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Chemistry and Biochemistry of Oxygen Therapeutics [[electronic resource] ] : From Transfusion to Artificial Blood
| Chemistry and Biochemistry of Oxygen Therapeutics [[electronic resource] ] : From Transfusion to Artificial Blood |
| Autore | Mozzarelli Andrea |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2011 |
| Descrizione fisica | 1 online resource (476 p.) |
| Disciplina |
615.8/36
615.836 |
| Altri autori (Persone) | BettatiStefano |
| Soggetto topico |
Hemoglobins - therapeutic use
Hemoglobins -- therapeutic use Nitric oxide - Physiological effect Nitric oxide -- Physiological effect Oxigen - Physiological effect Oxigen -- Physiological effect Oxygen - blood Oxygen -- blood Oxygen Consumption Oxygen Inhalation Therapy - methods Oxygen Inhalation Therapy -- methods Oxygen therapy SCIENCE / Life Sciences / Biochemistry Oxygen therapy - Physiological effect Oxygen - Physiological effect Nitric oxide Metabolic Phenomena Respiratory Therapy Investigative Techniques Body Fluids Globins Chalcogens Blood Proteins Gases Therapeutics Fluids and Secretions Elements Hemeproteins Inorganic Chemicals Proteins Amino Acids, Peptides, and Proteins Anatomy Oxygen Blood Hemoglobins Methods Oxygen Inhalation Therapy Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-283-17785-4
9786613177858 1-119-97542-5 1-119-97543-3 |
| Classificazione | SCI007000 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Chemistry and Biochemistry of Oxygen Therapeutics; Contents; List of Contributors; Preface; 1. Introduction; References; Part I. Oxygen: Chemistry, Biochemistry, Physiology and Toxicity; 2. Hemoglobin Reactivity and Regulation; 2.1 Introduction; 2.2 Oxygen Loading and Transport; 2.3 NO Reactivity with Hb; 2.4 Hb Oxidation; 2.5 Nitrite Reactivity with Hb; 2.6 Amino-acid Determinants of Hb Reactivity: Natural and Engineered Hbs; 2.6.1 Modulation of Oxygen Affinity and Cooperativity; 2.6.2 NO Reactivity and Oxidation; 2.7 Conclusion; Acknowledgments; References
3. The Major Physiological Control Mechanisms of Blood Flow and Oxygen Delivery3.1 Introduction; 3.2 Autoregulation of Blood Flow to Changes in Perfusion Pressure; 3.3 Metabolic Regulation of Blood Flow; 3.4 O2 Transport; 3.5 O2 Delivery; 3.6 Endothelial Control of Vasomotor Tone; 3.7 Effect of Cell-free Hb on Endothelial Function; 3.8 Hypoxic Hypoxia; 3.9 Carbon Monoxide Hypoxia; 3.10 Anemia; 3.11 Conclusion; References; 4. The Main Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen; 4.1 Introduction; 4.2 Role of Mammalian Mb in O2 Homeostasis 4.3 WhatLfs Missing in the Mb Knockout Mouse4.4 Evolutionary Origins of Mb and the Nitrogen Cycle; 4.5 Human Hb: Evolved Sensor of pO2 and Redox; 4.6 Broad Reactivity and Influence of NO: Lessons from the Microcosm Hb; 4.7 Some Fish Demonstrate a Fundamental "Need" for Hb-dependent NO Cycling, as in Humans; 4.8 Reactions of NO with Hb that Preserve NO Bioactivity; 4.9 Mammalian RBC/Hb.NO Interactions; 4.10 A Mutant Mouse Challenges the SNO-Hb Hypothesis, but does not Overthrow it; 4.11 Signaling by Hb-derived SNO: A Metabolically Responsive, Regulated Pathway 4.12 Signaling by Hb-derived SNO: Pathway Complexity Revealed by Multiple Defects in Disease States4.13 Therapeutic Implications of the Hb.NO Signaling System; 4.14 HBOCs, NO, and SNO; 4.15 Other Gaseous Hb Ligands of Potential Therapeutic Significance; 4.16 NO-related Enzymatic Activities of Hb: Reconciling Nitrite Reductase and SNO Synthase Functions; 4.17 Measuring Biologically Relevant Hb.NO Adducts; 4.18 Conclusion; Acknowledgments; References; 5. The Role of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury; 5.1 Introduction 5.2 Redox System and Free Radicals in Biological Systems5.3 Pathophysiology of Ischemia/Reperfusion Injury; 5.3.1 Cell Death; 5.3.2 The Inflammatory Response; 5.4 Protection Against I/R Injury; 5.4.1 Ischemic Pre- and Post-conditioning; 5.4.2 Pharmacological Conditioning; 5.4.2.1 The Protective Role of ROS and Antioxidants; 5.4.2.2 The Protective Role of NO; 5.4.2.3 NO-based Therapies for I/R Injury; 5.5 Conclusion; Acknowledgments; References; Part II. Medical Needs for Oxygen Supply; 6. Acute Traumatic Hemorrhage and Anemia; 6.1 Introduction; 6.2 Blood Transfusion in Trauma 6.2.1 Massive Transfusion |
| Record Nr. | UNINA-9910139631203321 |
Mozzarelli Andrea
|
||
| Hoboken, : Wiley, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemistry and Biochemistry of Oxygen Therapeutics [[electronic resource] ] : From Transfusion to Artificial Blood
| Chemistry and Biochemistry of Oxygen Therapeutics [[electronic resource] ] : From Transfusion to Artificial Blood |
| Autore | Mozzarelli Andrea |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2011 |
| Descrizione fisica | 1 online resource (476 p.) |
| Disciplina |
615.8/36
615.836 |
| Altri autori (Persone) | BettatiStefano |
| Soggetto topico |
Hemoglobins - therapeutic use
Hemoglobins -- therapeutic use Nitric oxide - Physiological effect Nitric oxide -- Physiological effect Oxigen - Physiological effect Oxigen -- Physiological effect Oxygen - blood Oxygen -- blood Oxygen Consumption Oxygen Inhalation Therapy - methods Oxygen Inhalation Therapy -- methods Oxygen therapy SCIENCE / Life Sciences / Biochemistry Oxygen therapy - Physiological effect Oxygen - Physiological effect Nitric oxide Metabolic Phenomena Respiratory Therapy Investigative Techniques Body Fluids Globins Chalcogens Blood Proteins Gases Therapeutics Fluids and Secretions Elements Hemeproteins Inorganic Chemicals Proteins Amino Acids, Peptides, and Proteins Anatomy Oxygen Blood Hemoglobins Methods Oxygen Inhalation Therapy Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-283-17785-4
9786613177858 1-119-97542-5 1-119-97543-3 |
| Classificazione | SCI007000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Chemistry and Biochemistry of Oxygen Therapeutics; Contents; List of Contributors; Preface; 1. Introduction; References; Part I. Oxygen: Chemistry, Biochemistry, Physiology and Toxicity; 2. Hemoglobin Reactivity and Regulation; 2.1 Introduction; 2.2 Oxygen Loading and Transport; 2.3 NO Reactivity with Hb; 2.4 Hb Oxidation; 2.5 Nitrite Reactivity with Hb; 2.6 Amino-acid Determinants of Hb Reactivity: Natural and Engineered Hbs; 2.6.1 Modulation of Oxygen Affinity and Cooperativity; 2.6.2 NO Reactivity and Oxidation; 2.7 Conclusion; Acknowledgments; References
3. The Major Physiological Control Mechanisms of Blood Flow and Oxygen Delivery3.1 Introduction; 3.2 Autoregulation of Blood Flow to Changes in Perfusion Pressure; 3.3 Metabolic Regulation of Blood Flow; 3.4 O2 Transport; 3.5 O2 Delivery; 3.6 Endothelial Control of Vasomotor Tone; 3.7 Effect of Cell-free Hb on Endothelial Function; 3.8 Hypoxic Hypoxia; 3.9 Carbon Monoxide Hypoxia; 3.10 Anemia; 3.11 Conclusion; References; 4. The Main Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen; 4.1 Introduction; 4.2 Role of Mammalian Mb in O2 Homeostasis 4.3 WhatLfs Missing in the Mb Knockout Mouse4.4 Evolutionary Origins of Mb and the Nitrogen Cycle; 4.5 Human Hb: Evolved Sensor of pO2 and Redox; 4.6 Broad Reactivity and Influence of NO: Lessons from the Microcosm Hb; 4.7 Some Fish Demonstrate a Fundamental "Need" for Hb-dependent NO Cycling, as in Humans; 4.8 Reactions of NO with Hb that Preserve NO Bioactivity; 4.9 Mammalian RBC/Hb.NO Interactions; 4.10 A Mutant Mouse Challenges the SNO-Hb Hypothesis, but does not Overthrow it; 4.11 Signaling by Hb-derived SNO: A Metabolically Responsive, Regulated Pathway 4.12 Signaling by Hb-derived SNO: Pathway Complexity Revealed by Multiple Defects in Disease States4.13 Therapeutic Implications of the Hb.NO Signaling System; 4.14 HBOCs, NO, and SNO; 4.15 Other Gaseous Hb Ligands of Potential Therapeutic Significance; 4.16 NO-related Enzymatic Activities of Hb: Reconciling Nitrite Reductase and SNO Synthase Functions; 4.17 Measuring Biologically Relevant Hb.NO Adducts; 4.18 Conclusion; Acknowledgments; References; 5. The Role of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury; 5.1 Introduction 5.2 Redox System and Free Radicals in Biological Systems5.3 Pathophysiology of Ischemia/Reperfusion Injury; 5.3.1 Cell Death; 5.3.2 The Inflammatory Response; 5.4 Protection Against I/R Injury; 5.4.1 Ischemic Pre- and Post-conditioning; 5.4.2 Pharmacological Conditioning; 5.4.2.1 The Protective Role of ROS and Antioxidants; 5.4.2.2 The Protective Role of NO; 5.4.2.3 NO-based Therapies for I/R Injury; 5.5 Conclusion; Acknowledgments; References; Part II. Medical Needs for Oxygen Supply; 6. Acute Traumatic Hemorrhage and Anemia; 6.1 Introduction; 6.2 Blood Transfusion in Trauma 6.2.1 Massive Transfusion |
| Record Nr. | UNINA-9910806996303321 |
|
Mozzarelli Andrea
|
||
| Hoboken, : Wiley, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nitric Oxide : Biology and Pathobiology
| Nitric Oxide : Biology and Pathobiology |
| Autore | Ignarro Louis J |
| Edizione | [3rd ed.] |
| Pubbl/distr/stampa | San Diego : , : Elsevier Science & Technology, , 2017 |
| Descrizione fisica | 1 online resource (436 pages) |
| Disciplina | 572/.53 |
| Altri autori (Persone) | FreemanBruce |
| Soggetto topico |
Nitric oxide - Physiological effect
Nitric oxide - Pathophysiology |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover -- Title Page -- Copyright Page -- Contents -- Contributors -- Introduction and Overview -- Chapter 1 - A Concise History of the Discovery of Mammalian Nitric Oxide (Nitrogen Monoxide) Biogenesis -- Introduction -- NO and NOx Prior to 1986 -- Ancient Human/NOx, NO Relationships -- The Discovery of NO and 19th-Century Studies -- 20th-Century NO Prior to 1986 -- 1986-88: Convergence of the Discovery of Endogenous NO in the Immune, Cardiovascular, and Nervous Systems -- NO in the Immune System Prior to 1986-88 -- NO in the Cardiovascular System Prior to 1986-88 -- NO in the Nervous System Prior to 1986-88 -- The Convergence: 1986-88 -- Conclusions -- References -- Chapter 2 - An Integrated View of the Chemical Biology of NO, CO, H2S, and O2 -- Introduction -- Nitric Oxide -- Carbon Monoxide -- Hydrogen Sulfide -- Dioxygen -- Superoxide -- Hydrogen Peroxide -- Hydroxyl Radical -- Chemical Biology of NO, CO, H2S, and O2 Interactions -- Interactions at Metal Centers: Heme Proteins -- The Effect of O2 and Derived Species on the Chemical Biology of NO, CO, and H2S -- Interaction of NO and H2S -- Thiols/Thiol Proteins and NO, CO, O2, and H2S Chemical Biology -- Summary -- References -- Chapter 3 - Detection of Nitric Oxide and Peroxynitrite in Biological Systems: A State-of-the-Art Review -- Detection of Nitric Oxide -- Introduction -- Detection of Nitrate and Nitrite -- Griess Reaction -- Chemiluminescence Detection of Nitrite/Nitrate -- Other Methods for Nitrite/Nitrate -- Probes for NO Detection -- Nitronyl Nitroxides -- Iron Dithiocarbamates -- Diaminofluorescein (DAF) -- S-Nitrosothiol Detection -- Detection of Liberated Nitrogen Oxides From S-Nitrosothiols -- Saville Reaction -- Chemiluminescence -- Detection of Protein S-Nitrosothiols -- Biotin Switch Assay -- Other Methods -- Detection of Peroxynitrite Using Boronate-Based Probes.
Introduction -- Oxidation of Boronates by Peroxynitrite and Other Biologically Relevant Oxidants -- Free Radical Pathway for the Reaction Between Boronates and ONOO− -- Real-Time Monitoring of ONOO− Formed In Situ in Cell-Free Systems -- Differentiation Between Different Oxidants Using Boronic Probes -- Detection of Peroxynitrite in Cellular Systems -- Perspectives for In Vivo Detection of Peroxynitrite -- Acknowledgment -- References -- Chapter 4 - S-Nitrosothiols and Nitric Oxide Biology -- Introduction -- RSNO Biochemistry: How Do RSNOs Relate to NO -- S-Nitrosothiol Levels and Targets In Vivo -- SNO Antibody -- RSNO Metabolism -- RSNO Formation -- Transnitrosation -- Denitrosation -- RSNO Transport -- Emerging Modulators of RSNO: Hydrogen Sulfide and Reactive Sulfur Species -- Biological Effects of RSNOs-Evidence and Interpretation -- RSNO Therapeutics -- RSNO as NO Donors -- Summary -- References -- Chapter 5 - Cooperative Interactions Between NO and H2S: Chemistry, Biology, Physiology, Pathophysiology -- Chemical Aspects of the NO/H2S Cross-Talk -- Introduction -- Basic Chemical Properties of Sulfide as Compared to NO -- Bioactive Intermediates of the Reaction Between NO and Sulfide (and its Various Metabolites): S/N Hybrid Molecules and Poly... -- HSNO/ONS− -- ONSS− -- Polysulfides -- SULFI/NO -- Regulation of NOS Activity by H2S -- Regulation of PIP3/AKT/eNOS by Sulfide -- Regulation of eNOS Activity Via H2S-Mediated Sulfhydration -- Inhibitory Effect of H2S on NOS Activity -- Inhibitory Effect of NO on CBS Activity -- Regulation of NOS Expression by H2S -- Regulation of eNOS Expression by H2S -- Regulation of iNOS Expression by H2S -- Regulation of nNOS Expression by H2S -- Regulation of CBS, CSE, or 3-MST by NO -- Support of the NO/cGMP/PKG Signaling Axis by H2S -- H2S, a Redox Reactivator of Soluble Guanylate Cyclase. H2S, an "Endogenous Viagra": Inhibition of PDE Activity by H2S -- Direct Reaction of H2S With cGMP: Formation of 8-SH-cGMP -- Oxidative Activation of Protein Kinase G by Sulfide-Derived Polysulfides -- Support of NO Signaling Through H2S/ROS Interactions -- Implications -- Implications of the NO/H2S Cooperative Interactions for the Regulation of Vascular Tone, Vascular Growth, and Remodeling -- Potential Cooperative Actions of NO and H2S in the Central and Peripheral Nervous System -- Potential Cooperative Actions of NO and H2S in Cancer -- On the Interdependence of NO and H2S Signaling and Cytoprotection -- Outlook: Future Therapeutic Directions -- References -- Chapter 6 - Heme Protein Metabolism of NO and Nitrite -- Introduction -- NO Inactivation by Reaction With Heme Proteins -- NO Reactions With Ferrous Hemoglobins to Form Iron-Nitrosyl Complexes [Fe(II)-NO] -- Effects of Red Blood Cell Compartmentalization of Hemoglobin on NO Reaction Rates -- NO Generation by Reaction of Nitrite With Deoxygenated Heme Proteins -- Conclusions -- Acknowledgments -- References -- Chapter 7 - Cross-Regulation Between iNOS/NO and Wnt/β-Catenin Signaling Pathways -- List of Abbreviations -- Introduction -- NO-Induced Posttranslational Modification of Wnt/β-Catenin Signaling Proteins -- iNOS-Derived NO Promotes β-Catenin Phosphorylation -- iNOS-Derived NO Induces Nitration and S-Nitrosation of Proteins Related to Wnt/β-Catenin Signaling Pathway -- iNOS/NO Induces Genetic Changes of Wnt/β-Catenin Pathway-Related Components -- Mutation of β-Catenin -- Loss of APC Heterozygosity -- iNOS/NO Regulates Wnt/β-Catenin Signaling -- iNOS/NO Targets Wnt/β-Catenin Signaling -- iNOS/NO Inversed DKK1 Expression Upregulated Wnt/β-Catenin Pathway -- iNOS/NO Regulates Both β-Catenin/TCF and NF-kB Transcriptional Functions -- iNOS Physically Interacts With β-Catenin. Wnt/β-Catenin Signaling Regulates iNOS/NO Pathway -- iNOS is a Targeted Gene of Wnt/β-Catenin Pathway -- Wnt/β-Catenin Regulated NF-kB Depending on the Induction of iNOS -- Conclusions -- References -- Chapter 8 - Regulation and Physiological Functions of NO-Sensitive Guanylyl Cyclase -- Introduction -- Isoforms and Molecular Properties of NO-Sensitive GC -- Activation of NO-GC by NO -- Novel Activators of NO-GC -- NO-GC Sensitizers and Heme-Mimetics in Clinical Testing -- NO-GC Inhibitors -- The NO/cGMP Signaling Cascade -- NO/cGMP-Induced Physiological Functions as Deduced From Genetic Deletion -- Blood Pressure Control -- Significance of NO-GC in Platelets -- Modulation of Synaptic Transmission -- LTP Is Lost in Both NO-GC KOs -- NO/cGMP in Glutamatergic Neurons -- NO/cGMP in GABAergic Neurons -- References -- Chapter 9 - Uncoupling of eNOS in Cardiovascular Disease -- Synthesis and Function of Endothelial NO -- The Phenomenon of eNOS Uncoupling -- Molecular Mechanisms of eNOS Uncoupling -- Uncoupling of eNOS in Cardiovascular Disease -- Hypertension -- Diabetes -- Atherosclerosis -- Pharmacological Prevention of eNOS Uncoupling -- Conclusions -- References -- Chapter 10 - Synthesis, Actions, and Perspectives of Nitric Oxide in Photosynthetic Organisms -- Nitric Oxide Synthesis in Photosynthetic Organisms -- Structure, Diversity, and Occurrence of Nitric Oxide Synthases (NOS) in Photosynthetic Organisms: Canonical NOS Is Absent i... -- Photosynthetic Organisms Do Not Synthetize the Biopterin Cofactor Required by NOS: The Role of Tetrahydrofolate -- Plants Possess Alternative Sources for NO Production -- Actions and Targets of NO in Photosynthetic Organisms -- NO as a Bioactive Signaling Molecule of Stress Responses in Land Plants -- Implications of NO in the Stress Responses of the Aquatic Photosynthetic Microorganisms. NO Is a Key Player in Auxin-Mediated Processes Leading to Root Growth and Development -- Targets and Molecular Mechanisms Underpinning NO Actions in Photosynthetic Organisms -- The Potential of NOS to Improve the Fitness of Crop Plants -- Concluding Remarks and Perspectives -- References -- Chapter 11 - Mitochondria and Nitric Oxide -- Introduction -- Sources of NO of Relevance to Mitochondria -- NO Inhibition of Cytochrome c Oxidase -- S-Nitrosation of Respiratory Complex i and Other Mitochondrial Proteins -- Mitochondrial Generation and Effects of Nitrated Fatty Acids -- Mitochondrial Generation and Effects of Peroxynitrite -- Cellular NO Signaling Regulation of Mitochondrial Dynamics and Number -- Summary and Integration of Concepts -- Acknowledgments -- References -- Chapter 12 - Nitric Oxide Formation From Inorganic Nitrate -- Introduction -- Sources of Nitrate and Nitrite -- The Enterosalivary Circulation of Nitrate -- Dietary Nitrate and Gastric Cancer -- Intragastric Generation of Nitric Oxide -- Interactions Between Nitrite and Other Dietary Compounds -- Systemic NO Generation From Nitrite -- Nitrite as a Vasodilator -- Mechanisms of Nitrite Reduction -- Dietary Nitrate and Cardiovascular Function -- Blood Pressure -- Pulmonary Hypertension -- Leukocyte and Platelet Activation -- Diabetes and Metabolic Syndrome -- How Is Inorganic Nitrate Bioactivated? -- Ergogenic Effects of Dietary Nitrate -- Nutritional Aspects -- References -- Chapter 13 - Biochemistry of Molybdopterin Nitrate/Nitrite Reductases -- Introduction -- Microbial Nitrate Reductases -- Eukaryotic Nitrate and Nitrite Reductases -- Xanthine Oxidoreductase -- Nitrate/Nitrite and Reducing Substrates -- Microenvironmental pH -- O2 Concentration -- Immobilization of XO on the Endothelial Glycocalyx -- Isoform of XOR -- Aldehyde Oxidase -- Sulfite Oxidase. Mitochondrial Amidoxime Reducing Component. |
| Record Nr. | UNINA-9910583324303321 |
|
Ignarro Louis J
|
||
| San Diego : , : Elsevier Science & Technology, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nitric oxide donors [[electronic resource] ] : for pharmaceutical and biological applications / / edited by Peng George Wang, Tingwei Bill Cai, Naoyuki Taniguchi
| Nitric oxide donors [[electronic resource] ] : for pharmaceutical and biological applications / / edited by Peng George Wang, Tingwei Bill Cai, Naoyuki Taniguchi |
| Pubbl/distr/stampa | Weinheim ; ; [Great Britain], : Wiley-VCH, c2005 |
| Descrizione fisica | 1 online resource (414 p.) |
| Disciplina | 572.54 |
| Altri autori (Persone) |
WangPeng George
CaiTingwai Bill TaniguchiNaoyuki <1942-> |
| Soggetto topico |
Nitric oxide
Nitric oxide - Physiological effect Drugs - Design Pharmaceutical chemistry |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-51948-7
9786610519484 3-527-60375-1 3-527-60384-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Nitric Oxide Donors; Contents; Preface; List of Contributors; Part 1 Chemistry of NO Donors; 1 NO and NO Donors; 1.1 Introduction to NO Biosynthesis and NO donors; 1.1.1 Nitric Oxide Synthases; 1.1.2 Chemistry of Reactive Nitrogen Species; 1.2 Classification of NO Donors; 1.3 New Classes of NO Donors under Development; 1.3.1 Nitroarene; 1.3.2 Hydroxamic Acids; 1.4 Development of NO-Drug Hybrid Molecules; 1.4.1 Nitrate Hybrid Molecules; 1.4.2 Furoxan Hybrid Molecules; 1.5 New Therapeutic Applications of NO Donors; 1.5.1 NO Donors against Cancer
1.5.1.1 Diazeniumdiolates (NONOates) as Promising Anticancer Drugs1.5.1.2 The Synergistic Effect of NO and Anticancer Drugs; 1.5.1.3 NO-NSAIDs as a New Generation of Anti-tumoral Agents; 1.5.1.4 Other NO Donors with Anticancer Activity; 1.5.2 NO against Virus; 1.5.2.1 HIV-1 Induces NO Production; 1.5.2.2 Antiviral and Proviral Activity of NO; 1.5.3 Inhibition of Bone Resorption; 1.5.4 Treatment of Diabetes; 1.5.5 Thromboresistant Polymeric Films; 1.5.6 Inhibition of Cysteine Proteases; 1.6 Conclusion; References; 2 Organic Nitrates and Nitrites; 2.1 Organic Nitrates 2.1.1 Direct Chemical Reaction between Organic Nitrates and Thiols2.1.2 Glutathione-S-transferase; 2.1.3 Cytochrome P-450-dependent Systems; 2.1.4 Membrane-bound Enzyme of Vascular Smooth Muscle Cells; 2.1.5 Xanthine Oxidoreductase; 2.1.6 Mitochondrial Aldehyde Dehydrogenase; 2.1.7 Tolerance; 2.2 Organic Nitrites; 2.3 Conclusions; References; 3 N-Nitroso Compounds; 3.1 Introduction; 3.2 N-Nitrosamines; 3.2.1 Synthesis of Nitrosamines; 3.2.2 Physical Properties and Reactions of N-Nitrosamines; 3.2.3 Structure-Activity Relationship of N-Nitrosamines; 3.2.4 Application of N-Nitrosamines 3.3 N-Hydroxy-N-nitrosoamines3.3.1 Biologically Active N-Hydroxy-N-nitrosamine Compounds; 3.3.2 Synthesis of N-Hydroxy-N-nitrosamines; 3.3.3 Properties of N-Hydroxy-N-nitrosamines; 3.3.4 Reactivity of N-Hydroxo-N-nitrosamines; 3.4 N-Nitrosimines; 3.4.1 Mechanism of Thermal Reaction of N-Nitrosoimine; 3.4.2 Properties of N-Nitrosoimines; 3.4.3 Synthesis of N-Nitrosoimines; 3.5 N-Diazeniumdiolates; 3.5.1 Mechanism of NO Release; 3.5.2 Synthesis of N-Diazeniumdiolates; 3.5.2.1 Ionic Diazeniumdiolates; 3.5.2.2 O-derivatized Diazeniumdiolates; 3.5.3 Reactions of N-Diazeniumdiolates 3.5.4 Clinical Applications3.5.4.1 Reversal of Cerebral Vasospasm; 3.5.4.2 Treatment of Impotency; 3.5.4.3 Nonthrombogenic Blood-contact Surfaces; 3.5.5 Future Directions; References; 4 The Role of S-Nitrosothiols in the Biological Milieu; 4.1 Structure and Cellular Reactivity of RSNOs; 4.1.1 RSNO Structure; 4.1.1.1 Enzymatic Consumption of RSNOs; 4.1.2 Formation of RSNOs in the Biological Milieu; 4.1.2.1 Nitrite Mediated; 4.1.2.2 NO Mediated; 4.1.2.3 NO Oxidation Products Mediated; 4.1.2.4 Metalloprotein Mediated; 4.1.2.5 Transnitrosation; 4.2 Postulated Physiological roles of RSNOs 4.2.1 Regulation of Blood Flow by HbSNO |
| Record Nr. | UNINA-9910144298603321 |
| Weinheim ; ; [Great Britain], : Wiley-VCH, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nitric oxide donors [[electronic resource] ] : for pharmaceutical and biological applications / / edited by Peng George Wang, Tingwei Bill Cai, Naoyuki Taniguchi
| Nitric oxide donors [[electronic resource] ] : for pharmaceutical and biological applications / / edited by Peng George Wang, Tingwei Bill Cai, Naoyuki Taniguchi |
| Pubbl/distr/stampa | Weinheim ; ; [Great Britain], : Wiley-VCH, c2005 |
| Descrizione fisica | 1 online resource (414 p.) |
| Disciplina | 572.54 |
| Altri autori (Persone) |
WangPeng George
CaiTingwai Bill TaniguchiNaoyuki <1942-> |
| Soggetto topico |
Nitric oxide
Nitric oxide - Physiological effect Drugs - Design Pharmaceutical chemistry |
| ISBN |
1-280-51948-7
9786610519484 3-527-60375-1 3-527-60384-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Nitric Oxide Donors; Contents; Preface; List of Contributors; Part 1 Chemistry of NO Donors; 1 NO and NO Donors; 1.1 Introduction to NO Biosynthesis and NO donors; 1.1.1 Nitric Oxide Synthases; 1.1.2 Chemistry of Reactive Nitrogen Species; 1.2 Classification of NO Donors; 1.3 New Classes of NO Donors under Development; 1.3.1 Nitroarene; 1.3.2 Hydroxamic Acids; 1.4 Development of NO-Drug Hybrid Molecules; 1.4.1 Nitrate Hybrid Molecules; 1.4.2 Furoxan Hybrid Molecules; 1.5 New Therapeutic Applications of NO Donors; 1.5.1 NO Donors against Cancer
1.5.1.1 Diazeniumdiolates (NONOates) as Promising Anticancer Drugs1.5.1.2 The Synergistic Effect of NO and Anticancer Drugs; 1.5.1.3 NO-NSAIDs as a New Generation of Anti-tumoral Agents; 1.5.1.4 Other NO Donors with Anticancer Activity; 1.5.2 NO against Virus; 1.5.2.1 HIV-1 Induces NO Production; 1.5.2.2 Antiviral and Proviral Activity of NO; 1.5.3 Inhibition of Bone Resorption; 1.5.4 Treatment of Diabetes; 1.5.5 Thromboresistant Polymeric Films; 1.5.6 Inhibition of Cysteine Proteases; 1.6 Conclusion; References; 2 Organic Nitrates and Nitrites; 2.1 Organic Nitrates 2.1.1 Direct Chemical Reaction between Organic Nitrates and Thiols2.1.2 Glutathione-S-transferase; 2.1.3 Cytochrome P-450-dependent Systems; 2.1.4 Membrane-bound Enzyme of Vascular Smooth Muscle Cells; 2.1.5 Xanthine Oxidoreductase; 2.1.6 Mitochondrial Aldehyde Dehydrogenase; 2.1.7 Tolerance; 2.2 Organic Nitrites; 2.3 Conclusions; References; 3 N-Nitroso Compounds; 3.1 Introduction; 3.2 N-Nitrosamines; 3.2.1 Synthesis of Nitrosamines; 3.2.2 Physical Properties and Reactions of N-Nitrosamines; 3.2.3 Structure-Activity Relationship of N-Nitrosamines; 3.2.4 Application of N-Nitrosamines 3.3 N-Hydroxy-N-nitrosoamines3.3.1 Biologically Active N-Hydroxy-N-nitrosamine Compounds; 3.3.2 Synthesis of N-Hydroxy-N-nitrosamines; 3.3.3 Properties of N-Hydroxy-N-nitrosamines; 3.3.4 Reactivity of N-Hydroxo-N-nitrosamines; 3.4 N-Nitrosimines; 3.4.1 Mechanism of Thermal Reaction of N-Nitrosoimine; 3.4.2 Properties of N-Nitrosoimines; 3.4.3 Synthesis of N-Nitrosoimines; 3.5 N-Diazeniumdiolates; 3.5.1 Mechanism of NO Release; 3.5.2 Synthesis of N-Diazeniumdiolates; 3.5.2.1 Ionic Diazeniumdiolates; 3.5.2.2 O-derivatized Diazeniumdiolates; 3.5.3 Reactions of N-Diazeniumdiolates 3.5.4 Clinical Applications3.5.4.1 Reversal of Cerebral Vasospasm; 3.5.4.2 Treatment of Impotency; 3.5.4.3 Nonthrombogenic Blood-contact Surfaces; 3.5.5 Future Directions; References; 4 The Role of S-Nitrosothiols in the Biological Milieu; 4.1 Structure and Cellular Reactivity of RSNOs; 4.1.1 RSNO Structure; 4.1.1.1 Enzymatic Consumption of RSNOs; 4.1.2 Formation of RSNOs in the Biological Milieu; 4.1.2.1 Nitrite Mediated; 4.1.2.2 NO Mediated; 4.1.2.3 NO Oxidation Products Mediated; 4.1.2.4 Metalloprotein Mediated; 4.1.2.5 Transnitrosation; 4.2 Postulated Physiological roles of RSNOs 4.2.1 Regulation of Blood Flow by HbSNO |
| Record Nr. | UNINA-9910830161903321 |
| Weinheim ; ; [Great Britain], : Wiley-VCH, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nitric oxide donors [[electronic resource] ] : for pharmaceutical and biological applications / / edited by Peng George Wang, Tingwei Bill Cai, Naoyuki Taniguchi
| Nitric oxide donors [[electronic resource] ] : for pharmaceutical and biological applications / / edited by Peng George Wang, Tingwei Bill Cai, Naoyuki Taniguchi |
| Pubbl/distr/stampa | Weinheim ; ; [Great Britain], : Wiley-VCH, c2005 |
| Descrizione fisica | 1 online resource (414 p.) |
| Disciplina | 572.54 |
| Altri autori (Persone) |
WangPeng George
CaiTingwai Bill TaniguchiNaoyuki <1942-> |
| Soggetto topico |
Nitric oxide
Nitric oxide - Physiological effect Drugs - Design Pharmaceutical chemistry |
| ISBN |
1-280-51948-7
9786610519484 3-527-60375-1 3-527-60384-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Nitric Oxide Donors; Contents; Preface; List of Contributors; Part 1 Chemistry of NO Donors; 1 NO and NO Donors; 1.1 Introduction to NO Biosynthesis and NO donors; 1.1.1 Nitric Oxide Synthases; 1.1.2 Chemistry of Reactive Nitrogen Species; 1.2 Classification of NO Donors; 1.3 New Classes of NO Donors under Development; 1.3.1 Nitroarene; 1.3.2 Hydroxamic Acids; 1.4 Development of NO-Drug Hybrid Molecules; 1.4.1 Nitrate Hybrid Molecules; 1.4.2 Furoxan Hybrid Molecules; 1.5 New Therapeutic Applications of NO Donors; 1.5.1 NO Donors against Cancer
1.5.1.1 Diazeniumdiolates (NONOates) as Promising Anticancer Drugs1.5.1.2 The Synergistic Effect of NO and Anticancer Drugs; 1.5.1.3 NO-NSAIDs as a New Generation of Anti-tumoral Agents; 1.5.1.4 Other NO Donors with Anticancer Activity; 1.5.2 NO against Virus; 1.5.2.1 HIV-1 Induces NO Production; 1.5.2.2 Antiviral and Proviral Activity of NO; 1.5.3 Inhibition of Bone Resorption; 1.5.4 Treatment of Diabetes; 1.5.5 Thromboresistant Polymeric Films; 1.5.6 Inhibition of Cysteine Proteases; 1.6 Conclusion; References; 2 Organic Nitrates and Nitrites; 2.1 Organic Nitrates 2.1.1 Direct Chemical Reaction between Organic Nitrates and Thiols2.1.2 Glutathione-S-transferase; 2.1.3 Cytochrome P-450-dependent Systems; 2.1.4 Membrane-bound Enzyme of Vascular Smooth Muscle Cells; 2.1.5 Xanthine Oxidoreductase; 2.1.6 Mitochondrial Aldehyde Dehydrogenase; 2.1.7 Tolerance; 2.2 Organic Nitrites; 2.3 Conclusions; References; 3 N-Nitroso Compounds; 3.1 Introduction; 3.2 N-Nitrosamines; 3.2.1 Synthesis of Nitrosamines; 3.2.2 Physical Properties and Reactions of N-Nitrosamines; 3.2.3 Structure-Activity Relationship of N-Nitrosamines; 3.2.4 Application of N-Nitrosamines 3.3 N-Hydroxy-N-nitrosoamines3.3.1 Biologically Active N-Hydroxy-N-nitrosamine Compounds; 3.3.2 Synthesis of N-Hydroxy-N-nitrosamines; 3.3.3 Properties of N-Hydroxy-N-nitrosamines; 3.3.4 Reactivity of N-Hydroxo-N-nitrosamines; 3.4 N-Nitrosimines; 3.4.1 Mechanism of Thermal Reaction of N-Nitrosoimine; 3.4.2 Properties of N-Nitrosoimines; 3.4.3 Synthesis of N-Nitrosoimines; 3.5 N-Diazeniumdiolates; 3.5.1 Mechanism of NO Release; 3.5.2 Synthesis of N-Diazeniumdiolates; 3.5.2.1 Ionic Diazeniumdiolates; 3.5.2.2 O-derivatized Diazeniumdiolates; 3.5.3 Reactions of N-Diazeniumdiolates 3.5.4 Clinical Applications3.5.4.1 Reversal of Cerebral Vasospasm; 3.5.4.2 Treatment of Impotency; 3.5.4.3 Nonthrombogenic Blood-contact Surfaces; 3.5.5 Future Directions; References; 4 The Role of S-Nitrosothiols in the Biological Milieu; 4.1 Structure and Cellular Reactivity of RSNOs; 4.1.1 RSNO Structure; 4.1.1.1 Enzymatic Consumption of RSNOs; 4.1.2 Formation of RSNOs in the Biological Milieu; 4.1.2.1 Nitrite Mediated; 4.1.2.2 NO Mediated; 4.1.2.3 NO Oxidation Products Mediated; 4.1.2.4 Metalloprotein Mediated; 4.1.2.5 Transnitrosation; 4.2 Postulated Physiological roles of RSNOs 4.2.1 Regulation of Blood Flow by HbSNO |
| Record Nr. | UNINA-9910841890003321 |
| Weinheim ; ; [Great Britain], : Wiley-VCH, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nitric oxide in plant physiology [[electronic resource] /] / edited by Shamsul Hayat ... [et al.]
| Nitric oxide in plant physiology [[electronic resource] /] / edited by Shamsul Hayat ... [et al.] |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2010 |
| Descrizione fisica | 1 online resource (230 p.) |
| Disciplina | 572.542 |
| Altri autori (Persone) | HayatShamsul |
| Soggetto topico |
Plants - Effect of nitrogen on
Nitric oxide - Physiological effect Plant chemical defenses |
| ISBN |
1-282-30628-6
9786612306280 3-527-62913-0 3-527-62914-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Nitric Oxide in Plant Physiology; Contents; Preface; List of Contributors; 1 Nitric Oxide: Chemistry, Biosynthesis, and Physiological Role; 1.1 Introduction; 1.2 Nitric Oxide Chemistry; 1.3 Biosynthesis of Nitric Oxide; 1.4 Physiological Role of Nitric Oxide; 1.4.1 Effect of Nitric Oxide on Seed Dormancy; 1.4.2 Effect of Nitric Oxide on Growth; 1.4.3 Effect of Nitric Oxide on Senescence; 1.4.4 Effect of Nitric Oxide on Nitrate Reductase Activity; 1.4.5 Effect of Nitric Oxide on Respiration; 1.4.6 Effect of Nitric Oxide on Stomatal Movement; 1.4.7 Effect of Nitric Oxide on Chlorophyll Content
1.4.8 Effect of Nitric Oxide on Photosynthesis1.4.9 Effect of Nitric Oxide on Antioxidant System; 1.4.10 Effect of Nitric Oxide on Programmed Cell Death; 1.5 Nitric Oxide and Cross Talk with Classical Plant Hormones; 1.5.1 Auxins and Nitric Oxide; 1.5.2 Abscisic Acid and Nitric Oxide; 1.5.3 Cytokinins, Gibberellins, and Nitric Oxide; 1.5.4 Ethylene and Nitric Oxide; References; 2 Electron Paramagnetic Resonance as a Tool to Study Nitric Oxide Generation in Plants; 2.1 Introduction; 2.1.1 Chemistry of Nitrogen-Active Species; 2.1.2 Biological Effects of NO; 2.2 Methods of NO Detection 2.2.1 Determination of NO by Specific Electrodes2.2.2 Determination of NO by Spectrophotometric and Fluorometric Methods; 2.2.3 Determination of NO by Electron Paramagnetic Resonance; 2.2.3.1 Specific Experimental Advances; 2.3 Use of EPR Methodology for Assaying Enzyme Activities; 2.3.1 NOS-Like Dependent NO Generation; 2.3.2 Nitrate Reductase-Dependent NO Generation; 2.4 Application of EPR Methods to Assess NO Generation During Plant Development; 2.5 Conclusions; References; 3 Calcium, NO, and cGMP Signaling in Plant Cell Polarity; 3.1 Introduction 3.2 Cell Polarity and Plant Gametophyte Development3.3 Calcium Signaling in Pollen and Fern Spores; 3.4 NO/cGMP Signaling in Pollen and Fern Spores; 3.5 NO/cGMP in Pollen-Pistil Interactions; 3.6 Ovule Targeting and NO/cGMP; 3.7 Ca2+/NO/cGMP Connection?; 3.8 Closing Perspectives; References; 4 Nitric Oxide and Abiotic Stress in Higher Plants; 4.1 Introduction; 4.2 Nitric Oxide and Related Molecules; 4.2.1 Chemistry of Nitric Oxide in Plant Cells; 4.2.2 Reactive Nitrogen Species; 4.3 Cellular Targets of NO; 4.3.1 Nitrosylated Metals; 4.3.2 Protein S-Nitrosylation 4.3.3 Protein Tyrosine Nitration4.3.4 Nitrolipids; 4.3.5 Nucleic Acid Nitration; 4.3.6 NO and Gene Regulation; 4.4 Functions of NO in Plant Abiotic Stress; 4.4.1 Salinity; 4.4.2 Ultraviolet Radiation; 4.4.3 Ozone; 4.4.4 Mechanical Wounding; 4.4.5 Toxic Metals (Cadmium and Aluminum); 4.5 Concluding Remarks; References; 5 Polyamines and Cytokinin: Is Nitric Oxide Biosynthesis the Key to Overlapping Functions?; 5.1 Introduction; 5.2 Cytokinin- and Polyamine-Induced NO Biosynthesis; 5.3 Tissue Distribution of Zeatin-Induced and PA-Induced NO Formation 5.4 Nitric Oxide, Cytokinin, and Polyamines in Plant Growth and Development and in Abiotic and Biotic Stresses |
| Record Nr. | UNINA-9910139777303321 |
| Weinheim, : Wiley-VCH, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nitric oxide in plant physiology [[electronic resource] /] / edited by Shamsul Hayat ... [et al.]
| Nitric oxide in plant physiology [[electronic resource] /] / edited by Shamsul Hayat ... [et al.] |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2010 |
| Descrizione fisica | 1 online resource (230 p.) |
| Disciplina | 572.542 |
| Altri autori (Persone) | HayatShamsul |
| Soggetto topico |
Plants - Effect of nitrogen on
Nitric oxide - Physiological effect Plant chemical defenses |
| ISBN |
1-282-30628-6
9786612306280 3-527-62913-0 3-527-62914-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Nitric Oxide in Plant Physiology; Contents; Preface; List of Contributors; 1 Nitric Oxide: Chemistry, Biosynthesis, and Physiological Role; 1.1 Introduction; 1.2 Nitric Oxide Chemistry; 1.3 Biosynthesis of Nitric Oxide; 1.4 Physiological Role of Nitric Oxide; 1.4.1 Effect of Nitric Oxide on Seed Dormancy; 1.4.2 Effect of Nitric Oxide on Growth; 1.4.3 Effect of Nitric Oxide on Senescence; 1.4.4 Effect of Nitric Oxide on Nitrate Reductase Activity; 1.4.5 Effect of Nitric Oxide on Respiration; 1.4.6 Effect of Nitric Oxide on Stomatal Movement; 1.4.7 Effect of Nitric Oxide on Chlorophyll Content
1.4.8 Effect of Nitric Oxide on Photosynthesis1.4.9 Effect of Nitric Oxide on Antioxidant System; 1.4.10 Effect of Nitric Oxide on Programmed Cell Death; 1.5 Nitric Oxide and Cross Talk with Classical Plant Hormones; 1.5.1 Auxins and Nitric Oxide; 1.5.2 Abscisic Acid and Nitric Oxide; 1.5.3 Cytokinins, Gibberellins, and Nitric Oxide; 1.5.4 Ethylene and Nitric Oxide; References; 2 Electron Paramagnetic Resonance as a Tool to Study Nitric Oxide Generation in Plants; 2.1 Introduction; 2.1.1 Chemistry of Nitrogen-Active Species; 2.1.2 Biological Effects of NO; 2.2 Methods of NO Detection 2.2.1 Determination of NO by Specific Electrodes2.2.2 Determination of NO by Spectrophotometric and Fluorometric Methods; 2.2.3 Determination of NO by Electron Paramagnetic Resonance; 2.2.3.1 Specific Experimental Advances; 2.3 Use of EPR Methodology for Assaying Enzyme Activities; 2.3.1 NOS-Like Dependent NO Generation; 2.3.2 Nitrate Reductase-Dependent NO Generation; 2.4 Application of EPR Methods to Assess NO Generation During Plant Development; 2.5 Conclusions; References; 3 Calcium, NO, and cGMP Signaling in Plant Cell Polarity; 3.1 Introduction 3.2 Cell Polarity and Plant Gametophyte Development3.3 Calcium Signaling in Pollen and Fern Spores; 3.4 NO/cGMP Signaling in Pollen and Fern Spores; 3.5 NO/cGMP in Pollen-Pistil Interactions; 3.6 Ovule Targeting and NO/cGMP; 3.7 Ca2+/NO/cGMP Connection?; 3.8 Closing Perspectives; References; 4 Nitric Oxide and Abiotic Stress in Higher Plants; 4.1 Introduction; 4.2 Nitric Oxide and Related Molecules; 4.2.1 Chemistry of Nitric Oxide in Plant Cells; 4.2.2 Reactive Nitrogen Species; 4.3 Cellular Targets of NO; 4.3.1 Nitrosylated Metals; 4.3.2 Protein S-Nitrosylation 4.3.3 Protein Tyrosine Nitration4.3.4 Nitrolipids; 4.3.5 Nucleic Acid Nitration; 4.3.6 NO and Gene Regulation; 4.4 Functions of NO in Plant Abiotic Stress; 4.4.1 Salinity; 4.4.2 Ultraviolet Radiation; 4.4.3 Ozone; 4.4.4 Mechanical Wounding; 4.4.5 Toxic Metals (Cadmium and Aluminum); 4.5 Concluding Remarks; References; 5 Polyamines and Cytokinin: Is Nitric Oxide Biosynthesis the Key to Overlapping Functions?; 5.1 Introduction; 5.2 Cytokinin- and Polyamine-Induced NO Biosynthesis; 5.3 Tissue Distribution of Zeatin-Induced and PA-Induced NO Formation 5.4 Nitric Oxide, Cytokinin, and Polyamines in Plant Growth and Development and in Abiotic and Biotic Stresses |
| Record Nr. | UNINA-9910820213803321 |
| Weinheim, : Wiley-VCH, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
