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LC-NMR and other hyphenated NMR techniques [[electronic resource] ] : overview and applications / / Maria Victoria Silva Elipe
| LC-NMR and other hyphenated NMR techniques [[electronic resource] ] : overview and applications / / Maria Victoria Silva Elipe |
| Autore | Silva Elipe Maria V. <1963-> |
| Pubbl/distr/stampa | Hoboken, NJ : , : Wiley, , c2012 |
| Descrizione fisica | 1 online resource (240 p.) |
| Disciplina | 543/.66 |
| Collana | THEi Wiley ebooks |
| Soggetto topico |
Nuclear magnetic resonance spectroscopy - Industrial applications
Organic compounds - Analysis Drug development |
| ISBN |
1-283-33226-4
9786613332264 1-118-13538-5 1-118-13539-3 1-118-13536-9 |
| Classificazione | SCI078000 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
LC-NMR and Other Hyphenated NMR Techniques: Overview and Applications; Contents; Preface; Abbreviations, Symbols, and Units; 1. Basic Concepts of NMR Spectroscopy; 1.1 Introduction; 1.2 Basic Knowledge Regarding the Physics of NMR Spectroscopy; 1.3 Basic Parameters for NMR Interpretation; 1.3.1 Chemical Shift; 1.3.2 Spin-Spin Coupling Constants; 1.3.3 Spin Systems; 1.3.4 Signal Intensities; 1.3.5 Bond Correlations; 1.3.6 Spatial Correlations; 1.3.7 Other Topics; 1.4 Conclusions; References; 2. Historical Development of NMR and LC-NMR; 2.1 Introduction; 2.2 Historical Development of NMR
2.3 Historical Development of LC-NMR2.4 Historical Development of Other Analytical Techniques Hyphenated with NMR; 2.5 Current Trends; References; 3. Basic Technical Aspects and Operation of LC-NMR and LC-MS-NMR; 3.1 Introduction; 3.2 Technical Considerations Regarding LC-NMR; 3.2.1 Solvent Compatibility; 3.2.2 Solvent Suppression; 3.2.3 NMR Flow Cell; 3.2.4 LC-NMR Sensitivity; 3.3 Technical Considerations Regarding LC-MS-NMR; 3.3.1 Deuterated Solvents; 3.4 Modes of Operation of LC-NMR; 3.4.1 On-Flow Mode; 3.4.2 Stop-Flow Mode; 3.4.3 Time-Sliced Mode; 3.4.4 Loop Collection Mode 3.5 Modes of Operation of LC-MS-NMR3.5.1 On-Flow Mode; 3.5.2 Stop-Flow Mode; 3.6 Other Modes of Operation; 3.7 Challenging Considerations; 3.7.1 Air Bubbles; 3.7.2 Carryover with and Without an Autosampler; 3.7.3 Sample Solubility and Precipitation; 3.7.4 Flow Cell and System Cleaning; 3.7.5 Flow Rate and Magnetic Susceptibility; 3.7.6 Quantitation; 3.8 Conclusions; References; 4. Applications of LC-NMR; 4.1 Introduction; 4.2 Applications of LC-NMR; 4.2.1 Natural Products; 4.2.2 Drug Metabolism; 4.2.3 Drug Discovery; 4.2.4 Impurity Characterization; 4.2.5 Degradation Products 4.2.6 Food Analysis4.2.7 Polymers; 4.2.8 Metabolomics and Metabonomics; 4.2.9 Isomers, Tautomers, and Chiral Compounds; 4.2.10 Others Areas; 4.3 Conclusions and Future Trends; References; 5. Applications of LC-MS-NMR; 5.1 Introduction; 5.2 Applications of LC-MS-NMR; 5.2.1 Natural Products; 5.2.2 Drug Metabolism; 5.2.3 Drug Discovery and Development; 5.2.4 Metabolomics and Metabonomics; 5.2.5 Others Areas; 5.3 Conclusions and Future Trends; References; 6. Hyphenation of NMR with Other Analytical Separation Techniques; 6.1 Introduction; 6.2 GC-NMR; 6.3 GPC-NMR; 6.4 SEC-NMR; 6.5 SFC-NMR 6.6 SFE-NMR6.7 CE-NMR; 6.8 CEC-NMR; 6.9 CZE-NMR; 6.10 cITP-NMR; 6.11 CapLC-NMR; 6.12 SPE-NMR; 6.13 SPE-MS-NMR; 6.14 Conclusions and Future Trends; References; 7. Special Topics and Applications Related to LC-NMR; 7.1 Introduction; 7.2 Off-Line Versus Online NMR for Structural Elucidation; 7.2.1 Cases Solved Off-Line; 7.2.2 Cases Solved Online; 7.3 Analysis of Chiral Molecules by NMR; 7.3.1 Classical Approach: Off-Line; 7.3.2 Nonclassical Approach: Online; 7.4 Monitoring Chemical Reactions In Situ; 7.4.1 Classical Approach: Off-Line; 7.4.2 Nonclassical Approach: Online 7.5 Analysis of Mixtures Off-Line, Online, and by Other NMR Methodologies |
| Record Nr. | UNINA-9910139558903321 |
Silva Elipe Maria V. <1963->
|
||
| Hoboken, NJ : , : Wiley, , c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
LC-NMR and other hyphenated NMR techniques : overview and applications / / Maria Victoria Silva Elipe
| LC-NMR and other hyphenated NMR techniques : overview and applications / / Maria Victoria Silva Elipe |
| Autore | Silva Elipe Maria V. <1963-> |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley, c2012 |
| Descrizione fisica | 1 online resource (240 p.) |
| Disciplina | 543/.66 |
| Collana | THEi Wiley ebooks |
| Soggetto topico |
Nuclear magnetic resonance spectroscopy - Industrial applications
Organic compounds - Analysis Drug development |
| ISBN |
1-283-33226-4
9786613332264 1-118-13538-5 1-118-13539-3 1-118-13536-9 |
| Classificazione | SCI078000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
LC-NMR and Other Hyphenated NMR Techniques: Overview and Applications; Contents; Preface; Abbreviations, Symbols, and Units; 1. Basic Concepts of NMR Spectroscopy; 1.1 Introduction; 1.2 Basic Knowledge Regarding the Physics of NMR Spectroscopy; 1.3 Basic Parameters for NMR Interpretation; 1.3.1 Chemical Shift; 1.3.2 Spin-Spin Coupling Constants; 1.3.3 Spin Systems; 1.3.4 Signal Intensities; 1.3.5 Bond Correlations; 1.3.6 Spatial Correlations; 1.3.7 Other Topics; 1.4 Conclusions; References; 2. Historical Development of NMR and LC-NMR; 2.1 Introduction; 2.2 Historical Development of NMR
2.3 Historical Development of LC-NMR2.4 Historical Development of Other Analytical Techniques Hyphenated with NMR; 2.5 Current Trends; References; 3. Basic Technical Aspects and Operation of LC-NMR and LC-MS-NMR; 3.1 Introduction; 3.2 Technical Considerations Regarding LC-NMR; 3.2.1 Solvent Compatibility; 3.2.2 Solvent Suppression; 3.2.3 NMR Flow Cell; 3.2.4 LC-NMR Sensitivity; 3.3 Technical Considerations Regarding LC-MS-NMR; 3.3.1 Deuterated Solvents; 3.4 Modes of Operation of LC-NMR; 3.4.1 On-Flow Mode; 3.4.2 Stop-Flow Mode; 3.4.3 Time-Sliced Mode; 3.4.4 Loop Collection Mode 3.5 Modes of Operation of LC-MS-NMR3.5.1 On-Flow Mode; 3.5.2 Stop-Flow Mode; 3.6 Other Modes of Operation; 3.7 Challenging Considerations; 3.7.1 Air Bubbles; 3.7.2 Carryover with and Without an Autosampler; 3.7.3 Sample Solubility and Precipitation; 3.7.4 Flow Cell and System Cleaning; 3.7.5 Flow Rate and Magnetic Susceptibility; 3.7.6 Quantitation; 3.8 Conclusions; References; 4. Applications of LC-NMR; 4.1 Introduction; 4.2 Applications of LC-NMR; 4.2.1 Natural Products; 4.2.2 Drug Metabolism; 4.2.3 Drug Discovery; 4.2.4 Impurity Characterization; 4.2.5 Degradation Products 4.2.6 Food Analysis4.2.7 Polymers; 4.2.8 Metabolomics and Metabonomics; 4.2.9 Isomers, Tautomers, and Chiral Compounds; 4.2.10 Others Areas; 4.3 Conclusions and Future Trends; References; 5. Applications of LC-MS-NMR; 5.1 Introduction; 5.2 Applications of LC-MS-NMR; 5.2.1 Natural Products; 5.2.2 Drug Metabolism; 5.2.3 Drug Discovery and Development; 5.2.4 Metabolomics and Metabonomics; 5.2.5 Others Areas; 5.3 Conclusions and Future Trends; References; 6. Hyphenation of NMR with Other Analytical Separation Techniques; 6.1 Introduction; 6.2 GC-NMR; 6.3 GPC-NMR; 6.4 SEC-NMR; 6.5 SFC-NMR 6.6 SFE-NMR6.7 CE-NMR; 6.8 CEC-NMR; 6.9 CZE-NMR; 6.10 cITP-NMR; 6.11 CapLC-NMR; 6.12 SPE-NMR; 6.13 SPE-MS-NMR; 6.14 Conclusions and Future Trends; References; 7. Special Topics and Applications Related to LC-NMR; 7.1 Introduction; 7.2 Off-Line Versus Online NMR for Structural Elucidation; 7.2.1 Cases Solved Off-Line; 7.2.2 Cases Solved Online; 7.3 Analysis of Chiral Molecules by NMR; 7.3.1 Classical Approach: Off-Line; 7.3.2 Nonclassical Approach: Online; 7.4 Monitoring Chemical Reactions In Situ; 7.4.1 Classical Approach: Off-Line; 7.4.2 Nonclassical Approach: Online 7.5 Analysis of Mixtures Off-Line, Online, and by Other NMR Methodologies |
| Record Nr. | UNINA-9910829093403321 |
|
Silva Elipe Maria V. <1963->
|
||
| Hoboken, NJ, : Wiley, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
NMR spectroscopy : basic principles, concepts and applications in chemistry / / Harald Gunther
| NMR spectroscopy : basic principles, concepts and applications in chemistry / / Harald Gunther |
| Autore | Gunther Harald |
| Edizione | [Third completely revised and updated edition.] |
| Pubbl/distr/stampa | Weinheim an der Bergstrasse, Germany : , : Wiley-VCH, , 2013 |
| Descrizione fisica | 1 online resource (736 pages) : illustrations, photographs |
| Disciplina | 543.0877 |
| Soggetto topico |
Nuclear magnetic resonance spectroscopy
Nuclear magnetic resonance spectroscopy - Industrial applications |
| ISBN |
9783527674756
3527674756 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910796096103321 |
|
Gunther Harald
|
||
| Weinheim an der Bergstrasse, Germany : , : Wiley-VCH, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
NMR spectroscopy : basic principles, concepts and applications in chemistry / / Harald Gunther
| NMR spectroscopy : basic principles, concepts and applications in chemistry / / Harald Gunther |
| Autore | Gunther Harald |
| Edizione | [Third completely revised and updated edition.] |
| Pubbl/distr/stampa | Weinheim an der Bergstrasse, Germany : , : Wiley-VCH, , 2013 |
| Descrizione fisica | 1 online resource (736 pages) : illustrations, photographs |
| Disciplina | 543.0877 |
| Soggetto topico |
Nuclear magnetic resonance spectroscopy
Nuclear magnetic resonance spectroscopy - Industrial applications |
| ISBN |
9783527674756
3527674756 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910814651103321 |
|
Gunther Harald
|
||
| Weinheim an der Bergstrasse, Germany : , : Wiley-VCH, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
NMR spectroscopy : basic principles, concepts and applications in chemistry / / Harald Günther
| NMR spectroscopy : basic principles, concepts and applications in chemistry / / Harald Günther |
| Autore | Günther Harald |
| Edizione | [Third completely revised and updated edition.] |
| Pubbl/distr/stampa | Weinheim an der Bergstrasse, Germany : , : Wiley-VCH, , 2013 |
| Descrizione fisica | 1 online resource (736 p.) |
| Disciplina | 543.0877 |
| Soggetto topico |
Nuclear magnetic resonance spectroscopy
Nuclear magnetic resonance spectroscopy - Industrial applications |
| Soggetto genere / forma | Electronic books. |
| ISBN |
3-527-33004-6
3-527-67477-2 3-527-67475-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
NMR Spectroscopy; Title Page; Copyright; Contents; Preface; Chapter 1 Introduction; 1.1 Literature; 1.2 Units and Constants; References; Part I Basic Principles and Applications; Chapter 2 The Physical Basis of the Nuclear Magnetic Resonance Experiment. Part I; 2.1 The Quantum Mechanical Model for the Isolated Proton; 2.2 Classical Description of the NMR Experiment; 2.3 Experimental Verification of Quantized Angular Momentum and of the Resonance Equation; 2.4 The NMR Experiment on Compact Matter and the Principle of the NMR Spectrometer; 2.4.1 How to Measure an NMR Spectrum
2.5 Magnetic Properties of Nuclei beyond the ProtonReferences; Chapter 3 The Proton Magnetic Resonance Spectra of Organic Molecules - Chemical Shift and Spin-Spin Coupling; 3.1 The Chemical Shift; 3.1.1 Chemical Shift Measurements; 3.1.2 Integration of the Spectrum; 3.1.3 Structural Dependence of the Resonance Frequency - A General Survey; 3.2 Spin-Spin Coupling; 3.2.1 Simple Rules for the Interpretation of Multiplet Structures; 3.2.2 Spin-Spin Coupling with Other Nuclei; 3.2.2.1 Nuclei of Spin I=12; 3.2.2.2 Nuclei of Spin I>12; 3.2.3 Limits of the Simple Splitting Rules 3.2.3.1 The Notion of Magnetic Equivalence3.2.3.2 Significance of the Ratio J/ν0δ; 3.2.4 Spin-Spin Decoupling; 3.2.5 Two-Dimensional NMR - the COSY Experiment; 3.2.6 Structural Dependence of Spin-Spin Coupling - A General Survey; References; Chapter 4 General Experimental Aspects of Nuclear Magnetic Resonance Spectroscopy; 4.1 Sample Preparation and Sample Tubes; 4.2 Internal and External Standards; Solvent Effects; 4.3 Tuning the Spectrometer; 4.4 Increasing the Sensitivity; 4.5 Measurement of Spectra at Different Temperatures; References; Textbooks; Review Articles Chapter 5 Proton Chemical Shifts and Spin-Spin Coupling Constants as Functions of Structure5.1 Origin of Proton Chemical Shifts; 5.1.1 Influence of the Electron Density at the Proton; 5.1.2 Influence of the Electron Density at Neighboring Carbon Atoms; 5.1.3 The Influence of Induced Magnetic Moments of Neighboring Atoms and Bonds; 5.1.4 Ring Current Effect in Cyclic Conjugated π-Systems; 5.1.5 Alternative Methods to Measure Diatropicity; 5.1.6 Diamagnetic Anisotropy of the Cyclopropane Ring; 5.1.7 Electric Field Effect of Polar Groups and the van-der-Waals Effect 5.1.8 Chemical Shifts through Hydrogen Bonding5.1.9 Chemical Shifts of Protons in Organometallic Compounds; 5.1.10 Solvent Effects; 5.1.11 Empirical Substituent Constants; 5.1.11.1 Tables of Proton Resonances in Organic Molecules; 5.2 Proton-Proton Spin-Spin Coupling and Chemical Structure; 5.2.1 The Geminal Coupling Constant (2J); 5.2.1.1 Dependence on the Hybridization of the Methylene Carbon; 5.2.1.2 Effect of Substituents; 5.2.1.3 A Molecular Orbital Model for the Interpretation of Substituent Effects on 2J; 5.2.2 The Vicinal Coupling Constant (3J) 5.2.2.1 Dependence on the Dihedral Angle |
| Record Nr. | UNINA-9910453340603321 |
|
Günther Harald
|
||
| Weinheim an der Bergstrasse, Germany : , : Wiley-VCH, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
