Advances in biology and therapy of multiple myeloma . Volume 1 Basic science / / Nikhil C. Munshi, Kenneth C. Anderson, editors |
Pubbl/distr/stampa | New York, : Springer, c2013 |
Descrizione fisica | 1 online resource (321 p.) |
Disciplina |
616.99/418
616.9941806 |
Altri autori (Persone) |
MunshiNikhil C
AndersonKenneth C |
Soggetto topico |
Bone marrow - Diseases
Myelodysplastic syndromes |
ISBN |
1-283-84894-5
1-4614-4666-X |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Genomic strategies determining progressions from MGUS to Multiple Myeloma -- Prognostic implication of Genetic changes (Cytogenetics, and FISH, gains and losses of DNA by SNP array and aCGH) in risk stratification in myeloma -- Advances in MM gene expression profiling -- Growth factors in MM -- Role of Wnt signaling pathways in multiple myeloma pathogenesis -- mTOR pathway in multiple myeloma -- Jak/STAT signaling in the pathogenesis and treatment of multiple myeloma -- Role of extracellular matrix in myeloma biology -- Osteoclasts: Potential target for blocking microenvironmental support of myeloma -- Targeting the BAFF/APRIL cytokine network in multiple myeloma -- Role of Osteoblast in myeloma pathology -- Migration and homing in Multiple Myeloma -- Genes and proteins of myeloma endothelial cells to search specific targets of the tumor vasculature -- Epigenetic regulation of myeloma within its bone marrow microenvironment -- Targeting mulitple myeloma tumor angiogenesis: focus on VEGF -- Novel in vivo model in myeloma -- Index. |
Record Nr. | UNINA-9910437850803321 |
New York, : Springer, c2013 | ||
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Lo trovi qui: Univ. Federico II | ||
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Advances in malignant hematology / / edited by Hussain I. Saba, Ghulam J. Mufti |
Edizione | [First edition.] |
Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, NJ, : Wiley-Blackwell, 2011 |
Descrizione fisica | 1 online resource (444 pages) |
Disciplina | 616.99/446 |
Altri autori (Persone) |
MuftiG. J
SabaHussain I |
Soggetto topico |
Leukemia
Lymphomas Myelodysplastic syndromes |
ISBN |
1-283-40811-2
9786613408112 1-4443-9399-5 1-4443-9401-0 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Advances in Malignant Hematology -- Contents -- List of Contributors -- Acknowledgement -- Preface -- List of Main Abbreviations -- PART 1: Hematopoiesis -- 1 Normal and Malignant Hematopoiesis -- 2 The Leukemia Genome -- PART 2: Myeloid Malignancies -- 3 Myeloproliferative Neoplasms -- 4 Molecular Pathogenesis of BCR-ABL in Chronic Myeloid Leukemia -- 5 Standard Management of Patients with Chronic Myeloid Leukemia -- 6 The Molecular Biology of Acute Myeloid Leukemia -- 7 Acute Myeloid Leukemia -- 8 Acute Promyelocytic Leukemia -- 9 A Pluralistic Approach to the Study of Myelodysplastic Syndromes: Evolving Pathology of the Seed via the Soil -- 10 Myelodysplastic Syndrome: A Review of Current Care -- 11 Supportive Care in Myelodysplastic Syndrome -- PART 3: Lymphoid Malignancies -- 12 Molecular Biology of Chronic Lymphoproliferative Disorders -- 13 Chronic Lymphocytic Leukemia -- 14 Acute Lymphoblastic Leukemia -- 15 Large Granular Lymphocyte Leukemia -- 16 Hairy Cell Leukemia -- 17 Molecular Basis of B-cell Lymphomas -- 18 Non-Hodgkin Lymphomas -- 19 Hodgkin Lymphoma -- PART 4: Plasma Cell Disorders -- 20 Multiple Myeloma: Molecular Biology, Diagnosis and Treatment -- 21 Waldenström's Macroglobulinemia -- 22 Primary Systemic Amyloidosis (AL) -- PART 5: Bone Marrow Transplantation and Quality of Life -- 23 Advances in Allogeneic Hematopoietic Cell Transplantation: Progress in Transplantation Technology and Disease-Specific Outcomes -- 24 Quality of Life after the Diagnosis of Hematologic Malignancies -- Index -- Colour Plates. |
Record Nr. | UNINA-9910130881703321 |
Chichester, West Sussex ; ; Hoboken, NJ, : Wiley-Blackwell, 2011 | ||
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Lo trovi qui: Univ. Federico II | ||
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Myelodysplastic syndromes / / Joachim Deeg ... [et. al.] |
Autore | Deeg Joachim |
Edizione | [2nd ed. 2013.] |
Pubbl/distr/stampa | New York, : Springer, 2013 |
Descrizione fisica | 1 online resource (245 p.) |
Disciplina | 616 |
Collana | Hematologic malignancies |
Soggetto topico |
Myelodysplastic syndromes
Hematological oncology |
ISBN | 3-642-36229-X |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Clincial Presentation and Differential Diagnosis -- Epidemiology and Etiology -- Cytogenetic Diagnosis of Myelodysplastic Syndromes -- MDS Stem Cell Biology -- The Biology of Myelodysplastic Syndrome Associated with Isolated del(5q) -- Other -- Overlap with MPN -- Classification and Staging of Myelodysplastic Syndromes -- Immunophenotyping in Myelodysplastic Syndrome -- Prognostic Models for Patients with Myelodysplastic Syndromes -- Low Risk MDS -- Management of High-Risk Myelodysplastic Syndrome -- Hematopoietic Cell Transplantation -- MDS in Children. |
Record Nr. | UNINA-9910437991603321 |
Deeg Joachim
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New York, : Springer, 2013 | ||
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Lo trovi qui: Univ. Federico II | ||
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Myelodysplastic syndromes / / edited by Ota Fuchs |
Pubbl/distr/stampa | Rijeka, Croatia : , : IntechOpen, , [2016] |
Descrizione fisica | 1 online resource (210 pages) |
Disciplina | 616.41 |
Soggetto topico | Myelodysplastic syndromes |
ISBN |
953-51-7296-4
953-51-2587-7 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910317694503321 |
Rijeka, Croatia : , : IntechOpen, , [2016] | ||
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Lo trovi qui: Univ. Federico II | ||
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Myelodysplastic syndromes [[electronic resource] ] : from pathogenesis to diagnosis and therapy / / Hamid Sayar, editor |
Pubbl/distr/stampa | New York, : Nova Science Publishers, 2013 |
Descrizione fisica | 1 online resource (309 p.) |
Altri autori (Persone) | SayarHamid |
Collana | Recent advances in hematology research |
Soggetto topico |
Myelodysplastic syndromes
Bone marrow - Diseases |
Soggetto genere / forma | Electronic books. |
ISBN | 1-62417-580-5 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910465560603321 |
New York, : Nova Science Publishers, 2013 | ||
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Lo trovi qui: Univ. Federico II | ||
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Myelodysplastic syndromes [[electronic resource] ] : from pathogenesis to diagnosis and therapy / / Hamid Sayar, editor |
Pubbl/distr/stampa | New York, : Nova Science Publishers, 2013 |
Descrizione fisica | 1 online resource (309 p.) |
Altri autori (Persone) | SayarHamid |
Collana | Recent advances in hematology research |
Soggetto topico |
Myelodysplastic syndromes
Bone marrow - Diseases |
ISBN | 1-62417-580-5 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910792010203321 |
New York, : Nova Science Publishers, 2013 | ||
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Lo trovi qui: Univ. Federico II | ||
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Myelodysplastic syndromes : from pathogenesis to diagnosis and therapy / / Hamid Sayar, editor |
Edizione | [1st ed.] |
Pubbl/distr/stampa | New York, : Nova Science Publishers, 2013 |
Descrizione fisica | 1 online resource (309 p.) |
Altri autori (Persone) | SayarHamid |
Collana | Recent advances in hematology research |
Soggetto topico |
Myelodysplastic syndromes
Bone marrow - Diseases |
ISBN | 1-62417-580-5 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Intro -- MYELODYSPLASTIC SYNDROMES -- MYELODYSPLASTIC SYNDROMES -- Contents -- Preface -- An Introduction to Myelodysplastic Syndromes: Presentation, Diagnosis, Classification, and Prognostication -- Abstract -- Introduction -- Etiology -- Pathobiology -- Cytogenetic, Genetic, and Epigenetic Alterations -- Cytogenetic Abnormalities -- Genetic Abnormalities -- Epigenetic Abnormalities -- Role of Immune System -- Bone Marrow Microenvironment -- Deregulated Apoptosis (Programmed Cell Death) -- Clinical Presentation -- Diagnosis -- Bone Marrow Aspirate -- Practical Technique to Assure Adequate Bone Marrow Particle Collection -- Bone Marrow Biopsy -- Touch Imprint and Clot Section -- Flow Cytometry -- Cytogenetics -- Atypical Forms of MDS -- MDS with Myelofibrosis -- Hypoplastic MDS -- Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN) -- Therapy Related MDS (t-MDS) -- 5q- Syndrome -- Classification -- Prognostication -- International Prognostic Scoring System (IPSS) -- WHO Prognostic Scoring System (WPSS) -- MD Anderson Cancer Center (MDACC) Model -- Revised IPSS (IPSS-R) -- Other Prognostic Factors -- Cytogenetics -- Bone Marrow Fibrosis -- Hypoplastic MDS -- Therapy-Related MDS (t-MDS) -- 5q- Syndrome -- Neutropania -- Thrombocytopenia -- References -- Diagnostic Approach to Myelodysplastic Syndromes -- Abstract -- Introduction -- Diagnostic Approach -- Morphologic Features -- Immunophenotyping by Flow Cytometry -- Cytogenetic and Genetic Features -- Classification of Myelodisplastic Syndromes -- Refractory Cytopenia with Unilineage Dysplasia (RCUD) -- Refractory Anemia with Ring Sideroblasts (RARS) -- Refractory Cytopenia with Multilineage Dysplasia (RCMD) -- Refractory Anemia with Excess of Blasts (RAEB) -- Myelodysplastic Syndrome with Isolated del(5q) -- Myelodysplastic Syndrome, Unclassifiable (MDS-U).
Myelodysplastic Syndromes with Unique Morphological Features -- MDS with Fibrosis (MDS-F) -- Hypoplastic MDS (h-MDS) -- Erythroid-Predominant MDS (MDS-E) -- Conclusion -- References -- Cytogenetic Features of Myelodysplastic Syndromes -- Abstract -- Introduction -- Cytogenetic Findings -- Cytogenetic Alterations and their Molecular Counterparts -- Y Chromosome Loss -- Rearrangements (3q) -- Deletion (5q) -- Rearrangements of 5q33 -- Partial or Total Loss of Chromosome 7: -7/del(7q) -- Trisomy 8 -- Deletion (17p) -- Deletion (20q) -- Complex Karyotype -- Risk Stratification of Cytogenetic Findings in MDS -- Conclusion -- Acknowledgments -- References -- Molecular Genetic Abnormalitiesin Myelodysplastic Syndromes -- Abstract -- Introduction -- Mutations in Epigenetic Regulators in MDS -- Mutations of the DNMT3A Gene -- Mutations of the TET2 Gene -- Mutations of the IDH1 and IDH2 Genes -- Mutations of the EZH2 Gene -- Mutations of the UTX Gene -- Mutations of the ASXL1 Gene -- Mutations of the c-CBL Gene -- RUNX1 Mutations -- RAS Mutations in MDS -- TP53 Mutations -- Mutations in RNA Splicing Machinery -- Mutations in Other Genes in MDS Patients -- Conclusion and Perspectives -- Acknowledgments -- References -- Epigenetic Changes in the Pathogenesis and Therapyof Myelodysplastic Syndromes -- Abstract -- Introduction -- Regulation of Gene Expression by DNA Methylation -- Types of Histone Methylation Modification and Their Regulatory Mechanisms -- Histone Acetylation Status -- MicroRNAs and Epigenetic Machinery -- Protein EVI1 and Epigenetic Machinery -- Epigenetic Therapy in MDS -- Azacitidine Clinical Studies -- Decitabine Clinical Studies -- Comparison of Azacitidine and Decitabine -- Biomarkers of Sensitivity to Hypomethylating Agents -- Resistance to Hypomethylating Agents -- New Hypomethylating Agents. Combinations of Hypomethylating Agents with Histone Deacetylase Inhibitors or Other Drugs -- Conclusion and Perspectives -- Acknowledgments -- References -- Conventional and Molecular Cytogenetic Techniques and TheirApplication in Myelodysplastic Syndromes -- Abstract -- Introduction -- Work-Up at Diagnosis and Prognostic Means -- Conventional Cytogenetics in MDS -- CC Application in MDS -- Molecular Cytogenetics in MDS -- Fluorescence in-Situ Hybridization: Principle -- FISH Application in MDS -- FISH: Technical Considerations and Limitations -- Comparative Genomic Hybridization: Principle -- Array Based Karyotyping -- Array-CGH: Principle and General Features -- SNP-Array: Principle and General Features -- Technical Considerations of Array Karyotyping -- Detection of Copy Number Changes and Copy-Neutral Loss of Heterozygosity -- CGH and Array-CGH: Application and Limitation in MDS -- SNP-A: Application and Limitation in MDS -- Next Generation Sequencing or Second Generation Sequencing (NGS) -- Somatically Acquired Point Mutations in MDS -- Molecular Cytogenetics Provides New Insights in MDS Pathogenesis and Progression to Acute Leukemia -- Molecular Cytogenetics Insights in Tailoring Patient Management -- Conclusion -- References -- Pathogenesis of 5q- Syndromeand Its Therapy -- Abstract -- Introduction -- Possible Role of Candidate Genes from CDR in 5q- Syndrome -- Role of SPARC in 5q- Syndrome -- RPS14 and Ribosomopathies -- Role of miR-145 and miR-146a in 5q- Syndrome -- The Importance of p53 in the Molecular Mechanism of 5q- Syndrome -- Activation of p53 by Ribosome Dysfunction in Model Systems -- Activation of p53 and Up-Regulation of the p53 Pathway in 5q- Syndrome -- Relation between p53 and miR145 -- Role of Other Genes in 5q- Syndrome -- Role of Genes Positioned on 5q Chromosome -- Role of Genes not Positioned on 5q Chromosome. Treatment of 5q- Syndrome -- Conclusion and Perspectives -- Acknowledgments -- References -- Cytogenetic and Molecular Dissection of Chromosome 20 Alterations in Myelodysplastic Syndromes: Identification of Deleted and Retained Regions -- Abstract -- Introduction -- Deletions of the Long Arm of Chromosome 20 -- Monosomy of Chromosome 20 -- Derivatives and Dicentrics of Chromosome 20 -- Isoderivatives of the Long Arm of Chromosome 20 -- Reciprocal Translocations Involving Chromosome 20 -- Commonly Deleted and Retained Regionsof Chromosome 20 -- Candidate Genes -- Candidate Genes Present in the CDR -- Candidate Genes Present in the Proximal CRR -- Candidate Genes Present in the Distal CRR -- Conclusion -- Acknowledgments -- References -- The Cellular Evolutionary Entity,Epigenetic Alterations and Microenvironment of Myelodysplastic Syndromes -A Working Hypothesis of MDS Pathogenesis -- Abstract -- The Hematopoietic Cells in MDS -- The MDS Bone Marrow Cellularity -- Cellular Diversity in MDS -- The Clonal Origin, Evolution and Fate of MDS Cells -- MDS Stem Cells in Animal Models -- Molecular Changes in MDS -- Alteration of Gene Expression Profile -- Mutated Genes Involving Epigenetic Regulation and Reprogramming -- The Microenvironment of Bone Marrow Niches and HSCs in MDS -- Structural and Physiological Effects of Niches on HSC Development in the Normal Bone Marrow -- Changes in Structure and Possible Effects of Niches on HSCs in MDS -- Possible Role of Immune System in Development of MDS -- A Working Hypothesis on Mechanism of MDS Pathogenesis -- The Schema and an Overall Explanation of Our Hypothesis -- Epigenetic Alterations as an Early Event in MDS Clone Formation -- Effect of Environmental Niches on Regulation of Metabolism and Alteration in Epigenetics of HSCs -- The Concept of MDS Stem Cell Coexistance with Normal HSCs. Implications and Perspectives -- Disclosure of Interest Conflict -- Grant Support -- Acknowledgments -- References -- Treatment of Lower-Risk Myelodysplastic Syndromes -- Abstract -- Introduction -- Risk Stratification -- MDS Patient with Anemia -- Del (5q) -- Immunosuppressive Therapy -- Lenalidomide in Non-Del (5q) MDS -- Anemic Patient Failing Less Intensive Therapies -- Erythropoiesis Stimulating Agents (ESA) and Addition of Granulocyte Growth Factors -- Available ESA -- Lower-Risk MDS with Thrombocytopeniaor Neutropenia -- Role of Granulocyte Growth Factors (GCSF and GM-CSF) for Neutropenia -- Prophylactic Antibiotics in Neutropenic Patients -- Prognostic Value of Thrombocytopneia -- Thrombopoietin Mimetics -- Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) -- Chronic Myelomonocytic Leukemia (CMML) -- Iron Overload -- Immunosuppression -- Anti-Thymocyte Globulin (ATG) Single Agent -- Cyclosporine Single Agent -- Combination of ATG and Cyclosporine -- Summary -- Conclusion -- References -- Treatment of Higher-Risk Myelodysplastic Syndromes -- Abstract -- Introduction -- Risk Stratification -- Lower-Risk MDS that are Treated Similar to Higher-Risk Disease -- Higher-Risk MDS -- Evaluation of Response in Patients with MDS: The IWG Response Criteria -- DNA Hypomethylating Agents -- Azacitidine -- Decitabine -- Azacitidine Versus Decitabine -- Route, Scheduling, Dosing and Duration of Treatment -- Toxicities and Adverse Events -- Sequential Treatment with Hypomethylating Agents -- Hypomethylating Agents in Low Risk MDS -- Hypomethylating Agents in Poor-Risk Cytogenetics -- TET-2 Mutations and Response to Hypomethylating Agents -- Hypomethylating Agents in the Elderly -- Resistance to Hypomethylating Agents -- Outcomes after Failure of Hypomethylating Agents -- High Intensity (Induction) Chemotherapy. Hematopoietic Stem Cell Transplantation (HSCT). |
Record Nr. | UNINA-9910810020703321 |
New York, : Nova Science Publishers, 2013 | ||
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Lo trovi qui: Univ. Federico II | ||
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Novel insights into pathophysiology, diagnostics and treatment of myelodysplastic syndromes / / editors, Rainer Haas, Ulrich Germing |
Pubbl/distr/stampa | London, England : , : Future Medicine Ltd, , 2014 |
Descrizione fisica | 1 online resource (128 pages) : color illustrations, graphs |
Disciplina | 616.41 |
Collana | Future Medicine |
Soggetto topico | Myelodysplastic syndromes |
Soggetto genere / forma | Electronic books. |
ISBN |
1-78084-433-6
1-78084-432-8 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910467835203321 |
London, England : , : Future Medicine Ltd, , 2014 | ||
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Lo trovi qui: Univ. Federico II | ||
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Novel insights into pathophysiology, diagnostics and treatment of myelodysplastic syndromes / / editors, Rainer Haas, Ulrich Germing |
Pubbl/distr/stampa | London, England : , : Future Medicine Ltd, , 2014 |
Descrizione fisica | 1 online resource (128 pages) : color illustrations, graphs |
Disciplina | 616.41 |
Collana | Future Medicine |
Soggetto topico | Myelodysplastic syndromes |
ISBN |
1-78084-433-6
1-78084-432-8 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910794876003321 |
London, England : , : Future Medicine Ltd, , 2014 | ||
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Lo trovi qui: Univ. Federico II | ||
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Novel insights into pathophysiology, diagnostics and treatment of myelodysplastic syndromes / / editors, Rainer Haas, Ulrich Germing |
Pubbl/distr/stampa | London, England : , : Future Medicine Ltd, , 2014 |
Descrizione fisica | 1 online resource (128 pages) : color illustrations, graphs |
Disciplina | 616.41 |
Collana | Future Medicine |
Soggetto topico | Myelodysplastic syndromes |
ISBN |
1-78084-433-6
1-78084-432-8 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910818390303321 |
London, England : , : Future Medicine Ltd, , 2014 | ||
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Lo trovi qui: Univ. Federico II | ||
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