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Hot-melt extrusion [[electronic resource] ] : pharmaceutical applications / / edited by Dennis Douroumis
| Hot-melt extrusion [[electronic resource] ] : pharmaceutical applications / / edited by Dennis Douroumis |
| Pubbl/distr/stampa | Chichester, West Sussex, U.K., : Wiley, 2012 |
| Descrizione fisica | 1 online resource (400 p.) |
| Disciplina | 615.1/9 |
| Altri autori (Persone) | DouroumisDionysios |
| Collana | Advances in pharmaceutical technology |
| Soggetto topico |
Molding (Chemical technology)
Drugs - Extrusion Pharmaceutical chemistry Drug delivery systems |
| ISBN |
1-118-30787-9
1-280-58887-X 9786613618702 0-470-71141-8 0-470-71140-X |
| Classificazione | SCI013040 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Hot-melt Extrusion: Pharmaceutical Applications; Contents; List of Contributors; Preface; 1. Single-screw Extrusion: Principles; 1.1 Introduction; 1.2 Ideal Compounding; 1.3 Basics of the Single-screw Extruder; 1.3.1 Screw Feed Section; 1.3.2 Screw Compressor Section; 1.3.3 Screw Metering Section; 1.3.4 Mixers; 1.3.5 Limitations of Conventional Single-screw Mixers; 1.4 SSE Elongational Mixers; 1.5 Summary; References; 2. Twin-screw Extruders for Pharmaceutical Hot-melt Extrusion: Technology, Techniques and Practices; 2.1 Introduction; 2.2 Extruder Types and Working Principle
2.3 Individual Parts of a TSE 2.3.1 Drive Unit; 2.3.2 Screws; 2.3.3 Screw Elements; 2.3.4 Distributive Flow Elements; 2.3.5 Discharge Feed Screw; 2.3.6 Barrel; 2.4 Downstreaming; 2.5 Individual Processing Sections of the TSE; 2.5.1 Feeding Section; 2.5.2 Conveying/Melting Section; 2.5.3 Mixing Section; 2.5.4 Venting Section; 2.5.5 Extrusion Section; 2.6 Feeding of Solids; 2.7 TSE Operating Parameters; 2.7.1 Filling Level; 2.7.2 Screw Speed; 2.7.3 Feed Rate; 2.7.4 Residence Time Distribution; 2.7.5 Effect of Screw Speed and Feed Rate on Melt Temperature 2.8 Setting up an HME Process using QbD Principles 2.8.1 Understanding Knowledge Space; 2.8.2 Defining Design Space; 2.8.3 Determining Control Space; 2.9 Summary; References; 3. Hot-melt Extrusion Developments in the Pharmaceutical Industry; 3.1 Introduction; 3.2 Advantages of HME as Drug Delivery Technology; 3.3 Formulations used for HME Applications; 3.3.1 Active Pharmaceutical Ingredient; 3.3.2 Solid Dispersions; 3.3.3 Bioavailability Improvement; 3.3.4 Controlled Delivery Systems; 3.3.5 Plasticizers; 3.4 Characterization of Extrudates; 3.4.1 Thermal Analysis; 3.4.2 Atomic Force Microscopy 3.4.3 Residence Time 3.4.4 Spectroscopic Techniques; 3.4.5 X-ray Diffraction (XRD); 3.4.6 Microscopy; 3.4.7 Drug Release; 3.5 Hot-melt Extruded Dosage Forms; 3.5.1 Oral Drug Delivery; 3.5.2 Films; 3.5.3 Vaginal Rings and Implants; 3.6 A View to the Future; References; 4. Solubility Parameters for Prediction of Drug/Polymer Miscibility in Hot-melt Extruded Formulations; 4.1 Introduction; 4.2 Solid Dispersions; 4.3 Basic Assumptions for the Drug-polymer Miscibility Prediction; 4.4 Solubility and the Flory-Huggins Theory; 4.5 Miscibility Estimation of Drug and Monomers; 4.6 Summary; References 5. The Influence of Plasticizers in Hot-melt Extrusion 5.1 Introduction; 5.2 Traditional Plasticizers; 5.3 Non-traditional Plasticizers; 5.4 Specialty Plasticizers; 5.5 Conclusions; References; 6. Applications of Poly(meth)acrylate Polymers in Melt Extrusion; 6.1 Introduction; 6.2 Polymer Characteristics; 6.2.1 Chemical Structure and Molecular Weight; 6.2.2 Glass Transition Temperature; 6.2.3 Plasticizers; 6.2.4 Thermostability; 6.2.5 Viscosity; 6.2.6 Specific Heat Capacity; 6.2.7 Hygroscopicity; 6.3 Melt Extrusion of Poly(methacrylates) to Design Pharmaceutical Oral Dosage Forms 6.4 Solubility Enhancement |
| Record Nr. | UNINA-9910141449003321 |
| Chichester, West Sussex, U.K., : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Hot-melt extrusion : pharmaceutical applications / / edited by Dennis Douroumis
| Hot-melt extrusion : pharmaceutical applications / / edited by Dennis Douroumis |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Chichester, West Sussex, U.K., : Wiley, 2012 |
| Descrizione fisica | 1 online resource (400 p.) |
| Disciplina | 615.1/9 |
| Altri autori (Persone) | DouroumisDionysios |
| Collana | Advances in pharmaceutical technology |
| Soggetto topico |
Molding (Chemical technology)
Drugs - Extrusion Pharmaceutical chemistry Drug delivery systems |
| ISBN |
1-118-30787-9
1-280-58887-X 9786613618702 0-470-71141-8 0-470-71140-X |
| Classificazione | SCI013040 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Hot-melt Extrusion: Pharmaceutical Applications; Contents; List of Contributors; Preface; 1. Single-screw Extrusion: Principles; 1.1 Introduction; 1.2 Ideal Compounding; 1.3 Basics of the Single-screw Extruder; 1.3.1 Screw Feed Section; 1.3.2 Screw Compressor Section; 1.3.3 Screw Metering Section; 1.3.4 Mixers; 1.3.5 Limitations of Conventional Single-screw Mixers; 1.4 SSE Elongational Mixers; 1.5 Summary; References; 2. Twin-screw Extruders for Pharmaceutical Hot-melt Extrusion: Technology, Techniques and Practices; 2.1 Introduction; 2.2 Extruder Types and Working Principle
2.3 Individual Parts of a TSE 2.3.1 Drive Unit; 2.3.2 Screws; 2.3.3 Screw Elements; 2.3.4 Distributive Flow Elements; 2.3.5 Discharge Feed Screw; 2.3.6 Barrel; 2.4 Downstreaming; 2.5 Individual Processing Sections of the TSE; 2.5.1 Feeding Section; 2.5.2 Conveying/Melting Section; 2.5.3 Mixing Section; 2.5.4 Venting Section; 2.5.5 Extrusion Section; 2.6 Feeding of Solids; 2.7 TSE Operating Parameters; 2.7.1 Filling Level; 2.7.2 Screw Speed; 2.7.3 Feed Rate; 2.7.4 Residence Time Distribution; 2.7.5 Effect of Screw Speed and Feed Rate on Melt Temperature 2.8 Setting up an HME Process using QbD Principles 2.8.1 Understanding Knowledge Space; 2.8.2 Defining Design Space; 2.8.3 Determining Control Space; 2.9 Summary; References; 3. Hot-melt Extrusion Developments in the Pharmaceutical Industry; 3.1 Introduction; 3.2 Advantages of HME as Drug Delivery Technology; 3.3 Formulations used for HME Applications; 3.3.1 Active Pharmaceutical Ingredient; 3.3.2 Solid Dispersions; 3.3.3 Bioavailability Improvement; 3.3.4 Controlled Delivery Systems; 3.3.5 Plasticizers; 3.4 Characterization of Extrudates; 3.4.1 Thermal Analysis; 3.4.2 Atomic Force Microscopy 3.4.3 Residence Time 3.4.4 Spectroscopic Techniques; 3.4.5 X-ray Diffraction (XRD); 3.4.6 Microscopy; 3.4.7 Drug Release; 3.5 Hot-melt Extruded Dosage Forms; 3.5.1 Oral Drug Delivery; 3.5.2 Films; 3.5.3 Vaginal Rings and Implants; 3.6 A View to the Future; References; 4. Solubility Parameters for Prediction of Drug/Polymer Miscibility in Hot-melt Extruded Formulations; 4.1 Introduction; 4.2 Solid Dispersions; 4.3 Basic Assumptions for the Drug-polymer Miscibility Prediction; 4.4 Solubility and the Flory-Huggins Theory; 4.5 Miscibility Estimation of Drug and Monomers; 4.6 Summary; References 5. The Influence of Plasticizers in Hot-melt Extrusion 5.1 Introduction; 5.2 Traditional Plasticizers; 5.3 Non-traditional Plasticizers; 5.4 Specialty Plasticizers; 5.5 Conclusions; References; 6. Applications of Poly(meth)acrylate Polymers in Melt Extrusion; 6.1 Introduction; 6.2 Polymer Characteristics; 6.2.1 Chemical Structure and Molecular Weight; 6.2.2 Glass Transition Temperature; 6.2.3 Plasticizers; 6.2.4 Thermostability; 6.2.5 Viscosity; 6.2.6 Specific Heat Capacity; 6.2.7 Hygroscopicity; 6.3 Melt Extrusion of Poly(methacrylates) to Design Pharmaceutical Oral Dosage Forms 6.4 Solubility Enhancement |
| Record Nr. | UNINA-9910810636803321 |
| Chichester, West Sussex, U.K., : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Microcellular injection molding [[electronic resource] /] / Jingyi Xu
| Microcellular injection molding [[electronic resource] /] / Jingyi Xu |
| Autore | Xu Jingyi |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2010 |
| Descrizione fisica | 1 online resource (630 p.) |
| Disciplina | 668.4/12 |
| Collana | Wiley series on plastics engineering and technology |
| Soggetto topico |
Molding (Chemical technology)
Foamed materials Microfluidics |
| ISBN |
1-118-05787-2
1-282-64324-X 9786612643248 0-470-64281-5 0-470-64280-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
MICROCELLULAR INJECTION MOLDING; CONTENTS; FOREWORD; PREFACE; 1: INTRODUCTION; 2: BASICS OF MICROCELLULAR INJECTION MOLDING; 3: MORPHOLOGY OF MICROCELLULAR MATERIALS; 4: MATERIALS FOR MICROCELLULAR INJECTION MOLDING; 5: DESIGN OF MICROCELLULAR INJECTION MOLDING; 6: PROCESS FOR MICROCELLULAR INJECTION MOLDING; 7: EQUIPMENT AND MACHINES FOR MICROCELLULAR INJECTION MOLDING; 8: SPECIAL PROCESSES; 9: MODELING OF MICROCELLULAR INJECTION MOLDING; 10: POST PROCESSING AND PROPERTY TEST OF MICROCELLULAR INJECTION MOLDING; 11: MARKETS AND APPLICATIONS OF MICROCELLULAR INJECTION MOLDING
12: COST SAVINGS FOR MICROCELLULAR INJECTION MOLDINGNOMENCLATURE; APPENDIX A (CHAPTER 7); APPENDIX B (CHAPTER 7); APPENDIX C (CHAPTER 5); APPENDIX D (CHAPTER 5); APPENDIX E (CHAPTER 5); APPENDIX F (CHAPTER 6); APPENDIX G (CHAPTER 9); APPENDIX H (GLOSSARY); INDEX |
| Record Nr. | UNINA-9910139192603321 |
Xu Jingyi
|
||
| Hoboken, N.J., : Wiley, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Microcellular injection molding / / Jingyi Xu
| Microcellular injection molding / / Jingyi Xu |
| Autore | Xu Jingyi |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2010 |
| Descrizione fisica | 1 online resource (630 p.) |
| Disciplina | 668.4/12 |
| Collana | Wiley series on plastics engineering and technology |
| Soggetto topico |
Molding (Chemical technology)
Foamed materials Microfluidics |
| ISBN |
1-118-05787-2
1-282-64324-X 9786612643248 0-470-64281-5 0-470-64280-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
MICROCELLULAR INJECTION MOLDING; CONTENTS; FOREWORD; PREFACE; 1: INTRODUCTION; 2: BASICS OF MICROCELLULAR INJECTION MOLDING; 3: MORPHOLOGY OF MICROCELLULAR MATERIALS; 4: MATERIALS FOR MICROCELLULAR INJECTION MOLDING; 5: DESIGN OF MICROCELLULAR INJECTION MOLDING; 6: PROCESS FOR MICROCELLULAR INJECTION MOLDING; 7: EQUIPMENT AND MACHINES FOR MICROCELLULAR INJECTION MOLDING; 8: SPECIAL PROCESSES; 9: MODELING OF MICROCELLULAR INJECTION MOLDING; 10: POST PROCESSING AND PROPERTY TEST OF MICROCELLULAR INJECTION MOLDING; 11: MARKETS AND APPLICATIONS OF MICROCELLULAR INJECTION MOLDING
12: COST SAVINGS FOR MICROCELLULAR INJECTION MOLDINGNOMENCLATURE; APPENDIX A (CHAPTER 7); APPENDIX B (CHAPTER 7); APPENDIX C (CHAPTER 5); APPENDIX D (CHAPTER 5); APPENDIX E (CHAPTER 5); APPENDIX F (CHAPTER 6); APPENDIX G (CHAPTER 9); APPENDIX H (GLOSSARY); INDEX |
| Record Nr. | UNINA-9910811426803321 |
|
Xu Jingyi
|
||
| Hoboken, N.J., : Wiley, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
