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Cortical spreading depression of leao : from mitochondrial function to brain metabolic score (BMS) / / Avraham Mayevsky and Judith Sonn
| Cortical spreading depression of leao : from mitochondrial function to brain metabolic score (BMS) / / Avraham Mayevsky and Judith Sonn |
| Autore | Mayevsky Avraham |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2022] |
| Descrizione fisica | 1 online resource (429 pages) |
| Disciplina | 616.07 |
| Soggetto topico |
Mitochondrial pathology
Brain - Metabolism - Disorders |
| ISBN | 3-031-08068-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface 1 -- Preface 2 -- Aim of the Book -- Acknowledgments -- I -- II -- Contents -- Chapter 1: Introduction and Historical Background -- 1.1 Leão' Cortical Spreading Depression (CSD) -- 1.1.1 Aristides Leão: Life History -- 1.1.2 The Discovery of the "Spreading Depression" -- 1.1.3 Back to Brazil -- 1.1.4 Conclusion -- 1.1.5 Aristides Leão: The Four Seminal Publications (1944-1947) -- 1.2 Oxygen Homeostasis in the Brain -- 1.2.1 The Discovery of Oxygen -- 1.2.2 The Discovery of the Mitochondrial Function -- 1.3 Monitoring of Brain Mitochondrial Function in Vivo -- 1.4 Brain Energy Metabolism and Mitochondrial Function During CSD -- References -- Chapter 2: Basic Principles and Technology of NADH and Multiparametric Monitoring Used in Studying Cortical Spreading Depression (CSD) -- 2.1 Introduction -- 2.2 From NADH Monitoring to Multiparametric Monitoring Systems -- 2.2.1 Fiber-Optic-Based Fluorometer/Reflectometer -- 2.2.2 Simultaneous Monitoring of NADH by DC Fluorometer Reflectometer Together with Monitoring of Systemic Blood Pressure and Electrocortical Activity (ECoG) -- 2.2.3 Simultaneous Monitoring of NADH Together with Extracellular K+, DC Steady Potential, and ECoG -- 2.2.4 Monitoring of Brain NADH Together with Tissue pO2 and ECoG -- 2.2.5 Multiparametric Assembly for Recording of NADH, Extracellular K+, H+, DC Steady Potential, and ECoG -- 2.2.5.1 Electrode Assembly -- 2.2.5.2 Correction for Local DC Biopotential -- 2.2.5.3 NADH Fluorescence Measurement -- 2.2.6 Monitoring of NADH, pO2, Extracellular K+, DC, and ECoG, Outside and Inside Hyperbaric Chamber -- 2.2.7 Simultaneous Real-Time Monitoring of Brain NADH, HbO2, ECoG, DC Potential, and Extracellular K+ and Ca2+ -- 2.2.8 Simultaneous Real-Time Monitoring of Brain NADH, CBF, ECoG, DC Potential, and Extracellular K+ and Ca2+.
2.2.9 Simultaneous Monitoring of Brain NADH, CBF, ECoG, DC Potential, and Extracellular K+, Ca+2, H+ -- 2.2.10 Multiparametric Monitoring of Neurosurgical Patients -- 2.2.11 Monitoring of the Mechanism of CSD Propagation -- 2.2.12 Multisite Monitoring of NADH and DC Potential in Rats Under Various Conditions -- 2.2.13 Multisite Multiparametric Monitoring of NADH, CBF, and DC Potential in Rats Under Experimental Conditions -- References -- Chapter 3: Single Point and Multisite Monitoring of Brain NADH Fluorescence Under CSD -- 3.1 Introduction -- 3.2 Single Point Monitoring of NADH -- 3.3 Two Points Monitoring of NADH -- 3.4 Four Points Monitoring of NADH -- References -- Chapter 4: Sequence of Physiological Responses Recorded During Induced CSD Event -- 4.1 Introduction -- 4.2 Effects of CSD on Cerebral Blood Flow and Brain Oxygen Consumption -- 4.2.1 Introduction -- 4.2.2 Methods -- 4.2.3 Results -- 4.2.4 Discussion -- 4.3 Sequence of Events Recorded During the CSD Cycle -- 4.3.1 The Use of the MPA System -- 4.3.2 CSD Initiation and Contralateral Responses -- 4.3.3 Discussion -- References -- Chapter 5: Spontaneous Development of CSD Related to Brain Pathophysiological Conditions -- 5.1 Introduction -- 5.2 During Anoxia, Hypoxia, and Ischemia -- 5.3 During Exposure to Hyperbaric Hyperoxia (HBO) -- 5.3.1 First Study-HBO Effects on Mitochondrial Function -- 5.3.1.1 Introduction -- 5.3.1.2 Methodology -- 5.3.1.3 Results -- 5.3.1.4 Discussion -- 5.3.2 Second Study-Protection Against Oxygen Toxicity by Trimethadione -- 5.3.3 Third Study-Effects of CO2 Under HBO -- 5.3.4 More Factors Affecting HBO Toxicity -- 5.3.5 Fifth Study-Multiparametric Monitoring of CSD Under HBO -- 5.3.5.1 Introduction -- 5.3.5.2 Methods -- 5.3.5.3 Results -- 5.3.5.4 Discussion -- 5.4 During Drug-Induced Seizure Activity -- 5.5 Development of CSD During and After Head Injury. 5.5.1 First Study-Development of the TBI Model -- 5.5.1.1 Introduction -- 5.5.1.2 Technological Aspects -- 5.5.1.3 Results -- 5.5.1.4 Discussion -- 5.5.2 Second Study-Level of ICP and CSD After TBI -- 5.5.2.1 Introduction -- 5.5.2.2 Methods -- 5.5.2.3 Results -- 5.5.2.4 Discussion -- References -- Untitled -- Chapter 6: The Effects of Brain Metabolic and Other Perturbations on the Responses to Induced CSD -- 6.1 Effects of Oxygen Availability -- 6.1.1 Introduction -- 6.1.2 Effects of Hypoxia and Hyperoxia on the Responses to CSD -- 6.1.3 Responses to CSD Under Ischemia -- 6.1.4 Responses to CSD Under Partial Ischemia-Statistical Analysis -- 6.2 Effect of Anesthesia on the Responses to CSD -- 6.3 Effects of Hypothermia on the Responses to CSD -- 6.3.1 Introduction -- 6.3.2 Our Studies -- 6.4 Responses to CSD in the Aging Rat -- References -- Chapter 7: Effects of Pharmacological Agents on CSD -- 7.1 Effects of Carbon Monoxide -- 7.1.1 First Study -- 7.1.1.1 Introduction -- 7.1.1.2 Methods -- 7.1.1.3 Results and Discussion -- 7.1.2 Second Study -- 7.1.2.1 Introduction -- 7.1.2.2 Methods -- 7.1.2.2.1 Data Collection and Analysis -- 7.1.2.3 Results -- 7.1.2.4 Discussion -- 7.1.3 Third Study -- 7.1.3.1 Introduction -- 7.1.3.2 Methods -- 7.1.3.3 Results -- 7.1.3.4 Discussion -- 7.1.4 Fourth Study -- 7.1.4.1 Introduction -- 7.1.4.2 Methods -- 7.1.4.3 Results -- 7.1.4.4 Discussion -- 7.2 Nitric Oxide -- 7.2.1 First Study -- 7.2.1.1 Introduction -- 7.2.1.2 Methods -- 7.2.1.3 Results -- 7.2.1.4 Discussion -- 7.2.2 Second Study: The Effect of CSD Under Nitric Oxide (NO) Synthase Inhibition -- 7.2.2.1 Introduction -- 7.2.2.2 Methods -- 7.2.2.3 Results -- 7.2.2.3.1 The Variation of the Measured Parameters in the Control Study -- 7.2.2.3.2 Results: The Effect of L-NAME Injection on the Measured Parameters. 7.2.2.3.3 Results: The Effect of CSD Waves on the Measured Parameters -- 7.2.2.3.4 Results: CSD Amplitudes -- 7.2.2.3.5 Results: CSD Wave Duration -- 7.2.2.3.6 Results: Recovery from CSD Wave -- 7.2.2.4 Summary -- 7.3 Alcohol Effects -- 7.3.1 First Study -- 7.3.2 Second Study: The Effects of Ethanol on the Responses to CSD -- 7.3.2.1 Introduction -- 7.3.2.2 Methods -- 7.3.2.3 Results -- 7.3.2.3.1 Amplitude Values -- 7.3.2.3.2 Wave Frequency (FRQ) -- 7.3.2.3.3 Propagation Rate: VTP (Mm/Min) -- 7.3.2.4 Discussion -- 7.3.2.4.1 Reflectance -- 7.3.2.4.2 NADH Redox State -- 7.3.2.4.3 DC Potential -- 7.3.2.4.4 CSD Wave Frequency and Propagation Rate -- References -- Chapter 8: Clinical Monitoring of Cortical Spreading Depression (CSD) in the Human Brain -- 8.1 Introduction -- 8.2 Monitoring of NADH and Other Parameters in Patients -- 8.3 The Discovery of CSD in the Human Cerebral Cortex -- 8.3.1 Introduction -- 8.3.2 Methods -- 8.3.2.1 The Development of the Monitoring System -- 8.3.2.2 Construction of the Multiprobe Assembly (MPA) -- 8.3.2.3 Patient Preparation -- 8.3.3 Results -- 8.3.4 Discussion -- References -- Chapter 9: CSD and the LifenLight Score (LLS) -- 9.1 Introduction -- 9.1.1 The Developed Concept -- 9.1.2 Brain LifenLight Score (LLS) -- 9.2 Methodology Used -- 9.2.1 The Multiparametric Monitoring System -- 9.2.2 Time Sharing Fluorometer Reflectometer (TSFR) -- 9.2.3 Mitochondrial NADH Redox State (NADH) -- 9.2.4 Microcirculatory Blood Oxygenation -- 9.2.5 Microcirculatory Blood Flow -- 9.2.6 Animal Preparation -- 9.2.7 Real-Time Data Acquisition -- 9.2.8 LifenLight Score (LLS) -- 9.3 Results -- 9.4 Discussion -- References -- Chapter 10: Discussion and Conclusions -- 10.1 Introduction -- 10.2 The Discovery of CSD in the Human Cerebral Cortex -- 10.3 NADH Responses to CSD In Vivo vs. Isolated Mitochondria In Vitro. 10.4 Cortical Spreading Depression (CSD) under Pathophysiological Conditions -- 10.5 Modeling Brain Energy Metabolism and Function -- 10.5.1 Introduction -- 10.5.2 The Mathematical Model -- 10.5.3 Results -- 10.5.4 Model Discussion -- 10.6 Future Perspectives -- References -- Appendix -- Introduction -- Chapter 1: Electrical Properties of Spreading Depression -- Spontaneous Electroencephalographic Activity -- Evoked Potentials -- Slow Potentials -- Unit Activity -- Membrane Potentials -- Impedance Changes -- Chapter 5: Chemical Aspects of Spreading Depression -- Ion and Water Transport and Distribution During Spreading Depression -- Spreading Cortical Depression and Labile Chemical Compounds in the Brain -- Amino Acids and Spreading Depression -- Biochemical Correlates of the Functional Changes Accompanying Spreading Depression -- Protein Metabolism in the Course of Spreading Depression -- Chapter 7: Mechanism of Spreading Depression -- Vascular Mechanisms -- Electric Fields -- Humoral Transmission -- Potassium Hypothesis -- Glutamic Acid Hypothesis -- Concomitant Phenomena -- References -- Index. |
| Record Nr. | UNINA-9910619281703321 |
Mayevsky Avraham
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| Cham, Switzerland : , : Springer, , [2022] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Current Strategies for the Biochemical Diagnosis and Monitoring of Mitochondrial Disease / / edited by Iain P. Hargreaves
| Current Strategies for the Biochemical Diagnosis and Monitoring of Mitochondrial Disease / / edited by Iain P. Hargreaves |
| Pubbl/distr/stampa | Basel : , : MDPI - Multidisciplinary Digital Publishing Institute, , 2018 |
| Descrizione fisica | 1 online resource (vii, 238 pages) : illusrations |
| Disciplina | 616.07 |
| Soggetto topico | Mitochondrial pathology |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910674042703321 |
| Basel : , : MDPI - Multidisciplinary Digital Publishing Institute, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Current strategies for the biochemical diagnosis and monitoring of mitochondrial disease / / edited by Iain Hargreaves
| Current strategies for the biochemical diagnosis and monitoring of mitochondrial disease / / edited by Iain Hargreaves |
| Pubbl/distr/stampa | Basel, Switzerland : , : MDPI, , [2018] |
| Descrizione fisica | 1 online resource (238 pages) : illustrations |
| Disciplina | 616.07 |
| Soggetto topico | Mitochondrial pathology |
| ISBN | 3-03897-241-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | About the Special Issue Editor vii -- Iain P. Hargreaves Biochemical Assessment and Monitoring of Mitochondrial Disease Reprinted from: J. Clin. Med. 2018, 7, 66, doi: 10.3390/jcm7040066 1 -- Iain Hargreaves, Nimesh Mody, John Land and Simon Heales Blood Mononuclear Cell Mitochondrial Respiratory Chain Complex IV Activity is Decreased in Multiple Sclerosis Patients: Effects of β-Interferon Treatment Reprinted from: J. Clin. Med. 2018, 7, 36, doi: 10.3390/jcm7020036 4 -- Arun Ghose, Christopher M. Taylor, Alexander J. Howie, Anapurna Chalasani, Iain Hargreaves and David V. Milford Measurement of Respiratory Chain Enzyme Activity in Human Renal Biopsy Specimens Reprinted from: J. Clin. Med. 2017, 6, 90, doi: 10.3390/jcm6090090 10 -- Alireza Morovat, Gayani Weerasinghe, Victoria Nesbitt, Monika Hofer, Thomas Agnew, Geralrine Quaghebeur, Kate Sergeant, Carl Fratter, Nishan Guha, Mehdi Mirzazadeh and Joanna Poulton Use of FGF-21 as a Biomarker of Mitochondrial Disease in Clinical Practice Reprinted from: J. Clin. Med. 2017, 6, 80, doi: 10.3390/jcm6080080 16 -- Paule B´enit, Dominique Chr´etien, Mathieu Porceddu, Constantin Yanicostas, Malgorzata Rak and Pierre Rustin An Effective, Versatile, and Inexpensive Device for Oxygen Uptake Measurement Reprinted from: J. Clin. Med. 2017, 6, 58, doi: 10.3390/jcm6060058 30 -- Corinne Alban, Elena Fatale, Abed Joulani, Polina Ilin and Ann Saada The Relationship between Mitochondrial Respiratory Chain Activities in Muscle and Metabolites in Plasma and Urine: A Retrospective Study Reprinted from: J. Clin. Med. 2017, 6, 31, doi: 10.3390/jcm6030031 40 -- Luc´ıa G ´omez-Tatay, Jos ´e M. Hern´andez-Andreu and Justo Aznar Mitochondrial Modification Techniques and Ethical Issues Reprinted from: J. Clin. Med. 2017, 6, 25, doi: 10.3390/jcm6030025 49 -- Leanna M. Delhey, Ekim Nur Kilinc, Li Yin, John C. Slattery, Marie L. Tippett, Shannon Rose, Sirish C. Bennuri, Stephen G. Kahler, Shirish Damle, Agustin Legido, Michael J. Goldenthal and Richard E. Frye The Effect of Mitochondrial Supplements on Mitochondrial Activity in Children with Autism Spectrum Disorder Reprinted from: J. Clin. Med. 2017, 6, 18, doi: 10.3390/jcm6020018 65 -- Josef Finsterer and Sinda Zarrouk-Mahjoub Biomarkers for Detecting Mitochondrial Disorders Reprinted from: J. Clin. Med. 2018, 7, 16, doi: 10.3390/jcm7020016 77 -- Mesfer Al Shahrani, Simon Heales, Iain Hargreaves and Michael Orford Oxidative Stress: Mechanistic Insights into Inherited Mitochondrial Disorders and Parkinson's Disease Reprinted from: J. Clin. Med. 2017, 6, 100, doi: 10.3390/jcm6110100 . 86 -- Radha Ramachandran and Anthony S. Wierzbicki Statins, Muscle Disease and Mitochondria Reprinted from: J. Clin. Med. 2017, 6, 75, doi: 10.3390/jcm6080075 103 -- Karolina M. Stepien, Robert Heaton, Scott Rankin, Alex Murphy, James Bentley, Darren Sexton and Iain P. Hargreaves Evidence of Oxidative Stress and Secondary Mitochondrial Dysfunction in Metabolic and Non-Metabolic Disorders Reprinted from: J. Clin. Med. 2017, 6, 71, doi: 10.3390/jcm6070071 116 -- Rahul Phadke Myopathology of Adult and Paediatric Mitochondrial Diseases Reprinted from: J. Clin. Med. 2017, 6, 64, doi: 10.3390/jcm6070064 141 -- Eleni Paleologou, Naila Ismayilova and Maria Kinali Use of the Ketogenic Diet to Treat Intractable Epilepsy in Mitochondrial Disorders Reprinted from: J. Clin. Med. 2017, 6, 56, doi: 10.3390/jcm6060056 165 -- Tamilarasan Udhayabanu, Andreea Manole, Mohan Rajeshwari, Perumal Varalakshmi, Henry Houlden and Balasubramaniem Ashokkumar Riboflavin Responsive Mitochondrial Dysfunction in Neurodegenerative Diseases Reprinted from: J. Clin. Med. 2017, 6, 52, doi: 10.3390/jcm6050052 179 -- Gregory M. Enns and Tina M. Cowan Glutathione as a Redox Biomarker in Mitochondrial Disease-Implications for Therapy Reprinted from: J. Clin. Med. 2017, 6, 50, doi: 10.3390/jcm6050050 192 -- Delia Yubero, George Allen, Rafael Artuch and Raquel Montero The Value of Coenzyme Q10 Determination in Mitochondrial Patients Reprinted from: J. Clin. Med. 2017, 6, 37, doi: 10.3390/jcm6040037 209 -- Juan Carlos Rodr´ıguez-Aguilera, Ana Bel ´en Cort´es, Daniel J. M. Fern ´andez-Ayala and Pl ´acido Navas Biochemical Assessment of Coenzyme Q10 Deficiency Reprinted from: J. Clin. Med. 2017, 6, 27, doi: 10.3390/jcm6030027 219. |
| Record Nr. | UNINA-9910765830903321 |
| Basel, Switzerland : , : MDPI, , [2018] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug-induced mitochondrial dysfunction [[electronic resource] /] / edited by James A. Dykens, Yvonne Will
| Drug-induced mitochondrial dysfunction [[electronic resource] /] / edited by James A. Dykens, Yvonne Will |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2008 |
| Descrizione fisica | 1 online resource (648 p.) |
| Disciplina |
615.9
615/.1 |
| Altri autori (Persone) |
DykensJames Alan <1951->
WillYvonne |
| Soggetto topico |
Drugs - Toxicology
Mitochondrial pathology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-93752-5
9786611937522 0-470-37253-2 0-470-37252-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DRUG-INDUCED MITOCHONDRIAL DYSFUNCTION; CONTENTS; CONTRIBUTORS; PREFACE; PART I BASIC CONCEPTS; 1 Basic Mitochondrial Physiology in Cell Viability and Death; 2 Basic Molecular Biology of Mitochondrial Replication; 3 Drug-Associated Mitochondrial Toxicity; 4 Pharmacogenetics of Mitochondrial Drug Toxicity; PART II ORGAN DRUG TOXICITY: MITOCHONDRIAL ETIOLOGY; 5 Features and Mechanisms of Drug-Induced Liver Injury; 6 Cardiovascular Toxicity of Mitochondrial Origin; 7 Skeletal Muscle and Mitochondrial Toxicity; 8 Manifestations of Drug Toxicity on Mitochondria in the Nervous System
9 Lipoatrophy and Other Manifestations of Antiretroviral Therapeutics10 Nephrotoxicity; 11 Drug Effects in Patients with Mitochondrial Diseases; PART III ASSESSMENT OF MITOCHONDRIAL FUNCTION IN VITRO AND IN VIVO; 12 Polarographic Oxygen Sensors, the Oxygraph, and High-Resolution Respirometry to Assess Mitochondrial Function; 13 Use of Oxygen-Sensitive Fluorescent Probes for the Assessment of Mitochondrial Function; 14 Mitochondrial Dysfunction Assessed Quantitatively in Real Time by Measuring the Extracellular Flux of Oxygen and Protons 15 Assessment of Mitochondrial Respiratory Complex Function In Vitro and In Vivo16 OXPHOS Complex Activity Assays and Dipstick Immunoassays for Assessment of OXPHOS Protein Levels; 17 Use of Fluorescent Reporters to Measure Mitochondrial Membrane Potential and the Mitochondrial Permeability Transition; 18 Compartmentation of Redox Signaling and Control: Discrimination of Oxidative Stress in Mitochondria, Cytoplasm, Nuclei, and Endoplasmic Reticulum; 19 Assessing Mitochondrial Protein Synthesis in Drug Toxicity Screening 20 Mitochondrial Toxicity of Antiviral Drugs: A Challenge to Accurate Diagnosis21 Clinical Assessment of Mitochondrial Function via [(13)C]Methionine Exhalation; 22 Assessment of Mitochondrial Dysfunction by Microscopy; 23 Development of Animal Models of Drug-Induced Mitochondrial Toxicity; 24 Noninvasive Assessment of Mitochondrial Function Using Nuclear Magnetic Resonance Spectroscopy; 25 Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations; INDEX |
| Record Nr. | UNINA-9910144101203321 |
| Hoboken, N.J., : John Wiley & Sons, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug-induced mitochondrial dysfunction [[electronic resource] /] / edited by James A. Dykens, Yvonne Will
| Drug-induced mitochondrial dysfunction [[electronic resource] /] / edited by James A. Dykens, Yvonne Will |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2008 |
| Descrizione fisica | 1 online resource (648 p.) |
| Disciplina |
615.9
615/.1 |
| Altri autori (Persone) |
DykensJames Alan <1951->
WillYvonne |
| Soggetto topico |
Drugs - Toxicology
Mitochondrial pathology |
| ISBN |
1-281-93752-5
9786611937522 0-470-37253-2 0-470-37252-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DRUG-INDUCED MITOCHONDRIAL DYSFUNCTION; CONTENTS; CONTRIBUTORS; PREFACE; PART I BASIC CONCEPTS; 1 Basic Mitochondrial Physiology in Cell Viability and Death; 2 Basic Molecular Biology of Mitochondrial Replication; 3 Drug-Associated Mitochondrial Toxicity; 4 Pharmacogenetics of Mitochondrial Drug Toxicity; PART II ORGAN DRUG TOXICITY: MITOCHONDRIAL ETIOLOGY; 5 Features and Mechanisms of Drug-Induced Liver Injury; 6 Cardiovascular Toxicity of Mitochondrial Origin; 7 Skeletal Muscle and Mitochondrial Toxicity; 8 Manifestations of Drug Toxicity on Mitochondria in the Nervous System
9 Lipoatrophy and Other Manifestations of Antiretroviral Therapeutics10 Nephrotoxicity; 11 Drug Effects in Patients with Mitochondrial Diseases; PART III ASSESSMENT OF MITOCHONDRIAL FUNCTION IN VITRO AND IN VIVO; 12 Polarographic Oxygen Sensors, the Oxygraph, and High-Resolution Respirometry to Assess Mitochondrial Function; 13 Use of Oxygen-Sensitive Fluorescent Probes for the Assessment of Mitochondrial Function; 14 Mitochondrial Dysfunction Assessed Quantitatively in Real Time by Measuring the Extracellular Flux of Oxygen and Protons 15 Assessment of Mitochondrial Respiratory Complex Function In Vitro and In Vivo16 OXPHOS Complex Activity Assays and Dipstick Immunoassays for Assessment of OXPHOS Protein Levels; 17 Use of Fluorescent Reporters to Measure Mitochondrial Membrane Potential and the Mitochondrial Permeability Transition; 18 Compartmentation of Redox Signaling and Control: Discrimination of Oxidative Stress in Mitochondria, Cytoplasm, Nuclei, and Endoplasmic Reticulum; 19 Assessing Mitochondrial Protein Synthesis in Drug Toxicity Screening 20 Mitochondrial Toxicity of Antiviral Drugs: A Challenge to Accurate Diagnosis21 Clinical Assessment of Mitochondrial Function via [(13)C]Methionine Exhalation; 22 Assessment of Mitochondrial Dysfunction by Microscopy; 23 Development of Animal Models of Drug-Induced Mitochondrial Toxicity; 24 Noninvasive Assessment of Mitochondrial Function Using Nuclear Magnetic Resonance Spectroscopy; 25 Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations; INDEX |
| Record Nr. | UNINA-9910829877903321 |
| Hoboken, N.J., : John Wiley & Sons, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug-induced mitochondrial dysfunction / / edited by James A. Dykens, Yvonne Will
| Drug-induced mitochondrial dysfunction / / edited by James A. Dykens, Yvonne Will |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2008 |
| Descrizione fisica | 1 online resource (648 p.) |
| Disciplina | 615/.1 |
| Altri autori (Persone) |
DykensJames Alan <1951->
WillYvonne |
| Soggetto topico |
Drugs - Toxicology
Mitochondrial pathology |
| ISBN |
1-281-93752-5
9786611937522 0-470-37253-2 0-470-37252-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DRUG-INDUCED MITOCHONDRIAL DYSFUNCTION; CONTENTS; CONTRIBUTORS; PREFACE; PART I BASIC CONCEPTS; 1 Basic Mitochondrial Physiology in Cell Viability and Death; 2 Basic Molecular Biology of Mitochondrial Replication; 3 Drug-Associated Mitochondrial Toxicity; 4 Pharmacogenetics of Mitochondrial Drug Toxicity; PART II ORGAN DRUG TOXICITY: MITOCHONDRIAL ETIOLOGY; 5 Features and Mechanisms of Drug-Induced Liver Injury; 6 Cardiovascular Toxicity of Mitochondrial Origin; 7 Skeletal Muscle and Mitochondrial Toxicity; 8 Manifestations of Drug Toxicity on Mitochondria in the Nervous System
9 Lipoatrophy and Other Manifestations of Antiretroviral Therapeutics10 Nephrotoxicity; 11 Drug Effects in Patients with Mitochondrial Diseases; PART III ASSESSMENT OF MITOCHONDRIAL FUNCTION IN VITRO AND IN VIVO; 12 Polarographic Oxygen Sensors, the Oxygraph, and High-Resolution Respirometry to Assess Mitochondrial Function; 13 Use of Oxygen-Sensitive Fluorescent Probes for the Assessment of Mitochondrial Function; 14 Mitochondrial Dysfunction Assessed Quantitatively in Real Time by Measuring the Extracellular Flux of Oxygen and Protons 15 Assessment of Mitochondrial Respiratory Complex Function In Vitro and In Vivo16 OXPHOS Complex Activity Assays and Dipstick Immunoassays for Assessment of OXPHOS Protein Levels; 17 Use of Fluorescent Reporters to Measure Mitochondrial Membrane Potential and the Mitochondrial Permeability Transition; 18 Compartmentation of Redox Signaling and Control: Discrimination of Oxidative Stress in Mitochondria, Cytoplasm, Nuclei, and Endoplasmic Reticulum; 19 Assessing Mitochondrial Protein Synthesis in Drug Toxicity Screening 20 Mitochondrial Toxicity of Antiviral Drugs: A Challenge to Accurate Diagnosis21 Clinical Assessment of Mitochondrial Function via [(13)C]Methionine Exhalation; 22 Assessment of Mitochondrial Dysfunction by Microscopy; 23 Development of Animal Models of Drug-Induced Mitochondrial Toxicity; 24 Noninvasive Assessment of Mitochondrial Function Using Nuclear Magnetic Resonance Spectroscopy; 25 Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations; INDEX |
| Record Nr. | UNINA-9910876981103321 |
| Hoboken, N.J., : John Wiley & Sons, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The functions, disease-related dysfunctions, and therapeutic targeting of neuronal mitochondria / / edited by Valentin K. Gribkoff, Elizabeth A. Jonas, J. Marie Hardwick ; contributors, Kambiz N. Alavian [and forty six others]
| The functions, disease-related dysfunctions, and therapeutic targeting of neuronal mitochondria / / edited by Valentin K. Gribkoff, Elizabeth A. Jonas, J. Marie Hardwick ; contributors, Kambiz N. Alavian [and forty six others] |
| Pubbl/distr/stampa | [Place of publication not identified] : , : Wiley, , 2015 |
| Descrizione fisica | 1 online resource (526 p.) |
| Disciplina | 572.869 |
| Collana | Wiley Series on Neuropharmacology |
| Soggetto topico |
Mitochondrial pathology
Mitochondria - Formation Nervous system - Diseases - Treatment |
| ISBN |
1-119-01710-6
1-119-01712-2 1-119-01672-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Mitochondrial permeability transition : look from a different angle / N. Brustovetsky -- The mitochondrial permeability transition pore, the c-subunit of the F1Fo ATP synthase, cellular development and synaptic efficiency / E.A. Jonas, G.A. Porter, Jr., G. Beutner, N. Mnatsakanyan and K.A. Alavian -- Mitochondrial channels in neurodegeneration / P.M. Peixoto, K.W. Kinnally and Evgeny Pavlov -- Mitochondrial Ca2+ transport in the control of neuronal functions : molecular and cellular mechanisms / Y.M. Usachev -- AMP-activated protein kinase (AMPK) as a cellular energy sensor and therapeutic target for neuroprotection / P. Weisova, S. Pfeiffer and J.H.M. Prehn -- HDAC6 : a molecule with multiple functions in neurodegenerative diseases / Y. Yan and R. Jiao -- Neuronal mitochondrial transport / A.L. Knight, Y. Chen, T. Sun and Z.-H. Sheng -- Mitochondria in control of hypothalamic metabolic circuits / C.M. Nasrallah and T.L. Horvath -- Mitochondria anchored at the synapse / G.A. Spirou, D. Jackson and G.A. Perkins -- Neuronal mitochondria are different : relevance to neurodegenerative disease / S.B. Berman and J.M. Hardwick -- PINK1 as a sensor for mitochondrial function : dual roles / E.K. Steer, M.K. Dail and C.T. Chu -- A get-together to tear it apart : the mitochondrion meets the cellular turnover machinery / G.-L. McLelland and E.A. Fon -- Mitochondrial involvement in neurodegenerative dementia / L. Bonanni, V. Frazzini, A. Thomas and M. Onofrj -- Neuronal mitochondria as a target for the discovery and development of new therapeutics / V.K. Gribkoff -- Mitochondria as a therapeutic target for Alzheimer's disease / C.H.-L. Hung, S.S.-Y. Chung, S.M.-Y. Lee and R.C.-C. Chang -- Mitochondria in Parkinson disease / G. Arena and E.M. Valente -- Therapeutic targeting of neuronal mitochondria in brain injury / H.M. Yonutas, E.D. Hall and P.G. Sullivan -- The use of fibroblasts from patients with inherited mitochondrial disorders for pathomechanistic studies and evaluation of therapies / D. Soiferman and A. Saada. |
| Record Nr. | UNINA-9910131618203321 |
| [Place of publication not identified] : , : Wiley, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The functions, disease-related dysfunctions, and therapeutic targeting of neuronal mitochondria / / edited by Valentin K. Gribkoff, Elizabeth A. Jonas, J. Marie Hardwick ; contributors, Kambiz N. Alavian [and forty six others]
| The functions, disease-related dysfunctions, and therapeutic targeting of neuronal mitochondria / / edited by Valentin K. Gribkoff, Elizabeth A. Jonas, J. Marie Hardwick ; contributors, Kambiz N. Alavian [and forty six others] |
| Pubbl/distr/stampa | [Place of publication not identified] : , : Wiley, , 2015 |
| Descrizione fisica | 1 online resource (526 p.) |
| Disciplina | 572.869 |
| Collana | Wiley Series on Neuropharmacology |
| Soggetto topico |
Mitochondrial pathology
Mitochondria - Formation Nervous system - Diseases - Treatment |
| ISBN |
1-119-01710-6
1-119-01712-2 1-119-01672-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Mitochondrial permeability transition : look from a different angle / N. Brustovetsky -- The mitochondrial permeability transition pore, the c-subunit of the F1Fo ATP synthase, cellular development and synaptic efficiency / E.A. Jonas, G.A. Porter, Jr., G. Beutner, N. Mnatsakanyan and K.A. Alavian -- Mitochondrial channels in neurodegeneration / P.M. Peixoto, K.W. Kinnally and Evgeny Pavlov -- Mitochondrial Ca2+ transport in the control of neuronal functions : molecular and cellular mechanisms / Y.M. Usachev -- AMP-activated protein kinase (AMPK) as a cellular energy sensor and therapeutic target for neuroprotection / P. Weisova, S. Pfeiffer and J.H.M. Prehn -- HDAC6 : a molecule with multiple functions in neurodegenerative diseases / Y. Yan and R. Jiao -- Neuronal mitochondrial transport / A.L. Knight, Y. Chen, T. Sun and Z.-H. Sheng -- Mitochondria in control of hypothalamic metabolic circuits / C.M. Nasrallah and T.L. Horvath -- Mitochondria anchored at the synapse / G.A. Spirou, D. Jackson and G.A. Perkins -- Neuronal mitochondria are different : relevance to neurodegenerative disease / S.B. Berman and J.M. Hardwick -- PINK1 as a sensor for mitochondrial function : dual roles / E.K. Steer, M.K. Dail and C.T. Chu -- A get-together to tear it apart : the mitochondrion meets the cellular turnover machinery / G.-L. McLelland and E.A. Fon -- Mitochondrial involvement in neurodegenerative dementia / L. Bonanni, V. Frazzini, A. Thomas and M. Onofrj -- Neuronal mitochondria as a target for the discovery and development of new therapeutics / V.K. Gribkoff -- Mitochondria as a therapeutic target for Alzheimer's disease / C.H.-L. Hung, S.S.-Y. Chung, S.M.-Y. Lee and R.C.-C. Chang -- Mitochondria in Parkinson disease / G. Arena and E.M. Valente -- Therapeutic targeting of neuronal mitochondria in brain injury / H.M. Yonutas, E.D. Hall and P.G. Sullivan -- The use of fibroblasts from patients with inherited mitochondrial disorders for pathomechanistic studies and evaluation of therapies / D. Soiferman and A. Saada. |
| Record Nr. | UNINA-9910812984803321 |
| [Place of publication not identified] : , : Wiley, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mitochondria / / Immo E. Scheffler
| Mitochondria / / Immo E. Scheffler |
| Autore | Scheffler Immo E |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Liss, c2008 |
| Descrizione fisica | 1 online resource (494 p.) |
| Disciplina | 571.6/57 |
| Soggetto topico |
Mitochondria
Mitochondrial pathology |
| ISBN |
1-118-20985-0
1-281-09424-2 9786611094249 0-470-19177-5 0-470-19176-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | History -- Evolutionary origin of mitochondria -- Structure and morphology. Integration into the cell -- Biogenesis of mitochondria -- Mitochondrial electron transfer and oxidative phosphorylation -- Metabolic pathways inside mitochondria -- Mitochondrial mutations and disease -- Mitochondrial DNA sequencing and anthropology -- Mitochondria and pharmacology. |
| Record Nr. | UNINA-9910144735203321 |
|
Scheffler Immo E
|
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| Hoboken, N.J., : Wiley-Liss, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mitochondria and their role in cardiovascular disease / / by Jose Marin-Garcia ; with contributions by Alexander Akhmedov and Vitalyi Rybin, Gordon W. Moe
| Mitochondria and their role in cardiovascular disease / / by Jose Marin-Garcia ; with contributions by Alexander Akhmedov and Vitalyi Rybin, Gordon W. Moe |
| Autore | Marin-Garcia Jose <1936-> |
| Pubbl/distr/stampa | New York, : Springer, c2013 |
| Descrizione fisica | 1 online resource (494 p.) |
| Disciplina |
616.99/4042
616.994042 |
| Altri autori (Persone) |
AkhmedovAlexander
RybinVitalyi MoeGordon W |
| Soggetto topico |
Cardiovascular system - Diseases
Mitochondrial pathology |
| ISBN |
1-283-86499-1
1-4614-4599-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction to mitochondria in the heart -- Methods to study mitochondrial structure and function- Mitochondrial structure, composition and dynamics -- Mitochondrial biogenesis -- Mechanisms of bioenergy production in mitochondria -- Bioenergetics interplay between cardiac mitochondria and other subcellular compartments -- Endothelial mitochondria: Contribution to cardiovascular function and disease -- Heart mitochondria: Receivers and transmitters of signals -- Stem cells and mitochondria -- Cell death pathways and mitochondria -- Mitochondria in pediatric cardiovascular diseases -- Mitochondrial in the aging heart -- The role of mitochondria in atherosclerosis -- The role of mitochondria in hypertension -- Role of mitochondria in ischemia and cardioprotection -- Mitochondrial dynamics in health and disease -- Mitochondria play an essential role in heart failure -- Mitochondria and cardiac dysrhythmias -- Diabetes and cardiac mitochondria -- The role of mitochondria in metabolic syndrome and insulin resistance.-Thyroid hormone and myocardial mitochondria -- Targeting the mitochondria in cardiovascular diseases -- Current progress and future perspectives: Towards mitochondrial medicine. |
| Record Nr. | UNINA-9910437995203321 |
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Marin-Garcia Jose <1936->
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| New York, : Springer, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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