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Autophagy and neurodegeneration / / David Rubinsztein
| Autophagy and neurodegeneration / / David Rubinsztein |
| Autore | Rubinsztein David (Cambridge Institute for Medical Research, UK) |
| Pubbl/distr/stampa | London, : Henry Stewart Talks, 2018 |
| Descrizione fisica | 1 online resource (1 streaming video file (39 min.) : color, sound) |
| Collana | Autophagy and lysosomal storage diseases |
| Soggetto topico |
Cell death
Lysosomes Nervous system - Degeneration Ataxin-3 Autophagy - physiology Lysosomes - metabolism Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurodegenerative Diseases - therapy Signal Transduction - physiology |
| Formato | Videoregistrazioni  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Contents: Autophagy-lysosome pathway -- Autophagy signaling (canonical & non-canonical) -- Neurodegenerative diseases impairing autophagy -- Exploring pathogenic mechanism -- Ataxin 3 & autophagy -- Autophagy and neurodegeneration. |
| Record Nr. | UNINA-9910888489103321 |
Rubinsztein David (Cambridge Institute for Medical Research, UK)
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| London, : Henry Stewart Talks, 2018 | ||
| Videoregistrazioni | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular neurodegeneration
| Molecular neurodegeneration |
| Pubbl/distr/stampa | [London], : BioMed Central, 2006- |
| Soggetto topico |
Molecular neurobiology
Neurobiology Nervous system - Diseases Neurodegenerative Diseases - genetics Neurodegenerative Diseases - therapy Neurodegenerative Diseases - immunology Neurobiologie moléculaire Neurobiologie Système nerveux - Maladies Neurology Molecular Biology Degenerative Diseases |
| Soggetto genere / forma |
Periodical
Fulltext Internet Resources. Periodicals. periodicals. Périodiques. |
| Soggetto non controllato | Neuroscience |
| ISSN | 1750-1326 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | MN |
| Record Nr. | UNISA-996211128403316 |
| [London], : BioMed Central, 2006- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Molecular neurodegeneration
| Molecular neurodegeneration |
| Pubbl/distr/stampa | [London], : BioMed Central, 2006- |
| Soggetto topico |
Molecular neurobiology
Neurobiology Nervous system - Diseases Neurodegenerative Diseases - genetics Neurodegenerative Diseases - therapy Neurodegenerative Diseases - immunology Neurobiologie moléculaire Neurobiologie Système nerveux - Maladies Neurology Molecular Biology Degenerative Diseases |
| Soggetto genere / forma |
Periodical
Fulltext Internet Resources. Periodicals. periodicals. Périodiques. |
| Soggetto non controllato | Neuroscience |
| ISSN | 1750-1326 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | MN |
| Record Nr. | UNINA-9910144453603321 |
| [London], : BioMed Central, 2006- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Parkinson's and Alzheimer's today : about neurodegeneration and its therapy / / Lars P. Klimaschewski
| Parkinson's and Alzheimer's today : about neurodegeneration and its therapy / / Lars P. Klimaschewski |
| Autore | Klimaschewski Lars P. |
| Pubbl/distr/stampa | Berlin, Germany : , : Springer, , [2022] |
| Descrizione fisica | 1 online resource (163 pages) |
| Disciplina | 616.831 |
| Soggetto topico |
Parkinson's disease
Alzheimer's disease Neurodegenerative Diseases - epidemiology Neurodegenerative Diseases - therapy Parkinson Disease Alzheimer Disease |
| ISBN | 3-662-66369-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Intro -- Preface -- Contents -- 1 Introduction to Brain Development: Why do We Need so Many Nerve Cells? -- 1.1 Neurons and Glia in the Central Nervous System -- 1.2 What Happens During Brain Development? -- 1.3 Evolutionarily Old Brain Parts are Simpler in Structure than the Neocortex -- 1.4 What Distinguishes the Left from the Right Brain? -- 1.5 Brain Development in Childhood and Adolescence -- 1.6 The Child's Brain is Enormously Plastic and can Still Heal -- 1.7 Is a Large Brain "Smarter" than a Small One? -- 1.8 Absolute and Relative Brain Weight -- 1.9 With the Second Evolutionary Leap, Our Brain Reaches its Maximum Size -- 1.10 Neural Stem Cells Remain Capable of Dividing for a Long Time -- 1.11 The Frontal Lobe is Especially Important for Higher Brain Functions -- 1.12 The Prefrontal Cortex Encodes Human Specific Properties -- 1.13 Brain Performance in Comparison -- Further Reading -- 2 Aging and Neurodegenerative Diseases: Why do Nerve Cells Die? -- 2.1 The Normal Aging Process -- 2.1.1 Mechanisms of Cellular Aging -- DNA Telomeres Determine the Number of Cell Divisions -- Aging Cells Maintain a Chronic Inflammation -- The Importance of Protein Homeostasis for Cellular Aging -- Self-cleaning of Nerve Cells -- Two Sides of a Coin: Oxygen Radicals -- Endogenous Radical Scavengers Protect Our Nerve Cells -- Chronic Inflammatory Processes in the Brain -- 2.1.2 Neuronal Cell Death -- How do neurons die? -- 2.1.3 Blood Supply of the Aging Brain -- Barrier Disorders are Not Uncommon in the Elderly -- 2.2 Parkinson's Disease -- 2.2.1 General Pathomechanisms -- The Problem with Parkinson's Begins in the Lower Brainstem -- 2.2.2 Special Morphology of Affected Neurons -- Special Requirements for Highly Branched Neurons -- Many Amine-releasing Neurons are Constantly Active and Therefore More Easily Stressed -- 2.2.3 Specific Causes of Parkinson's Disease -- 2.2.4 Alpha-synuclein: A Key Protein in Parkinson's Disease -- Fibrils Are More Dangerous Than Aggregates -- Aggregates Are Not Only Found in Nerve Cells -- 2.2.5 The Prion Theory of Parkinson's Disease -- Cranial Nerves Transport Pathological Proteins into the Brain -- The Difficulties of a Clear Pathogenesis of Parkinson's Disease -- 2.3 Dementia and Alzheimer's Disease -- 2.3.1 How Does Alzheimer's Disease Manifest Itself? -- 2.3.2 General Pathomechanisms -- The Amyloid Pathology -- The Many Effects of Aβ Peptides -- 2.3.3 The Disturbed Protein Homeostasis in Alzheimer's Disease -- 2.3.4 Tau Pathology -- Pathological Effects of p-tau and Aβ -- Episodic Memory is Already Impaired in the Early Stage of Alzheimer's -- 2.3.5 The Prion Theory in Alzheimer's Disease -- The Relevance of Cerebrospinal Fluid Drainage for Neurodegeneration -- 2.4 Inflammatory Components of Alzheimer's and Parkinson's Disease -- 2.5 Viral Infections in Neurodegenerative Diseases -- Further Reading -- 3 Saving or Replacing Nerve Cells: Which Strategy is More Successful? -- 3.1 Parkinson's Disease -- 3.1.1 Pharmacological Therapy -- 3.1.2 Surgical and physical therapy -- 3.1.3 Therapy with Neurotrophic Factors -- 3.1.4 Therapy with Antisense Oligonucleotides -- 3.1.5 Alpha-synuclein Aggregation Inhibitors and Specific Immunotherapy -- 3.1.6 Stem Cell Therapy -- 3.1.7 Other Causal Therapeutic Approaches -- 3.2 Dementia and Alzheimer's Disease -- 3.2.1 Cholinergica -- 3.2.2 Therapy with Secretase Inhibitors -- 3.2.3 Therapy with Neurotrophic Factors -- 3.2.4 Immunotherapy -- 3.2.5 Stem Cell Therapy -- 3.2.6 Other Causal Therapeutic Approaches -- 3.2.7 Symptomatic Therapy -- 3.2.8 Which Measures Promise the most Success? -- 3.3 Diagnosis and Therapy of Neuronal Degeneration-quo vadis? -- Further Reading -- Glossary. |
| Record Nr. | UNINA-9910633926003321 |
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Klimaschewski Lars P.
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| Berlin, Germany : , : Springer, , [2022] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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