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Cellular signal transduction in toxicology and pharmacology : data collection, analysis, and interpretation / / edited by Jonathan W. Boyd (West Virginia University, Morgantown, WV, US), Richard R. Neubig (Michigan State University, MI, US)
| Cellular signal transduction in toxicology and pharmacology : data collection, analysis, and interpretation / / edited by Jonathan W. Boyd (West Virginia University, Morgantown, WV, US), Richard R. Neubig (Michigan State University, MI, US) |
| Autore | Boyd Jonathan |
| Edizione | [1st edition] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , [2019] |
| Descrizione fisica | 1 online resource (333 pages) |
| Disciplina | 571.74 |
| Soggetto topico |
Cellular signal transduction
Molecular toxicology Molecular pharmacology |
| ISBN |
1-119-06025-7
1-119-06016-8 1-119-06020-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910554806403321 |
Boyd Jonathan
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| Hoboken, New Jersey : , : Wiley, , [2019] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cellular signal transduction in toxicology and pharmacology : data collection, analysis, and interpretation / / edited by Jonathan W. Boyd (West Virginia University, Morgantown, WV, US), Richard R. Neubig (Michigan State University, MI, US)
| Cellular signal transduction in toxicology and pharmacology : data collection, analysis, and interpretation / / edited by Jonathan W. Boyd (West Virginia University, Morgantown, WV, US), Richard R. Neubig (Michigan State University, MI, US) |
| Autore | Boyd Jonathan |
| Edizione | [1st edition] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , [2019] |
| Descrizione fisica | 1 online resource (333 pages) |
| Disciplina | 571.74 |
| Soggetto topico |
Cellular signal transduction
Molecular toxicology Molecular pharmacology |
| ISBN |
1-119-06025-7
1-119-06016-8 1-119-06020-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910830367903321 |
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Boyd Jonathan
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| Hoboken, New Jersey : , : Wiley, , [2019] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
G protein-coupled receptors [[electronic resource] ] : molecular pharmacology from academic concept to pharmaceutical research / / Georges Vauquelin, Bengt von Mentzer
| G protein-coupled receptors [[electronic resource] ] : molecular pharmacology from academic concept to pharmaceutical research / / Georges Vauquelin, Bengt von Mentzer |
| Autore | Vauquelin Georges |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2007 |
| Descrizione fisica | 1 online resource (266 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) | MentzerBengt von |
| Soggetto topico |
G proteins - Receptors
Molecular pharmacology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-34870-1
9786612348709 0-470-51665-8 0-470-51664-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chemical messengers and the cell membrane -- Radioligand binding studies -- Functional studies -- G protein-coupled receptors -- Concluding remarks. |
| Record Nr. | UNINA-9910144735803321 |
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Vauquelin Georges
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||
| Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
G protein-coupled receptors [[electronic resource] ] : molecular pharmacology from academic concept to pharmaceutical research / / Georges Vauquelin, Bengt von Mentzer
| G protein-coupled receptors [[electronic resource] ] : molecular pharmacology from academic concept to pharmaceutical research / / Georges Vauquelin, Bengt von Mentzer |
| Autore | Vauquelin Georges |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2007 |
| Descrizione fisica | 1 online resource (266 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) | MentzerBengt von |
| Soggetto topico |
G proteins - Receptors
Molecular pharmacology |
| ISBN |
1-282-34870-1
9786612348709 0-470-51665-8 0-470-51664-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chemical messengers and the cell membrane -- Radioligand binding studies -- Functional studies -- G protein-coupled receptors -- Concluding remarks. |
| Record Nr. | UNINA-9910830463003321 |
|
Vauquelin Georges
|
||
| Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
G protein-coupled receptors : molecular pharmacology from academic concept to pharmaceutical research / / Georges Vauquelin, Bengt von Mentzer
| G protein-coupled receptors : molecular pharmacology from academic concept to pharmaceutical research / / Georges Vauquelin, Bengt von Mentzer |
| Autore | Vauquelin Georges |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2007 |
| Descrizione fisica | 1 online resource (266 p.) |
| Disciplina | 615/.1 |
| Altri autori (Persone) | MentzerBengt von |
| Soggetto topico |
G proteins - Receptors
Molecular pharmacology |
| ISBN |
1-282-34870-1
9786612348709 0-470-51665-8 0-470-51664-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chemical messengers and the cell membrane -- Radioligand binding studies -- Functional studies -- G protein-coupled receptors -- Concluding remarks. |
| Record Nr. | UNINA-9910877188803321 |
|
Vauquelin Georges
|
||
| Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of molecular descriptors [[electronic resource] /] / edited by Roberto Todeschini and Vivianna Consonni
| Handbook of molecular descriptors [[electronic resource] /] / edited by Roberto Todeschini and Vivianna Consonni |
| Pubbl/distr/stampa | Weinheim ; ; Chichester, : Wiley-VCH, 2000 |
| Descrizione fisica | 1 online resource (691 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) |
ConsonniViviana
TodeschiniRoberto |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drugs - Design
Drug development Molecular pharmacology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-76406-X
9786611764067 3-527-61310-2 3-527-61311-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Handbook of Molecular Descriptors; Contents; Introduction; User's Guide; Notations and Symbols; Acronyms; A - Z; Greek Alphabet Entries; Numerical Entries; Appendix A. Greek Alphabet; Appendix B. Symbols of Molecular Descriptors; Appendix C. Software; References |
| Record Nr. | UNINA-9910144132903321 |
| Weinheim ; ; Chichester, : Wiley-VCH, 2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of molecular descriptors [[electronic resource] /] / edited by Roberto Todeschini and Vivianna Consonni
| Handbook of molecular descriptors [[electronic resource] /] / edited by Roberto Todeschini and Vivianna Consonni |
| Pubbl/distr/stampa | Weinheim ; ; Chichester, : Wiley-VCH, 2000 |
| Descrizione fisica | 1 online resource (691 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) |
ConsonniViviana
TodeschiniRoberto |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drugs - Design
Drug development Molecular pharmacology |
| ISBN |
1-281-76406-X
9786611764067 3-527-61310-2 3-527-61311-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Handbook of Molecular Descriptors; Contents; Introduction; User's Guide; Notations and Symbols; Acronyms; A - Z; Greek Alphabet Entries; Numerical Entries; Appendix A. Greek Alphabet; Appendix B. Symbols of Molecular Descriptors; Appendix C. Software; References |
| Record Nr. | UNINA-9910830797203321 |
| Weinheim ; ; Chichester, : Wiley-VCH, 2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of molecular descriptors / / edited by Roberto Todeschini and Vivianna Consonni
| Handbook of molecular descriptors / / edited by Roberto Todeschini and Vivianna Consonni |
| Pubbl/distr/stampa | Weinheim ; ; Chichester, : Wiley-VCH, 2000 |
| Descrizione fisica | 1 online resource (691 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) |
ConsonniViviana
TodeschiniRoberto |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drugs - Design
Drug development Molecular pharmacology |
| ISBN |
1-281-76406-X
9786611764067 3-527-61310-2 3-527-61311-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Handbook of Molecular Descriptors; Contents; Introduction; User's Guide; Notations and Symbols; Acronyms; A - Z; Greek Alphabet Entries; Numerical Entries; Appendix A. Greek Alphabet; Appendix B. Symbols of Molecular Descriptors; Appendix C. Software; References |
| Record Nr. | UNINA-9910877578803321 |
| Weinheim ; ; Chichester, : Wiley-VCH, 2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The molecular aspect of natural secondary metabolite products in health and disease / / edited by Toshio Morikawa
| The molecular aspect of natural secondary metabolite products in health and disease / / edited by Toshio Morikawa |
| Pubbl/distr/stampa | Basel, Switzerland : , : MDPI - Multidisciplinary Digital Publishing Institute, , [2018] |
| Descrizione fisica | 1 online resource (226 pages) : illustrations |
| Disciplina | 615.7 |
| Soggetto topico | Molecular pharmacology |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910598168503321 |
| Basel, Switzerland : , : MDPI - Multidisciplinary Digital Publishing Institute, , [2018] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Molecular biology in medicinal chemistry [[electronic resource] /] / edited by Th. Dingermann, D. Steinhilber and G. Folkers
| Molecular biology in medicinal chemistry [[electronic resource] /] / edited by Th. Dingermann, D. Steinhilber and G. Folkers |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, 2004 |
| Descrizione fisica | 1 online resource (437 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) |
DingermannTheodor
FolkersGerd SteinhilberDieter <1959-> |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Chiral drugs
Genomics Molecular biology Molecular pharmacology Pharmacogenomics |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-52027-2
9786610520275 3-527-60518-5 3-527-60266-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Molecular Biology in Medicinal Chemistry; Contents; Preface; Foreword; Contributors; Part I Molecular Targets; 1 Cellular Assays in Drug Discovery; 1.1 Introduction; 1.1.1 Positioning Cellular Assays; 1.1.2 Impact on Drug Discovery; 1.1.3 Classification of Cellular Assays; 1.1.4 Progress in Tools and Technologies for Cellular Compound Profiling; 1.2 Membrane Proteins and Fast Cellular Responses; 1.2.1 Receptors; 1.2.1.1 FLIPR Technology for Detection of Intracellular Calcium Release; 1.2.1.2 Competitive Immunoassay for Detection of Intracellular cAMP
1.2.1.3 Enzyme Fragment Complementation (EFC) Technology1.2.2 Membrane Transport Proteins; 1.2.2.1 Ion Channels; 1.2.2.2 MDR Proteins; 1.3 Gene and Protein Expression Profiling in High-throughput Formats; 1.3.1 Reporter Gene Assays in Lead Finding; 1.3.2 Reporter Gene Assays in Lead Optimization; 1.4 Spatio-temporal Assays and Subpopulation Analysis; 1.4.1 Phosphorylation Stage-specific Antibodies; 1.4.2 Target-protein-specific Antibodies; 1.4.3 Protein-GFP Fusions; 1.4.4 Fluorescence Resonance Energy Transfer (FRET) 1.4.5 GPCR Activation using Bioluminescence Resonance Energy Transfer (BRET)1.4.6 Protein Fragment Complementation Assays (PCA); 1.5 Phenotypic Assays; 1.5.1 Proliferation/Respiration/Toxicity; 1.5.2 Apoptosis; 1.5.3 Differentiation; 1.5.4 Monitoring Cell Metabolism; 1.5.5 Other Phenotypic Assays; Acknowledgments; References; 2 Gene Knockout Models; 2.1 Introduction; 2.2 Gene Knockout Mice; 2.2.1 ES Cells; 2.2.2 Targeting Vector; 2.2.3 Selection of Recombinant ES Cells; 2.2.4 Injection of Recombinant ES Cells into Blastocysts and Blastocyst Transfer to Pseudopregnant Recipients 2.2.5 Chimeras and F1 and F2 Offspring2.3 Tissue-Specific Gene Expression; 2.3.1 Ligand-Activated CRE Recombinases; 2.3.2 The Tetracycline/Doxycycline-Inducible Expression System; 2.4 Transgenic Mice; 2.5 Targeted Gene Disruption in Drosophila; 2.6 Targeted Gene Knockdown in Zebrafish; 2.7 Targeted Caenorhabditis Elegans Deletion Strains; References; 3 Reporter Gene Assay Systems for the Investigation of G-protein-coupled Receptors; 3.1 Receptors and Cellular Communication; 3.1.1 Ion Channel-linked Receptors; 3.1.2 Enzyme-linked Cell-surface Receptors; 3.1.3 GPCRs 3.2 Affinity and Activity of GPCR Ligands3.3 The Role of Transcription Factors in Gene Expression; 3.3.1 CREB; 3.3.2 SRF; 3.3.3 STAT Proteins; 3.3.4 c-Jun; 3.3.5 NF-AT; 3.4 Reporter Genes; 3.4.1 CAT; 3.4.2 β-Gal; 3.4.3 β-Glucuronidase; 3.4.4 AP; 3.4.5 SEAP; 3.4.6 β-Lactamase; 3.4.7 Luciferase; 3.4.8 GFP; 3.5 Reporter Gene Assay Systems for the Investigation of GPCRs; 3.5.1 Application of Luciferase as a Reporter Gene; 3.5.2 Application of other Reporter Genes for the Investigation of GPCRs; References; 4 From the Human Genome to New Drugs: The Potential of Orphan G-protein-coupled Receptors 4.1 Introduction |
| Record Nr. | UNINA-9910146243903321 |
| Weinheim, : Wiley-VCH, 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Molecular pharmacology
(30)
- Drug development (9)
- Drugs - Design (9)
- Chiral drugs (5)
- Bioorganic chemistry (3)