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Assessment of exposure-response functions for rocket-emission toxicants [[electronic resource] /] / Subcommittee on Rocket-Emission Toxicants, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
| Assessment of exposure-response functions for rocket-emission toxicants [[electronic resource] /] / Subcommittee on Rocket-Emission Toxicants, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1998 |
| Descrizione fisica | 1 online resource (226 p.) |
| Disciplina | 615.9/02 |
| Soggetto topico |
Rockets (Aeronautics) - Fuel - Toxicology
Toxicology - Dose-response relationship Hydrogen chloride - Toxicology Nitrogen dioxide - Toxicology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-18650-X
9786610186501 0-309-59213-5 0-585-02098-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910455383603321 |
| Washington, D.C., : National Academy Press, 1998 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Assessment of exposure-response functions for rocket-emission toxicants [[electronic resource] /] / Subcommittee on Rocket-Emission Toxicants, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
| Assessment of exposure-response functions for rocket-emission toxicants [[electronic resource] /] / Subcommittee on Rocket-Emission Toxicants, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1998 |
| Descrizione fisica | 1 online resource (226 p.) |
| Disciplina | 615.9/02 |
| Soggetto topico |
Rockets (Aeronautics) - Fuel - Toxicology
Toxicology - Dose-response relationship Hydrogen chloride - Toxicology Nitrogen dioxide - Toxicology |
| ISBN |
0-309-17384-1
1-280-18650-X 9786610186501 0-309-59213-5 0-585-02098-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910778619803321 |
| Washington, D.C., : National Academy Press, 1998 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Assessment of exposure-response functions for rocket-emission toxicants / / Subcommittee on Rocket-Emission Toxicants, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
| Assessment of exposure-response functions for rocket-emission toxicants / / Subcommittee on Rocket-Emission Toxicants, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1998 |
| Descrizione fisica | 1 online resource (226 p.) |
| Disciplina | 615.9/02 |
| Soggetto topico |
Rockets (Aeronautics) - Fuel - Toxicology
Toxicology - Dose-response relationship Hydrogen chloride - Toxicology Nitrogen dioxide - Toxicology |
| ISBN |
0-309-17384-1
1-280-18650-X 9786610186501 0-309-59213-5 0-585-02098-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Assessment of Exposure-Response Functions for Rocket-Emission Toxicants -- Copyright -- OTHER REPORTS OF THE BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY -- OTHER REPORTS OF THE COMMITTEE ON TOXICOLOGY -- PREFACE -- Contents -- ABBREVIATIONS -- SUMMARY -- DESCRIPTION OF THE LATRA MODEL -- THE SUBCOMMITTEE'S CONCLUSIONS AND RECOMMENDATIONS -- TOXICOLOGICAL DATA BASE -- IDENTIFICATION OF SENSITIVE SUBGROUPS -- DEFINITION OF SEVERITY OF EFFECTS -- STRUCTURE OF THE LATRA-ERF MODEL -- 1 INTRODUCTION -- DEVELOPMENT OF LATRA -- ORGANIZATION OF THIS REPORT -- 2 DESCRIPTION OF THE LAUNCH AREA TOXIC RISK ANALYSIS (LATRA) MODEL -- TOXICITY OF ROCKET EMISSIONS -- IDENTIFICATION OF SENSITIVE POPULATIONS -- DEFINITION OF SEVERITY OF EFFECTS -- SELECTION OF THE EXPOSURE-RESPONSE MODEL AND INDEPENDENT VARIABLE -- QUANTIFICATION OF THE EXPOSURE-RESPONSE FUNCTIONS -- REPRESENTATION OF UNCERTAINTIES -- 3 SUBPOPULATIONS SENSITIVE TO AIR CONTAMINATION -- LITERATURE REVIEW FOR SENSITIVE SUBPOPULATIONS -- CHEMICAL-SPECIFIC VARIATION IN HUMAN SENSITIVITY -- HYDROGEN CHLORIDE -- NITROGEN DIOXIDE -- NITRIC ACID -- OZONE -- SULFUR DIOXIDE -- LIMITATIONS OF EXISTING STUDIES -- COMMON RISK-ASSESSMENT PRACTICES FOR SENSITIVE SUBPOPULATIONS -- DEFINING SENSITIVE POPULATIONS -- CONCLUSIONS AND RECOMMENDATIONS -- DEFINING SENSITIVE SUBGROUPS -- QUANTIFYING THE DEGREE OF DIFFERENCE IN SENSITIVITY BETWEEN SENSITIVE AND NORMAL SUBGROUPS -- 4 EFFECT SEVERITY -- PRECEDENT FOR SEVERITY DESCRIPTORS -- SEVERITY OF EFFECT IN TOXICOLOGY -- EPA DEFINITION OF ADVERSE EFFECTS -- AMERICAN THORACIC SOCIETY DEFINITION OF ADVERSE EFFECTS -- LATRA'S USE OF THE TERM ''SEVERITY -- CONCLUSIONS AND RECOMMENDATIONS -- 5 EVALUATION OF THE LATRA EXPOSURE-RESPONSE FUNCTIONS -- THE LATRA-ERF MODEL -- SELECTION OF INDEPENDENT VARIABLES -- CHOICE OF EXPOSURE-RESPONSE MODEL -- SENSITIVE SUBGROUPS.
SEVERITY OF EFFECTS -- EXPOSURE-RESPONSE VALUES -- REPRESENTATION OF UNCERTAINTIES -- OTHER FEATURES OF LATRA -- ALTERNATIVE APPROACHES -- GENERAL CONSIDERATIONS IN DOSE-RESPONSE MODELS -- ORDINAL REGRESSION -- MAXIMUM ENTROPY INFERENCE -- HAZARD-QUOTIENT-HAZARD-INDEX APPROACH -- CONCLUSIONS AND RECOMMENDATIONS -- SELECTION OF THE INDEPENDENT VARIABLE -- CHOICE AND QUANTIFICATION OF EXPOSURE-RESPONSE MODEL -- SENSITIVE SUBGROUPS -- SEVERITY OF EFFECTS -- REPRESENTATION AND PROPAGATION OF UNCERTAINTIES -- OTHER FEATURES OF LATRA -- 6 EXPOSURE-RESPONSE FUNCTIONS FOR ROCKET-EMISSION TOXICANTS -- NITRIC ACID -- HEALTHY ADULTS -- SENSITIVE SUBJECTS -- HYDROGEN CHLORIDE -- MORTALITY -- CORNEAL OPACITY -- DOSE-RESPONSE FOR MILD, MODERATE, AND SERIOUS EFFECTS -- NITROGEN DIOXIDE -- MORTALITY -- AIRWAY RESPONSIVENESS IN HUMANS -- CONTINUOUS (NONQUANTAL) MEASUREMENTS -- CONCLUSIONS AND RECOMMENDATIONS -- REFERENCES -- Appendix A AIR FORCE EXPOSURE LIMITS FOR ROCKET EMISSIONS -- ROCKET EMISSIONS -- DEFINITIONS OF TIER LIMITS -- COMPARISON OF REWG TIER RECOMMENDATIONS AND LATRA ERFS -- REFERENCES -- Appendix B DEFINITIONS OF CURRENT EXPOSURE GUIDANCE LEVELS -- REFERENCES -- Appendix C AMERICAN THORACIC SOCIETY'S LIST OF ADVERSE RESPIRATORY HEALTH EFFECTS -- REFERENCES -- Appendix D ACUTE TOXICITY OF HYDROGEN CHLORIDE -- BACKGROUND INFORMATION -- PHYSICAL AND CHEMICAL PROPERTIES -- SOURCES AND OCCURRENCE -- PHARMACOKINETICS AND METABOLISM -- SUMMARY OF TOXICITY INFORMATION -- EFFECTS IN HUMANS -- One-Time Exposure -- Accidental Exposures -- Repeated Exposures -- Potentially Sensitive Populations -- EFFECTS IN ANIMALS -- One-Time Exposure -- Developmental and Reproductive Toxicities -- One-Time Exposures--Combined Exposures Simulating Sensitive Populations -- Repeated Exposures -- ESTABLISHED INHALATION EXPOSURE LIMITS -- EVALUATION OF TOXICITY INFORMATION. RESEARCH NEEDS -- REFERENCES -- Appendix E ACUTE TOXICITY OF NITROGEN DIOXIDE -- BACKGROUND INFORMATION -- PHYSICAL AND CHEMICAL PROPERTIES -- SOURCES AND OCCURRENCE -- PHARMACOKINETICS AND METABOLISM -- SUMMARY OF TOXICITY INFORMATION -- EFFECTS IN HUMANS -- Accidental Exposures -- Human Clinical Studies -- Epidemiological Studies -- EFFECTS IN ANIMALS -- Mortality -- Pulmonary Injury -- Effects on Lung Function -- Effects on Lung Biochemistry -- Host Defense Mechanisms -- Extrapulmonary Effects -- ESTABLISHED INHALATION EXPOSURE LIMITS -- EVALUATION OF TOXICITY INFORMATION -- RESEARCH NEEDS -- REFERENCES -- Appendix F ACUTE TOXICITY OF NITRIC ACID -- BACKGROUND INFORMATION -- PHYSICAL AND CHEMICAL PROPERTIES -- OCCURRENCE AND USE -- PHARMACOKINETICS AND METABOLISM -- SUMMARY OF TOXICITY INFORMATION -- EFFECTS IN HUMANS -- EFFECTS IN ANIMALS -- ESTABLISHED INHALATION EXPOSURE LIMITS -- EVALUATION OF TOXICITY INFORMATION -- RESEARCH NEEDS -- REFERENCES. |
| Record Nr. | UNINA-9910828722303321 |
| Washington, D.C., : National Academy Press, 1998 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
