Synthetic multivalent molecules [[electronic resource] ] : concepts and biomedical applications / / Seok-ki Choi |
Autore | Choi Seok-ki <1964-> |
Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2004 |
Descrizione fisica | 1 online resource (446 p.) |
Disciplina |
615.31
615/.31 |
Soggetto topico |
Multivalent molecules - Synthesis
Multivalent molecules - Design Multivalent molecules - Physiological effect |
Soggetto genere / forma | Electronic books. |
ISBN |
1-280-54191-1
9786610541911 0-471-57770-7 0-471-57890-8 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
SYNTHETIC MULTIVALENT MOLECULES; CONTENTS; Preface; Notes for Organization and Classification; Abbreviations; 1 Introduction; 1.1 Nomenclature and Definitions; 1.1.1 Valency; 1.1.2 Linkers; 1.1.3 Scaffolds; 1.1.4 Ligand Density; 1.1.5 Homo- and Heterovalent Molecules; 1.2 Mechanistic Aspects of Multivalent Interaction; 1.2.1 Affinity Constant and Avidity; 1.2.2 Thermodynamics; 1.2.3 Kinetics; 1.2.4 Steric Effects; 1.3 Biological Roles of Multivalent Ligands; 2 Multivalent Molecules Applied to Viral Targets; 2.1 Influenza Virus; 2.1.1 Hemagglutinin; 2.1.1.1 Divalent Sialic Acid
2.1.1.2 Tetravalent Sialoside2.1.1.3 Dendrimers Presenting Sialosides; 2.1.1.4 Sialic Acid Displayed in Liposomes; 2.1.1.5 Polymerized Liposome Presenting Sialic Acid; 2.1.1.6 Sialic Acid in Langmuir-Blodget Monolayers; 2.1.1.7 Sialic Acid Presented on Biopolymer Surfaces; 2.1.1.8 Poly(acrylamide) Presenting Sialosides; 2.1.1.9 Poly(acrylic acid) Presenting Sialosides; 2.1.1.10 Poly(acrylamide) Presenting C-Sialosides; 2.1.1.11 Postmodification of Activated Polymers; 2.1.1.12 Modes of Action of Polymeric Sialosides; 2.1.1.13 OPTCOL Assay; 2.1.1.14 ter-Poly(acrylic acid) Presenting Sialosides 2.1.1.15 Poly(glutamic acid) Presenting Lysogangliosides2.1.1.16 Poly(glutamic acid) Bearing Sialic Acid-Containing Trisaccharides; 2.1.1.17 Poly(acrylamide) Bearing Sialic Acid Linked at the C(4) Position; 2.1.1.18 Poly(acrylamide) Tethering 9-O-Acetylsialosides; 2.1.1.19 Neoglycoprotein Displaying Sialic Acids; 2.1.1.20 Natural b-Inhibitors; 2.1.2 Neuraminidase; 2.1.2.1 Poly(glutamic acid) Presenting NA Inhibitors; 2.2 Human Immunodeficiency Virus; 2.2.1 HIV-1 Protease; 2.2.1.1 Divalent Terminal Peptides; 2.2.2 HIV-1 Reverse Transcriptase; 2.2.2.1 Heterodimers Composed of NRTI and NNRTI 2.2.3 Glycoprotein 120 (gp120) on Viral Surfaces2.2.3.1 Neoglycoprotein-Displaying CD4 Peptide; 2.2.3.2 Galactosyl Ceramide Immobilized on Viral Surfaces; 2.2.3.3 Multivalent Anions; 2.2.3.4 Bivalent Antagonists of CXCR4; 2.2.4 Surface Carbohydrates on HIV; 2.2.4.1 Oligomannose Sugars Present on gp120; 2.2.4.2 Modes of CVN Recognition; 2.3 Rotavirus; 2.4 Polyoma Virus; 2.5 Picorna Virus; 2.6 Respiratory Syncytial Virus; 2.7 Dengue Virus; 2.8 Nucleic Acids of Viruses; 2.8.1 RNA-Protein Interactions; 2.8.1.1 Neomycin B Linked to Acridine; 2.8.1.2 Neamine Linked to Pyrene-Carboxylic Acid 2.8.2 RNA-Enzyme Interactions2.8.3 Binders to the Minor Groove of Viral DNA; 2.8.3.1 Hairpin-Shaped Polyamide Dimers; 2.8.3.2 H-Shaped Polyamide Dimers; 2.8.3.3 Naturally Occurring Dimers; 2.9 Synthetic Multivalent Vaccines; 2.9.1 Peptide-Based Anti-influenza Vaccines; 2.9.2 Gp41-Based Anti-HIV Vaccine; 2.9.3 Peptide-Based Anti-FMDV Vaccines; 3 Multivalent Molecules Applied to Bacterial Targets; 3.1 Targets in Bacterial Cell Membranes; 3.1.1 D-Ala-D-Ala Peptide Precursors; 3.1.1.1 Mode of Action by Antibiotics of the Vancomycin Class; 3.1.1.2 Dimerization of Glycopeptide Antibiotics 3.1.1.3 Di- and Trivalent Vancomycin |
Record Nr. | UNINA-9910146077703321 |
Choi Seok-ki <1964->
![]() |
||
Hoboken, N.J., : Wiley, c2004 | ||
![]() | ||
Lo trovi qui: Univ. Federico II | ||
|
Synthetic multivalent molecules [[electronic resource] ] : concepts and biomedical applications / / Seok-ki Choi |
Autore | Choi Seok-ki <1964-> |
Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2004 |
Descrizione fisica | 1 online resource (446 p.) |
Disciplina |
615.31
615/.31 |
Soggetto topico |
Multivalent molecules - Synthesis
Multivalent molecules - Design Multivalent molecules - Physiological effect |
ISBN |
1-280-54191-1
9786610541911 0-471-57770-7 0-471-57890-8 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
SYNTHETIC MULTIVALENT MOLECULES; CONTENTS; Preface; Notes for Organization and Classification; Abbreviations; 1 Introduction; 1.1 Nomenclature and Definitions; 1.1.1 Valency; 1.1.2 Linkers; 1.1.3 Scaffolds; 1.1.4 Ligand Density; 1.1.5 Homo- and Heterovalent Molecules; 1.2 Mechanistic Aspects of Multivalent Interaction; 1.2.1 Affinity Constant and Avidity; 1.2.2 Thermodynamics; 1.2.3 Kinetics; 1.2.4 Steric Effects; 1.3 Biological Roles of Multivalent Ligands; 2 Multivalent Molecules Applied to Viral Targets; 2.1 Influenza Virus; 2.1.1 Hemagglutinin; 2.1.1.1 Divalent Sialic Acid
2.1.1.2 Tetravalent Sialoside2.1.1.3 Dendrimers Presenting Sialosides; 2.1.1.4 Sialic Acid Displayed in Liposomes; 2.1.1.5 Polymerized Liposome Presenting Sialic Acid; 2.1.1.6 Sialic Acid in Langmuir-Blodget Monolayers; 2.1.1.7 Sialic Acid Presented on Biopolymer Surfaces; 2.1.1.8 Poly(acrylamide) Presenting Sialosides; 2.1.1.9 Poly(acrylic acid) Presenting Sialosides; 2.1.1.10 Poly(acrylamide) Presenting C-Sialosides; 2.1.1.11 Postmodification of Activated Polymers; 2.1.1.12 Modes of Action of Polymeric Sialosides; 2.1.1.13 OPTCOL Assay; 2.1.1.14 ter-Poly(acrylic acid) Presenting Sialosides 2.1.1.15 Poly(glutamic acid) Presenting Lysogangliosides2.1.1.16 Poly(glutamic acid) Bearing Sialic Acid-Containing Trisaccharides; 2.1.1.17 Poly(acrylamide) Bearing Sialic Acid Linked at the C(4) Position; 2.1.1.18 Poly(acrylamide) Tethering 9-O-Acetylsialosides; 2.1.1.19 Neoglycoprotein Displaying Sialic Acids; 2.1.1.20 Natural b-Inhibitors; 2.1.2 Neuraminidase; 2.1.2.1 Poly(glutamic acid) Presenting NA Inhibitors; 2.2 Human Immunodeficiency Virus; 2.2.1 HIV-1 Protease; 2.2.1.1 Divalent Terminal Peptides; 2.2.2 HIV-1 Reverse Transcriptase; 2.2.2.1 Heterodimers Composed of NRTI and NNRTI 2.2.3 Glycoprotein 120 (gp120) on Viral Surfaces2.2.3.1 Neoglycoprotein-Displaying CD4 Peptide; 2.2.3.2 Galactosyl Ceramide Immobilized on Viral Surfaces; 2.2.3.3 Multivalent Anions; 2.2.3.4 Bivalent Antagonists of CXCR4; 2.2.4 Surface Carbohydrates on HIV; 2.2.4.1 Oligomannose Sugars Present on gp120; 2.2.4.2 Modes of CVN Recognition; 2.3 Rotavirus; 2.4 Polyoma Virus; 2.5 Picorna Virus; 2.6 Respiratory Syncytial Virus; 2.7 Dengue Virus; 2.8 Nucleic Acids of Viruses; 2.8.1 RNA-Protein Interactions; 2.8.1.1 Neomycin B Linked to Acridine; 2.8.1.2 Neamine Linked to Pyrene-Carboxylic Acid 2.8.2 RNA-Enzyme Interactions2.8.3 Binders to the Minor Groove of Viral DNA; 2.8.3.1 Hairpin-Shaped Polyamide Dimers; 2.8.3.2 H-Shaped Polyamide Dimers; 2.8.3.3 Naturally Occurring Dimers; 2.9 Synthetic Multivalent Vaccines; 2.9.1 Peptide-Based Anti-influenza Vaccines; 2.9.2 Gp41-Based Anti-HIV Vaccine; 2.9.3 Peptide-Based Anti-FMDV Vaccines; 3 Multivalent Molecules Applied to Bacterial Targets; 3.1 Targets in Bacterial Cell Membranes; 3.1.1 D-Ala-D-Ala Peptide Precursors; 3.1.1.1 Mode of Action by Antibiotics of the Vancomycin Class; 3.1.1.2 Dimerization of Glycopeptide Antibiotics 3.1.1.3 Di- and Trivalent Vancomycin |
Record Nr. | UNINA-9910830426003321 |
Choi Seok-ki <1964->
![]() |
||
Hoboken, N.J., : Wiley, c2004 | ||
![]() | ||
Lo trovi qui: Univ. Federico II | ||
|
Synthetic multivalent molecules : concepts and biomedical applications / / Seok-ki Choi |
Autore | Choi Seok-ki <1964-> |
Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2004 |
Descrizione fisica | 1 online resource (446 p.) |
Disciplina | 615/.31 |
Soggetto topico |
Multivalent molecules - Synthesis
Multivalent molecules - Design Multivalent molecules - Physiological effect |
ISBN |
1-280-54191-1
9786610541911 0-471-57770-7 0-471-57890-8 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
SYNTHETIC MULTIVALENT MOLECULES; CONTENTS; Preface; Notes for Organization and Classification; Abbreviations; 1 Introduction; 1.1 Nomenclature and Definitions; 1.1.1 Valency; 1.1.2 Linkers; 1.1.3 Scaffolds; 1.1.4 Ligand Density; 1.1.5 Homo- and Heterovalent Molecules; 1.2 Mechanistic Aspects of Multivalent Interaction; 1.2.1 Affinity Constant and Avidity; 1.2.2 Thermodynamics; 1.2.3 Kinetics; 1.2.4 Steric Effects; 1.3 Biological Roles of Multivalent Ligands; 2 Multivalent Molecules Applied to Viral Targets; 2.1 Influenza Virus; 2.1.1 Hemagglutinin; 2.1.1.1 Divalent Sialic Acid
2.1.1.2 Tetravalent Sialoside2.1.1.3 Dendrimers Presenting Sialosides; 2.1.1.4 Sialic Acid Displayed in Liposomes; 2.1.1.5 Polymerized Liposome Presenting Sialic Acid; 2.1.1.6 Sialic Acid in Langmuir-Blodget Monolayers; 2.1.1.7 Sialic Acid Presented on Biopolymer Surfaces; 2.1.1.8 Poly(acrylamide) Presenting Sialosides; 2.1.1.9 Poly(acrylic acid) Presenting Sialosides; 2.1.1.10 Poly(acrylamide) Presenting C-Sialosides; 2.1.1.11 Postmodification of Activated Polymers; 2.1.1.12 Modes of Action of Polymeric Sialosides; 2.1.1.13 OPTCOL Assay; 2.1.1.14 ter-Poly(acrylic acid) Presenting Sialosides 2.1.1.15 Poly(glutamic acid) Presenting Lysogangliosides2.1.1.16 Poly(glutamic acid) Bearing Sialic Acid-Containing Trisaccharides; 2.1.1.17 Poly(acrylamide) Bearing Sialic Acid Linked at the C(4) Position; 2.1.1.18 Poly(acrylamide) Tethering 9-O-Acetylsialosides; 2.1.1.19 Neoglycoprotein Displaying Sialic Acids; 2.1.1.20 Natural b-Inhibitors; 2.1.2 Neuraminidase; 2.1.2.1 Poly(glutamic acid) Presenting NA Inhibitors; 2.2 Human Immunodeficiency Virus; 2.2.1 HIV-1 Protease; 2.2.1.1 Divalent Terminal Peptides; 2.2.2 HIV-1 Reverse Transcriptase; 2.2.2.1 Heterodimers Composed of NRTI and NNRTI 2.2.3 Glycoprotein 120 (gp120) on Viral Surfaces2.2.3.1 Neoglycoprotein-Displaying CD4 Peptide; 2.2.3.2 Galactosyl Ceramide Immobilized on Viral Surfaces; 2.2.3.3 Multivalent Anions; 2.2.3.4 Bivalent Antagonists of CXCR4; 2.2.4 Surface Carbohydrates on HIV; 2.2.4.1 Oligomannose Sugars Present on gp120; 2.2.4.2 Modes of CVN Recognition; 2.3 Rotavirus; 2.4 Polyoma Virus; 2.5 Picorna Virus; 2.6 Respiratory Syncytial Virus; 2.7 Dengue Virus; 2.8 Nucleic Acids of Viruses; 2.8.1 RNA-Protein Interactions; 2.8.1.1 Neomycin B Linked to Acridine; 2.8.1.2 Neamine Linked to Pyrene-Carboxylic Acid 2.8.2 RNA-Enzyme Interactions2.8.3 Binders to the Minor Groove of Viral DNA; 2.8.3.1 Hairpin-Shaped Polyamide Dimers; 2.8.3.2 H-Shaped Polyamide Dimers; 2.8.3.3 Naturally Occurring Dimers; 2.9 Synthetic Multivalent Vaccines; 2.9.1 Peptide-Based Anti-influenza Vaccines; 2.9.2 Gp41-Based Anti-HIV Vaccine; 2.9.3 Peptide-Based Anti-FMDV Vaccines; 3 Multivalent Molecules Applied to Bacterial Targets; 3.1 Targets in Bacterial Cell Membranes; 3.1.1 D-Ala-D-Ala Peptide Precursors; 3.1.1.1 Mode of Action by Antibiotics of the Vancomycin Class; 3.1.1.2 Dimerization of Glycopeptide Antibiotics 3.1.1.3 Di- and Trivalent Vancomycin |
Record Nr. | UNINA-9910877175003321 |
Choi Seok-ki <1964->
![]() |
||
Hoboken, N.J., : Wiley, c2004 | ||
![]() | ||
Lo trovi qui: Univ. Federico II | ||
|