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Antisense RNA Design, Delivery, and Analysis / / edited by Virginia Arechavala-Gomeza, Alejandro Garanto
Antisense RNA Design, Delivery, and Analysis / / edited by Virginia Arechavala-Gomeza, Alejandro Garanto
Autore Arechavala-Gomeza Virginia
Edizione [1st ed. 2022.]
Pubbl/distr/stampa New York, : Springer Nature, 2022
Descrizione fisica 1 online resource (XVII, 422 p. 69 illus., 59 illus. in color.)
Disciplina 615.5
Collana Methods in Molecular Biology
Soggetto topico Therapeutics
Biomaterials
Nucleic acids
Nucleic Acid
Àcids nucleics
RNA
Teràpia genètica
Soggetto genere / forma Llibres electrònics
ISBN 9781071620106
107162010X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction and History of the Chemistry of Nucleic Acids Therapeutics -- Antisense RNA Therapeutics: A Brief Overview -- Design of Bifunctional Antisense Oligonucleotides for Exon Inclusion -- Design and Delivery of SINEUP: A New Modular Tool to Increase Protein Translation -- How to Design U1 snRNA Molecules for Splicing Rescue -- Conjugation of Nucleic Acids and Drugs to Gold Nanoparticles -- Determination of Optimum Ratio of Cationic Polymers and Small Interfering RNA with Agarose Gel Retardation Assay -- Generation of Protein-Phosphorodiamidate Morpholino Oligomer Conjugates for Efficient Cellular Delivery via Anthrax Protective Antigen -- Development and Use of Cellular Systems to Assess and Correct Splicing Defects -- Modeling Splicing Variants Amenable to Antisense Therapy by Use of CRISPR-Cas9-Based Gene Editing in HepG2 Cells -- In Vitro Models for the Evaluation of Antisense Oligonucleotides in Skin -- In Vitro Delivery of PMOs in Myoblasts by Electroporation -- Rapid Determination of MBNL1 Protein Levels by Quantitative Dot Blot for Evaluation of Antisense Oligonucleotides in Myotonic Dystrophy Myoblasts -- Evaluation of Exon Skipping and Dystrophin Restoration in In Vitro Models of Duchenne Muscular Dystrophy -- Generation of Human iPSC-Derived Myotubes to Investigate RNA-Based Therapies In Vitro -- Eye on a Dish Models to Evaluate Splicing Modulation -- Establishment of In Vitro Brain Models for AON Delivery -- Considerations for Generating Humanized Mouse Models to Test Efficacy of Antisense Oligonucleotides -- Generation of Humanized Zebrafish Models for the In Vivo Assessment of Antisense Oligonucleotide-Based Splice Modulation Therapies -- Use of Small Animal Models for Duchenne and Parameters to Assess Efficiency upon Antisense Treatment -- In Vivo Models for the Evaluation of Antisense Oligonucleotides in Skin -- Delivery of Antisense Oligonucleotides to the Mouse Retina -- Delivery of Antisense Oligonucleotides to the Mouse Brain by Intracerebroventricular Injections -- Intrathecal Delivery of Therapeutic Oligonucleotides for Potent Modulation of Gene Expression in the Central Nervous System -- Preclinical Safety Assessment of Therapeutic Oligonucleotides -- Preclinical Evaluation of the Renal Toxicity of Oligonucleotide Therapeutics in Mice -- Protocol for Isolation and Culture of Mouse Hepatocytes (HCs), Kupffer Cells (KCs), and Liver Sinusoidal Endothelial Cells (LSECs) in Analyses of Hepatic Drug Distribution -- Patent Considerations When Embarking on New Antisense Drug Programs.
Record Nr. UNINA-9910552988503321
Arechavala-Gomeza Virginia  
New York, : Springer Nature, 2022
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Chemical Biology of Nucleic Acids : Fundamentals and Clinical Applications / / edited by Volker A. Erdmann, Wojciech T. Markiewicz, Jan Barciszewski
Chemical Biology of Nucleic Acids : Fundamentals and Clinical Applications / / edited by Volker A. Erdmann, Wojciech T. Markiewicz, Jan Barciszewski
Edizione [1st ed. 2014.]
Pubbl/distr/stampa Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014
Descrizione fisica 1 online resource (599 p.)
Disciplina 572.8
Collana RNA Technologies
Soggetto topico Biomaterials
Nucleic acids
Medicine - Research
Biology - Research
Medical genetics
Nucleic Acid
Biomedical Research
Medical Genetics
ISBN 3-642-54452-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto RNA as Major Components in Chemical Evolvable Systems -- How the Early Genetic Code Was Established? - Inference from the Analysis of Extant Animal Mitochondrial Decoding Systems -- Isomerization of RNA Phosphodiester Linkages -- Effects of Ionic Liquid and Liposomes on the Structure, Stability and Function of Nucleic Acids -- Oxidative Damage on RNA Nucleobases -- Use of FRET to Study Dynamics of DNA Replication -- Design, Characterization and Application of Imidazopyridopyrimidine:Naphthyridine Base-Pairing Motifs Consisting of Four Hydrogen Bonds -- Creation of Unnatural Base Pair Systems Toward New DNA/RNA Biotechnologies -- Flexible Nucleobase Analogues. Novel Tools for Exploring the Nucleic Acids -- Sequence Selective Recognition of Double-Stranded RNA -- Determining Transient Nucleic Acid Structures by NMR -- Diastereomer-Specific Repertoire of 7′R- or 7′S-Me-Carba-Locked Nucleic Acids (cLNAs) in Antisense Oligo/RNA Duplexes and Engineering of Physicochemical and Enzymological Properties -- Challenges and Opportunities for Oligonucleotide-Based Therapeutics by Antisense and RNA Interference Mechanisms -- Progress in Chemically Modified Nucleic Acid Aptamers -- Aptamers as Molecular Smugglers -- Biochemical Aspects of Subcellular RNA Transport and Localization -- Small Size, Big Impact: Bacterial Functional Nucleic Acids and Their Applications -- Towards Defined DNA and RNA Delivery Vehicles Using Nucleic Acid Nanotechnology -- Targeted Editing of Therapeutic Genes Using DNA-Based Transcriptional Activators: Scope and Challenges -- Interaction of DNA Intramolecular Structures with Their Complementary Strands: A Thermodynamic Approach for the Control of Gene Expression -- Site Directed Spin Labelling of RNA for Distance Measurements by EPR -- Chemo-Enzymatic Strategies to Modify RNA in vitro or in Living Cells -- Metal Dependence of Ligand Binding and Heavy-Atom Derivatization of Evolutionarily Distinct PreQ1 Riboswitches -- DNA G-Quadruplexes and I-Motifs in Therapeutics and Diagnostics -- Peptides Targeting G-Quadruplex Structures -- Synthesis of Site-Specifically Modified Long-Mer RNAs -- Synthesis and Exon-Skipping Activity of Chemically-Modified RNAs -- mRNA and snRNA Cap Analogs: Synthesis and Applications -- Innovative Chemistry for Synthesis of Regular RNA, 5’-Triphosphate RNA or 5’-Capped RNA.
Record Nr. UNINA-9910298309903321
Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014
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Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance / / edited by Peter Igaz
Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance / / edited by Peter Igaz
Edizione [1st ed. 2015.]
Pubbl/distr/stampa Basel : , : Springer Basel : , : Imprint : Springer, , 2015
Descrizione fisica 1 online resource (292 p.)
Disciplina 572.88
Collana Experientia Supplementum
Soggetto topico Molecular genetics
Biomaterials
Nucleic acids
Clinical biochemistry
Molecular Genetics
Nucleic Acid
Medical Biochemistry
ISBN 3-0348-0955-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Part I: General features and technical issues related to circulating microRNA -- 1. Introduction to microRNAs: biogenesis, action, relevance of tissue microRNAs in disease pathogenesis, diagnosis and therapy. The concept of circulating microRNAs -- 2. Extracellular microRNAs in membrane vesicles and non-vesicular carriers -- 3. Technical aspects related to the analysis of circulating microRNAs -- Part II: Diagnostic relevance of circulating microRNAs -- 4. Circulating blood-borne microRNAs as biomarkers in solid tumors -- 5. Circulating microRNA as biomarkers in hematological malignancies -- 6 Circulating microRNAs as biomarkers in cardiovascular diseases -- 7 Circulating microRNAs in neurodegenerative diseases -- 8 Circulating extracellular microRNA in systemic autoimmunity -- 9. Circulating microRNAs in inflammatory bowel diseases -- 10. Circulating microRNAs in diabetes progression: discovery, validation and research translation -- 11. Diagnostic relevance of microRNAs in other body fluids including urine, feces and saliva -- Part III: Potential biological relevance of circulating microRNA -- 12 Circulating microRNAs as hormones – intercellular and inter-organ conveyors of epigenetic information? -- 13. Are circulating microRNAs involved in tumor surveillance? -- 14.-Hypothetic interindividual and interspecies relevance of microRNAs released in body fluids.
Record Nr. UNINA-9910298268103321
Basel : , : Springer Basel : , : Imprint : Springer, , 2015
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Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring : An Introduction / / edited by Peter B. Gahan
Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring : An Introduction / / edited by Peter B. Gahan
Edizione [1st ed. 2015.]
Pubbl/distr/stampa Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2015
Descrizione fisica 1 online resource (476 p.)
Disciplina 612.0157
Collana Advances in Predictive, Preventive and Personalised Medicine
Soggetto topico Medicine - Research
Biology - Research
Medicine, Preventive
Health promotion
Cancer
Biomaterials
Nucleic acids
Pharmaceutical chemistry
Biomedical Research
Health Promotion and Disease Prevention
Cancer Biology
Nucleic Acid
Medicinal Chemistry
ISBN 94-017-9168-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Part I. BACKGROUND -- CHAPTER 1 Introduction - Brief History and the present and future status of CNAPS -- CHAPTER 2 The biology of CNAPS -- Part II. METHODOLOGY -- CHAPTER 3 Pre-analytical requirements for analysing nucleic acids from blood -- CHAPTER 4. Circulating DNA and miRNA isolation -- CHAPTER 5 Detection of genetic alterations by nucleic acid analysis: use of pcr and mass spectroscopy-based methods -- CHAPTER 6 Genomic approaches to the analysis of cell free nucleic acids -- Part III APPLICATIONS -- CHAPTER 7 CNAPS and General Medicine -- CHAPTER 8 Fetal CNAPS – DNA/RNA -- CHAPTER 9 Circulating nucleic acids and Diabetes mellitus -- CHAPTER 10 Extracellular nucleic acids and cancer -- CHAPTER 11 Other bodily fluids as non-invasive sources of Cell-free DNA/RNA -- CHAPTER 12 CNAPS in therapy monitoring -- Part IV OTHER ASPECTCS -- CHAPTER 13 Quality Assurance -- CHAPTER 14 Societal Aspects: Ethics.
Record Nr. UNINA-9910300235703321
Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2015
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Competitive Strategies in Life Sciences / / by Basanta Kumara Behera, Ram Prasad, Shyambhavee Behera
Competitive Strategies in Life Sciences / / by Basanta Kumara Behera, Ram Prasad, Shyambhavee Behera
Autore Behera Basanta Kumara
Edizione [1st ed. 2020.]
Pubbl/distr/stampa Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2020
Descrizione fisica 1 online resource (XV, 189 p. 84 illus., 56 illus. in color.)
Disciplina 574.19283
Collana New Paradigms of Living Systems
Soggetto topico Biomaterials
Nucleic acids
Bioinformatics
Biology - Technique
Nucleic Acid
Computational and Systems Biology
Biological Techniques
ISBN 9789811575907
9811575908
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Chapter 1. Strategies in Life sciences -- Chapter 2. Management and Manufacturing process of biologics -- Chapter 3. Downstream processes -- Chapter 4. Bioprinting -- Chapter 5. Biopharmaceuticals: New Frontier.
Record Nr. UNINA-9910863298503321
Behera Basanta Kumara  
Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2020
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Crime Scene Management within Forensic science / / edited by Jaskaran Singh, Neeta Raj Sharma
Crime Scene Management within Forensic science / / edited by Jaskaran Singh, Neeta Raj Sharma
Edizione [1st ed. 2021.]
Pubbl/distr/stampa Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2021
Descrizione fisica 1 online resource (239 pages)
Disciplina 363.252
Collana Biomedical and Life Sciences Series
Soggetto topico Medicine - Research
Biology - Research
Medical jurisprudence
Biomaterials
Nucleic acids
Biomedical Research
Forensic Medicine
Nucleic Acid
ISBN 981-16-4091-2
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto 1 Initial response at crime scenes and prioritization of efforts -- 2 Crime scene processing: documentation and evaluation -- 3 Crime Scene Searching: An Exploration of Forensic Evidence -- 4 Collection, Preservation and Packaging: Forensic Evidence Management -- 5 Paint, Soil and Glass Evidences: A Silent Witnesses -- 6 Questioned Document Examination: A Prevalent Dispute -- 7 Medicolegal Examination: A Guide to the Criminal Investigation System -- 8 Examination of Tampered Voice. .
Record Nr. UNINA-9910520075403321
Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2021
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DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases / / edited by Volker A. Erdmann, Jan Barciszewski
DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases / / edited by Volker A. Erdmann, Jan Barciszewski
Edizione [1st ed. 2013.]
Pubbl/distr/stampa Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2013
Descrizione fisica 1 online resource (464 p.)
Disciplina 575.2/1
612.015
Altri autori (Persone) ErdmannV. A <1941-> (Volker A.)
BarciszewskiJan
Collana RNA Technologies
Soggetto topico Medicine - Research
Biology - Research
Biomaterials
Nucleic acids
Medical genetics
Biomedical Research
Nucleic Acid
Medical Genetics
ISBN 3-642-36853-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction -- RNA Nanotechnology: methods for synthesis, conjugation, assembly and application of RNA nanoparticles -- Adsorption of double-stranded DNA to graphene oxide preventing enzymatic digestion -- Electrogenerated chemiluminescence of conjugated polymer films from patterned electrodes -- Use of RNA structure flexibility data in nanostructure modeling -- Informatic resources for identifying and annotating structural RNA motifs -- A nanostructure made of a bacterial noncoding RNA -- HAPIscreen, a method for high-throughput aptamer identification -- Characterization of photophysical and base-mimicking properties of a novel fluorescent adenine analogue in DNA -- Bifacial nucleoside as a surrogate for both T and A in duplex DNA -- Functionally important structural elements of U12 snRNA -- Self-assembling RNA nanorings based on RNAI/II inverse kissing complexes -- Automatic molecular weaving prototyped by using single-stranded DNA -- Nucleic Acid Aptamers: Clinical Applications and Promising New Horizons -- Nanotextured Substrates With Immobilized Aptamers for Cancer Cell Isolation and Cytology -- Targeting cancer with peptide aptamers -- Synthetic, biofunctional nucleic acid-based molecular devices -- Inducible site-selective bottom-up assembly of virus-derived nanotube arrays on RNA-equipped wafers -- Special delivery: targeted therapy with small RNAs, RNAi nanomedicines: challenges and opportunities within the immune system -- Pyrene-functionalized oligonucleotides and locked nucleic acids (LNAs): Tools for fundamental research, diagnostics, and nanotechnology -- Stabilizing RNA by the sonochemical formation of RNA nanospheres. Sonochemical synthesis of DNA nanospheres -- Nucleic acid based molecular devices -- Nanoparticle therapeutics: FDA approval, clinical trials, regulatory pathways, and case study -- A sol-gel-based microfluidics system enhances the efficiency of RNA aptamer selection -- Hierarchical nanotextured microelectrodes overcome the molecular transport barrier to achieve rapid, direct bacterial detection -- Recent developments in lipid-based pharmaceutical nanocarriers -- Targeted delivery of RNAi therapeutics for cancer therapy -- DNAsomes: Multifunctional DNA-based nanocarriers -- Reversible and Controllable Nanolocomotion of an RNA-Processing Machinery -- Scavenger receptors mediate cellular uptake of polyvalent oligonucleotide-functionalized gold nanoparticles -- A highly sensitive microRNA biosensor based on ruthenium oxide nanoparticle-initiated polymerization of aniline -- Preparation and high-resolution microscopy of gold cluster labeled nucleic acid conjugates and nanodevices -- Kinetically grafting G-quadruplexes onto DNA nanostructures for structure and function encoding via a DNA machine -- Synthesis of glycerol nucleic acid (GNA) phosphoramidite monomers and oligonucleotide polymers -- Cancer immunotherapy and nanomedicine -- RNA nanotechnology: inspired by DNA -- From nanotechnology to nanomedicine: applications to cancer research -- Comparative structural and functional studies of nanoparticle formulations for DNA and siRNA delivery -- Advances in novel drug delivery strategies for breast cancer therapy -- DNA origami: a history and current perspective -- Nanoparticles: a promising modality in the treatment of sarcomas -- Gold nanorod delivery of an ssRNA immune activator inhibits pandemic H1N1 influenza viral replication -- Recent developments in oligonucleotide conjugation -- In vivo delivery of small interfering RNA to tumors and their vasculature by novel dendritic nanocarriers -- DNA and carbon nanotubes as medicine -- LHRH-targeted nanoparticles for cancer therapeutics -- Nanoparticle-aptamer conjugates for cancer cell targeting and detection -- Evaluation of targets for ovarian cancer gene silencing therapy: in vitro and in vivo approaches -- Prediction and design of DNA and RNA structures -- siRNA applications in nanomedicine.
Record Nr. UNINA-9910437613503321
Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2013
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DNA Nanotechnology : From Structure to Functionality / / edited by Chunhai Fan, Yonggang Ke
DNA Nanotechnology : From Structure to Functionality / / edited by Chunhai Fan, Yonggang Ke
Edizione [1st ed. 2020.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020
Descrizione fisica 1 online resource (IX, 406 p.)
Disciplina 572.86
Collana Topics in Current Chemistry Collections
Soggetto topico Nanotechnology
Biotechnology
Biomaterials
Nucleic acids
Nanoscience
Nucleic Acid
Nanophysics
ISBN 3-030-54806-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Towards Active Self-assembly through DNA Nanotechnology -- Tailoring DNA self-assembly to build hydrogels -- DNA-Programmed Chemical Synthesis of Polymers and Inorganic Nanomaterials -- Engineering Functional DNA-Protein Conjugates for Biosensing, Biomedical, and Nanoassembly Applications -- DNA-Scaffolded Proximity Assembly and Confinement of Multienzyme Reactions -- Directional assembly of nanoparticles by DNA shapes: towards designed architectures and functionality -- Oligonucleotide-Polymer Conjugates: From Molecular Basic to Practical Application -- Biotechnological and Therapeutic Applications of Natural Nucleic Acid Structural Motifs -- DNA driven Nanoparticle Assemblies for Biosensing and Bioimaging -- Aptamer-functionalized DNA Nanostructures for Biological Applications -- High-performance biosensing based on autonomous enzyme-free DNA circuits -- DNA strand displacement reaction: a powerful tool for discriminating single nucleotide variants.
Record Nr. UNINA-9910420950803321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020
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Epigenetic Mechanisms of Cell Programming and Reprogramming / / edited by Gang Pei
Epigenetic Mechanisms of Cell Programming and Reprogramming / / edited by Gang Pei
Edizione [1st ed. 2023.]
Pubbl/distr/stampa Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023
Descrizione fisica 1 online resource (68 pages)
Disciplina 572
Altri autori (Persone) PeiGang
Collana Reports of China’s Basic Research
Soggetto topico Biochemistry
Cytology
Medical genetics
Biomaterials
Nucleic acids
Cell Biology
Medical Genetics
Nucleic Acid
ISBN 9789811974199
9811974195
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto 1. Project Overview -- 2. Domestic and Foreign Research -- 3. Major Research Achievements -- 4.Outlook.
Record Nr. UNINA-9910736984503321
Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023
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Functional Nucleic Acids Detection in Food Safety : Theories and Applications / / by Wentao Xu
Functional Nucleic Acids Detection in Food Safety : Theories and Applications / / by Wentao Xu
Autore Xu Wentao
Edizione [1st ed. 2016.]
Pubbl/distr/stampa Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2016
Descrizione fisica 1 online resource (484 p.)
Disciplina 570
Soggetto topico Biomaterials
Nucleic acids
Food science
Public health
Nucleic Acid
Food Science
Public Health
ISBN 981-10-1618-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto 1 Introduction: a brief guide to targets and strategies of functional nucleic acids detection in food safety -- 2 Adaptable methods to extract nucleic acid targets and evaluate quality -- 3 Basic rules in nucleic acids-mediated amplification and hybridization methods in food safety detection: a review -- 4 Reference materials: a golden criterion in nucleic acids identification -- 5 Reference gene: in-species universality versus between-species uniquity -- 6 PCR-based technologies for identifying unknown gene sequences -- 7 A developed accurate digital PCR detection technology in food safety -- 8 Development of accurate nucleic acids detection technology for target quantification -- 9 Recent progress in high-throughput detection technology for food safety -- 10 Detecting targets without thermal cycling in food: isothermal amplification and hybridization -- 11 Aptamers and their application -- 12 Lateral Flow Nucleic Acid Biosensors -- 13 Nucleic Acid Biosensors for food safety -- 14 Alternative PCR methods for detecting GM crops & food in agriculture and the food chain: a review -- 15 The identification and detection technology of research in microorganism include living or dead bacteria -- 16 Characterization of microbial diversity in food chain: a molecular review -- 17 Identification and assessment of heavy metal pollution using nucleic acid-mediated technologies -- 18 Genotoxicity detection at the molecular level in food safety assessment: conventional methods and developments -- 19 A molecular review of the detection of specific nucleic acids by amplification and hybridization Characterization of microbial diversity in the food chain: a molecular review.
Record Nr. UNINA-9910253899703321
Xu Wentao  
Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2016
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