acids / / Z. Shabarova, A. Bogdanov, translated by Vladimir Vopyan
Autore Shabarova Z (Zoe)
Pubbl/distr/stampa Weinheim, Germany ; ; New York, New York : , : VCH, , [1994]
Descrizione fisica 1 online resource (606 p.)
Disciplina 574.87328
Soggetto topico Nucleic acids
ISBN 1-281-75881-7
9786611758813
3-527-61593-8
3-527-61592-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Advanced Organic Chemistry of Nucleic Acids; Contents; 1 Structure of Nucleosides; 1.1 Introduction; 1.2 Pyrimidine and Purine Bases; 1.2.1 Pyrimidines; 1.2.2 Purines; 1.2.3 Nomenclature of Pyrimidines and Purines; 1.2.4 Abbreviations; 1.3 Carbohydrate Moieties of Nucleosides; 1.4 Bonding Between Carbohydrate Moiety and Heterocyclic Base; 1.4.1 Purine Nucleosides; 1.4.2 Pyrimidine Nucleosides; 1.5 Size of the Oxide Ring in the Sugar; 1.6 Configuration of the Glycoside (Anomeric) Center; 1.7 Nomenclature and Abridged Formulas of Nucleosides; 1.8 Minor Nucleosides; 1.9 Pseudouridine
1.10 Nucleoside Antibiotics1.10.1 Purine Nucleosides; 1.10.2 Pyrimidine Nucleosides; 1.11 Other Nucleosides; References; 2 Properties of Nucleosides; 2.1 Heterocyclic Bases; 2.1.1 General Concepts; 2.1.2 Tautomerism; 2.1.3 Reactions with Electrophilic Reagents; 2.1.4 Reactions with Nucleophilic Reagents; 2.1.5 Addition Reactions; 2.1.6 Reactions Involving Exocyclic Amino Groups; 2.2 Reactions at the Carbohydrate Moiety; 2.2.1 Substitution for Hydrogen Atoms in Hydroxyl Groups; 2.2.2 Oxidation; 2.3 Reactions Involving Heterocyclic Bases and the Carbohydrate Moiety
2.4 Stability of N-Glycosidic Bonds2.4.1 Effect of the Heterocyclic Base Species; 2.4.2 Effect of Substituents in the Carbohydrate Moiety; 2.4.3 Mechanism of Hydrolysis of N-Glycosidic Bonds; 2.5 Properties of Pseudouridine; References; 3 Structure of Nucleotides; 3.1 Introduction; 3.2 Nomenclature and Isomerism; 3.3 Structure of Nucleotides; 3.3.1 Nucleoside 5'-Phosphates; 3.3.2 Nucleoside 3'- and 2'-Phosphates; 3.3.3 Nucleoside Cyclic Phosphates; 3.3.4 Nucleoside 3'(2').5'-Diphosphates; 3.4 General Comments Regarding the Structure of Monomer Units in Nucleic Acids; References
4 Properties of Nucleotides4.1 Acid-Base Behavior; 4.1.1 Ionization of Bases; 4.1.2 Ionization of Hydroxyl Groups in Pentose; 4.1.3 Ionization of the Phosphate Group; 4.2 Formation of Derivatives with Metals; 4.3 Reactions at Heterocyclic Bases and Pentose; 4.4 Some Properties of the Phosphate Group (General Concepts); 4.4.1 Structure of the Phosphate Group and the Mechanism of Nucleophilic Substitution at the Phosphorus Atom; 4.4.2 Catalysis of Nucleophilic Substitution at the Phosphorus Atom; 4.4.3 Hydrolysis of Alkyl Phosphates; 4.4.4 Cyclic Phosphates; 4.4.5 B-Elimination Reactions
4.5 Reactions of Nucleotides Involving the Phosphate Group4.5.1 Chemical and Enzymatic Dephosphorylation; 4.5.2 Migration of the Phosphate Group; 4.5.3 Alkylation of the Phosphate Group; 4.5.4 Activation of the Phosphate Group in Nucleotides . Synthesis of Some Derivatives with Respect to the Phosphate Group; 4.5.5 Acylation of the Phosphate Group; 4.6 Properties of Nucleotide Derivatives with Substituents in the Phosphate Group; 4.6.1 Nucleoside Cyclic Phosphates; 4.6.2 Alkyl Esters of Nucleotides; 4.6.3 Mixed Anhydrides of Nucleotides; 4.6.4 Amides of Nucleotides
4.7 Hydrolysis of N-Glycosidic Bonds
Record Nr. UNINA-9910830338503321
Shabarova Z (Zoe)  
Weinheim, Germany ; ; New York, New York : , : VCH, , [1994]
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advances and challenges in the delivery of nucleic acid therapeutics . Volume 1 / / editors, Olivia Merkel, Mansoor Amiji
Advances and challenges in the delivery of nucleic acid therapeutics . Volume 1 / / editors, Olivia Merkel, Mansoor Amiji
Pubbl/distr/stampa London, England : , : Future Science Ltd, , 2015
Descrizione fisica 1 online resource (136 pages) : illustrations (some color)
Disciplina 572.8
Soggetto topico Antisense nucleic acids
Nucleic acids
Soggetto genere / forma Electronic books.
ISBN 1-910419-93-1
1-910419-92-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910464376103321
London, England : , : Future Science Ltd, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advances and challenges in the delivery of nucleic acid therapeutics . Volume 2. / / editors, Olivia Merkel, Mansoor Amiji
Advances and challenges in the delivery of nucleic acid therapeutics . Volume 2. / / editors, Olivia Merkel, Mansoor Amiji
Pubbl/distr/stampa London, England : , : Future Science Ltd, , 2015
Descrizione fisica 1 online resource (129 pages) : illustrations (some color)
Disciplina 572.8
Soggetto topico Antisense nucleic acids
Nucleic acids
Soggetto genere / forma Electronic books.
ISBN 1-910419-96-6
1-910419-95-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910464375403321
London, England : , : Future Science Ltd, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advances and challenges in the delivery of nucleic acid therapeutics . Volume 2. / / editors, Olivia Merkel, Mansoor Amiji
Advances and challenges in the delivery of nucleic acid therapeutics . Volume 2. / / editors, Olivia Merkel, Mansoor Amiji
Pubbl/distr/stampa London, England : , : Future Science Ltd, , 2015
Descrizione fisica 1 online resource (129 pages) : illustrations (some color)
Disciplina 572.8
Soggetto topico Antisense nucleic acids
Nucleic acids
ISBN 1-910419-96-6
1-910419-95-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910789501003321
London, England : , : Future Science Ltd, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advances and challenges in the delivery of nucleic acid therapeutics . Volume 1 / / editors, Olivia Merkel, Mansoor Amiji
Advances and challenges in the delivery of nucleic acid therapeutics . Volume 1 / / editors, Olivia Merkel, Mansoor Amiji
Pubbl/distr/stampa London, England : , : Future Science Ltd, , 2015
Descrizione fisica 1 online resource (136 pages) : illustrations (some color)
Disciplina 572.8
Soggetto topico Antisense nucleic acids
Nucleic acids
ISBN 1-910419-93-1
1-910419-92-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910789499403321
London, England : , : Future Science Ltd, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advances and challenges in the delivery of nucleic acid therapeutics . Volume 1 / / editors, Olivia Merkel, Mansoor Amiji
Advances and challenges in the delivery of nucleic acid therapeutics . Volume 1 / / editors, Olivia Merkel, Mansoor Amiji
Pubbl/distr/stampa London, England : , : Future Science Ltd, , 2015
Descrizione fisica 1 online resource (136 pages) : illustrations (some color)
Disciplina 572.8
Soggetto topico Antisense nucleic acids
Nucleic acids
ISBN 1-910419-93-1
1-910419-92-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910827771803321
London, England : , : Future Science Ltd, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advances and challenges in the delivery of nucleic acid therapeutics . Volume 2. / / editors, Olivia Merkel, Mansoor Amiji
Advances and challenges in the delivery of nucleic acid therapeutics . Volume 2. / / editors, Olivia Merkel, Mansoor Amiji
Pubbl/distr/stampa London, England : , : Future Science Ltd, , 2015
Descrizione fisica 1 online resource (129 pages) : illustrations (some color)
Disciplina 572.8
Soggetto topico Antisense nucleic acids
Nucleic acids
ISBN 1-910419-96-6
1-910419-95-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910827671003321
London, England : , : Future Science Ltd, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Antisense RNA Design, Delivery, and Analysis / / edited by Virginia Arechavala-Gomeza, Alejandro Garanto
Antisense RNA Design, Delivery, and Analysis / / edited by Virginia Arechavala-Gomeza, Alejandro Garanto
Autore Arechavala-Gomeza Virginia
Edizione [1st ed. 2022.]
Pubbl/distr/stampa New York, : Springer Nature, 2022
Descrizione fisica 1 online resource (XVII, 422 p. 69 illus., 59 illus. in color.)
Disciplina 615.5
Collana Methods in Molecular Biology
Soggetto topico Therapeutics
Biomaterials
Nucleic acids
Nucleic Acid
Àcids nucleics
RNA
Teràpia genètica
Soggetto genere / forma Llibres electrònics
ISBN 1-0716-2010-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction and History of the Chemistry of Nucleic Acids Therapeutics -- Antisense RNA Therapeutics: A Brief Overview -- Design of Bifunctional Antisense Oligonucleotides for Exon Inclusion -- Design and Delivery of SINEUP: A New Modular Tool to Increase Protein Translation -- How to Design U1 snRNA Molecules for Splicing Rescue -- Conjugation of Nucleic Acids and Drugs to Gold Nanoparticles -- Determination of Optimum Ratio of Cationic Polymers and Small Interfering RNA with Agarose Gel Retardation Assay -- Generation of Protein-Phosphorodiamidate Morpholino Oligomer Conjugates for Efficient Cellular Delivery via Anthrax Protective Antigen -- Development and Use of Cellular Systems to Assess and Correct Splicing Defects -- Modeling Splicing Variants Amenable to Antisense Therapy by Use of CRISPR-Cas9-Based Gene Editing in HepG2 Cells -- In Vitro Models for the Evaluation of Antisense Oligonucleotides in Skin -- In Vitro Delivery of PMOs in Myoblasts by Electroporation -- Rapid Determination of MBNL1 Protein Levels by Quantitative Dot Blot for Evaluation of Antisense Oligonucleotides in Myotonic Dystrophy Myoblasts -- Evaluation of Exon Skipping and Dystrophin Restoration in In Vitro Models of Duchenne Muscular Dystrophy -- Generation of Human iPSC-Derived Myotubes to Investigate RNA-Based Therapies In Vitro -- Eye on a Dish Models to Evaluate Splicing Modulation -- Establishment of In Vitro Brain Models for AON Delivery -- Considerations for Generating Humanized Mouse Models to Test Efficacy of Antisense Oligonucleotides -- Generation of Humanized Zebrafish Models for the In Vivo Assessment of Antisense Oligonucleotide-Based Splice Modulation Therapies -- Use of Small Animal Models for Duchenne and Parameters to Assess Efficiency upon Antisense Treatment -- In Vivo Models for the Evaluation of Antisense Oligonucleotides in Skin -- Delivery of Antisense Oligonucleotides to the Mouse Retina -- Delivery of Antisense Oligonucleotides to the Mouse Brain by Intracerebroventricular Injections -- Intrathecal Delivery of Therapeutic Oligonucleotides for Potent Modulation of Gene Expression in the Central Nervous System -- Preclinical Safety Assessment of Therapeutic Oligonucleotides -- Preclinical Evaluation of the Renal Toxicity of Oligonucleotide Therapeutics in Mice -- Protocol for Isolation and Culture of Mouse Hepatocytes (HCs), Kupffer Cells (KCs), and Liver Sinusoidal Endothelial Cells (LSECs) in Analyses of Hepatic Drug Distribution -- Patent Considerations When Embarking on New Antisense Drug Programs.
Record Nr. UNINA-9910552988503321
Arechavala-Gomeza Virginia  
New York, : Springer Nature, 2022
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui