Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
| ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide |
| Autore | Tsaioun Katya |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2012 |
| Descrizione fisica | 1 online resource (524 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) | KatesSteven A |
| Soggetto topico |
Drug Design
Drug Toxicity Drugs - Testing Drugs --Testing --Juvenile literature Pharmaceutical Preparations - chemistry Pharmacokinetics Metabolic Phenomena Drug Discovery Pharmacological Phenomena Natural Science Disciplines Kinetics Chemicals and Drugs Poisoning Biochemical Phenomena Chemistry, Pharmaceutical Substance-Related Disorders Disciplines and Occupations Investigative Techniques Physiological Phenomena Phenomena and Processes Chemical Phenomena Diseases Pharmacology Analytical, Diagnostic and Therapeutic Techniques and Equipment Biological Science Disciplines Chemistry Pharmaceutical Preparations Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-280-59122-6
9786613621054 0-470-91509-9 0-470-91511-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions
2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs 2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods 2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution 4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools 4.5.7 Tools for Studying Drug Excretion |
| Record Nr. | UNINA-9910133588303321 |
Tsaioun Katya
|
||
| Hoboken, : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
| ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide |
| Autore | Tsaioun Katya |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2012 |
| Descrizione fisica | 1 online resource (524 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) | KatesSteven A |
| Soggetto topico |
Drug Design
Drug Toxicity Drugs - Testing Drugs --Testing --Juvenile literature Pharmaceutical Preparations - chemistry Pharmacokinetics Metabolic Phenomena Drug Discovery Pharmacological Phenomena Natural Science Disciplines Kinetics Chemicals and Drugs Poisoning Biochemical Phenomena Chemistry, Pharmaceutical Substance-Related Disorders Disciplines and Occupations Investigative Techniques Physiological Phenomena Phenomena and Processes Chemical Phenomena Diseases Pharmacology Analytical, Diagnostic and Therapeutic Techniques and Equipment Biological Science Disciplines Chemistry Pharmaceutical Preparations Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-280-59122-6
9786613621054 0-470-91509-9 0-470-91511-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions
2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs 2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods 2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution 4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools 4.5.7 Tools for Studying Drug Excretion |
| Record Nr. | UNINA-9910830164603321 |
|
Tsaioun Katya
|
||
| Hoboken, : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Amino Acid Metabolism [[electronic resource]]
| Amino Acid Metabolism [[electronic resource]] |
| Autore | Bender David A |
| Edizione | [3rd ed.] |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2012 |
| Descrizione fisica | 1 online resource (480 p.) |
| Disciplina |
572.65
572/.65 |
| Soggetto topico |
Amino acids - Metabolism
Amino Acids, Peptides, and Proteins Metabolic Phenomena Drugs Metabolism Amino Acids |
| ISBN |
1-118-35818-X
1-283-54246-3 9786613854919 1-118-35817-1 1-118-35751-5 1-118-35819-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
1.4.1 Purine synthesis 1.4.1.1 Phosphoribosyl pyrophosphate (PRPP) synthetase; 1.4.1.2 PRPP amidotransferase; 1.4.2 Purine catabolism and salvage; 1.4.2.1 Adenosine deaminase deficiency - severe combined immune deficiency; 1.4.2.2 Gout and hyperuricaemia; 1.4.2.3 HGPRT deficiency - the Lesch-Nyhan syndrome; 1.4.3 Pyrimidine synthesis; 1.4.3.1 Orotic aciduria; 1.4.4 Pyrimidine catabolism and salvage; 1.5 Deamination of amino acids; 1.5.1 Amino acid oxidases; 1.5.2 Amine oxidases; 1.5.3 Glutamate and alanine dehydrogenases; 1.5.4 Non-oxidative deamination of amino acids
1.5.5 Glutaminase and asparaginase 1.6 Excretion of nitrogenous waste; 1.6.1 Uricotelic and purinotelic species; 1.6.2 Ureotelic species; 1.6.2.1 Urea synthesis; 1.6.2.2 Inborn errors of metabolism affecting the urea synthesis cycle; 1.6.2.3 Entero-hepatic circulation of urea; 1.6.2.4 Canavanine; 1.7 Other nitrogenous compounds in human urine; 1.7.1 Aminoacidurias; Further reading; 2: Nitrogen Balance and Protein Turnover - Protein and Amino Acids in Human Nutrition; 2.1 Nitrogen balance and protein requirements; 2.1.1 Protein digestion and absorption 2.1.2 Protein digestibility and unavailable amino acids in dietary proteins 2.1.3 Obligatory nitrogen losses; 2.1.4 Dynamic equilibrium and tissue protein turnover; 2.1.5 Tissue protein catabolism; 2.1.5.1 Lysosomal autophagy; 2.1.5.2 Ubiquitin and the proteasome; 2.1.5.3 Active site proteolysis of apo-enzymes; 2.1.6 Whole body protein turnover; 2.1.6.1 The constant infusion, labelled precursor method; 2.1.6.2 The constant infusion, labelled end product method; 2.1.6.3 Rates of whole-body protein turnover; 2.1.6.4 The catabolic drive and amino acid oxidation 2.1.6.5 The energy cost of protein turnover |
| Record Nr. | UNINA-9910139693803321 |
|
Bender David A
|
||
| Hoboken, : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Amino Acid Metabolism
| Amino Acid Metabolism |
| Autore | Bender David A |
| Edizione | [3rd ed.] |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2012 |
| Descrizione fisica | 1 online resource (480 p.) |
| Disciplina |
572.65
572/.65 |
| Soggetto topico |
Amino acids - Metabolism
Amino Acids, Peptides, and Proteins Metabolic Phenomena Drugs Metabolism Amino Acids |
| ISBN |
1-118-35818-X
1-283-54246-3 9786613854919 1-118-35817-1 1-118-35751-5 1-118-35819-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
1.4.1 Purine synthesis 1.4.1.1 Phosphoribosyl pyrophosphate (PRPP) synthetase; 1.4.1.2 PRPP amidotransferase; 1.4.2 Purine catabolism and salvage; 1.4.2.1 Adenosine deaminase deficiency - severe combined immune deficiency; 1.4.2.2 Gout and hyperuricaemia; 1.4.2.3 HGPRT deficiency - the Lesch-Nyhan syndrome; 1.4.3 Pyrimidine synthesis; 1.4.3.1 Orotic aciduria; 1.4.4 Pyrimidine catabolism and salvage; 1.5 Deamination of amino acids; 1.5.1 Amino acid oxidases; 1.5.2 Amine oxidases; 1.5.3 Glutamate and alanine dehydrogenases; 1.5.4 Non-oxidative deamination of amino acids
1.5.5 Glutaminase and asparaginase 1.6 Excretion of nitrogenous waste; 1.6.1 Uricotelic and purinotelic species; 1.6.2 Ureotelic species; 1.6.2.1 Urea synthesis; 1.6.2.2 Inborn errors of metabolism affecting the urea synthesis cycle; 1.6.2.3 Entero-hepatic circulation of urea; 1.6.2.4 Canavanine; 1.7 Other nitrogenous compounds in human urine; 1.7.1 Aminoacidurias; Further reading; 2: Nitrogen Balance and Protein Turnover - Protein and Amino Acids in Human Nutrition; 2.1 Nitrogen balance and protein requirements; 2.1.1 Protein digestion and absorption 2.1.2 Protein digestibility and unavailable amino acids in dietary proteins 2.1.3 Obligatory nitrogen losses; 2.1.4 Dynamic equilibrium and tissue protein turnover; 2.1.5 Tissue protein catabolism; 2.1.5.1 Lysosomal autophagy; 2.1.5.2 Ubiquitin and the proteasome; 2.1.5.3 Active site proteolysis of apo-enzymes; 2.1.6 Whole body protein turnover; 2.1.6.1 The constant infusion, labelled precursor method; 2.1.6.2 The constant infusion, labelled end product method; 2.1.6.3 Rates of whole-body protein turnover; 2.1.6.4 The catabolic drive and amino acid oxidation 2.1.6.5 The energy cost of protein turnover |
| Record Nr. | UNINA-9910820769603321 |
|
Bender David A
|
||
| Hoboken, : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Body Composition in Sport, Exercise and Health [[electronic resource]]
| Body Composition in Sport, Exercise and Health [[electronic resource]] |
| Autore | Stewart Arthur D |
| Pubbl/distr/stampa | Hoboken, : Taylor and Francis, 2012 |
| Descrizione fisica | 1 online resource (241 p.) |
| Disciplina |
612.044
613.7 |
| Altri autori (Persone) | SuttonLaura |
| Soggetto topico |
Body composition
MEDICAL / Nutrition MEDICAL / Sports Medicine Physical fitness Sports - Physiological aspects Sports -- Physiological aspects SPORTS & RECREATION / General Recreation Metabolic Phenomena Biochemical Phenomena Human Activities Musculoskeletal Physiological Processes Body Constitution Physiological Phenomena Leisure Activities Chemical Phenomena Musculoskeletal Physiological Phenomena Musculoskeletal and Neural Physiological Phenomena Exercise Body Composition Sports Medicine Health & Biological Sciences Sports Medicine |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-87428-7
9786613715593 1-136-47830-2 0-203-13304-8 1-136-47829-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
BODY COMPOSITION IN SPORT, EXERCISE AND HEALTH; Copyright; CONTENTS; List of Figures and Tables; Notes on Contributors; Foreword; Preface; Acknowledgements; List of Abbreviations; 1 The concept of body composition and its applications; 2 Laboratory methods of body composition analysis; 3 Portable methods of body composition analysis; 4 Physique: phenotype, somatotype and 3D scanning; 5 Muscle tissue; 6 Bone tissue; 7 Anthropometric surrogates for fatness and health; 8 Body composition change; 9 Body composition in chronic disease and disability
10 Body composition: professional practice and an interdisciplinary toolkieIndex |
| Record Nr. | UNINA-9910453151603321 |
|
Stewart Arthur D
|
||
| Hoboken, : Taylor and Francis, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Body Composition in Sport, Exercise and Health [[electronic resource]]
| Body Composition in Sport, Exercise and Health [[electronic resource]] |
| Autore | Stewart Arthur D |
| Pubbl/distr/stampa | Hoboken, : Taylor and Francis, 2012 |
| Descrizione fisica | 1 online resource (241 p.) |
| Disciplina |
612.044
613.7 |
| Altri autori (Persone) | SuttonLaura |
| Soggetto topico |
Body composition
MEDICAL / Nutrition MEDICAL / Sports Medicine Physical fitness Sports - Physiological aspects Sports -- Physiological aspects SPORTS & RECREATION / General Recreation Metabolic Phenomena Biochemical Phenomena Human Activities Musculoskeletal Physiological Processes Body Constitution Physiological Phenomena Leisure Activities Chemical Phenomena Musculoskeletal Physiological Phenomena Musculoskeletal and Neural Physiological Phenomena Exercise Body Composition Sports Medicine Health & Biological Sciences Sports Medicine |
| ISBN |
1-280-87428-7
9786613715593 1-136-47830-2 0-203-13304-8 1-136-47829-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
BODY COMPOSITION IN SPORT, EXERCISE AND HEALTH; Copyright; CONTENTS; List of Figures and Tables; Notes on Contributors; Foreword; Preface; Acknowledgements; List of Abbreviations; 1 The concept of body composition and its applications; 2 Laboratory methods of body composition analysis; 3 Portable methods of body composition analysis; 4 Physique: phenotype, somatotype and 3D scanning; 5 Muscle tissue; 6 Bone tissue; 7 Anthropometric surrogates for fatness and health; 8 Body composition change; 9 Body composition in chronic disease and disability
10 Body composition: professional practice and an interdisciplinary toolkieIndex |
| Record Nr. | UNINA-9910779132603321 |
|
Stewart Arthur D
|
||
| Hoboken, : Taylor and Francis, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Body Composition in Sport, Exercise and Health [[electronic resource]]
| Body Composition in Sport, Exercise and Health [[electronic resource]] |
| Autore | Stewart Arthur D |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, : Taylor and Francis, 2012 |
| Descrizione fisica | 1 online resource (241 p.) |
| Disciplina |
612.044
613.7 |
| Altri autori (Persone) | SuttonLaura |
| Soggetto topico |
Body composition
MEDICAL / Nutrition MEDICAL / Sports Medicine Physical fitness Sports - Physiological aspects Sports -- Physiological aspects SPORTS & RECREATION / General Recreation Metabolic Phenomena Biochemical Phenomena Human Activities Musculoskeletal Physiological Processes Body Constitution Physiological Phenomena Leisure Activities Chemical Phenomena Musculoskeletal Physiological Phenomena Musculoskeletal and Neural Physiological Phenomena Exercise Body Composition Sports Medicine Health & Biological Sciences Sports Medicine |
| ISBN |
1-280-87428-7
9786613715593 1-136-47830-2 0-203-13304-8 1-136-47829-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
BODY COMPOSITION IN SPORT, EXERCISE AND HEALTH; Copyright; CONTENTS; List of Figures and Tables; Notes on Contributors; Foreword; Preface; Acknowledgements; List of Abbreviations; 1 The concept of body composition and its applications; 2 Laboratory methods of body composition analysis; 3 Portable methods of body composition analysis; 4 Physique: phenotype, somatotype and 3D scanning; 5 Muscle tissue; 6 Bone tissue; 7 Anthropometric surrogates for fatness and health; 8 Body composition change; 9 Body composition in chronic disease and disability
10 Body composition: professional practice and an interdisciplinary toolkieIndex |
| Record Nr. | UNINA-9910825127703321 |
|
Stewart Arthur D
|
||
| Hoboken, : Taylor and Francis, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemistry and Biochemistry of Oxygen Therapeutics [[electronic resource] ] : From Transfusion to Artificial Blood
| Chemistry and Biochemistry of Oxygen Therapeutics [[electronic resource] ] : From Transfusion to Artificial Blood |
| Autore | Mozzarelli Andrea |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2011 |
| Descrizione fisica | 1 online resource (476 p.) |
| Disciplina |
615.8/36
615.836 |
| Altri autori (Persone) | BettatiStefano |
| Soggetto topico |
Hemoglobins - therapeutic use
Hemoglobins -- therapeutic use Nitric oxide - Physiological effect Nitric oxide -- Physiological effect Oxigen - Physiological effect Oxigen -- Physiological effect Oxygen - blood Oxygen -- blood Oxygen Consumption Oxygen Inhalation Therapy - methods Oxygen Inhalation Therapy -- methods Oxygen therapy SCIENCE / Life Sciences / Biochemistry Oxygen therapy - Physiological effect Oxygen - Physiological effect Nitric oxide Metabolic Phenomena Respiratory Therapy Investigative Techniques Body Fluids Globins Chalcogens Blood Proteins Gases Therapeutics Fluids and Secretions Elements Hemeproteins Inorganic Chemicals Proteins Amino Acids, Peptides, and Proteins Anatomy Oxygen Blood Hemoglobins Methods Oxygen Inhalation Therapy Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-283-17785-4
9786613177858 1-119-97542-5 1-119-97543-3 |
| Classificazione | SCI007000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Chemistry and Biochemistry of Oxygen Therapeutics; Contents; List of Contributors; Preface; 1. Introduction; References; Part I. Oxygen: Chemistry, Biochemistry, Physiology and Toxicity; 2. Hemoglobin Reactivity and Regulation; 2.1 Introduction; 2.2 Oxygen Loading and Transport; 2.3 NO Reactivity with Hb; 2.4 Hb Oxidation; 2.5 Nitrite Reactivity with Hb; 2.6 Amino-acid Determinants of Hb Reactivity: Natural and Engineered Hbs; 2.6.1 Modulation of Oxygen Affinity and Cooperativity; 2.6.2 NO Reactivity and Oxidation; 2.7 Conclusion; Acknowledgments; References
3. The Major Physiological Control Mechanisms of Blood Flow and Oxygen Delivery3.1 Introduction; 3.2 Autoregulation of Blood Flow to Changes in Perfusion Pressure; 3.3 Metabolic Regulation of Blood Flow; 3.4 O2 Transport; 3.5 O2 Delivery; 3.6 Endothelial Control of Vasomotor Tone; 3.7 Effect of Cell-free Hb on Endothelial Function; 3.8 Hypoxic Hypoxia; 3.9 Carbon Monoxide Hypoxia; 3.10 Anemia; 3.11 Conclusion; References; 4. The Main Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen; 4.1 Introduction; 4.2 Role of Mammalian Mb in O2 Homeostasis 4.3 WhatLfs Missing in the Mb Knockout Mouse4.4 Evolutionary Origins of Mb and the Nitrogen Cycle; 4.5 Human Hb: Evolved Sensor of pO2 and Redox; 4.6 Broad Reactivity and Influence of NO: Lessons from the Microcosm Hb; 4.7 Some Fish Demonstrate a Fundamental "Need" for Hb-dependent NO Cycling, as in Humans; 4.8 Reactions of NO with Hb that Preserve NO Bioactivity; 4.9 Mammalian RBC/Hb.NO Interactions; 4.10 A Mutant Mouse Challenges the SNO-Hb Hypothesis, but does not Overthrow it; 4.11 Signaling by Hb-derived SNO: A Metabolically Responsive, Regulated Pathway 4.12 Signaling by Hb-derived SNO: Pathway Complexity Revealed by Multiple Defects in Disease States4.13 Therapeutic Implications of the Hb.NO Signaling System; 4.14 HBOCs, NO, and SNO; 4.15 Other Gaseous Hb Ligands of Potential Therapeutic Significance; 4.16 NO-related Enzymatic Activities of Hb: Reconciling Nitrite Reductase and SNO Synthase Functions; 4.17 Measuring Biologically Relevant Hb.NO Adducts; 4.18 Conclusion; Acknowledgments; References; 5. The Role of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury; 5.1 Introduction 5.2 Redox System and Free Radicals in Biological Systems5.3 Pathophysiology of Ischemia/Reperfusion Injury; 5.3.1 Cell Death; 5.3.2 The Inflammatory Response; 5.4 Protection Against I/R Injury; 5.4.1 Ischemic Pre- and Post-conditioning; 5.4.2 Pharmacological Conditioning; 5.4.2.1 The Protective Role of ROS and Antioxidants; 5.4.2.2 The Protective Role of NO; 5.4.2.3 NO-based Therapies for I/R Injury; 5.5 Conclusion; Acknowledgments; References; Part II. Medical Needs for Oxygen Supply; 6. Acute Traumatic Hemorrhage and Anemia; 6.1 Introduction; 6.2 Blood Transfusion in Trauma 6.2.1 Massive Transfusion |
| Record Nr. | UNINA-9910139631203321 |
|
Mozzarelli Andrea
|
||
| Hoboken, : Wiley, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cholesterol Regulation of Ion Channels and Receptors [[electronic resource]]
| Cholesterol Regulation of Ion Channels and Receptors [[electronic resource]] |
| Autore | Levitan Irena |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2012 |
| Descrizione fisica | 1 online resource (324 p.) |
| Disciplina |
572.5795
612.1/2 612.12 |
| Altri autori (Persone) | BarrantesFrancisco |
| Soggetto topico |
Cholesterol - metabolism
Cholesterol -- metabolism Ion Channels - metabolism Ion Channels -- metabolism Membrane Proteins - metabolism Membrane Proteins -- metabolism Cholesterol - Metabolism Ion channels - Metabolism Membrane proteins - Metabolism Proteins Membrane Glycoproteins Sterols Membrane Transport Proteins Metabolic Phenomena Cholestenes Amino Acids, Peptides, and Proteins Carrier Proteins Cholestanes Membrane Lipids Lipids Steroids Drugs Polycyclic Compounds Cholesterol Ion Channels Metabolism Membrane Proteins Human Anatomy & Physiology Health & Biological Sciences Animal Biochemistry |
| ISBN |
1-280-87984-X
9786613721150 1-118-34230-5 1-118-34231-3 1-118-34228-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CHOLESTEROL REGULATION OF ION CHANNELS AND RECEPTORS; CONTENTS; FOREWORD; PREFACE; CONTRIBUTORS; I CHOLESTEROL REGULATION OF MEMBRANE PROPERTIES; 1 CHOLESTEROL TRAFFICKING AND DISTRIBUTION BETWEEN CELLULAR MEMBRANES; 1.1 CHOLESTEROL-AN ESSENTIAL LIPID FOR NORMAL CELL FUNCTION; 1.2 CHOLESTEROL METABOLISM, SENSING, AND DISTRIBUTION BETWEEN CELLULAR MEMBRANES; 1.3 HOW DOES CHOLESTEROL ENTER MAMMALIAN CELLS?; 1.4 VESICULAR CHOLESTEROL TRAFFICKING ALONG THE ENDOCYTIC AND SECRETORY PATHWAY; 1.5 NONVESICULAR CHOLESTEROL TRANSPORT; 1.6 CHOLESTEROL EFFLUX FROM CELLS; REFERENCES
2 CHOLESTEROL REGULATION OF MEMBRANE PROTEIN FUNCTION BY CHANGES IN BILAYER PHYSICAL PROPERTIES-AN ENERGETIC PERSPECTIVE2.1 INTRODUCTION; 2.2 CHOLESTEROL REGULATION OF MEMBRANE PROTEINS: POSSIBLE MECHANISMS; 2.3 PROTEIN REGULATION BY CHOLESTEROL-INDUCED CHANGES IN BILAYER PHYSICAL PROPERTIES; 2.4 CHOLESTEROL-INDUCED CHANGES IN DGIII bilayer - QUANTITATIVE ESTIMATES; 2.5 METHODS FOR IDENTIFYING PROTEIN REGULATION BY CHANGES IN BILAYER PHYSICAL PROPERTIES; 2.6 CHOLESTEROL REGULATION OF MEMBRANE PROTEINS IN LIVING CELLS 2.7 PHYSIOLOGICAL ROLE OF CHOLESTEROL-INDUCED CHANGES IN BILAYER PHYSICAL PROPERTIES2.8 CONCLUSION; REFERENCES; II CHOLESTEROL REGULATION OF ION CHANNELS; 3 INSIGHTS INTO STRUCTURAL DETERMINANTS OF CHOLESTEROL SENSITIVITY OF KIR CHANNELS; 3.1 INTRODUCTION; 3.2 CHOLESTEROL SUPPRESSES Kir2 ACTIVITY IN VITRO AND IN VIVO; 3.3 EVIDENCE FOR SPECIFIC STEROL-PROTEIN INTERACTIONS IN THE REGULATION OF Kir CHANNELS; 3.4 STRUCTURAL DETERMINANTS OF CHOLESTEROL SENSITIVITY OF Kir2 CHANNELS; 3.5 PHYSIOLOGICAL IMPACT OF CHOLESTEROL-INDUCED SUPPRESSION OF KIR2 CHANNELS 3.6 CONCLUDING REMARKS AND FUTURE DIRECTIONSACKNOWLEDGMENTS; REFERENCES; 4 ROLE OF LIPID RAFTS IN THE REGULATION OF STORE-OPERATED CA2+ CHANNELS; 4.1 INTRODUCTION; 4.2 MOLECULAR COMPONENTS OF SOCE; 4.3 LIPID RAFT DOMAINS AND CAVEOLAE; 4.4 THE ROLE OF LIPID RAFT DOMAINS IN THE REGULATION OF TRPC1; 4.5 MOLECULAR COMPLEXITY IN THE REGULATION OF SOCE; 4.6 CONCLUSIONS; REFERENCES; 5 CHOLESTEROL REGULATION OF CARDIAC ION CHANNELS; 5.1 INTRODUCTION; 5.2 EFFECT OF CHOLESTEROL ON CARDIAC EXCITABILITY; 5.3 MECHANISMS OF CHOLESTEROL EFFECTS ON ION CHANNELS 5.4 CHOLESTEROL AS A TARGET FOR THERAPEUTIC AGENTSREFERENCES; 6 DIFFERENTIAL CONTRIBUTION OF BK SUBUNITS TO NONGENOMIC REGULATION OF CHANNEL FUNCTION BY STEROIDS; 6.1 BK CHANNELS AND STEROIDS; 6.2 CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 7 REGULATION OF K+ CHANNELS BY CHOLESTEROL-RICH MEMBRANE DOMAINS IN THE IMMUNE SYSTEM; 7.1 POTASSIUM CHANNELS IN THE IMMUNE SYSTEM; 7.2 REGULATION OF POTASSIUM CHANNELS BY MEMBRANE CHOLESTEROL AND LIPID RAFT MICRODOMAINS; 7.3 LOCALIZATION OF MAJOR VOLTAGE-DEPENDENT Kv1.3 AND Kv1.5 CHANNELS IN CHOLESTEROL-RICH MEMBRANE MICRODOMAINS IN LEUKOCYTES 7.4 MECHANISMS OF ION CHANNEL REGULATION: THE IMMUNOLOGICAL SYNAPSE |
| Record Nr. | UNINA-9910141264403321 |
|
Levitan Irena
|
||
| Hoboken, : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cholesterol Regulation of Ion Channels and Receptors
| Cholesterol Regulation of Ion Channels and Receptors |
| Autore | Levitan Irena |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2012 |
| Descrizione fisica | 1 online resource (324 p.) |
| Disciplina |
572.5795
612.1/2 612.12 |
| Altri autori (Persone) | BarrantesFrancisco |
| Soggetto topico |
Cholesterol - metabolism
Cholesterol -- metabolism Ion Channels - metabolism Ion Channels -- metabolism Membrane Proteins - metabolism Membrane Proteins -- metabolism Cholesterol - Metabolism Ion channels - Metabolism Membrane proteins - Metabolism Proteins Membrane Glycoproteins Sterols Membrane Transport Proteins Metabolic Phenomena Cholestenes Amino Acids, Peptides, and Proteins Carrier Proteins Cholestanes Membrane Lipids Lipids Steroids Drugs Polycyclic Compounds Cholesterol Ion Channels Metabolism Membrane Proteins Human Anatomy & Physiology Health & Biological Sciences Animal Biochemistry |
| ISBN |
1-280-87984-X
9786613721150 1-118-34230-5 1-118-34231-3 1-118-34228-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CHOLESTEROL REGULATION OF ION CHANNELS AND RECEPTORS; CONTENTS; FOREWORD; PREFACE; CONTRIBUTORS; I CHOLESTEROL REGULATION OF MEMBRANE PROPERTIES; 1 CHOLESTEROL TRAFFICKING AND DISTRIBUTION BETWEEN CELLULAR MEMBRANES; 1.1 CHOLESTEROL-AN ESSENTIAL LIPID FOR NORMAL CELL FUNCTION; 1.2 CHOLESTEROL METABOLISM, SENSING, AND DISTRIBUTION BETWEEN CELLULAR MEMBRANES; 1.3 HOW DOES CHOLESTEROL ENTER MAMMALIAN CELLS?; 1.4 VESICULAR CHOLESTEROL TRAFFICKING ALONG THE ENDOCYTIC AND SECRETORY PATHWAY; 1.5 NONVESICULAR CHOLESTEROL TRANSPORT; 1.6 CHOLESTEROL EFFLUX FROM CELLS; REFERENCES
2 CHOLESTEROL REGULATION OF MEMBRANE PROTEIN FUNCTION BY CHANGES IN BILAYER PHYSICAL PROPERTIES-AN ENERGETIC PERSPECTIVE2.1 INTRODUCTION; 2.2 CHOLESTEROL REGULATION OF MEMBRANE PROTEINS: POSSIBLE MECHANISMS; 2.3 PROTEIN REGULATION BY CHOLESTEROL-INDUCED CHANGES IN BILAYER PHYSICAL PROPERTIES; 2.4 CHOLESTEROL-INDUCED CHANGES IN DGIII bilayer - QUANTITATIVE ESTIMATES; 2.5 METHODS FOR IDENTIFYING PROTEIN REGULATION BY CHANGES IN BILAYER PHYSICAL PROPERTIES; 2.6 CHOLESTEROL REGULATION OF MEMBRANE PROTEINS IN LIVING CELLS 2.7 PHYSIOLOGICAL ROLE OF CHOLESTEROL-INDUCED CHANGES IN BILAYER PHYSICAL PROPERTIES2.8 CONCLUSION; REFERENCES; II CHOLESTEROL REGULATION OF ION CHANNELS; 3 INSIGHTS INTO STRUCTURAL DETERMINANTS OF CHOLESTEROL SENSITIVITY OF KIR CHANNELS; 3.1 INTRODUCTION; 3.2 CHOLESTEROL SUPPRESSES Kir2 ACTIVITY IN VITRO AND IN VIVO; 3.3 EVIDENCE FOR SPECIFIC STEROL-PROTEIN INTERACTIONS IN THE REGULATION OF Kir CHANNELS; 3.4 STRUCTURAL DETERMINANTS OF CHOLESTEROL SENSITIVITY OF Kir2 CHANNELS; 3.5 PHYSIOLOGICAL IMPACT OF CHOLESTEROL-INDUCED SUPPRESSION OF KIR2 CHANNELS 3.6 CONCLUDING REMARKS AND FUTURE DIRECTIONSACKNOWLEDGMENTS; REFERENCES; 4 ROLE OF LIPID RAFTS IN THE REGULATION OF STORE-OPERATED CA2+ CHANNELS; 4.1 INTRODUCTION; 4.2 MOLECULAR COMPONENTS OF SOCE; 4.3 LIPID RAFT DOMAINS AND CAVEOLAE; 4.4 THE ROLE OF LIPID RAFT DOMAINS IN THE REGULATION OF TRPC1; 4.5 MOLECULAR COMPLEXITY IN THE REGULATION OF SOCE; 4.6 CONCLUSIONS; REFERENCES; 5 CHOLESTEROL REGULATION OF CARDIAC ION CHANNELS; 5.1 INTRODUCTION; 5.2 EFFECT OF CHOLESTEROL ON CARDIAC EXCITABILITY; 5.3 MECHANISMS OF CHOLESTEROL EFFECTS ON ION CHANNELS 5.4 CHOLESTEROL AS A TARGET FOR THERAPEUTIC AGENTSREFERENCES; 6 DIFFERENTIAL CONTRIBUTION OF BK SUBUNITS TO NONGENOMIC REGULATION OF CHANNEL FUNCTION BY STEROIDS; 6.1 BK CHANNELS AND STEROIDS; 6.2 CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 7 REGULATION OF K+ CHANNELS BY CHOLESTEROL-RICH MEMBRANE DOMAINS IN THE IMMUNE SYSTEM; 7.1 POTASSIUM CHANNELS IN THE IMMUNE SYSTEM; 7.2 REGULATION OF POTASSIUM CHANNELS BY MEMBRANE CHOLESTEROL AND LIPID RAFT MICRODOMAINS; 7.3 LOCALIZATION OF MAJOR VOLTAGE-DEPENDENT Kv1.3 AND Kv1.5 CHANNELS IN CHOLESTEROL-RICH MEMBRANE MICRODOMAINS IN LEUKOCYTES 7.4 MECHANISMS OF ION CHANNEL REGULATION: THE IMMUNOLOGICAL SYNAPSE |
| Record Nr. | UNINA-9910823465003321 |
|
Levitan Irena
|
||
| Hoboken, : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Metabolic Phenomena
(27)
- Health & Biological Sciences (22)
- Chemical Phenomena (19)
- Metabolism (18)
- Biochemical Phenomena (14)