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Advances in cell and molecular diagnostics / / Pongali Raghavendra, Thammineni Pullaiah
| Advances in cell and molecular diagnostics / / Pongali Raghavendra, Thammineni Pullaiah |
| Autore | Raghavendra Pongali |
| Pubbl/distr/stampa | London, England : , : Academic Press, , 2018 |
| Descrizione fisica | 1 online resource (283 pages) : illustrations |
| Disciplina | 616.0756 |
| Soggetto topico |
Molecular diagnosis
Cells - Diagnostic use Pathology, Molecular |
| ISBN | 0-12-813680-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chapter 1. Cellular and Molecular Diagnostics: An Introduction -- Chapter 2. RNA-Based Applications in Diagnostic and Therapeutics for Cancer -- Chapter 3. Advancements in Genetic Applications for Cellular and Molecular Diagnostics -- Chapter 4. Biomedical Imaging Role in Cellular and Molecular Diagnostics -- Chapter 5. Breast Cancer-Targeted Therapy Using Nanocarriers -- Chapter 6. Human Papillomavirus- and Epstein- Barr Virus-Caused Tumor Diagnosis and Therapy -- Chapter 7. Pathogen Identification Using Novel Sequencing Methods -- Chapter 8. Future of Cellular and Molecular Diagnostics: Bench to Bedside. |
| Record Nr. | UNINA-9910583052103321 |
Raghavendra Pongali
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| London, England : , : Academic Press, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Applied immunohistochemistry & molecular morphology : AIMM / / official publication of the Society for Applied Immunohistochemistry
| Applied immunohistochemistry & molecular morphology : AIMM / / official publication of the Society for Applied Immunohistochemistry |
| Pubbl/distr/stampa | [Philadelphia, PA], : Lippincott Williams & Wilkins |
| Disciplina | 571 |
| Soggetto topico |
Diagnostic immunohistochemistry
Immunohistochemistry Cells - Morphology Molecular diagnosis Cells - ultrastructure Cytological Techniques |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 1533-4058 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
AIMM
Applied immunohistochemistry and molecular morphology |
| Record Nr. | UNINA-9910763986803321 |
| [Philadelphia, PA], : Lippincott Williams & Wilkins | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Biomolecular diagnostics news
| Biomolecular diagnostics news |
| Pubbl/distr/stampa | Norwalk, CT, : Business Communications Co., c2003- |
| Descrizione fisica | 1 online resource |
| Disciplina | 660 |
| Soggetto topico | Molecular diagnosis |
| Soggetto genere / forma | Periodicals. |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996207885903316 |
| Norwalk, CT, : Business Communications Co., c2003- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Clinical molecular diagnostics / / Shiyang Pan, Jinhai Tang, editors
| Clinical molecular diagnostics / / Shiyang Pan, Jinhai Tang, editors |
| Pubbl/distr/stampa | Gateway East, Singapore : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (888 pages) |
| Disciplina | 616.0756 |
| Soggetto topico |
Molecular diagnosis
Diagnòstic molecular |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 981-16-1037-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Foreword -- Coordinators -- Preface -- Acknowledgments -- Contents -- About the Editors and Contributors -- About the Editors -- Editorial Board -- Contributors -- Part I: Principles of Clinical Molecular Diagnostics -- 1: Molecules of Disease and Their Detection Methods -- 1.1 Overview -- 1.2 Molecular Mechanism of Diseases -- 1.3 Nucleic Acid Detection Methods -- 1.3.1 Nucleic Acid Amplification Technology -- 1.3.2 Sequencing Technology -- 1.3.3 Nucleic Acid Hybridization Technology -- 1.3.4 Chip Technology -- 1.3.5 Biosensing Technology -- 1.4 Protein Detection Methods -- 1.4.1 Spectrum Technology -- 1.4.2 Protein Chip Technology -- 1.4.3 Labeled Immunoassay -- 1.4.4 Mass Spectrometric Technique -- 1.5 Future Trends -- References -- 2: Assay Performance Evaluation -- 2.1 Precision -- 2.1.1 Terminology and Definitions -- 2.1.2 Overview of the Precision Evaluation Process (Fig. 2.1) -- 2.1.3 Features of the EP5-A2 Program -- 2.1.4 EP5-A2 Experimental Protocol and Requirements -- 2.1.4.1 Experimental Preparation -- Experimental Sample -- 2.1.4.2 Experimental Method -- 2.1.4.3 Quality Control -- 2.1.5 Data Collection, Processing, and Statistical Analysis -- 2.1.5.1 Experimental Data Record -- 2.1.5.2 Outlier Test -- 2.1.5.3 Repeatability Estimate -- 2.2 Accuracy -- 2.2.1 Definitions -- 2.2.2 Features of the EP9-A2 Program -- 2.2.3 EP9-A2 Experimental Protocol and Requirements -- 2.2.3.1 Experimental Preparation -- Sample Preparation -- Comparison Method Selection -- 2.2.3.2 Experimental Method -- 2.2.3.3 Quality Control -- 2.2.4 Simple Accuracy Evaluation Plan -- 2.2.4.1 Comparison of Patient Sample Results to Those of Another Procedure -- 2.2.4.2 Method of Setting Reference Materials -- Sources of Reference Materials -- Procedure for Demonstration of Accuracy with Reference Materials.
2.3 Sensitivity -- 2.3.1 Definitions -- 2.3.2 Discussion of Several Common Terms -- 2.3.3 Lower Limit of Linear Range (LLR), Biological Limit of Detection (BLD), and Functional Sensitivity (FS) -- 2.3.3.1 Lower Limit of Linear Range (LLR) -- 2.3.3.2 Biological Limit of Detection (BLD) -- 2.3.3.3 Functional Sensitivity (FS) -- 2.3.3.4 Experimental Precautions -- Blank Sample -- Detection Limit Sample -- Time Required for the Experiment -- 2.3.4 Limits of Blank, Limits of Detection, and Limits of Quantitation -- 2.3.4.1 Overview -- 2.3.4.2 General Method for Determining the Limits of Blank (LoB) -- 2.4 Analytical Measurement Range -- 2.4.1 Definitions -- 2.4.2 EP6-A Protocol and Requirements -- 2.4.2.1 Experimental Requirements -- Device Familiarization Period -- Duration of the Experiment -- Specimen of the Experiment -- Number of Samples -- Matrix Effects -- Selection of Materials Used to Supplement Samples -- Analyte Range -- Sample Preparation and Value Assignment -- 2.4.2.2 Analytical Sequence -- 2.4.2.3 Preliminary Data Check -- Outlier Inspection -- Determination of the Linear Range -- Degree of Nonlinearity -- Considerations for Random Error -- 2.5 Variation Factors of Pre-analysis -- 2.5.1 Collection, Transport, and Preservation of Nucleic Acid Test Specimens -- 2.5.1.1 Preparation of Specimen Collection Site -- 2.5.1.2 Type and Collection of Specimens -- 2.5.1.3 Sampling and Transport Containers -- 2.5.1.4 Anti-pollution in Specimen Collection -- 2.5.1.5 Evaluation of Sampling Quality -- References -- 3: Establishment of Biological Reference Interval -- 3.1 Biological Reference -- 3.1.1 Definitions and Terms -- 3.1.2 Clarifications -- 3.2 Establishment of Biological Reference Interval -- 3.2.1 Protocol Outline for Obtaining Reference Values and Establishing Reference Intervals. 3.2.1.1 New Analyte or Analytical Method -- 3.2.1.2 Previously Measured Analyte -- 3.2.2 Selection of Reference Individuals -- 3.2.2.1 Exclusion Criteria -- 3.2.2.2 Partitioning Criteria -- 3.2.2.3 Selection of Reference Individuals -- 3.2.2.4 Sample Questionnaire -- 3.2.3 Pre-analytical and Analytical Considerations -- 3.2.4 Analysis of Reference Values -- 3.2.4.1 Minimum Number of Reference Values -- 3.2.4.2 Treatment of Outlying Observations -- 3.2.4.3 Partitioning of Reference Values -- 3.3 Verification of Biological Reference Interval -- 3.4 Description of Biological Reference Interval -- 3.4.1 Laboratory Presentation -- 3.4.2 Manufacturer Presentation -- References -- 4: Ethics: Informed Consent, Patient Privacy -- 4.1 Overview -- 4.2 Informed Consent -- 4.2.1 Challenges -- 4.2.2 Regulations and Recommendations -- 4.2.3 What Should Be Included in the Informed Consent? -- 4.3 Patient Privacy and Confidentiality -- 4.3.1 Challenges -- 4.3.2 Regulations and Recommendations -- 4.3.3 How to Protect Patient Privacy? -- 4.4 Conclusion -- References -- 5: Bioinformatics -- 5.1 Overview -- 5.1.1 Concept and Background -- 5.1.2 Research Categories -- 5.1.3 Common International Bioinformatics Centers -- 5.1.4 Common Bioinformatics Database -- 5.2 Biological Sequence Analysis -- 5.2.1 Sequence Analysis -- 5.2.2 Multiple Sequence Analysis -- 5.2.3 Molecular Polygenetic Tree -- 5.2.4 Comparative Genomics -- 5.3 Transcriptomics Data Analysis -- 5.3.1 Gene Expression Profile Analysis -- 5.3.2 Functional Enrichment Analysis -- 5.3.3 Timing Analysis -- 5.3.4 Gene Co-expression Network Analysis -- 5.3.5 Analysis of Transcriptional Regulation -- 5.4 Protein Structure Analysis -- 5.4.1 Protein Structure Prediction -- 5.4.2 Protein-Protein Interaction -- 5.4.3 Protein Function Prediction. 5.5 Bioinformatics and Precision Medicine -- 5.5.1 Bioinformatics and Precision Medical Diagnosis -- 5.5.1.1 Genetic Testing -- 5.5.1.2 Detection of Pathogenic Microorganisms -- 5.5.2 Bioinformatics and Precision Medical Prevention and Treatment -- 5.5.3 Bioinformatics and the Future of Precision Medicine -- References -- 6: Report and Consultation -- 6.1 Overview -- 6.2 Genetic Variation and Description -- 6.2.1 The Level of Sequence Variation -- 6.2.2 Content of the Variant Description -- 6.2.3 Types of Variant Sequences -- 6.2.4 Expression of Variant Types Specific Abbreviations Are Used to Describe Different Types of Sequence Variations -- 6.2.5 Reference Sequence -- 6.3 Naming Rules -- 6.3.1 Specific Rules for DNA Levels -- 6.3.2 Detailed Rules for RNA Levels -- 6.3.3 Detailed Rules of Protein Levels -- 6.3.3.1 Amino Acid Coding -- 6.3.3.2 Silent Changes -- 6.3.3.3 Substitutions, Missense Changes -- 6.3.3.4 Amino Acid Deletion -- 6.3.3.5 Frameshift Mutation -- 6.3.3.6 Amino Acid Insertion, Repeat -- 6.3.4 Gene Pharmacology Genotype Terminology -- 6.3.5 Other -- 6.4 Application of Gene Mutation in Disease Diagnosis -- 6.4.1 Genetic Variation and Genetic Diagnosis -- 6.4.2 Application of Genetic Variation Detection in Disease Diagnosis -- 6.4.2.1 Molecular Diagnosis of Mendelian Genetic Disease -- 6.4.2.2 Prenatal Diagnosis and Prenatal and Postnatal Care -- 6.4.2.3 Molecular Genetic Testing of Complex Diseases -- 6.4.2.4 Diagnosis and Treatment of Tumors -- 6.4.2.5 Detection of Pathogenic Microorganisms -- 6.5 What Is Involved Before the Clinical Report -- 6.5.1 Content Covered by the Clinical Report -- 6.5.1.1 The Test Report Should Include the Following -- 6.5.1.2 DNA Sequencing Reports and Explanations Should Include. 6.5.1.3 Reports and Interpretations of Whole-Exon or Whole-Genome Next-Generation Sequencing Should also Include the Following -- 6.5.2 Clinical Interpretation of the Data -- 6.5.3 Clinical Molecular Diagnostic Testing Process and Precautions -- 6.5.3.1 Clinical Molecular Diagnostic Testing Process -- 6.5.3.2 Precautions for Clinical Reports -- 6.6 Reporting Model and Case Analysis -- 6.6.1 Tumor Molecular Diagnosis Report -- 6.6.1.1 Introduction to Non-small Cell Lung Cancer -- 6.6.1.2 Methods and Test Items for Clinical Molecular Diagnosis of Non-small Cell Lung Cancer -- Source of NSCLC Target Molecule Detection Project -- Detection Method of NSCLC Target Molecule -- For Example -- 6.6.2 Molecular Diagnosis Report of Infectious Diseases -- 6.6.2.1 Introduction to Hepatitis B -- 6.6.2.2 Method and Test Item for Clinical Molecular Diagnosis of Hepatitis B Virus -- Project Source -- Detection Method -- For Example -- 6.6.3 Noninvasive Prenatal Screening Results Report -- 6.6.3.1 Introduction to Noninvasive Prenatal Screening -- 6.6.3.2 Noninvasive Prenatal Screening Method and Test Project for Clinical Molecular Diagnosis -- 6.6.3.3 High Throughput Sequencing -- For Example -- 6.6.4 Genetic Disease Diagnosis Report -- 6.6.4.1 Clinical Molecular Diagnosis of G6PD Deficiency -- Introduction to G6PD Deficiency -- Methods and Test Items for Clinical Molecular Diagnosis of G6PD Deficiency -- Source of G6PD Deficiency Molecular Testing Project -- For Example -- References -- 7: Factors Associated with Variation -- 7.1 The Concept -- 7.2 Sampling -- 7.2.1 Specimen Collection -- 7.2.1.1 Time of Collection -- 7.2.1.2 Method of Collection -- Body Position and Part in Blood Collection -- Cuff -- Infusion -- 7.2.1.3 Volume of Specimen -- 7.2.1.4 Precautions for Sample Collection -- Collect Representative Specimens. Proper Use of Anticoagulant. |
| Record Nr. | UNINA-9910491026203321 |
| Gateway East, Singapore : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Diagnostic techniques in genetics [[electronic resource] /] / edited by Jean-Louis Serre ; translated by Isabelle and Simon Heath
| Diagnostic techniques in genetics [[electronic resource] /] / edited by Jean-Louis Serre ; translated by Isabelle and Simon Heath |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : Wiley, c2006 |
| Descrizione fisica | 1 online resource (272 p.) |
| Disciplina |
616.042
616/.042 |
| Altri autori (Persone) |
SerreJean Louis
HeathIsabelle HeathSimon |
| Soggetto topico |
Molecular genetics
Molecular diagnosis Genetic screening |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-74124-4
9786610741243 0-470-03336-3 0-470-87026-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Diagnostic Techniques in Genetics; Contents; Preface; List of Contributors; 1 Techniques and Tools in Molecular Biology Used in Genetic Diagnoses; 2 The Diagnosis of Inherited Diseases; 3 Molecular Diagnosis in Oncology; 4 Applications of Molecular Biology to Cytogenetics; 5 Screening and Identification of Pathogenic and Exogenic Agents; 6 Identification Using Genetic Fingerprints; 7 Molecular Genetics and Populations; Index; |
| Record Nr. | UNINA-9910143556403321 |
| Chichester, England ; ; Hoboken, NJ, : Wiley, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Diagnostic techniques in genetics [[electronic resource] /] / edited by Jean-Louis Serre ; translated by Isabelle and Simon Heath
| Diagnostic techniques in genetics [[electronic resource] /] / edited by Jean-Louis Serre ; translated by Isabelle and Simon Heath |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : Wiley, c2006 |
| Descrizione fisica | 1 online resource (272 p.) |
| Disciplina |
616.042
616/.042 |
| Altri autori (Persone) |
SerreJean Louis
HeathIsabelle HeathSimon |
| Soggetto topico |
Molecular genetics
Molecular diagnosis Genetic screening |
| ISBN |
1-280-74124-4
9786610741243 0-470-03336-3 0-470-87026-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Diagnostic Techniques in Genetics; Contents; Preface; List of Contributors; 1 Techniques and Tools in Molecular Biology Used in Genetic Diagnoses; 2 The Diagnosis of Inherited Diseases; 3 Molecular Diagnosis in Oncology; 4 Applications of Molecular Biology to Cytogenetics; 5 Screening and Identification of Pathogenic and Exogenic Agents; 6 Identification Using Genetic Fingerprints; 7 Molecular Genetics and Populations; Index; |
| Record Nr. | UNINA-9910831038403321 |
| Chichester, England ; ; Hoboken, NJ, : Wiley, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Diagnostic techniques in genetics / / edited by Jean-Louis Serre ; translated by Isabelle and Simon Heath
| Diagnostic techniques in genetics / / edited by Jean-Louis Serre ; translated by Isabelle and Simon Heath |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : Wiley, c2006 |
| Descrizione fisica | 1 online resource (272 p.) |
| Disciplina | 616/.042 |
| Altri autori (Persone) |
SerreJean Louis
HeathIsabelle HeathSimon |
| Soggetto topico |
Molecular genetics
Molecular diagnosis Genetic screening |
| ISBN |
9786610741243
9781280741241 1280741244 9780470033364 0470033363 9780470870266 0470870265 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Diagnostic Techniques in Genetics; Contents; Preface; List of Contributors; 1 Techniques and Tools in Molecular Biology Used in Genetic Diagnoses; 2 The Diagnosis of Inherited Diseases; 3 Molecular Diagnosis in Oncology; 4 Applications of Molecular Biology to Cytogenetics; 5 Screening and Identification of Pathogenic and Exogenic Agents; 6 Identification Using Genetic Fingerprints; 7 Molecular Genetics and Populations; Index; |
| Record Nr. | UNINA-9911020435103321 |
| Chichester, England ; ; Hoboken, NJ, : Wiley, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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DNA alterations in Lynch Syndrome : advances in molecular diagnosis and genetic counselling / / Matjaz Vogelsang, editor
| DNA alterations in Lynch Syndrome : advances in molecular diagnosis and genetic counselling / / Matjaz Vogelsang, editor |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | Dordrecht ; ; New York, : Springer, 2013 |
| Descrizione fisica | 1 online resource (202 p.) |
| Disciplina | 614.5999 |
| Altri autori (Persone) | VogelsangMatjaz |
| Soggetto topico |
Molecular diagnosis
Genetic counseling Syndromes |
| ISBN | 94-007-6597-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface -- Historical Development of Lynch Syndrome -- Molecular Mechanisms and Functions of DNA Mismatch Repair -- New Insights into Lynch Syndrome Diagnosis -- Genetic Testing, an Optimal Strategy for Lynch Syndrome Identification -- Functional Analyses Help to Assess the Pathogenicity of MMR Gene Variants of Uncertain Significance -- The Role of Epimutations of the Mismatch Repair Genes in the Development of Lynch Syndrome Related Cancers -- Mutations in non-MMR Genes Modifying or Mimicking Lynch Syndrome Phenotype -- Lynch Syndrome: Genetic Counselling of at-risk Individuals and Families -- Index. |
| Record Nr. | UNINA-9910437829503321 |
| Dordrecht ; ; New York, : Springer, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Expert review of molecular diagnostics
| Expert review of molecular diagnostics |
| Pubbl/distr/stampa | London, : Future Drugs Ltd., 2001- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Molecular diagnosis
Molecular Biology - methods Diagnostic Techniques and Procedures Genetics, Medical Pharmacogenetics |
| Soggetto genere / forma |
Periodicals.
Review Literature |
| ISSN | 1744-8352 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996335911103316 |
| London, : Future Drugs Ltd., 2001- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Expert review of molecular diagnostics
| Expert review of molecular diagnostics |
| Pubbl/distr/stampa | London, : Future Drugs Ltd., 2001- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Molecular diagnosis
Molecular Biology - methods Diagnostic Techniques and Procedures Genetics, Medical Pharmacogenetics |
| Soggetto genere / forma |
Periodical
Review Periodicals. |
| ISSN | 1744-8352 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910985990903321 |
| London, : Future Drugs Ltd., 2001- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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