Advanced organic chemistry of nucleic acids [[electronic resource] /] / Z. Shabarova, A. Bogdanov |
Autore | Shabarova Z (Zoe) |
Pubbl/distr/stampa | Weinheim ; ; New York, : VCH, c1994 |
Descrizione fisica | 1 online resource (606 p.) |
Disciplina |
547.79
574.87328 |
Altri autori (Persone) | BogdanovA (Alexey) |
Soggetto topico |
Nucleic acids
Chemistry, Organic |
Soggetto genere / forma | Electronic books. |
ISBN |
1-281-75881-7
9786611758813 3-527-61593-8 3-527-61592-X |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Advanced Organic Chemistry of Nucleic Acids; Contents; 1 Structure of Nucleosides; 1.1 Introduction; 1.2 Pyrimidine and Purine Bases; 1.2.1 Pyrimidines; 1.2.2 Purines; 1.2.3 Nomenclature of Pyrimidines and Purines; 1.2.4 Abbreviations; 1.3 Carbohydrate Moieties of Nucleosides; 1.4 Bonding Between Carbohydrate Moiety and Heterocyclic Base; 1.4.1 Purine Nucleosides; 1.4.2 Pyrimidine Nucleosides; 1.5 Size of the Oxide Ring in the Sugar; 1.6 Configuration of the Glycoside (Anomeric) Center; 1.7 Nomenclature and Abridged Formulas of Nucleosides; 1.8 Minor Nucleosides; 1.9 Pseudouridine
1.10 Nucleoside Antibiotics1.10.1 Purine Nucleosides; 1.10.2 Pyrimidine Nucleosides; 1.11 Other Nucleosides; References; 2 Properties of Nucleosides; 2.1 Heterocyclic Bases; 2.1.1 General Concepts; 2.1.2 Tautomerism; 2.1.3 Reactions with Electrophilic Reagents; 2.1.4 Reactions with Nucleophilic Reagents; 2.1.5 Addition Reactions; 2.1.6 Reactions Involving Exocyclic Amino Groups; 2.2 Reactions at the Carbohydrate Moiety; 2.2.1 Substitution for Hydrogen Atoms in Hydroxyl Groups; 2.2.2 Oxidation; 2.3 Reactions Involving Heterocyclic Bases and the Carbohydrate Moiety 2.4 Stability of N-Glycosidic Bonds2.4.1 Effect of the Heterocyclic Base Species; 2.4.2 Effect of Substituents in the Carbohydrate Moiety; 2.4.3 Mechanism of Hydrolysis of N-Glycosidic Bonds; 2.5 Properties of Pseudouridine; References; 3 Structure of Nucleotides; 3.1 Introduction; 3.2 Nomenclature and Isomerism; 3.3 Structure of Nucleotides; 3.3.1 Nucleoside 5'-Phosphates; 3.3.2 Nucleoside 3'- and 2'-Phosphates; 3.3.3 Nucleoside Cyclic Phosphates; 3.3.4 Nucleoside 3'(2').5'-Diphosphates; 3.4 General Comments Regarding the Structure of Monomer Units in Nucleic Acids; References 4 Properties of Nucleotides4.1 Acid-Base Behavior; 4.1.1 Ionization of Bases; 4.1.2 Ionization of Hydroxyl Groups in Pentose; 4.1.3 Ionization of the Phosphate Group; 4.2 Formation of Derivatives with Metals; 4.3 Reactions at Heterocyclic Bases and Pentose; 4.4 Some Properties of the Phosphate Group (General Concepts); 4.4.1 Structure of the Phosphate Group and the Mechanism of Nucleophilic Substitution at the Phosphorus Atom; 4.4.2 Catalysis of Nucleophilic Substitution at the Phosphorus Atom; 4.4.3 Hydrolysis of Alkyl Phosphates; 4.4.4 Cyclic Phosphates; 4.4.5 B-Elimination Reactions 4.5 Reactions of Nucleotides Involving the Phosphate Group4.5.1 Chemical and Enzymatic Dephosphorylation; 4.5.2 Migration of the Phosphate Group; 4.5.3 Alkylation of the Phosphate Group; 4.5.4 Activation of the Phosphate Group in Nucleotides . Synthesis of Some Derivatives with Respect to the Phosphate Group; 4.5.5 Acylation of the Phosphate Group; 4.6 Properties of Nucleotide Derivatives with Substituents in the Phosphate Group; 4.6.1 Nucleoside Cyclic Phosphates; 4.6.2 Alkyl Esters of Nucleotides; 4.6.3 Mixed Anhydrides of Nucleotides; 4.6.4 Amides of Nucleotides 4.7 Hydrolysis of N-Glycosidic Bonds |
Record Nr. | UNINA-9910144008903321 |
Shabarova Z (Zoe)
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Weinheim ; ; New York, : VCH, c1994 | ||
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Lo trovi qui: Univ. Federico II | ||
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Advanced organic chemistry of nucleic acids / / Z. Shabarova, A. Bogdanov, translated by Vladimir Vopyan |
Autore | Shabarova Z (Zoe) |
Pubbl/distr/stampa | Weinheim, Germany ; ; New York, New York : , : VCH, , [1994] |
Descrizione fisica | 1 online resource (606 p.) |
Disciplina | 574.87328 |
Soggetto topico | Nucleic acids |
ISBN |
1-281-75881-7
9786611758813 3-527-61593-8 3-527-61592-X |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Advanced Organic Chemistry of Nucleic Acids; Contents; 1 Structure of Nucleosides; 1.1 Introduction; 1.2 Pyrimidine and Purine Bases; 1.2.1 Pyrimidines; 1.2.2 Purines; 1.2.3 Nomenclature of Pyrimidines and Purines; 1.2.4 Abbreviations; 1.3 Carbohydrate Moieties of Nucleosides; 1.4 Bonding Between Carbohydrate Moiety and Heterocyclic Base; 1.4.1 Purine Nucleosides; 1.4.2 Pyrimidine Nucleosides; 1.5 Size of the Oxide Ring in the Sugar; 1.6 Configuration of the Glycoside (Anomeric) Center; 1.7 Nomenclature and Abridged Formulas of Nucleosides; 1.8 Minor Nucleosides; 1.9 Pseudouridine
1.10 Nucleoside Antibiotics1.10.1 Purine Nucleosides; 1.10.2 Pyrimidine Nucleosides; 1.11 Other Nucleosides; References; 2 Properties of Nucleosides; 2.1 Heterocyclic Bases; 2.1.1 General Concepts; 2.1.2 Tautomerism; 2.1.3 Reactions with Electrophilic Reagents; 2.1.4 Reactions with Nucleophilic Reagents; 2.1.5 Addition Reactions; 2.1.6 Reactions Involving Exocyclic Amino Groups; 2.2 Reactions at the Carbohydrate Moiety; 2.2.1 Substitution for Hydrogen Atoms in Hydroxyl Groups; 2.2.2 Oxidation; 2.3 Reactions Involving Heterocyclic Bases and the Carbohydrate Moiety 2.4 Stability of N-Glycosidic Bonds2.4.1 Effect of the Heterocyclic Base Species; 2.4.2 Effect of Substituents in the Carbohydrate Moiety; 2.4.3 Mechanism of Hydrolysis of N-Glycosidic Bonds; 2.5 Properties of Pseudouridine; References; 3 Structure of Nucleotides; 3.1 Introduction; 3.2 Nomenclature and Isomerism; 3.3 Structure of Nucleotides; 3.3.1 Nucleoside 5'-Phosphates; 3.3.2 Nucleoside 3'- and 2'-Phosphates; 3.3.3 Nucleoside Cyclic Phosphates; 3.3.4 Nucleoside 3'(2').5'-Diphosphates; 3.4 General Comments Regarding the Structure of Monomer Units in Nucleic Acids; References 4 Properties of Nucleotides4.1 Acid-Base Behavior; 4.1.1 Ionization of Bases; 4.1.2 Ionization of Hydroxyl Groups in Pentose; 4.1.3 Ionization of the Phosphate Group; 4.2 Formation of Derivatives with Metals; 4.3 Reactions at Heterocyclic Bases and Pentose; 4.4 Some Properties of the Phosphate Group (General Concepts); 4.4.1 Structure of the Phosphate Group and the Mechanism of Nucleophilic Substitution at the Phosphorus Atom; 4.4.2 Catalysis of Nucleophilic Substitution at the Phosphorus Atom; 4.4.3 Hydrolysis of Alkyl Phosphates; 4.4.4 Cyclic Phosphates; 4.4.5 B-Elimination Reactions 4.5 Reactions of Nucleotides Involving the Phosphate Group4.5.1 Chemical and Enzymatic Dephosphorylation; 4.5.2 Migration of the Phosphate Group; 4.5.3 Alkylation of the Phosphate Group; 4.5.4 Activation of the Phosphate Group in Nucleotides . Synthesis of Some Derivatives with Respect to the Phosphate Group; 4.5.5 Acylation of the Phosphate Group; 4.6 Properties of Nucleotide Derivatives with Substituents in the Phosphate Group; 4.6.1 Nucleoside Cyclic Phosphates; 4.6.2 Alkyl Esters of Nucleotides; 4.6.3 Mixed Anhydrides of Nucleotides; 4.6.4 Amides of Nucleotides 4.7 Hydrolysis of N-Glycosidic Bonds |
Record Nr. | UNISA-996197616303316 |
Shabarova Z (Zoe)
![]() |
||
Weinheim, Germany ; ; New York, New York : , : VCH, , [1994] | ||
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Lo trovi qui: Univ. di Salerno | ||
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Advanced organic chemistry of nucleic acids / / Z. Shabarova, A. Bogdanov, translated by Vladimir Vopyan |
Autore | Shabarova Z (Zoe) |
Pubbl/distr/stampa | Weinheim, Germany ; ; New York, New York : , : VCH, , [1994] |
Descrizione fisica | 1 online resource (606 p.) |
Disciplina | 574.87328 |
Soggetto topico | Nucleic acids |
ISBN |
1-281-75881-7
9786611758813 3-527-61593-8 3-527-61592-X |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Advanced Organic Chemistry of Nucleic Acids; Contents; 1 Structure of Nucleosides; 1.1 Introduction; 1.2 Pyrimidine and Purine Bases; 1.2.1 Pyrimidines; 1.2.2 Purines; 1.2.3 Nomenclature of Pyrimidines and Purines; 1.2.4 Abbreviations; 1.3 Carbohydrate Moieties of Nucleosides; 1.4 Bonding Between Carbohydrate Moiety and Heterocyclic Base; 1.4.1 Purine Nucleosides; 1.4.2 Pyrimidine Nucleosides; 1.5 Size of the Oxide Ring in the Sugar; 1.6 Configuration of the Glycoside (Anomeric) Center; 1.7 Nomenclature and Abridged Formulas of Nucleosides; 1.8 Minor Nucleosides; 1.9 Pseudouridine
1.10 Nucleoside Antibiotics1.10.1 Purine Nucleosides; 1.10.2 Pyrimidine Nucleosides; 1.11 Other Nucleosides; References; 2 Properties of Nucleosides; 2.1 Heterocyclic Bases; 2.1.1 General Concepts; 2.1.2 Tautomerism; 2.1.3 Reactions with Electrophilic Reagents; 2.1.4 Reactions with Nucleophilic Reagents; 2.1.5 Addition Reactions; 2.1.6 Reactions Involving Exocyclic Amino Groups; 2.2 Reactions at the Carbohydrate Moiety; 2.2.1 Substitution for Hydrogen Atoms in Hydroxyl Groups; 2.2.2 Oxidation; 2.3 Reactions Involving Heterocyclic Bases and the Carbohydrate Moiety 2.4 Stability of N-Glycosidic Bonds2.4.1 Effect of the Heterocyclic Base Species; 2.4.2 Effect of Substituents in the Carbohydrate Moiety; 2.4.3 Mechanism of Hydrolysis of N-Glycosidic Bonds; 2.5 Properties of Pseudouridine; References; 3 Structure of Nucleotides; 3.1 Introduction; 3.2 Nomenclature and Isomerism; 3.3 Structure of Nucleotides; 3.3.1 Nucleoside 5'-Phosphates; 3.3.2 Nucleoside 3'- and 2'-Phosphates; 3.3.3 Nucleoside Cyclic Phosphates; 3.3.4 Nucleoside 3'(2').5'-Diphosphates; 3.4 General Comments Regarding the Structure of Monomer Units in Nucleic Acids; References 4 Properties of Nucleotides4.1 Acid-Base Behavior; 4.1.1 Ionization of Bases; 4.1.2 Ionization of Hydroxyl Groups in Pentose; 4.1.3 Ionization of the Phosphate Group; 4.2 Formation of Derivatives with Metals; 4.3 Reactions at Heterocyclic Bases and Pentose; 4.4 Some Properties of the Phosphate Group (General Concepts); 4.4.1 Structure of the Phosphate Group and the Mechanism of Nucleophilic Substitution at the Phosphorus Atom; 4.4.2 Catalysis of Nucleophilic Substitution at the Phosphorus Atom; 4.4.3 Hydrolysis of Alkyl Phosphates; 4.4.4 Cyclic Phosphates; 4.4.5 B-Elimination Reactions 4.5 Reactions of Nucleotides Involving the Phosphate Group4.5.1 Chemical and Enzymatic Dephosphorylation; 4.5.2 Migration of the Phosphate Group; 4.5.3 Alkylation of the Phosphate Group; 4.5.4 Activation of the Phosphate Group in Nucleotides . Synthesis of Some Derivatives with Respect to the Phosphate Group; 4.5.5 Acylation of the Phosphate Group; 4.6 Properties of Nucleotide Derivatives with Substituents in the Phosphate Group; 4.6.1 Nucleoside Cyclic Phosphates; 4.6.2 Alkyl Esters of Nucleotides; 4.6.3 Mixed Anhydrides of Nucleotides; 4.6.4 Amides of Nucleotides 4.7 Hydrolysis of N-Glycosidic Bonds |
Record Nr. | UNINA-9910830338503321 |
Shabarova Z (Zoe)
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||
Weinheim, Germany ; ; New York, New York : , : VCH, , [1994] | ||
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Lo trovi qui: Univ. Federico II | ||
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Advances and challenges in the delivery of nucleic acid therapeutics . Volume 1 / / editors, Olivia Merkel, Mansoor Amiji |
Pubbl/distr/stampa | London, England : , : Future Science Ltd, , 2015 |
Descrizione fisica | 1 online resource (136 pages) : illustrations (some color) |
Disciplina | 572.8 |
Soggetto topico |
Antisense nucleic acids
Nucleic acids |
Soggetto genere / forma | Electronic books. |
ISBN |
1-910419-93-1
1-910419-92-3 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910464376103321 |
London, England : , : Future Science Ltd, , 2015 | ||
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Lo trovi qui: Univ. Federico II | ||
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Advances and challenges in the delivery of nucleic acid therapeutics . Volume 2. / / editors, Olivia Merkel, Mansoor Amiji |
Pubbl/distr/stampa | London, England : , : Future Science Ltd, , 2015 |
Descrizione fisica | 1 online resource (129 pages) : illustrations (some color) |
Disciplina | 572.8 |
Soggetto topico |
Antisense nucleic acids
Nucleic acids |
Soggetto genere / forma | Electronic books. |
ISBN |
1-910419-96-6
1-910419-95-8 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910464375403321 |
London, England : , : Future Science Ltd, , 2015 | ||
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Lo trovi qui: Univ. Federico II | ||
|
Advances and challenges in the delivery of nucleic acid therapeutics . Volume 2. / / editors, Olivia Merkel, Mansoor Amiji |
Pubbl/distr/stampa | London, England : , : Future Science Ltd, , 2015 |
Descrizione fisica | 1 online resource (129 pages) : illustrations (some color) |
Disciplina | 572.8 |
Soggetto topico |
Antisense nucleic acids
Nucleic acids |
ISBN |
1-910419-96-6
1-910419-95-8 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910789501003321 |
London, England : , : Future Science Ltd, , 2015 | ||
![]() | ||
Lo trovi qui: Univ. Federico II | ||
|
Advances and challenges in the delivery of nucleic acid therapeutics . Volume 1 / / editors, Olivia Merkel, Mansoor Amiji |
Pubbl/distr/stampa | London, England : , : Future Science Ltd, , 2015 |
Descrizione fisica | 1 online resource (136 pages) : illustrations (some color) |
Disciplina | 572.8 |
Soggetto topico |
Antisense nucleic acids
Nucleic acids |
ISBN |
1-910419-93-1
1-910419-92-3 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910789499403321 |
London, England : , : Future Science Ltd, , 2015 | ||
![]() | ||
Lo trovi qui: Univ. Federico II | ||
|
Advances and challenges in the delivery of nucleic acid therapeutics . Volume 1 / / editors, Olivia Merkel, Mansoor Amiji |
Pubbl/distr/stampa | London, England : , : Future Science Ltd, , 2015 |
Descrizione fisica | 1 online resource (136 pages) : illustrations (some color) |
Disciplina | 572.8 |
Soggetto topico |
Antisense nucleic acids
Nucleic acids |
ISBN |
1-910419-93-1
1-910419-92-3 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910827771803321 |
London, England : , : Future Science Ltd, , 2015 | ||
![]() | ||
Lo trovi qui: Univ. Federico II | ||
|
Advances and challenges in the delivery of nucleic acid therapeutics . Volume 2. / / editors, Olivia Merkel, Mansoor Amiji |
Pubbl/distr/stampa | London, England : , : Future Science Ltd, , 2015 |
Descrizione fisica | 1 online resource (129 pages) : illustrations (some color) |
Disciplina | 572.8 |
Soggetto topico |
Antisense nucleic acids
Nucleic acids |
ISBN |
1-910419-96-6
1-910419-95-8 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910827671003321 |
London, England : , : Future Science Ltd, , 2015 | ||
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Lo trovi qui: Univ. Federico II | ||
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Antisense RNA Design, Delivery, and Analysis / / edited by Virginia Arechavala-Gomeza, Alejandro Garanto |
Autore | Arechavala-Gomeza Virginia |
Edizione | [1st ed. 2022.] |
Pubbl/distr/stampa | New York, : Springer Nature, 2022 |
Descrizione fisica | 1 online resource (XVII, 422 p. 69 illus., 59 illus. in color.) |
Disciplina | 615.5 |
Collana | Methods in Molecular Biology |
Soggetto topico |
Therapeutics
Biomaterials Nucleic acids Nucleic Acid Àcids nucleics RNA Teràpia genètica |
Soggetto genere / forma | Llibres electrònics |
ISBN | 1-0716-2010-X |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Introduction and History of the Chemistry of Nucleic Acids Therapeutics -- Antisense RNA Therapeutics: A Brief Overview -- Design of Bifunctional Antisense Oligonucleotides for Exon Inclusion -- Design and Delivery of SINEUP: A New Modular Tool to Increase Protein Translation -- How to Design U1 snRNA Molecules for Splicing Rescue -- Conjugation of Nucleic Acids and Drugs to Gold Nanoparticles -- Determination of Optimum Ratio of Cationic Polymers and Small Interfering RNA with Agarose Gel Retardation Assay -- Generation of Protein-Phosphorodiamidate Morpholino Oligomer Conjugates for Efficient Cellular Delivery via Anthrax Protective Antigen -- Development and Use of Cellular Systems to Assess and Correct Splicing Defects -- Modeling Splicing Variants Amenable to Antisense Therapy by Use of CRISPR-Cas9-Based Gene Editing in HepG2 Cells -- In Vitro Models for the Evaluation of Antisense Oligonucleotides in Skin -- In Vitro Delivery of PMOs in Myoblasts by Electroporation -- Rapid Determination of MBNL1 Protein Levels by Quantitative Dot Blot for Evaluation of Antisense Oligonucleotides in Myotonic Dystrophy Myoblasts -- Evaluation of Exon Skipping and Dystrophin Restoration in In Vitro Models of Duchenne Muscular Dystrophy -- Generation of Human iPSC-Derived Myotubes to Investigate RNA-Based Therapies In Vitro -- Eye on a Dish Models to Evaluate Splicing Modulation -- Establishment of In Vitro Brain Models for AON Delivery -- Considerations for Generating Humanized Mouse Models to Test Efficacy of Antisense Oligonucleotides -- Generation of Humanized Zebrafish Models for the In Vivo Assessment of Antisense Oligonucleotide-Based Splice Modulation Therapies -- Use of Small Animal Models for Duchenne and Parameters to Assess Efficiency upon Antisense Treatment -- In Vivo Models for the Evaluation of Antisense Oligonucleotides in Skin -- Delivery of Antisense Oligonucleotides to the Mouse Retina -- Delivery of Antisense Oligonucleotides to the Mouse Brain by Intracerebroventricular Injections -- Intrathecal Delivery of Therapeutic Oligonucleotides for Potent Modulation of Gene Expression in the Central Nervous System -- Preclinical Safety Assessment of Therapeutic Oligonucleotides -- Preclinical Evaluation of the Renal Toxicity of Oligonucleotide Therapeutics in Mice -- Protocol for Isolation and Culture of Mouse Hepatocytes (HCs), Kupffer Cells (KCs), and Liver Sinusoidal Endothelial Cells (LSECs) in Analyses of Hepatic Drug Distribution -- Patent Considerations When Embarking on New Antisense Drug Programs. |
Record Nr. | UNINA-9910552988503321 |
Arechavala-Gomeza Virginia
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New York, : Springer Nature, 2022 | ||
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Lo trovi qui: Univ. Federico II | ||
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