Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Neurodegenerative diseases and metal ions [[electronic resource] /] / edited by Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel
| Neurodegenerative diseases and metal ions [[electronic resource] /] / edited by Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel |
| Pubbl/distr/stampa | Chichester, West Sussex, England ; ; Hoboken, NJ, : Wiley, c2006 |
| Descrizione fisica | 1 online resource (489 p.) |
| Disciplina |
572.51
616.8 |
| Altri autori (Persone) |
SigelAstrid
SigelHelmut SigelRoland K. O |
| Collana | Metal ions in life sciences |
| Soggetto topico |
Nervous system - Degeneration
Nervous system - Diseases Metal ions - Health aspects |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-51878-2
9786610518784 0-470-02811-4 0-470-02810-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Metal Ions in Life Sciences; Historical Development and Perspectives of the Series; Preface to Volume 1; Contents; Contributors to Volume 1; Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series; Contents of Volumes in the Metal Ions in Life Sciences Series; 1 The Role of Metal Ions in Neurology. An Introduction; 1 Introductory Remarks; 2 Comments on Metal Ions in Neurology; Acknowledgments; Abbreviations; References; 2 Protein Folding, Misfolding, and Disease; 1 Introduction; 2 Experimental Methods; 3 The Denatured State; 4 Protein Folding Dynamics
5 α-Synuclein and Parkinson's Disease6 Conclusions and Outlook; Acknowledgments; Abbreviations and Definitions; References; 3 Metal Ion Binding Properties of Proteins Related to Neurodegeneration; 1 Introduction; 2 Cu2+ Interactions with Mammalian Prion Proteins and Their Fragments; 3 Interactions of Metal Ions with the Amyloid Precursor Protein and Its Fragments; 4 Concluding Remarks; Acknowledgments; Abbreviations; References; 4 Metallic Prions: Mining the Core of Transmissible Spongiform Encephalopathies; 1 Introduction 2 Historical Connections Between Copper and Transmissible Spongiform Encephalopathies3 Copper Binding to Prion Protein; 4 Copper Coordination by Prion Protein; 5 Copper Uptake and Prion Protein Internalization; 6 Prion Protein as an Antioxidant; 7 Manganese Binding; 8 Transmissible Spongiform Encephalopathies and Metals; 9 Conclusions; Abbreviations; References; 5 The Role of Metal Ions in the Amyloid Precursor Protein and in Alzheimer's Disease; 1 Introduction; 2 Amyloid Precursor Protein and Brain Copper Homeostasis; 3 Amyloid Precursor Protein and Cu,Zn-Superoxide Dismutase-1 4 General ConclusionsAbbreviations; References; 6 The Role of Iron in the Pathogenesis of Parkinson's Disease; 1 Introduction; 2 Iron in the Etiology of Parkinson's Disease; 3 Sources of Increased Iron in Parkinson's Disease; 4 Consequences of Iron Overload in Parkinson's Disease; 5 General Conclusions; Acknowledgments; Abbreviations and Definitions; References; 7 In Vivo Assessment of Iron in Huntington's Disease and Other Age-Related Neurodegenerative Brain Diseases; 1 Introduction. Puzzling Changes in Cell Numbers in Huntington's Disease Brain 2 Human Brain Development and Disease Phenotypes3 Oligodendrocytes and Iron in Brain Development and Degeneration; 4 Transition Metal Metabolism and Proteinopathies; 5 In Vivo Measurement of Brain Iron; 6 Novel Treatment Considerations; 7 Conclusions; Acknowledgments; Abbreviations; References; 8 Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis; 1 Introduction; 2 Molecular Mechanisms of fALS SOD1 Pathogenesis; 3 Structural Features of Human SOD1; 4 'Wild-Type-like' fALS Mutants; 5 'Metal Binding Region' fALS Mutants; 6 Monomeric SOD1 and Pathogenesis; 7 Conclusions Acknowledgments |
| Record Nr. | UNINA-9910143703003321 |
| Chichester, West Sussex, England ; ; Hoboken, NJ, : Wiley, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Neurodegenerative diseases and metal ions [[electronic resource] /] / edited by Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel
| Neurodegenerative diseases and metal ions [[electronic resource] /] / edited by Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel |
| Pubbl/distr/stampa | Chichester, West Sussex, England ; ; Hoboken, NJ, : Wiley, c2006 |
| Descrizione fisica | 1 online resource (489 p.) |
| Disciplina |
572.51
616.8 |
| Altri autori (Persone) |
SigelAstrid
SigelHelmut SigelRoland K. O |
| Collana | Metal ions in life sciences |
| Soggetto topico |
Nervous system - Degeneration
Nervous system - Diseases Metal ions - Health aspects |
| ISBN |
1-280-51878-2
9786610518784 0-470-02811-4 0-470-02810-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Metal Ions in Life Sciences; Historical Development and Perspectives of the Series; Preface to Volume 1; Contents; Contributors to Volume 1; Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series; Contents of Volumes in the Metal Ions in Life Sciences Series; 1 The Role of Metal Ions in Neurology. An Introduction; 1 Introductory Remarks; 2 Comments on Metal Ions in Neurology; Acknowledgments; Abbreviations; References; 2 Protein Folding, Misfolding, and Disease; 1 Introduction; 2 Experimental Methods; 3 The Denatured State; 4 Protein Folding Dynamics
5 α-Synuclein and Parkinson's Disease6 Conclusions and Outlook; Acknowledgments; Abbreviations and Definitions; References; 3 Metal Ion Binding Properties of Proteins Related to Neurodegeneration; 1 Introduction; 2 Cu2+ Interactions with Mammalian Prion Proteins and Their Fragments; 3 Interactions of Metal Ions with the Amyloid Precursor Protein and Its Fragments; 4 Concluding Remarks; Acknowledgments; Abbreviations; References; 4 Metallic Prions: Mining the Core of Transmissible Spongiform Encephalopathies; 1 Introduction 2 Historical Connections Between Copper and Transmissible Spongiform Encephalopathies3 Copper Binding to Prion Protein; 4 Copper Coordination by Prion Protein; 5 Copper Uptake and Prion Protein Internalization; 6 Prion Protein as an Antioxidant; 7 Manganese Binding; 8 Transmissible Spongiform Encephalopathies and Metals; 9 Conclusions; Abbreviations; References; 5 The Role of Metal Ions in the Amyloid Precursor Protein and in Alzheimer's Disease; 1 Introduction; 2 Amyloid Precursor Protein and Brain Copper Homeostasis; 3 Amyloid Precursor Protein and Cu,Zn-Superoxide Dismutase-1 4 General ConclusionsAbbreviations; References; 6 The Role of Iron in the Pathogenesis of Parkinson's Disease; 1 Introduction; 2 Iron in the Etiology of Parkinson's Disease; 3 Sources of Increased Iron in Parkinson's Disease; 4 Consequences of Iron Overload in Parkinson's Disease; 5 General Conclusions; Acknowledgments; Abbreviations and Definitions; References; 7 In Vivo Assessment of Iron in Huntington's Disease and Other Age-Related Neurodegenerative Brain Diseases; 1 Introduction. Puzzling Changes in Cell Numbers in Huntington's Disease Brain 2 Human Brain Development and Disease Phenotypes3 Oligodendrocytes and Iron in Brain Development and Degeneration; 4 Transition Metal Metabolism and Proteinopathies; 5 In Vivo Measurement of Brain Iron; 6 Novel Treatment Considerations; 7 Conclusions; Acknowledgments; Abbreviations; References; 8 Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis; 1 Introduction; 2 Molecular Mechanisms of fALS SOD1 Pathogenesis; 3 Structural Features of Human SOD1; 4 'Wild-Type-like' fALS Mutants; 5 'Metal Binding Region' fALS Mutants; 6 Monomeric SOD1 and Pathogenesis; 7 Conclusions Acknowledgments |
| Record Nr. | UNINA-9910830600603321 |
| Chichester, West Sussex, England ; ; Hoboken, NJ, : Wiley, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Neurodegenerative diseases and metal ions / / edited by Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel
| Neurodegenerative diseases and metal ions / / edited by Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel |
| Pubbl/distr/stampa | Chichester, West Sussex, England ; ; Hoboken, NJ, : Wiley, c2006 |
| Descrizione fisica | 1 online resource (489 p.) |
| Disciplina | 616.8 |
| Altri autori (Persone) |
SigelAstrid
SigelHelmut SigelRoland K. O |
| Collana | Metal ions in life sciences |
| Soggetto topico |
Nervous system - Degeneration
Nervous system - Diseases Metal ions - Health aspects |
| ISBN |
1-280-51878-2
9786610518784 0-470-02811-4 0-470-02810-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Metal Ions in Life Sciences; Historical Development and Perspectives of the Series; Preface to Volume 1; Contents; Contributors to Volume 1; Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series; Contents of Volumes in the Metal Ions in Life Sciences Series; 1 The Role of Metal Ions in Neurology. An Introduction; 1 Introductory Remarks; 2 Comments on Metal Ions in Neurology; Acknowledgments; Abbreviations; References; 2 Protein Folding, Misfolding, and Disease; 1 Introduction; 2 Experimental Methods; 3 The Denatured State; 4 Protein Folding Dynamics
5 α-Synuclein and Parkinson's Disease6 Conclusions and Outlook; Acknowledgments; Abbreviations and Definitions; References; 3 Metal Ion Binding Properties of Proteins Related to Neurodegeneration; 1 Introduction; 2 Cu2+ Interactions with Mammalian Prion Proteins and Their Fragments; 3 Interactions of Metal Ions with the Amyloid Precursor Protein and Its Fragments; 4 Concluding Remarks; Acknowledgments; Abbreviations; References; 4 Metallic Prions: Mining the Core of Transmissible Spongiform Encephalopathies; 1 Introduction 2 Historical Connections Between Copper and Transmissible Spongiform Encephalopathies3 Copper Binding to Prion Protein; 4 Copper Coordination by Prion Protein; 5 Copper Uptake and Prion Protein Internalization; 6 Prion Protein as an Antioxidant; 7 Manganese Binding; 8 Transmissible Spongiform Encephalopathies and Metals; 9 Conclusions; Abbreviations; References; 5 The Role of Metal Ions in the Amyloid Precursor Protein and in Alzheimer's Disease; 1 Introduction; 2 Amyloid Precursor Protein and Brain Copper Homeostasis; 3 Amyloid Precursor Protein and Cu,Zn-Superoxide Dismutase-1 4 General ConclusionsAbbreviations; References; 6 The Role of Iron in the Pathogenesis of Parkinson's Disease; 1 Introduction; 2 Iron in the Etiology of Parkinson's Disease; 3 Sources of Increased Iron in Parkinson's Disease; 4 Consequences of Iron Overload in Parkinson's Disease; 5 General Conclusions; Acknowledgments; Abbreviations and Definitions; References; 7 In Vivo Assessment of Iron in Huntington's Disease and Other Age-Related Neurodegenerative Brain Diseases; 1 Introduction. Puzzling Changes in Cell Numbers in Huntington's Disease Brain 2 Human Brain Development and Disease Phenotypes3 Oligodendrocytes and Iron in Brain Development and Degeneration; 4 Transition Metal Metabolism and Proteinopathies; 5 In Vivo Measurement of Brain Iron; 6 Novel Treatment Considerations; 7 Conclusions; Acknowledgments; Abbreviations; References; 8 Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis; 1 Introduction; 2 Molecular Mechanisms of fALS SOD1 Pathogenesis; 3 Structural Features of Human SOD1; 4 'Wild-Type-like' fALS Mutants; 5 'Metal Binding Region' fALS Mutants; 6 Monomeric SOD1 and Pathogenesis; 7 Conclusions Acknowledgments |
| Record Nr. | UNINA-9910877103103321 |
| Chichester, West Sussex, England ; ; Hoboken, NJ, : Wiley, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
